标签归档：询价

Pericyclivine

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Pericyclivine 

Pericyclivine 是一种从 Catharanthus Roseus 中分离出来的单体吲哚生物碱，具有抗癌作用。

Pericyclivine

Pericyclivine Chemical Structure

CAS No. : 975-77-9

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

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生物活性

Pericyclivine is a monomeric indole alkaloid isolated from Catharanthus Roseus. Pericyclivine has anticancer effects[1][2].

体外研究
(In Vitro)

Pericyclivine shows cytotoxicity against the P-388 cell culture system with an ED50 of 13 μg/mL[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

322.40

Formula

C20H22N2O2
CAS 号

975-77-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. S Mukhopadhyay, et al. Catharanthus Alkaloids. XXXVI. Isolation of Vincaleukoblastine (VLB) and Periformyline From Catharanthus Trichophyllus and Pericyclivine From Catharanthus Roseus. J Nat Prod. May-Jun 1981;44(3):335-9.

    [2]. D G Kingston, et al. Plant Anticancer Agents V: New Bisindole Alkaloids From Tabernaemontana Johnstonii Stem Bark. J Pharm Sci. 1978 Feb;67(2):249-51.

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Pericyclivine

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Pericyclivine 

Pericyclivine 是一种从 Catharanthus Roseus 中分离出来的单体吲哚生物碱，具有抗癌作用。

Pericyclivine

Pericyclivine Chemical Structure

CAS No. : 975-77-9

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

Pericyclivine is a monomeric indole alkaloid isolated from Catharanthus Roseus. Pericyclivine has anticancer effects[1][2].

体外研究
(In Vitro)

Pericyclivine shows cytotoxicity against the P-388 cell culture system with an ED50 of 13 μg/mL[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

322.40

Formula

C20H22N2O2
CAS 号

975-77-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. S Mukhopadhyay, et al. Catharanthus Alkaloids. XXXVI. Isolation of Vincaleukoblastine (VLB) and Periformyline From Catharanthus Trichophyllus and Pericyclivine From Catharanthus Roseus. J Nat Prod. May-Jun 1981;44(3):335-9.

    [2]. D G Kingston, et al. Plant Anticancer Agents V: New Bisindole Alkaloids From Tabernaemontana Johnstonii Stem Bark. J Pharm Sci. 1978 Feb;67(2):249-51.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Pericyclivine

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Pericyclivine 

Pericyclivine 是一种从 Catharanthus Roseus 中分离出来的单体吲哚生物碱，具有抗癌作用。

Pericyclivine

Pericyclivine Chemical Structure

CAS No. : 975-77-9

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

Pericyclivine is a monomeric indole alkaloid isolated from Catharanthus Roseus. Pericyclivine has anticancer effects[1][2].

体外研究
(In Vitro)

Pericyclivine shows cytotoxicity against the P-388 cell culture system with an ED50 of 13 μg/mL[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

322.40

Formula

C20H22N2O2
CAS 号

975-77-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. S Mukhopadhyay, et al. Catharanthus Alkaloids. XXXVI. Isolation of Vincaleukoblastine (VLB) and Periformyline From Catharanthus Trichophyllus and Pericyclivine From Catharanthus Roseus. J Nat Prod. May-Jun 1981;44(3):335-9.

    [2]. D G Kingston, et al. Plant Anticancer Agents V: New Bisindole Alkaloids From Tabernaemontana Johnstonii Stem Bark. J Pharm Sci. 1978 Feb;67(2):249-51.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Igovomab

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Igovomab 

Igovomab 是一种用于成像的单克隆抗体。Igovomab 可用于卵巢癌研究。

Igovomab

Igovomab Chemical Structure

CAS No. : 171656-50-1

规格 是否有货
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250 mg   询价  
500 mg   询价  

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生物活性

Igovomab is a monoclonal antibody for imaging. Igovomab can be used for ovarian cancer research[1].

CAS 号

171656-50-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. John Williams, et al. A monoclonal antibody framework binding interface for meditopes, meditope delivery systems and methods for their use. WO2012048332A2.

