TLR7/8 agonist 4

发表于2024年5月19日由上海金畔生物科技有限公司

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

TLR7/8 agonist 4

TLR7/8 agonist 4 (compound 41) 是一种有效的 TLR7/8 激动剂。TLR7/8 agonist 4 具有抗癌活性。

TLR7/8 agonist 4 Chemical Structure

CAS No. : 2388520-33-8

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生物活性

TLR7/8 agonist 4 (compound 41) is a potent TLR7/8 agonist. TLR7/8 agonist 4 has anti-cancer activity^[1].

IC₅₀ & Target^[1]

TLR7

TLR8

分子量

324.42

Formula

C₁₈H₂₄N₆

CAS 号

2388520-33-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Shelley Erin ACKERMAN, et al. Macromolecule-supported tlr agonists. WO2020190762A1.

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TLR7/8 agonist 4 hydroxy-PEG10-acid

发表于2024年5月19日由上海金畔生物科技有限公司

TLR7/8 agonist 4 hydroxy-PEG10-acid

TLR7/8 agonist 4 hydroxy-PEG10-acid (compound 9) 是抗体-药物偶联物的一部分，由 TLR7/8 激活剂 TLR7/8 agonist 4 (HY-139018) 和可降解的 ADC linker hydroxy-PEG10-acid (HY-133307) 连接而成。

TLR7/8 agonist 4 hydroxy-PEG10-acid Chemical Structure

CAS No. : 2388520-17-8

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生物活性

TLR7/8 agonist 4 hydroxy-PEG10-acid (compound 9) is a drug-linker conjugate for ADC with potent antitumor activity by using TLR7/8 agonist 4 (HY-139018; a TLR7/8 agonist), linked via the cleavable ADC linker hydroxy-PEG10-acid (HY-133307)^[1].

IC₅₀ & Target^[1]

Traditional Cytotoxic Agents

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

837.01

Formula

C₄₁H₆₈N₆O₁₂

CAS 号

2388520-17-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Shelley Erin ACKERMAN, et al. Immunoconjugates targeting her2. WO2020190725A1.

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STING agonist-4

发表于2024年5月9日由上海金畔生物科技有限公司

STING agonist-4 纯度: 98.08%

STING agonist-4 是干扰素基因 (STING) 的受体激动剂的刺激剂，它的表观抑制常数 IC₅₀ 为 20 nM，STING agonist-4 是一种含两个对称相关的氨基苯并咪唑 (ABZI) 基的化合物。

STING agonist-4 Chemical Structure

CAS No. : 2138300-40-8

规格	价格	是否有货
5 mg	￥3500	In-stock
10 mg	￥5000	In-stock
50 mg	￥15000	In-stock
100 mg	￥21000	In-stock
200 mg		询价
500 mg		询价

* Please select Quantity before adding items.

STING agonist-4 相关产品

•相关化合物库:

Bioactive Compound Library Plus

生物活性

STING agonist-4 is an stimulator of Interferon Genes (STING) receptor agonist with an apparent inhibitory constant (IC₅₀) of 20 nM. STING agonist-4 is a two symmetry-related amidobenzimidazole (ABZI)-based compound to create linked ABZIs (diABZIs) with enhanced binding to STING and cellular function^[1].

IC₅₀ & Target

IC50: 20 nM (STING agonist-4)^[1]

体外研究
(In Vitro)

