TRPM4-IN-1 (CBA) is a potent and selective inhibitor of the cation channel TRPM4, with an IC50 of 1.5 μM. TRPM4-IN-1 can be used for the research of cardiac diseases and prostate cancer[1][2].
体外研究 (In Vitro)
TRPM4-IN-1 (compound 5) is a potent and selective inhibitor of TRPM4 current in TRPM4 overexpressed HEK293 cells[1]. TRPM4-IN-1 reversibly blocks endogenous TRPM4 currents in LNCaP (prostate cancer) cells[1]. TRPM4-IN-1 (50 μM; Overnight) restores functional expression of A432T, a loss‐of‐expression TRPM4 variant[1].
上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
Western Blot Analysis[1]
Cell Line:
HEK293 cells
Concentration:
50 μM
Incubation Time:
Overnight
Result:
Partial rescued the total and surface expression of A432T.
分子量
340.16
Formula
C15H11Cl2NO4
CAS 号
351424-20-9
运输条件
Room temperature in continental US; may vary elsewhere.
[1]. Lijo Cherian Ozhathil, et al. Identification of potent and selective small molecule inhibitors of the cation channel TRPM4. Br J Pharmacol. 2018 Jun; 175(12): 2504–2519.
[2]. Clémence Delalande, et al. Optimizing TRPM4 inhibitors in the MHFP6 chemical space. Eur J Med Chem. 2019 Mar 15;166:167-177.