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Flutax-2

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Flutax-2 

FLUTAX-2 是紫杉醇的活性荧光衍生物。FLUTAX-2 与聚合的 α,β 微管蛋白二聚体结合。FLUTAX-2 能够稳定 T. gallinae 和 T. foetus 滋养体的微管。

Flutax-2

Flutax-2 Chemical Structure

CAS No. : 301844-13-3

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

FLUTAX-2 is an active fluorescent derivative of Taxol. FLUTAX-2 binds to polymerized α,β-tubulin dimers. FLUTAX-2 is able to stabilize microtubules of intact T. gallinae and T. foetus trophozoites[1].

分子量

1319.27

Formula

C71H64F2N2O21
CAS 号

301844-13-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. P B Vieira, et al. Analysis of microtubule cytoskeleton distribution using a fluorescent taxoid in two trichomonadid protozoa: Trichomonas gallinae and Tritrichomonas foetus. Exp Parasitol. 2008 May;119(1):186-91.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Flutax-2

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Flutax-2 

FLUTAX-2 是紫杉醇的活性荧光衍生物。FLUTAX-2 与聚合的 α,β 微管蛋白二聚体结合。FLUTAX-2 能够稳定 T. gallinae 和 T. foetus 滋养体的微管。

Flutax-2

Flutax-2 Chemical Structure

CAS No. : 301844-13-3

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

FLUTAX-2 is an active fluorescent derivative of Taxol. FLUTAX-2 binds to polymerized α,β-tubulin dimers. FLUTAX-2 is able to stabilize microtubules of intact T. gallinae and T. foetus trophozoites[1].

分子量

1319.27

Formula

C71H64F2N2O21
CAS 号

301844-13-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. P B Vieira, et al. Analysis of microtubule cytoskeleton distribution using a fluorescent taxoid in two trichomonadid protozoa: Trichomonas gallinae and Tritrichomonas foetus. Exp Parasitol. 2008 May;119(1):186-91.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Flutax-2

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Flutax-2 

FLUTAX-2 是紫杉醇的活性荧光衍生物。FLUTAX-2 与聚合的 α,β 微管蛋白二聚体结合。FLUTAX-2 能够稳定 T. gallinae 和 T. foetus 滋养体的微管。

Flutax-2

Flutax-2 Chemical Structure

CAS No. : 301844-13-3

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

FLUTAX-2 is an active fluorescent derivative of Taxol. FLUTAX-2 binds to polymerized α,β-tubulin dimers. FLUTAX-2 is able to stabilize microtubules of intact T. gallinae and T. foetus trophozoites[1].

分子量

1319.27

Formula

C71H64F2N2O21
CAS 号

301844-13-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. P B Vieira, et al. Analysis of microtubule cytoskeleton distribution using a fluorescent taxoid in two trichomonadid protozoa: Trichomonas gallinae and Tritrichomonas foetus. Exp Parasitol. 2008 May;119(1):186-91.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Symphytine

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Symphytine 

Symphytine 从 Symphytum officinale 中分离出来一种吡啶生物碱，具有致癌性。

Symphytine

Symphytine Chemical Structure

CAS No. : 22571-95-5

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Symphytine is a pyrrolizidine alkaloid isolated from Symphytum officinale and has carcinogenicity[1].
体内研究
(In Vivo)

Symphytine (intraperitoneal injection; 13 mg/kg; 330 days) leads to survival for more than 330 days after the start of injections. Four of 20 rats (20%) had liver tumors: three has hemangioendothelial sarcoma and 1 has liver cell adenoma[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male inbred ACI rats[1]
Dosage: 13 mg/kg
Administration: Intraperitoneal injection; 330 days
Result: Led to hepatic tumor in rats.

