标签归档：rel

MC180295(Synonyms: (rel)-MC180295)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

MC180295 (Synonyms: (rel)-MC180295) 纯度: 98.41%

MC180295 ((rel)-MC180295) 是一种有效、选择性的 CDK9-Cyclin T1 抑制剂，IC50 值为 5 nM，对其选择性至少是对其他 CDK 激酶 22 倍。MC180295 ((rel)-MC180295) 同时抑制 GSK-3α 和 GSK-3β。MC180295 具有的抗肿瘤活性。

MC180295(Synonyms: (rel)-MC180295)

MC180295 Chemical Structure

CAS No. : 2237942-08-2

规格 价格 是否有货 数量
5 mg ￥2200 In-stock
10 mg ￥3550 In-stock
25 mg ￥6650 In-stock
50 mg ￥11700 In-stock
100 mg   询价  
200 mg   询价  

* Please select Quantity before adding items.

MC180295 相关产品

•相关化合物库:

  • Bioactive Compound Library Plus
  • Cell Cycle/DNA Damage Compound Library
  • Kinase Inhibitor Library
  • Anti-Cancer Compound Library
  • Anti-Aging Compound Library
  • Anti-Breast Cancer Compound Library
  • Anti-Pancreatic Cancer Compound Library
  • Anti-Blood Cancer Compound Library
  • Targeted Diversity Library

生物活性

MC180295 ((rel)-MC180295) is a potent and selective CDK9-Cyclin T1 inhibitor, with an IC50 of 5 nM, at least 22-fold more selective for CDK9 over other CDKs. MC180295 also inhibits GSK-3α and GSK-3β. MC180295 ((rel)-MC180295) has potent anti-tumor effect[1].

IC50 & Target[1]

CDK9- Cyclin T1

5 nM (IC50)

CDK1-Cyclin B

138 nM (IC50)

cdk2-cyclin A

233 nM (IC50)

cdk2-cyclin E

367 nM (IC50)

CDK3-Cyclin E

399 nM (IC50)

CDK4-Cyclin D

112 nM (IC50)

cdk5-p35

159 nM (IC50)

cdk5-p25

186 nM (IC50)

cdk6-cyclin D3

712 nM (IC50)

CDK7-CycH/MAT1

555 nM (IC50)

体外研究
(In Vitro)

MC180295 is a potent and selective CDK9-Cyclin T1 inhibitor, with an IC50 of 5 nM, at least 22-fold more selective for CDK9 over other CDKs, such as CDK1-Cyclin B (IC50, 138 nM), CDK2-Cyclin A (IC50, 233 nM), CDK2-Cyclin E (IC50, 367 nM), CDK3-Cyclin E (IC50, 399 nM), CDK4-Cyclin D (IC50, 112 nM), CDK5-P35 (IC50, 159 nM), CDK5-P25 (IC50, 186 nM), CDK6-Cyclin D3 (IC50, 712 nM), and CDK7-CycH/MAT1 (IC50, 555 nM). MC180295 also inhibits GSK-3α and GSK-3β[1].
MC180295 (500 nM) reactivates epigenetically silenced genes by targeting CDK9 without affecting DNA methylation[1].
MC180295 (0.1 μM) inhibits the proliferation in cancer cells[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

MC180295 (20 mg/kg, i.p., qod) inhibits significant anti-tumor activity in mice bearing SW48 cells, shows no inhibitory activity against human T cell growth in vivo[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

358.41

Formula

C17H18N4O3S
CAS 号

2237942-08-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
溶解性数据
In Vitro: 

DMSO : 100 mg/mL (279.01 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.7901 mL 13.9505 mL 27.9010 mL
5 mM 0.5580 mL 2.7901 mL 5.5802 mL
10 mM 0.2790 mL 1.3951 mL 2.7901 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Zhang H, et al. Targeting CDK9 Reactivates Epigenetically Silenced Genes in Cancer. Cell. 2018 Nov 15;175(5):1244-1258.e26.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

rel-Biotin-PEG3-C3-NH2

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

rel-Biotin-PEG3-C3-NH2 

rel-Biotin-PEG3-C3-NH2 是一种 PROTAC linker，属于 PEG 类。可用于合成 PROTAC 分子。

rel-Biotin-PEG3-C3-NH2

rel-Biotin-PEG3-C3-NH2 Chemical Structure

CAS No. : 1374658-86-2

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

rel-Biotin-PEG3-C3-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

446.60

Formula

C20H38N4O5S
CAS 号

1374658-86-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

(±)-Catechin(Synonyms: rel-Cianidanol; rel-Catechuic acid)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

(±)-Catechin (Synonyms: rel-Cianidanol; rel-Catechuic acid)

(±)-Catechin (rel-Cianidanol) 是 Catechin 的外消旋体。(±)-Catechin 具有两种形式 (+)-Catechin 及其对映体 (-)-Catechin。(+)-Catechin 抑制环氧合酶-1 (COX-1) 的 IC50 为 1.4 μM。 (±)-Catechin 具有抗肿瘤，抗肥胖，抗糖尿病，抗心血管，抗感染，保肝和神经保护作用。

(±)-Catechin(Synonyms: rel-Cianidanol; rel-Catechuic acid)

(±)-Catechin Chemical Structure

CAS No. : 7295-85-4

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

(±)-Catechin (rel-Cianidanol) is the racemate of Catechin. (±)-Catechin has two steric forms of (+)-Catechin and its enantiomer (-)-Catechin. (+)-Catechin inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM. Anticancer, anti-obesity, antidiabetic, anticardiovascular, anti-infectious, hepatoprotective, and neuroprotective effects[1].