STING agonist-4 (Compound 2) (0.3-30 μM; 2 hours) causes phosphorylation of IRF3 and STING that is inhibited by the TBK1 inhibitor BX795 and induces dose-dependent secretion of IFN-β with an EC₅₀ of 3.1 μM^[1].
STING agonist-4 (Compound 2) (0.001 nM-1 μM) inhibits binding of full-length STING to the solid support with an apparent dissociation constant (K_d) of approximately 1.6 nM^[1].
STING agonist-4 (Compound 2) (0-100 μM) is 18-fold more potent than cGAMP (an endogenous STING ligand), with an EC₅₀ of 53.9 μM^[1].
STING agonist-4 (Compound 2) (3 μM; 4 hours) promotes production of interferon γ-induced protein 10 (IP-10), IL-6 and TNF-α by a mechanism that is dependent on STING-mediated activation of TBK1^[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	Human peripheral blood mononuclear cells (PBMCs)
Concentration:	0.3 μM, 1 μM, 3 μM, 10 μM and 30 μM
Incubation Time:	2 hours
Result:	Caused phosphorylation of IRF3 and STING and induced secretion of IFN-β.

分子量

678.74

Formula

C₃₄H₃₈N₁₂O₄

CAS 号

2138300-40-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 10 mg/mL (14.73 mM; Need ultrasonic)

H₂O : < 0.1 mg/mL (insoluble)

*STING agonist-4 is usually formulated as a suspension.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.4733 mL	7.3666 mL	14.7332 mL
5 mM	0.2947 mL	1.4733 mL	2.9466 mL
10 mM	0.1473 mL	0.7367 mL	1.4733 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline

Solubility: 1 mg/mL (1.47 mM); Suspended solution; Need ultrasonic

此方案可获得 1 mg/mL (1.47 mM) 的均匀悬浊液，悬浊液可用于口服和腹腔注射。

以 1 mL 工作液为例，取 100 μL 10.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)

Solubility: 1 mg/mL (1.47 mM); Suspended solution; Need ultrasonic

此方案可获得 1 mg/mL (1.47 mM) 的均匀悬浊液，悬浊液可用于口服和腹腔注射。

以 1 mL 工作液为例，取 100 μL 10.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明

*以上所有助溶剂都可在上海金畔生物科技有限公司网站选购。

参考文献

[1]. Ramanjulu JM et al. Design of amidobenzimidazole STING receptor agonists with systemic activity. Nature. 2018 Dec;564(7736):439-443.

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TLR7/8 agonist 4 TFA

发表于2024年5月5日由上海金畔生物科技有限公司

TLR7/8 agonist 4 TFA

TLR7/8 agonist 4 TFA (compound 41) 是一种有效的 TLR7/8 激动剂。TLR7/8 agonist 4 具有抗癌活性。

TLR7/8 agonist 4 TFA Chemical Structure

CAS No. : 2388520-34-9

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

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生物活性

TLR7/8 agonist 4 TFA (compound 41) is a potent TLR7/8 agonist. TLR7/8 agonist 4 has anti-cancer activity^[1].

IC₅₀ & Target^[1]

TLR7

TLR8

分子量

438.45

Formula

C₂₀H₂₅F₃N₆O₂

CAS 号

2388520-34-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Shelley Erin ACKERMAN, et al. Macromolecule-supported tlr agonists. WO2020190762A1.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

TLR7/8 agonist 4 hydroxy-PEG10-acid hydrochloride

发表于2024年5月5日由上海金畔生物科技有限公司

TLR7/8 agonist 4 hydroxy-PEG10-acid hydrochloride

TLR7/8 agonist 4 hydroxy-PEG10-acid hydrochloride (compound 9) 是抗体-药物偶联物的一部分，由 TLR7/8 激活剂 TLR7/8 agonist 4 (HY-139018) 和可降解的 ADC linker hydroxy-PEG10-acid (HY-133307) 连接而成。

TLR7/8 agonist 4 hydroxy-PEG10-acid hydrochloride Chemical Structure

CAS No. : 2388520-36-1

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

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生物活性

TLR7/8 agonist 4 hydroxy-PEG10-acid hydrochloride (compound 9) is a drug-linker conjugate for ADC with potent antitumor activity by using TLR7/8 agonist 4 (HY-139018; a TLR7/8 agonist), linked via the cleavable ADC linker hydroxy-PEG10-acid (HY-133307)^[1].

