DK419 is a potent and orally active Wnt/β-catenin signaling inhibitor, with an IC50 of 0.19 μM. DK419 reduces protein lelvels of Axin2, β-catenin, c-Myc, Cyclin D1 and Survivin and induces production of pAMPK[1].
IC50 & Target
Wnt/β-catenin[1]
分子量
407.70
Formula
C16H8ClF6N3O
CAS 号
2102672-22-8
运输条件
Room temperature in continental US; may vary elsewhere.
[1]. Wang J, et al. Identification of DK419, a potent inhibitor of Wnt/β-catenin signaling and colorectal cancer growth. Bioorg Med Chem. 2018 Nov 1;26(20):5435-5442.