标签归档：silybin

Silybin(Synonyms: 水飞蓟宾)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Silybin (Synonyms: 水飞蓟宾)

Silybin 是一种从草蓟 (Silybum marianum) 种子中分离出来的黄素寡糖。Silybin 诱导凋亡 (apoptosis)，并具有保肝，抗氧化，抗炎，抗癌活性。

Silybin(Synonyms: 水飞蓟宾)

Silybin Chemical Structure

CAS No. : 802918-57-6

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

Silybin is a flavonolignan isolated from milk thistle (Silybum marianum) seeds. Silybin induces apoptosis and exhibits hepatoprotective, antioxidant, anti-inflammatory, anti-cancer activity[1][2].

体外研究
(In Vitro)

Silybin (0-200 mM; for 72 hours) has growth inhibition in a time- and dose-dependent manner[1].
Silybin (68 μM; for 72 hours) induces apoptosis and increases the cells in G1-phase of ~22%[1].
Silybin (68 μM; for 72 hours) induces AKT activity inhibition[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: HepG2 cell growth
Concentration: 0-200 mM
Incubation Time: For 72 hours
Result: Had growth inhibition in a time- and dose-dependent manner with an IC50 of 68 μM.

Apoptosis Analysis[1]

Cell Line: HepG2 cell growth
Concentration: 68 μM
Incubation Time: For 72 hours
Result: Induced apoptosis in a higher number of cells (60%) when compared to untreated cells.

Cell Cycle Analysis[1]

Cell Line: HepG2 cell growth
Concentration: 68 μM
Incubation Time: For 72 hours
Result: Increased the cells in G1-phase of ~22% and decreased of 47% the cells in S-phase.

Western Blot Analysis[1]

Cell Line: HepG2 cell growth
Concentration: 68 μM
Incubation Time: For 72 hours
Result: Induced AKT activity inhibition.

体内研究
(In Vivo)

Silybin (50, 100 mg/kg/day; given intragastrically for the last 4 weeks) significantly lowers both serum and hepatic lipid accumulation[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6J mice (6-8 weeks old) with nonalcoholic fatty liver disease (NAFLD)[2]
Dosage: 50, 100 mg/kg
Administration: Given intragastrically; daily; for the last 4 weeks
Result: Significantly lowered both serum and hepatic lipid accumulation.

Clinical Trial

分子量

482.44

Formula

C25H22O10
CAS 号

802918-57-6
中文名称

水飞蓟宾
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Silvia Zappavigna, et al. Silybin-Induced Apoptosis Occurs in Parallel to the Increase of Ceramides Synthesis and miRNAs Secretion in Human Hepatocarcinoma Cells. Int J Mol Sci. 2019 May 3;20(9):2190.

    [2]. Runbin Sun, et al. Silybin ameliorates hepatic lipid accumulation and modulates global metabolism in an NAFLD mouse model. Biomed Pharmacother. 2020 Mar;123:109721.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Silybin(Synonyms: 水飞蓟宾)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Silybin (Synonyms: 水飞蓟宾)

Silybin 是一种从草蓟 (Silybum marianum) 种子中分离出来的黄素寡糖。Silybin 诱导凋亡 (apoptosis)，并具有保肝，抗氧化，抗炎，抗癌活性。

Silybin(Synonyms: 水飞蓟宾)

Silybin Chemical Structure

CAS No. : 802918-57-6

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

Silybin is a flavonolignan isolated from milk thistle (Silybum marianum) seeds. Silybin induces apoptosis and exhibits hepatoprotective, antioxidant, anti-inflammatory, anti-cancer activity[1][2].

体外研究
(In Vitro)

Silybin (0-200 mM; for 72 hours) has growth inhibition in a time- and dose-dependent manner[1].
Silybin (68 μM; for 72 hours) induces apoptosis and increases the cells in G1-phase of ~22%[1].
Silybin (68 μM; for 72 hours) induces AKT activity inhibition[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: HepG2 cell growth
Concentration: 0-200 mM
Incubation Time: For 72 hours
Result: Had growth inhibition in a time- and dose-dependent manner with an IC50 of 68 μM.

Apoptosis Analysis[1]

Cell Line: HepG2 cell growth
Concentration: 68 μM
Incubation Time: For 72 hours
Result: Induced apoptosis in a higher number of cells (60%) when compared to untreated cells.

Cell Cycle Analysis[1]

Cell Line: HepG2 cell growth
Concentration: 68 μM
Incubation Time: For 72 hours
Result: Increased the cells in G1-phase of ~22% and decreased of 47% the cells in S-phase.

Western Blot Analysis[1]

Cell Line: HepG2 cell growth
Concentration: 68 μM
Incubation Time: For 72 hours
Result: Induced AKT activity inhibition.

体内研究
(In Vivo)

Silybin (50, 100 mg/kg/day; given intragastrically for the last 4 weeks) significantly lowers both serum and hepatic lipid accumulation[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6J mice (6-8 weeks old) with nonalcoholic fatty liver disease (NAFLD)[2]
Dosage: 50, 100 mg/kg
Administration: Given intragastrically; daily; for the last 4 weeks
Result: Significantly lowered both serum and hepatic lipid accumulation.

