标签归档：methylthioadenosine

5′-Methylthioadenosine-13C6(Synonyms: ‘-(Methylthio)-5′-deoxyadenosine-13C6; 5′-Deoxy-5′-(methylthio)adenosine-13C6; 5′-S-Methyl-5’-thioadenosine-13C6)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

5′-Methylthioadenosine-13C6 (Synonyms: ‘-(Methylthio)-5′-deoxyadenosine-13C6; 5′-Deoxy-5′-(methylthio)adenosine-13C6; 5′-S-Methyl-5’-thioadenosine-13C6)

5′-Methylthioadenosine-13C6 是一种 13C 标记的 5′-Methylthioadenosine。5′-Methylthioadenosine (5′-(Methylthio)-5′-deoxyadenosine) 是由 S-腺苷蛋氨酸 (SAM) 在多胺合成过程中生成的核苷。5′-Methylthioadenosine 通过抑制肿瘤细胞增殖、侵袭和诱导细胞凋亡 (apoptosis) 来抑制肿瘤，同时控制肿瘤组织的炎症微环境。5′-Methylthioadenosine 及其相关化合物对肿瘤发生具有显着的调节作用。

5

5′-Methylthioadenosine-13C6 Chemical Structure

CAS No. : 2421187-73-5

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

5′-Methylthioadenosine-13C6 is the 13C-labeled 5′-Methylthioadenosine. 5′-Methylthioadenosine (5′-(Methylthio)-5′-deoxyadenosine) is a nucleoside generated from S-adenosylmethionine (SAM) during polyamine synthesis[1]. 5′-Methylthioadenosine suppresses tumors by inhibiting tumor cell proliferation, invasion, and the induction of apoptosis while controlling the inflammatory micro-environments of tumor tissue. 5′-Methylthioadenosine and its associated materials have striking regulatory effects on tumorigenesis[2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

303.29

Formula

C513C6H15N5O3S
CAS 号

2421187-73-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Tang Y, et al. 5′-Methylthioadenosine attenuates ischemia reperfusion injury after liver transplantation in rats. Inflammation. 2014;37(5):1366-1373.

    [3]. Li Y, et al. 5′-Methylthioadenosine and Cancer: old molecules, new understanding. J Cancer. 2019;10(4):927-936.

    [4]. Tang B, et al. Specific Targeting of MTAP-Deleted Tumors with a Combination of 2′-Fluoroadenine and 5′-Methylthioadenosine. Cancer Res. 2018;78(15):4386-4395.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

5′-Methylthioadenosine-13C6(Synonyms: ‘-(Methylthio)-5′-deoxyadenosine-13C6; 5′-Deoxy-5′-(methylthio)adenosine-13C6; 5′-S-Methyl-5’-thioadenosine-13C6)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

5′-Methylthioadenosine-13C6 (Synonyms: ‘-(Methylthio)-5′-deoxyadenosine-13C6; 5′-Deoxy-5′-(methylthio)adenosine-13C6; 5′-S-Methyl-5’-thioadenosine-13C6)

5′-Methylthioadenosine-13C6 是一种 13C 标记的 5′-Methylthioadenosine。5′-Methylthioadenosine (5′-(Methylthio)-5′-deoxyadenosine) 是由 S-腺苷蛋氨酸 (SAM) 在多胺合成过程中生成的核苷。5′-Methylthioadenosine 通过抑制肿瘤细胞增殖、侵袭和诱导细胞凋亡 (apoptosis) 来抑制肿瘤，同时控制肿瘤组织的炎症微环境。5′-Methylthioadenosine 及其相关化合物对肿瘤发生具有显着的调节作用。