分子量

381.46

Formula

C20H31NO6
CAS 号

22571-95-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Hirono,et al.Induction of Hepatic Tumors in Rats by Senkirkine and Symphytine. J Natl Cancer Inst. 1979 Aug;63(2):469-72.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Symphytine

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Symphytine 

Symphytine 从 Symphytum officinale 中分离出来一种吡啶生物碱，具有致癌性。

Symphytine

Symphytine Chemical Structure

CAS No. : 22571-95-5

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Symphytine is a pyrrolizidine alkaloid isolated from Symphytum officinale and has carcinogenicity[1].
体内研究
(In Vivo)

Symphytine (intraperitoneal injection; 13 mg/kg; 330 days) leads to survival for more than 330 days after the start of injections. Four of 20 rats (20%) had liver tumors: three has hemangioendothelial sarcoma and 1 has liver cell adenoma[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male inbred ACI rats[1]
Dosage: 13 mg/kg
Administration: Intraperitoneal injection; 330 days
Result: Led to hepatic tumor in rats.

分子量

381.46

Formula

C20H31NO6
CAS 号

22571-95-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Hirono,et al.Induction of Hepatic Tumors in Rats by Senkirkine and Symphytine. J Natl Cancer Inst. 1979 Aug;63(2):469-72.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Symphytine

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Symphytine 

Symphytine 从 Symphytum officinale 中分离出来一种吡啶生物碱，具有致癌性。

Symphytine

Symphytine Chemical Structure

CAS No. : 22571-95-5

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Symphytine is a pyrrolizidine alkaloid isolated from Symphytum officinale and has carcinogenicity[1].
体内研究
(In Vivo)

Symphytine (intraperitoneal injection; 13 mg/kg; 330 days) leads to survival for more than 330 days after the start of injections. Four of 20 rats (20%) had liver tumors: three has hemangioendothelial sarcoma and 1 has liver cell adenoma[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male inbred ACI rats[1]
Dosage: 13 mg/kg
Administration: Intraperitoneal injection; 330 days
Result: Led to hepatic tumor in rats.

分子量

381.46

Formula

C20H31NO6
CAS 号

22571-95-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Hirono,et al.Induction of Hepatic Tumors in Rats by Senkirkine and Symphytine. J Natl Cancer Inst. 1979 Aug;63(2):469-72.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Cadein1

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Cadein1 

Cadein1 是一种异喹啉衍生物，在p53功能缺失的癌细胞中，可导致 G2/M 延迟和 caspase 依赖的凋亡。

Cadein1

Cadein1 Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

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生物活性

Cadein1, an isoquinolinium derivative, leads to a G2/M delay and caspase-dependent apoptosis in cancer cells with non- functional p53[1].

体外研究
(In Vitro)

Cadein1 may be a potent anti-cancer agent against human cancers, specifically p53-deficient cancers with functional MMR[1].
Cadein1 activates p38 in p53-defective cancer cells with functional MMR to induce cell death. Cadein1 (4 μM) induces p38 phosphorylation in a time-dependent manner in HeLa and HCT116-Ch3/E6 cells [1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

655.64

Formula

C33H48F2INO2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Eun Ryoung Jang, et al. A new isoquinolinium derivative, Cadein1, preferentially induces apoptosis in p53-defective cancer cells with functional mismatch repair via a p38-dependent pathway. J Biol Chem. 2010 Jan 29;285(5):2986-95.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Cadein1

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Cadein1 

Cadein1 是一种异喹啉衍生物，在p53功能缺失的癌细胞中，可导致 G2/M 延迟和 caspase 依赖的凋亡。

Cadein1

Cadein1 Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Cadein1, an isoquinolinium derivative, leads to a G2/M delay and caspase-dependent apoptosis in cancer cells with non- functional p53[1].

体外研究
(In Vitro)

Cadein1 may be a potent anti-cancer agent against human cancers, specifically p53-deficient cancers with functional MMR[1].
Cadein1 activates p38 in p53-defective cancer cells with functional MMR to induce cell death. Cadein1 (4 μM) induces p38 phosphorylation in a time-dependent manner in HeLa and HCT116-Ch3/E6 cells [1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

655.64

Formula

C33H48F2INO2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Eun Ryoung Jang, et al. A new isoquinolinium derivative, Cadein1, preferentially induces apoptosis in p53-defective cancer cells with functional mismatch repair via a p38-dependent pathway. J Biol Chem. 2010 Jan 29;285(5):2986-95.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Cadein1

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Cadein1 

Cadein1 是一种异喹啉衍生物，在p53功能缺失的癌细胞中，可导致 G2/M 延迟和 caspase 依赖的凋亡。

Cadein1

Cadein1 Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Cadein1, an isoquinolinium derivative, leads to a G2/M delay and caspase-dependent apoptosis in cancer cells with non- functional p53[1].