IC₅₀ & Target^[1]

Traditional Cytotoxic Agents

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

873.47

Formula

C₄₁H₆₉ClN₆O₁₂

CAS 号

2388520-36-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Shelley Erin ACKERMAN, et al. Immunoconjugates targeting her2. WO2020190725A1.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

TLR7/8 agonist 3

发表于2024年3月6日由上海金畔生物科技有限公司

TLR7/8 agonist 3 纯度: 99.02%

TLR7/8 agonist 3 是一种有效的 TLR7/8 激动剂，源于专利文献 WO2016057618，化合物 II。

TLR7/8 agonist 3 Chemical Structure

CAS No. : 642473-95-8

规格	价格	是否有货
10 mM * 1 mL in DMSO	￥3850	In-stock
5 mg	￥3500	In-stock
10 mg	￥5800	In-stock
25 mg	￥11000	In-stock
50 mg	￥17000	In-stock
100 mg	￥25000	In-stock
200 mg		询价
500 mg		询价

* Please select Quantity before adding items.

TLR7/8 agonist 3 相关产品

•相关化合物库:

Bioactive Compound Library Plus
Immunology/Inflammation Compound Library
Anti-Cancer Compound Library
Small Molecule Immuno-Oncology Compound Library
Antioxidants Compound Library
Reprogramming Compound Library
Oxygen Sensing Compound Library
Pyroptosis Compound Library

生物活性

TLR7/8 agonist 3 is a potent TLR7 and TLR8 agonist, extracted from patent WO2016057618 (compound of formula (II))^[1].

IC₅₀ & Target^[1]

TLR7

TLR8

分子量

313.40

Formula

C₁₇H₂₃N₅O

CAS 号

642473-95-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 50 mg/mL (159.54 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.1908 mL	15.9541 mL	31.9081 mL
5 mM	0.6382 mL	3.1908 mL	6.3816 mL
10 mM	0.3191 mL	1.5954 mL	3.1908 mL

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline

Solubility: ≥ 2.5 mg/mL (7.98 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (7.98 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (7.98 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (7.98 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
3.

请依序添加每种溶剂： 10% DMSO 90% corn oil

Solubility: ≥ 2.5 mg/mL (7.98 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (7.98 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在上海金畔生物科技有限公司网站选购。

参考文献

[1]. Martha A. MILLER, et al. Vaccine compositions and methods of use to treat neonatal subjects.

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TRPM8 agonist WS-3

发表于2024年3月3日由上海金畔生物科技有限公司

TRPM8 agonist WS-3 纯度: 99.35%

TRPM8 agonist WS-3 是 TRPM8 的激动剂，其 EC₅₀ 值为 3.7 μM。

TRPM8 agonist WS-3 Chemical Structure

CAS No. : 39711-79-0

规格	价格	是否有货
10 mM * 1 mL in DMSO	￥550	In-stock
500 mg	￥500	In-stock
1 g		询价
5 g		询价

* Please select Quantity before adding items.

TRPM8 agonist WS-3 相关产品

•相关化合物库:

Bioactive Compound Library Plus
Membrane Transporter/Ion Channel Compound Library
Neuronal Signaling Compound Library
Anti-Cancer Compound Library
Food Additive Library
Mechanoreceptors Compound Library

生物活性

TRPM8 agonist WS-3 is an agonist of TRPM8 with an EC₅₀ of 3.7 μM.

IC₅₀ & Target

EC50: 3.7 μM (TRPM8)^[1]

分子量

211.34

Formula

C₁₃H₂₅NO

CAS 号

39711-79-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : ≥ 100 mg/mL (473.17 mM)

H₂O : 1 mg/mL (4.73 mM; ultrasonic and heat to 60°C)

* “≥” means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	4.7317 mL	23.6586 mL	47.3171 mL
5 mM	0.9463 mL	4.7317 mL	9.4634 mL
10 mM	0.4732 mL	2.3659 mL	4.7317 mL

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline

Solubility: ≥ 2.5 mg/mL (11.83 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (11.83 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (11.83 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (11.83 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
3.