Clinical Trial

分子量

482.44

Formula

C25H22O10
CAS 号

802918-57-6
中文名称

水飞蓟宾
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Silvia Zappavigna, et al. Silybin-Induced Apoptosis Occurs in Parallel to the Increase of Ceramides Synthesis and miRNAs Secretion in Human Hepatocarcinoma Cells. Int J Mol Sci. 2019 May 3;20(9):2190.

    [2]. Runbin Sun, et al. Silybin ameliorates hepatic lipid accumulation and modulates global metabolism in an NAFLD mouse model. Biomed Pharmacother. 2020 Mar;123:109721.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Silybin(Synonyms: 水飞蓟宾)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Silybin (Synonyms: 水飞蓟宾)

Silybin 是一种从草蓟 (Silybum marianum) 种子中分离出来的黄素寡糖。Silybin 诱导凋亡 (apoptosis)，并具有保肝，抗氧化，抗炎，抗癌活性。

Silybin(Synonyms: 水飞蓟宾)

Silybin Chemical Structure

CAS No. : 802918-57-6

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

Silybin is a flavonolignan isolated from milk thistle (Silybum marianum) seeds. Silybin induces apoptosis and exhibits hepatoprotective, antioxidant, anti-inflammatory, anti-cancer activity[1][2].

体外研究
(In Vitro)

Silybin (0-200 mM; for 72 hours) has growth inhibition in a time- and dose-dependent manner[1].
Silybin (68 μM; for 72 hours) induces apoptosis and increases the cells in G1-phase of ~22%[1].
Silybin (68 μM; for 72 hours) induces AKT activity inhibition[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: HepG2 cell growth
Concentration: 0-200 mM
Incubation Time: For 72 hours
Result: Had growth inhibition in a time- and dose-dependent manner with an IC50 of 68 μM.

Apoptosis Analysis[1]

Cell Line: HepG2 cell growth
Concentration: 68 μM
Incubation Time: For 72 hours
Result: Induced apoptosis in a higher number of cells (60%) when compared to untreated cells.

Cell Cycle Analysis[1]

Cell Line: HepG2 cell growth
Concentration: 68 μM
Incubation Time: For 72 hours
Result: Increased the cells in G1-phase of ~22% and decreased of 47% the cells in S-phase.

Western Blot Analysis[1]

Cell Line: HepG2 cell growth
Concentration: 68 μM
Incubation Time: For 72 hours
Result: Induced AKT activity inhibition.

体内研究
(In Vivo)

Silybin (50, 100 mg/kg/day; given intragastrically for the last 4 weeks) significantly lowers both serum and hepatic lipid accumulation[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6J mice (6-8 weeks old) with nonalcoholic fatty liver disease (NAFLD)[2]
Dosage: 50, 100 mg/kg
Administration: Given intragastrically; daily; for the last 4 weeks
Result: Significantly lowered both serum and hepatic lipid accumulation.

Clinical Trial

分子量

482.44

Formula

C25H22O10
CAS 号

802918-57-6
中文名称

水飞蓟宾
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Silvia Zappavigna, et al. Silybin-Induced Apoptosis Occurs in Parallel to the Increase of Ceramides Synthesis and miRNAs Secretion in Human Hepatocarcinoma Cells. Int J Mol Sci. 2019 May 3;20(9):2190.

    [2]. Runbin Sun, et al. Silybin ameliorates hepatic lipid accumulation and modulates global metabolism in an NAFLD mouse model. Biomed Pharmacother. 2020 Mar;123:109721.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Silybin B(Synonyms: 水飞蓟宾B)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Silybin B (Synonyms: 水飞蓟宾B) 纯度: ≥99.0%

Silybin B 是从 Silybum marianum 中分离出的一种黄酮木脂素，具有抗肿瘤活性。Silybin B 是水飞蓟素最有效的抗纤维原性和抗低聚物成分，是一种有前景的抗阿尔茨海默病药物候选。

Silybin B(Synonyms: 水飞蓟宾B)

Silybin B Chemical Structure

CAS No. : 142797-34-0

规格 价格 是否有货 数量
1 mg ￥2000 In-stock
5 mg ￥4000 询价
10 mg   询价  
50 mg   询价  

* Please select Quantity before adding items.

生物活性

Silybin B, a flavonolignan separated from Silybum marianum, has anti-tumor activity. Silybin B is the most potent antifibrillogenic and anti-oligomeric component of silymarin and proposes it as a promising anti Alzheimer’s disease drug candidate[1][2].

分子量

482.44

Formula

C25H22O10
CAS 号

142797-34-0
中文名称

水飞蓟宾B
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献

  • [1]. An-Shen Lin, et al. Cancer Preventive Agents. 7. Antitumor-Promoting Effects of Seven Active Flavonolignans from Milk Thistle (Silybum marianum.) on Epstein-Barr Virus Activation, Pharmaceutical Biology, 45:10, 735-738.

    [2]. Sciacca MFM, et al. Inhibition of Aβ Amyloid Growth and Toxicity by Silybins: The Crucial Role of Stereochemistry. ACS Chem Neurosci. 2017 Aug 16;8(8):1767-1778.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务