体外研究
(In Vitro)

Cadein1 may be a potent anti-cancer agent against human cancers, specifically p53-deficient cancers with functional MMR[1].
Cadein1 activates p38 in p53-defective cancer cells with functional MMR to induce cell death. Cadein1 (4 μM) induces p38 phosphorylation in a time-dependent manner in HeLa and HCT116-Ch3/E6 cells [1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

655.64

Formula

C33H48F2INO2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Eun Ryoung Jang, et al. A new isoquinolinium derivative, Cadein1, preferentially induces apoptosis in p53-defective cancer cells with functional mismatch repair via a p38-dependent pathway. J Biol Chem. 2010 Jan 29;285(5):2986-95.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Sempervirine

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Sempervirine 

Sempervirine 是从 Gelsemium sempervirens 中分离得到的具有抗肿瘤活性的吲哚生物碱。Sempervirine 抑制 Raji、MDA-MB-231 和 HeLa 的肿瘤细胞 EC50 值分别为 2.7 μM、1.77 μM、1.96 μM。

Sempervirine

Sempervirine Chemical Structure

CAS No. : 549-92-8

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

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生物活性

Sempervirine is an indole alkaloid isolated from Gelsemium sempervirens with anti-tumor activities. Sempervirine is against sempervirine-sensitive tumor cells with EC50 values of 2.7 μM, 1.77 μM, and 1.96 μM for Raji, MDA-MB-231 and HeLa cells, respectively[2].

分子量

272.34

Formula

C19H16N2
CAS 号

549-92-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Noriyuki Kogure, et al. Total synthesis and full NMR assignment of ourouparine, a yohimbane-type indole alkaloid isolated from Gelsemium sempervirens. Journal of Natural Medicines volume 

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Sempervirine

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Sempervirine 

Sempervirine 是从 Gelsemium sempervirens 中分离得到的具有抗肿瘤活性的吲哚生物碱。Sempervirine 抑制 Raji、MDA-MB-231 和 HeLa 的肿瘤细胞 EC50 值分别为 2.7 μM、1.77 μM、1.96 μM。

Sempervirine

Sempervirine Chemical Structure

CAS No. : 549-92-8

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25 mg 询价

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生物活性

Sempervirine is an indole alkaloid isolated from Gelsemium sempervirens with anti-tumor activities. Sempervirine is against sempervirine-sensitive tumor cells with EC50 values of 2.7 μM, 1.77 μM, and 1.96 μM for Raji, MDA-MB-231 and HeLa cells, respectively[2].

分子量

272.34

Formula

C19H16N2
CAS 号

549-92-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Noriyuki Kogure, et al. Total synthesis and full NMR assignment of ourouparine, a yohimbane-type indole alkaloid isolated from Gelsemium sempervirens. Journal of Natural Medicines volume 

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Sempervirine

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Sempervirine 

Sempervirine 是从 Gelsemium sempervirens 中分离得到的具有抗肿瘤活性的吲哚生物碱。Sempervirine 抑制 Raji、MDA-MB-231 和 HeLa 的肿瘤细胞 EC50 值分别为 2.7 μM、1.77 μM、1.96 μM。

Sempervirine

Sempervirine Chemical Structure

CAS No. : 549-92-8

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

Sempervirine is an indole alkaloid isolated from Gelsemium sempervirens with anti-tumor activities. Sempervirine is against sempervirine-sensitive tumor cells with EC50 values of 2.7 μM, 1.77 μM, and 1.96 μM for Raji, MDA-MB-231 and HeLa cells, respectively[2].

分子量

272.34

Formula

C19H16N2
CAS 号

549-92-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Noriyuki Kogure, et al. Total synthesis and full NMR assignment of ourouparine, a yohimbane-type indole alkaloid isolated from Gelsemium sempervirens. Journal of Natural Medicines volume 

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

SU5208

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

SU5208 

SU5208 可抑制血管内皮生长因子受体2 (VEGFR2)。

SU5208

SU5208 Chemical Structure

CAS No. : 62540-08-3

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

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生物活性

SU5208 inhibits vascular endothelial growth factor receptor-2 (VEGFR2)[1].

