Haemanthamine

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Haemanthamine 

Haemanthamine 是从 Amaryllidaceae 植物中分离出来的一种蛇毒碱样生物碱,具有强大的抗癌活性。Haemanthamine 靶向核糖体以在翻译的延长阶段抑制蛋白质的生物合成。Haemanthamine 具有促凋亡,抗氧化剂,抗病毒,抗疟疾和抗惊厥活性。

Haemanthamine

Haemanthamine Chemical Structure

CAS No. : 466-75-1

规格 是否有货
5 mg 询价
10 mg 询价

* Please select Quantity before adding items.

生物活性

Haemanthamine is a crinine-type alkaloid isolated from the Amaryllidaceae plants with potent anticancer activity. Haemanthamine targets ribosomal that inhibits protein biosynthesis during the elongation stage of translation. Haemanthamine has pro-apoptotic, antioxidant, antiviral, antimalarial and anticonvulsant activities[1][2].

体外研究
(In Vitro)

Haemanthamine (1-100 µM; 24-48 hours; A2780 cells) treatment shows a time- and dose-dependent decrease in cell viability[2].
Haemanthamine (10 µM; 24-72 hours; A2780 cells) treatment leads to a significant inhibition of A2780 cell proliferation[2].
Haemanthamine binds at the A-site cleft of the peptidyl transferase center on the large ribosomal subunit, creating unique molecular interactions with the 25S rRNA. Haemanthamine has a highly specific inhibitory effect on pre-rRNA processing, leading to the activation of a p53-dependent antitumoral surveillance pathway known as nucleolar stress[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: A2780 ovarian cancer cells
Concentration: 1 µM, 10 µM, 50 µM, 100 µM
Incubation Time: 24 hours, 48 hours
Result: Showed a time- and dose-dependent decrease in cell viability.

Cell Proliferation Assay[2]

Cell Line: A2780 ovarian cancer cells
Concentration: 10 µM
Incubation Time: 24 hours, 48 hours, 72 hours
Result: Led to a significant inhibition of A2780 cell proliferation.

体内研究
(In Vivo)

A pharmacokinetic study of Haemanthamine in rats shows a rapid distribution phase of 30 min, a half-life of 70.4 min, and a major clearance through renal elimination. The high distribution volume of 13.7 L/kg suggests a high intracellular penetration, and its plasmatic concentration remains higher than 1 μM for at least 1 hr after a single 10-mg/kg administration[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

301.34

Formula

C17H19NO4

CAS 号

466-75-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Pellegrino S, et al. The Amaryllidaceae Alkaloid Haemanthamine Binds the Eukaryotic Ribosome to Repress Cancer Cell Growth. Structure. 2018 Mar 6;26(3):416-425.e4.

    [2]. Seifrtová M, et al. Haemanthamine alters sodium butyrate-induced histone acetylation, p21WAF1/Cip1 expression, Chk1 and Chk2 activation and leads to increased growth inhibition and death in A2780 ovarian cancer cells. Phytomedicine. 2017 Nov 15;35:1-10.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Haemanthamine hydrochloride

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Haemanthamine hydrochloride 

Haemanthamine hydrochloride 是从 Amaryllidaceae 植物中分离出来的一种蛇毒碱样生物碱,具有强大的抗癌活性。Haemanthamine hydrochloride 靶向核糖体以在翻译的延长阶段抑制蛋白质的生物合成。Haemanthamine hydrochloride 具有促凋亡,抗氧化剂,抗病毒,抗疟疾和抗惊厥活性。

Haemanthamine hydrochloride

Haemanthamine hydrochloride Chemical Structure

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

Haemanthamine hydrochloride is a crinine-type alkaloid isolated from the Amaryllidaceae plants with potent anticancer activity. Haemanthamine hydrochloride targets ribosomal that inhibits protein biosynthesis during the elongation stage of translation. Haemanthamine hydrochloride has pro-apoptotic, antioxidant, antiviral, antimalarial and anticonvulsant activities[1][2].

