标签归档：qinghaosu

Artemisinin-d4(Synonyms: Qinghaosu-d4; NSC 369397-d4)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Artemisinin-d4 (Synonyms: Qinghaosu-d4; NSC 369397-d4)

Artemisinin-d4 (Qinghaosu-d4) 是 Artemisinin 的氘代物。Artemisinin (Qinghaosu) 是一种倍半萜烯内酯，从青蒿 (Artemisia annua L.) 植物的地上部分分离的抗疟疾药物。Artemisinin 以剂量依赖性方式降低 pAKT 来抑制 AKT 信号通路。Artemisinin 可减少癌细胞的增殖，迁移，侵袭，肿瘤发生和转移，同时 Artemisinin 有神经保护作用。

Artemisinin-d4(Synonyms: Qinghaosu-d4; NSC 369397-d4)

Artemisinin-d4 Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Artemisinin-d4 (Qinghaosu-d4) is the deuterium labeled Artemisinin. Artemisinin (Qinghaosu), a sesquiterpene lactone, is an anti-malarial drug isolated from the aerial parts of Artemisia annua L. plants[1]. Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects[2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

286.36

Formula

C15H18D4O5
中文名称

青蒿素 d4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Zeng Z, et al. Artemisinin protects PC12 cells against β-amyloid-induced apoptosis through activation of the ERK1/2 signaling pathway. Redox Biol. 2017 Apr 4;12:625-633.

    [3]. Lin SP, et al. Artemisinin Prevents Glutamate-Induced Neuronal Cell Death Via Akt Pathway Activation. Front Cell Neurosci. 2018 Apr 20;12:108.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Artemisinin-d4(Synonyms: Qinghaosu-d4; NSC 369397-d4)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Artemisinin-d4 (Synonyms: Qinghaosu-d4; NSC 369397-d4)

Artemisinin-d4 (Qinghaosu-d4) 是 Artemisinin 的氘代物。Artemisinin (Qinghaosu) 是一种倍半萜烯内酯，从青蒿 (Artemisia annua L.) 植物的地上部分分离的抗疟疾药物。Artemisinin 以剂量依赖性方式降低 pAKT 来抑制 AKT 信号通路。Artemisinin 可减少癌细胞的增殖，迁移，侵袭，肿瘤发生和转移，同时 Artemisinin 有神经保护作用。

Artemisinin-d4(Synonyms: Qinghaosu-d4; NSC 369397-d4)

Artemisinin-d4 Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Artemisinin-d4 (Qinghaosu-d4) is the deuterium labeled Artemisinin. Artemisinin (Qinghaosu), a sesquiterpene lactone, is an anti-malarial drug isolated from the aerial parts of Artemisia annua L. plants[1]. Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects[2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

286.36

Formula

C15H18D4O5
中文名称

青蒿素 d4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Zeng Z, et al. Artemisinin protects PC12 cells against β-amyloid-induced apoptosis through activation of the ERK1/2 signaling pathway. Redox Biol. 2017 Apr 4;12:625-633.

    [3]. Lin SP, et al. Artemisinin Prevents Glutamate-Induced Neuronal Cell Death Via Akt Pathway Activation. Front Cell Neurosci. 2018 Apr 20;12:108.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Artemisinin-d4(Synonyms: Qinghaosu-d4; NSC 369397-d4)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Artemisinin-d4 (Synonyms: Qinghaosu-d4; NSC 369397-d4)

Artemisinin-d4 (Qinghaosu-d4) 是 Artemisinin 的氘代物。Artemisinin (Qinghaosu) 是一种倍半萜烯内酯，从青蒿 (Artemisia annua L.) 植物的地上部分分离的抗疟疾药物。Artemisinin 以剂量依赖性方式降低 pAKT 来抑制 AKT 信号通路。Artemisinin 可减少癌细胞的增殖，迁移，侵袭，肿瘤发生和转移，同时 Artemisinin 有神经保护作用。

Artemisinin-d4(Synonyms: Qinghaosu-d4; NSC 369397-d4)

Artemisinin-d4 Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Artemisinin-d4 (Qinghaosu-d4) is the deuterium labeled Artemisinin. Artemisinin (Qinghaosu), a sesquiterpene lactone, is an anti-malarial drug isolated from the aerial parts of Artemisia annua L. plants[1]. Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects[2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

286.36

Formula

C15H18D4O5
中文名称

青蒿素 d4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Zeng Z, et al. Artemisinin protects PC12 cells against β-amyloid-induced apoptosis through activation of the ERK1/2 signaling pathway. Redox Biol. 2017 Apr 4;12:625-633.