IC50 & Target[1]

VEGFR2

 

分子量

227.28

Formula

C13H9NOS
CAS 号

62540-08-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Camila Muñoz, et al. Study of differences in the VEGFR2 inhibitory activities between semaxanib and SU5205 using 3D-QSAR, docking, and molecular dynamics simulations. J Mol Graph Model. 2012 Feb;32:39-48.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

LyP-1

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

LyP-1 

LyP-1 是一种环状 9 个氨基酸的肿瘤的定位肽，在多种肿瘤相关细胞中，选择性结合其 p32 receptor 蛋白。

LyP-1

LyP-1 Chemical Structure

CAS No. : 454487-07-1

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

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LyP-1 的其他形式现货产品:

LyP-1 TFA

生物活性

LyP-1 is a cyclic 9‐amino‐acids tumor homing peptide and selectively bind to p32 receptors overexpressed in various tumor-associated cells[1].

体内研究
(In Vivo)

LyP-1 (8 weeks) shows a remarkable reduction in plaque formation and plaque occupation rates in the LyP-1-treated group. In addition, a higher apoptotic rate in macrophages released from hypoxic plaques is observed after the treatment of LyP-1when compared to control peptide[1].
The LyP-1 peptide is labeled with a near-infrared fluorophore (Cy5.5) for optical imaging.
At days 3, 7, 14 and 21 after inoculation with 4T1 cells, tumor-bearing BALB/C mice is injected Cy5.5-LyP-1 (0.8 nmol) through the middle phalanges of the upper extremities of the tumor-bearing mice. The fluorescence intensities were 0.024, 0.038, 0.048 and 0.106×106 photon/cm2/sec respectively at days 3, 7, 14 and 21 after tumor cell inoculation, which are 1.02, 1.63, 2.04, and 4.52-fold higher than in the contralateral LNs. Cy5.5-LyP-1 staining in LNs co-localized with LYVE-1, suggesting lymphatics-specific binding of LyP-1 peptide[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

992.14

Formula

C36H65N17O12S2
CAS 号

454487-07-1
Sequence Shortening

CGNKRTRGC (Disulfide bridge: Cys1-Cys9)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Fan Zhang, et al.Imaging tumor-induced sentinel lymph node lymphangiogenesis with LyP-1 peptide. Amino Acids. 2012 Jun;42(6):2343-51.

    [2]. Ningning Song, et al. Recent progress in LyP-1-based strategies for targeted imaging and therapy. Drug Deliv. 2019 Dec;26(1):363-375.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

SU5208

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

SU5208 

SU5208 可抑制血管内皮生长因子受体2 (VEGFR2)。

SU5208

SU5208 Chemical Structure

CAS No. : 62540-08-3

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

SU5208 inhibits vascular endothelial growth factor receptor-2 (VEGFR2)[1].

IC50 & Target[1]

VEGFR2

 

分子量

227.28

Formula

C13H9NOS
CAS 号

62540-08-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Camila Muñoz, et al. Study of differences in the VEGFR2 inhibitory activities between semaxanib and SU5205 using 3D-QSAR, docking, and molecular dynamics simulations. J Mol Graph Model. 2012 Feb;32:39-48.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

SU5208

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

SU5208 

SU5208 可抑制血管内皮生长因子受体2 (VEGFR2)。

SU5208

SU5208 Chemical Structure

CAS No. : 62540-08-3

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

SU5208 inhibits vascular endothelial growth factor receptor-2 (VEGFR2)[1].

IC50 & Target[1]

VEGFR2

 

分子量

227.28

Formula

C13H9NOS
CAS 号

62540-08-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Camila Muñoz, et al. Study of differences in the VEGFR2 inhibitory activities between semaxanib and SU5205 using 3D-QSAR, docking, and molecular dynamics simulations. J Mol Graph Model. 2012 Feb;32:39-48.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务