5

5′-Methylthioadenosine-13C6 Chemical Structure

CAS No. : 2421187-73-5

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

5′-Methylthioadenosine-13C6 is the 13C-labeled 5′-Methylthioadenosine. 5′-Methylthioadenosine (5′-(Methylthio)-5′-deoxyadenosine) is a nucleoside generated from S-adenosylmethionine (SAM) during polyamine synthesis[1]. 5′-Methylthioadenosine suppresses tumors by inhibiting tumor cell proliferation, invasion, and the induction of apoptosis while controlling the inflammatory micro-environments of tumor tissue. 5′-Methylthioadenosine and its associated materials have striking regulatory effects on tumorigenesis[2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

303.29

Formula

C513C6H15N5O3S
CAS 号

2421187-73-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Tang Y, et al. 5′-Methylthioadenosine attenuates ischemia reperfusion injury after liver transplantation in rats. Inflammation. 2014;37(5):1366-1373.

    [3]. Li Y, et al. 5′-Methylthioadenosine and Cancer: old molecules, new understanding. J Cancer. 2019;10(4):927-936.

    [4]. Tang B, et al. Specific Targeting of MTAP-Deleted Tumors with a Combination of 2′-Fluoroadenine and 5′-Methylthioadenosine. Cancer Res. 2018;78(15):4386-4395.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

5′-Methylthioadenosine-13C6(Synonyms: ‘-(Methylthio)-5′-deoxyadenosine-13C6; 5′-Deoxy-5′-(methylthio)adenosine-13C6; 5′-S-Methyl-5’-thioadenosine-13C6)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

5′-Methylthioadenosine-13C6 (Synonyms: ‘-(Methylthio)-5′-deoxyadenosine-13C6; 5′-Deoxy-5′-(methylthio)adenosine-13C6; 5′-S-Methyl-5’-thioadenosine-13C6)

5′-Methylthioadenosine-13C6 是一种 13C 标记的 5′-Methylthioadenosine。5′-Methylthioadenosine (5′-(Methylthio)-5′-deoxyadenosine) 是由 S-腺苷蛋氨酸 (SAM) 在多胺合成过程中生成的核苷。5′-Methylthioadenosine 通过抑制肿瘤细胞增殖、侵袭和诱导细胞凋亡 (apoptosis) 来抑制肿瘤，同时控制肿瘤组织的炎症微环境。5′-Methylthioadenosine 及其相关化合物对肿瘤发生具有显着的调节作用。

5

5′-Methylthioadenosine-13C6 Chemical Structure

CAS No. : 2421187-73-5

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

5′-Methylthioadenosine-13C6 is the 13C-labeled 5′-Methylthioadenosine. 5′-Methylthioadenosine (5′-(Methylthio)-5′-deoxyadenosine) is a nucleoside generated from S-adenosylmethionine (SAM) during polyamine synthesis[1]. 5′-Methylthioadenosine suppresses tumors by inhibiting tumor cell proliferation, invasion, and the induction of apoptosis while controlling the inflammatory micro-environments of tumor tissue. 5′-Methylthioadenosine and its associated materials have striking regulatory effects on tumorigenesis[2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

303.29

Formula

C513C6H15N5O3S
CAS 号

2421187-73-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Tang Y, et al. 5′-Methylthioadenosine attenuates ischemia reperfusion injury after liver transplantation in rats. Inflammation. 2014;37(5):1366-1373.

    [3]. Li Y, et al. 5′-Methylthioadenosine and Cancer: old molecules, new understanding. J Cancer. 2019;10(4):927-936.