体外研究
(In Vitro)

Haemanthamine (1-100 µM; 24-48 hours; A2780 cells) treatment shows a time- and dose-dependent decrease in cell viability[2].
Haemanthamine (10 µM; 24-72 hours; A2780 cells) treatment leads to a significant inhibition of A2780 cell proliferation[2].
Haemanthamine binds at the A-site cleft of the peptidyl transferase center on the large ribosomal subunit, creating unique molecular interactions with the 25S rRNA. Haemanthamine has a highly specific inhibitory effect on pre-rRNA processing, leading to the activation of a p53-dependent antitumoral surveillance pathway known as nucleolar stress[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: A2780 ovarian cancer cells
Concentration: 1 µM, 10 µM, 50 µM, 100 µM
Incubation Time: 24 hours, 48 hours
Result: Showed a time- and dose-dependent decrease in cell viability.

Cell Proliferation Assay[2]

Cell Line: A2780 ovarian cancer cells
Concentration: 1 µM, 10 µM, 50 µM, 100 µM
Incubation Time: 24 hours, 48 hours, 72 hours
Result: Led to a significant inhibition of A2780 cell proliferation.

体内研究
(In Vivo)

A pharmacokinetic study of Haemanthamine in rats shows a rapid distribution phase of 30 min, a half-life of 70.4 min, and a major clearance through renal elimination. The high distribution volume of 13.7 L/kg suggests a high intracellular penetration, and its plasmatic concentration remains higher than 1 μM for at least 1 hr after a single 10-mg/kg administration[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

337.80

Formula

C17H20ClNO4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Pellegrino S, et al. The Amaryllidaceae Alkaloid Haemanthamine Binds the Eukaryotic Ribosome to Repress Cancer Cell Growth. Structure. 2018 Mar 6;26(3):416-425.e4.

    [2]. Seifrtová M, et al. Haemanthamine alters sodium butyrate-induced histone acetylation, p21WAF1/Cip1 expression, Chk1 and Chk2 activation and leads to increased growth inhibition and death in A2780 ovarian cancer cells. Phytomedicine. 2017 Nov 15;35:1-10.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Haemanthamine

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Haemanthamine 

Haemanthamine 是从 Amaryllidaceae 植物中分离出来的一种蛇毒碱样生物碱,具有强大的抗癌活性。Haemanthamine 靶向核糖体以在翻译的延长阶段抑制蛋白质的生物合成。Haemanthamine 具有促凋亡,抗氧化剂,抗病毒,抗疟疾和抗惊厥活性。

Haemanthamine

Haemanthamine Chemical Structure

CAS No. : 466-75-1

规格 是否有货
5 mg 询价
10 mg 询价

* Please select Quantity before adding items.

生物活性

Haemanthamine is a crinine-type alkaloid isolated from the Amaryllidaceae plants with potent anticancer activity. Haemanthamine targets ribosomal that inhibits protein biosynthesis during the elongation stage of translation. Haemanthamine has pro-apoptotic, antioxidant, antiviral, antimalarial and anticonvulsant activities[1][2].

体外研究
(In Vitro)

Haemanthamine (1-100 µM; 24-48 hours; A2780 cells) treatment shows a time- and dose-dependent decrease in cell viability[2].
Haemanthamine (10 µM; 24-72 hours; A2780 cells) treatment leads to a significant inhibition of A2780 cell proliferation[2].
Haemanthamine binds at the A-site cleft of the peptidyl transferase center on the large ribosomal subunit, creating unique molecular interactions with the 25S rRNA. Haemanthamine has a highly specific inhibitory effect on pre-rRNA processing, leading to the activation of a p53-dependent antitumoral surveillance pathway known as nucleolar stress[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: A2780 ovarian cancer cells
Concentration: 1 µM, 10 µM, 50 µM, 100 µM
Incubation Time: 24 hours, 48 hours
Result: Showed a time- and dose-dependent decrease in cell viability.

Cell Proliferation Assay[2]

Cell Line: A2780 ovarian cancer cells
Concentration: 10 µM
Incubation Time: 24 hours, 48 hours, 72 hours
Result: Led to a significant inhibition of A2780 cell proliferation.