    [3]. Lin SP, et al. Artemisinin Prevents Glutamate-Induced Neuronal Cell Death Via Akt Pathway Activation. Front Cell Neurosci. 2018 Apr 20;12:108.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Artemisinin(Synonyms: 青蒿素; Qinghaosu; NSC 369397)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Artemisinin (Synonyms: 青蒿素; Qinghaosu; NSC 369397) 纯度: 99.03%

Artemisinin (Qinghaosu) 是一种倍半萜烯内酯，从青蒿 (Artemisia annua L.) 植物的地上部分分离的抗疟疾药物。Artemisinin 以剂量依赖性方式降低 pAKT 来抑制 AKT 信号通路。Artemisinin 可减少癌细胞的增殖，迁移，侵袭，肿瘤发生和转移，同时 Artemisinin 有神经保护作用。

Artemisinin(Synonyms: 青蒿素; Qinghaosu; NSC 369397)

Artemisinin Chemical Structure

CAS No. : 63968-64-9

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1 mL in DMSO ￥737 In-stock
200 mg ￥670 In-stock
500 mg ￥1116 In-stock
1 g   询价  
5 g   询价  

* Please select Quantity before adding items.

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生物活性

Artemisinin (Qinghaosu), a sesquiterpene lactone, is an anti-malarial drug isolated from the aerial parts of Artemisia annua L. plants[1]. Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects[2].

IC50 & Target[2]

pAKT

 

体外研究
(In Vitro)

Artemisinin (Qinghaosu) (25 or 50 μM; 24 hours) concentration-dependently suppresses Aβ25-35 induced cytotoxicity in PC12 cells[1].
Artemisinin (1-100 μM; 24  hours) selectively inhibits cancer cell growth in a dose-dependent manner with IC50 values of 31.30 ± 0.73 μM in UMRC-2 cells and 23.97 ± 0.92 CAKI-2 cells[2].
Artemisinin (25, 50 μM; 24 hours) suppresses the phosphorylation of AKT in UMRC-2 and CAKI-2 cells in a dose-dependent manner[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[1]

Cell Line: PC12 cells
Concentration: 25 or 50 μM
Incubation Time: 24 hours
Result: Protected and rescue PC12 cells against Aβ25-35-induced cell death.

Cell Viability Assay[2]

Cell Line: RCC cells, RCC cell lines UMRC-2 and CAKI-2, and normal renal cell HK-2
Concentration: 1, 5, 10, 50, and 100 μM
Incubation Time: 24 hours
Result: Selectively inhibited cancer cell growth in a dose-dependent manner.

Western Blot Analysis[2]

Cell Line: UMRC-2 and CAKI-2 cells
Concentration: 25, 50 μM
Incubation Time: 24 hours
Result: Decreased pAKT in a dose-dependent manner.

体内研究
(In Vivo)

Artemisinin (gavage; 20 mg/kg/day; for two weeks) suppresses UMRC-2 xenograft tumor growth[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 4-6 weeks old male nude mice[2]
Dosage: 20 mg/kg
Administration: gavage; every day for two weeks
Result: Suppressed UMRC-2 xenograft tumor growth.

Clinical Trial

分子量

282.33

Formula

C15H22O5
CAS 号

63968-64-9
中文名称

青蒿素
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 50 mg/mL (177.10 mM; Need ultrasonic)

H2O : 0.1 mg/mL (0.35 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.5420 mL 17.7098 mL 35.4195 mL
5 mM 0.7084 mL 3.5420 mL 7.0839 mL
10 mM 0.3542 mL 1.7710 mL 3.5420 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (7.37 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (7.37 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (7.37 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (7.37 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
  • 3.

    请依序添加每种溶剂： 10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (7.37 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (7.37 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
参考文献

  • [1]. Zeng Z, et al. Artemisinin protects PC12 cells against β-amyloid-induced apoptosis through activation of the ERK1/2 signaling pathway. Redox Biol. 2017 Apr 4;12:625-633.

    [2]. Lin SP, et al. Artemisinin Prevents Glutamate-Induced Neuronal Cell Death Via Akt Pathway Activation. Front Cell Neurosci. 2018 Apr 20;12:108.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务