    [4]. Tang B, et al. Specific Targeting of MTAP-Deleted Tumors with a Combination of 2′-Fluoroadenine and 5′-Methylthioadenosine. Cancer Res. 2018;78(15):4386-4395.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

5′-Methylthioadenosine(Synonyms: 5′-(Methylthio)-5′-deoxyadenosine; 5′-Deoxy-5′-(methylthio)adenosine; 5′-S-Methyl-5′-thioadenosine)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

5′-Methylthioadenosine (Synonyms: 5′-(Methylthio)-5′-deoxyadenosine; 5′-Deoxy-5′-(methylthio)adenosine; 5′-S-Methyl-5′-thioadenosine) 纯度: 99.67%

5′-Methylthioadenosine (5′-(Methylthio)-5′-deoxyadenosine) 是由 S-腺苷蛋氨酸 (SAM) 在多胺合成过程中生成的核苷。5′-Methylthioadenosine 通过抑制肿瘤细胞增殖、侵袭和诱导细胞凋亡 (apoptosis) 来抑制肿瘤，同时控制肿瘤组织的炎症微环境。5′-Methylthioadenosine 及其相关化合物对肿瘤发生具有显着的调节作用。

5

5′-Methylthioadenosine Chemical Structure

CAS No. : 2457-80-9

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥550 In-stock
25 mg ￥500 In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

5′-Methylthioadenosine 相关产品

•相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Apoptosis Compound Library
  • Metabolism/Protease Compound Library
  • Natural Product Library
  • Anti-Cancer Compound Library
  • Human Endogenous Metabolite Compound Library
  • Nucleotide Compound Library
  • Alkaloids Library
  • Gut Microbial Metabolite Library
  • Microbial Metabolite Library
  • Food-Sourced Compound Library

生物活性

5′-Methylthioadenosine (5′-(Methylthio)-5′-deoxyadenosine) is a nucleoside generated from S-adenosylmethionine (SAM) during polyamine synthesis[1]. 5′-Methylthioadenosine suppresses tumors by inhibiting tumor cell proliferation, invasion, and the induction of apoptosis while controlling the inflammatory micro-environments of tumor tissue. 5′-Methylthioadenosine and its associated materials have striking regulatory effects on tumorigenesis[2].

IC50 & Target

Human Endogenous Metabolite

 

Microbial Metabolite

 

体外研究
(In Vitro)

5′-Methylthioadenosine protects MTAP+ cells significantly better than MTAP− cells from 6TG (6′-thioguanine) toxicity[3].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[3]

Cell Line: MTAP+ and MTAP− NIH3T3 cells, isogenic MTAP+ and MTAP− cell line derived from a human HT1080 fibrosarcoma cell line
Concentration: 6TG and 2FA in combination with 10 μM MTA
Incubation Time: 48 hours
Result: Significantly increased IC50 concentration in MTAP+ cells, but no significant change in MTAP− cells.

体内研究
(In Vivo)

The 2FA (2′-fluoroadenine) + MTA (5′-Methylthioadenosine) combination (100 mg/kg MTA; 20 mg/kg 2FA) inhibits tumor growth of four different MTAP− human tumor cell lines in mouse xenograft models[3].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

297.33

Formula

C11H15N5O3S
CAS 号

2457-80-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶解性数据
In Vitro: 

DMSO : 50 mg/mL (168.16 mM; Need ultrasonic)

DMF : 2.5 mg/mL (8.41 mM; Need ultrasonic)

H2O : 1 mg/mL (3.36 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.3633 mL 16.8163 mL 33.6327 mL
5 mM 0.6727 mL 3.3633 mL 6.7265 mL
10 mM 0.3363 mL 1.6816 mL 3.3633 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (8.41 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (8.41 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (8.41 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (8.41 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
  • 3.

    请依序添加每种溶剂： 10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (8.41 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (8.41 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
参考文献

  • [1]. Tang Y, et al. 5′-Methylthioadenosine attenuates ischemia reperfusion injury after liver transplantation in rats. Inflammation. 2014;37(5):1366-1373.

    [2]. Li Y, et al. 5′-Methylthioadenosine and Cancer: old molecules, new understanding. J Cancer. 2019;10(4):927-936.

    [3]. Tang B, et al. Specific Targeting of MTAP-Deleted Tumors with a Combination of 2′-Fluoroadenine and 5′-Methylthioadenosine. Cancer Res. 2018;78(15):4386-4395.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务