体内研究
(In Vivo)

A pharmacokinetic study of Haemanthamine in rats shows a rapid distribution phase of 30 min, a half-life of 70.4 min, and a major clearance through renal elimination. The high distribution volume of 13.7 L/kg suggests a high intracellular penetration, and its plasmatic concentration remains higher than 1 μM for at least 1 hr after a single 10-mg/kg administration[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

301.34

Formula

C17H19NO4

CAS 号

466-75-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Pellegrino S, et al. The Amaryllidaceae Alkaloid Haemanthamine Binds the Eukaryotic Ribosome to Repress Cancer Cell Growth. Structure. 2018 Mar 6;26(3):416-425.e4.

    [2]. Seifrtová M, et al. Haemanthamine alters sodium butyrate-induced histone acetylation, p21WAF1/Cip1 expression, Chk1 and Chk2 activation and leads to increased growth inhibition and death in A2780 ovarian cancer cells. Phytomedicine. 2017 Nov 15;35:1-10.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Haemanthamine hydrochloride

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Haemanthamine hydrochloride 

Haemanthamine hydrochloride 是从 Amaryllidaceae 植物中分离出来的一种蛇毒碱样生物碱,具有强大的抗癌活性。Haemanthamine hydrochloride 靶向核糖体以在翻译的延长阶段抑制蛋白质的生物合成。Haemanthamine hydrochloride 具有促凋亡,抗氧化剂,抗病毒,抗疟疾和抗惊厥活性。

Haemanthamine hydrochloride

Haemanthamine hydrochloride Chemical Structure

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

Haemanthamine hydrochloride is a crinine-type alkaloid isolated from the Amaryllidaceae plants with potent anticancer activity. Haemanthamine hydrochloride targets ribosomal that inhibits protein biosynthesis during the elongation stage of translation. Haemanthamine hydrochloride has pro-apoptotic, antioxidant, antiviral, antimalarial and anticonvulsant activities[1][2].

体外研究
(In Vitro)

Haemanthamine (1-100 µM; 24-48 hours; A2780 cells) treatment shows a time- and dose-dependent decrease in cell viability[2].
Haemanthamine (10 µM; 24-72 hours; A2780 cells) treatment leads to a significant inhibition of A2780 cell proliferation[2].
Haemanthamine binds at the A-site cleft of the peptidyl transferase center on the large ribosomal subunit, creating unique molecular interactions with the 25S rRNA. Haemanthamine has a highly specific inhibitory effect on pre-rRNA processing, leading to the activation of a p53-dependent antitumoral surveillance pathway known as nucleolar stress[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: A2780 ovarian cancer cells
Concentration: 1 µM, 10 µM, 50 µM, 100 µM
Incubation Time: 24 hours, 48 hours
Result: Showed a time- and dose-dependent decrease in cell viability.

Cell Proliferation Assay[2]

Cell Line: A2780 ovarian cancer cells
Concentration: 1 µM, 10 µM, 50 µM, 100 µM
Incubation Time: 24 hours, 48 hours, 72 hours
Result: Led to a significant inhibition of A2780 cell proliferation.

体内研究
(In Vivo)

A pharmacokinetic study of Haemanthamine in rats shows a rapid distribution phase of 30 min, a half-life of 70.4 min, and a major clearance through renal elimination. The high distribution volume of 13.7 L/kg suggests a high intracellular penetration, and its plasmatic concentration remains higher than 1 μM for at least 1 hr after a single 10-mg/kg administration[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

337.80

Formula

C17H20ClNO4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Pellegrino S, et al. The Amaryllidaceae Alkaloid Haemanthamine Binds the Eukaryotic Ribosome to Repress Cancer Cell Growth. Structure. 2018 Mar 6;26(3):416-425.e4.

    [2]. Seifrtová M, et al. Haemanthamine alters sodium butyrate-induced histone acetylation, p21WAF1/Cip1 expression, Chk1 and Chk2 activation and leads to increased growth inhibition and death in A2780 ovarian cancer cells. Phytomedicine. 2017 Nov 15;35:1-10.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务