分子量

290.27

Formula

C15H14O6
CAS 号

7295-85-4
中文名称

(±)-儿茶素
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Mamoru Isemura. Catechin in Human Health and Disease. Molecules. 2019 Feb 1;24(3):528.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

(±)-Catechin(Synonyms: rel-Cianidanol; rel-Catechuic acid)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

(±)-Catechin (Synonyms: rel-Cianidanol; rel-Catechuic acid)

(±)-Catechin (rel-Cianidanol) 是 Catechin 的外消旋体。(±)-Catechin 具有两种形式 (+)-Catechin 及其对映体 (-)-Catechin。(+)-Catechin 抑制环氧合酶-1 (COX-1) 的 IC50 为 1.4 μM。 (±)-Catechin 具有抗肿瘤，抗肥胖，抗糖尿病，抗心血管，抗感染，保肝和神经保护作用。

(±)-Catechin(Synonyms: rel-Cianidanol; rel-Catechuic acid)

(±)-Catechin Chemical Structure

CAS No. : 7295-85-4

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

(±)-Catechin (rel-Cianidanol) is the racemate of Catechin. (±)-Catechin has two steric forms of (+)-Catechin and its enantiomer (-)-Catechin. (+)-Catechin inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM. Anticancer, anti-obesity, antidiabetic, anticardiovascular, anti-infectious, hepatoprotective, and neuroprotective effects[1].

分子量

290.27

Formula

C15H14O6
CAS 号

7295-85-4
中文名称

(±)-儿茶素
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Mamoru Isemura. Catechin in Human Health and Disease. Molecules. 2019 Feb 1;24(3):528.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

(±)-Catechin(Synonyms: rel-Cianidanol; rel-Catechuic acid)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

(±)-Catechin (Synonyms: rel-Cianidanol; rel-Catechuic acid)

(±)-Catechin (rel-Cianidanol) 是 Catechin 的外消旋体。(±)-Catechin 具有两种形式 (+)-Catechin 及其对映体 (-)-Catechin。(+)-Catechin 抑制环氧合酶-1 (COX-1) 的 IC50 为 1.4 μM。 (±)-Catechin 具有抗肿瘤，抗肥胖，抗糖尿病，抗心血管，抗感染，保肝和神经保护作用。

(±)-Catechin(Synonyms: rel-Cianidanol; rel-Catechuic acid)

(±)-Catechin Chemical Structure

CAS No. : 7295-85-4

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

(±)-Catechin (rel-Cianidanol) is the racemate of Catechin. (±)-Catechin has two steric forms of (+)-Catechin and its enantiomer (-)-Catechin. (+)-Catechin inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM. Anticancer, anti-obesity, antidiabetic, anticardiovascular, anti-infectious, hepatoprotective, and neuroprotective effects[1].

分子量

290.27

Formula

C15H14O6
CAS 号

7295-85-4
中文名称

(±)-儿茶素
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Mamoru Isemura. Catechin in Human Health and Disease. Molecules. 2019 Feb 1;24(3):528.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

rel-Zotatifin(Synonyms: rel-eFT226)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

rel-Zotatifin (Synonyms: rel-eFT226)

reli -Zotatifin是Zotatifin的外消旋异构体，作为eIF4A抑制剂，活性小于Zotatifin。Zotatifin (eFT226) 是一种有效，选择性和耐受性良好的 eIF4A 抑制剂。Zotatifin 可促进 eIF4A 与 5′-UTRs 中具有识别基序的特定 mRNA 序列结合 (IC50=2 nM)，并干扰 eIF4F 起始复合物的组装。

rel-Zotatifin(Synonyms: rel-eFT226)

rel-Zotatifin Chemical Structure

CAS No. : 2098191-54-7

规格 价格 是否有货 数量
1 mg ￥6500 In-stock
5 mg ￥18500 In-stock
10 mg   询价  
50 mg   询价  

* Please select Quantity before adding items.

rel-Zotatifin 相关产品

•相关化合物库:

  • Bioactive Compound Library Plus

生物活性

rel-Zotatifin is the racemic isomer of Zotatifin, acts as an eIF4A inhibitor with activity less than Zotatifin. Zotatifin (eFT226) is a potent, selective, and well-tolerated eIF4A inhibitor. Zotatifin promotes eIF4A binding to specific mRNA sequences with recognition motifs in the 5’-UTRs (IC50=2 nM) and interferes with the assembly of the eIF4F initiation complex[1].

分子量

487.55

Formula

C28H29N3O5
CAS 号

2098191-54-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献

  • [1]. Peggy A. Thompson, et al. Preclinical Evaluation of eFT226, a Novel, Potent and Selective eIF4A Inhibitor with Anti-tumor Activity in B-cell Malignancies.

    [2]. Gordon DE, et al. A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.Nature. 2020 Apr 30.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务