请依序添加每种溶剂： 10% DMSO 90% corn oil

Solubility: ≥ 2.5 mg/mL (11.83 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (11.83 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在上海金畔生物科技有限公司网站选购。

参考文献

[1]. Behrendt HJ, et al. Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay. Br J Pharmacol. 2004 Feb;141(4):737-45.

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CB2 receptor agonist 3(Synonyms: GP2a)

发表于2023年12月28日由上海金畔生物科技有限公司

CB2 receptor agonist 3 (Synonyms: GP2a)

CB2 receptor agonist 3 是一种稳健和选择性的 CB2 大麻素激动剂，对 CB2 和 CB1 的 K_i 分别为 7.6 和 900 nM。CB2 receptor agonist 3 显著增加 HL-60 细胞 P-ERK1/2 的表达。

CB2 receptor agonist 3 Chemical Structure

CAS No. : 919077-81-9

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

* Please select Quantity before adding items.

生物活性	CB2 receptor agonist 3 is a robust and selective CB2 cannabinoid agonist with K_is of 7.6 and 900 nM for CB2 and CB1, respectively. CB2 receptor agonist 3 significantly increases P-ERK 1/2 expression in HL-60 cells^[1].
体外研究 (In Vitro)	CB2 receptor agonist 3 (Compound 2a) is also shown to be agonist in an in vitro model based on human promyelocytic leukemia HL-60 cells^[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	440.36
Formula	C₂₄H₂₃Cl₂N₃O
CAS 号	919077-81-9
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Murineddu G, et al. Tricyclic pyrazoles. 4. Synthesis and biological evaluation of analogues of the robust and selective CB2 cannabinoid ligand 1-(2′,4′-dichlorophenyl)-6-methyl-N-piperidin-1-yl-1,4-dihydroindeno[1,2-c]pyrazole-3-carboxamide. J Med Chem. 2006;49(25):7502-7512.

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CB2 receptor agonist 3(Synonyms: GP2a)

发表于2023年12月28日由上海金畔生物科技有限公司

CB2 receptor agonist 3 (Synonyms: GP2a)

CB2 receptor agonist 3 Chemical Structure

CAS No. : 919077-81-9

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

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生物活性	CB2 receptor agonist 3 is a robust and selective CB2 cannabinoid agonist with K_is of 7.6 and 900 nM for CB2 and CB1, respectively. CB2 receptor agonist 3 significantly increases P-ERK 1/2 expression in HL-60 cells^[1].
体外研究 (In Vitro)	CB2 receptor agonist 3 (Compound 2a) is also shown to be agonist in an in vitro model based on human promyelocytic leukemia HL-60 cells^[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	440.36
Formula	C₂₄H₂₃Cl₂N₃O
CAS 号	919077-81-9
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Murineddu G, et al. Tricyclic pyrazoles. 4. Synthesis and biological evaluation of analogues of the robust and selective CB2 cannabinoid ligand 1-(2′,4′-dichlorophenyl)-6-methyl-N-piperidin-1-yl-1,4-dihydroindeno[1,2-c]pyrazole-3-carboxamide. J Med Chem. 2006;49(25):7502-7512.

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CB2 receptor agonist 3(Synonyms: GP2a)

发表于2023年12月28日由上海金畔生物科技有限公司

CB2 receptor agonist 3 (Synonyms: GP2a)

CB2 receptor agonist 3 Chemical Structure

CAS No. : 919077-81-9

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生物活性	CB2 receptor agonist 3 is a robust and selective CB2 cannabinoid agonist with K_is of 7.6 and 900 nM for CB2 and CB1, respectively. CB2 receptor agonist 3 significantly increases P-ERK 1/2 expression in HL-60 cells^[1].
体外研究 (In Vitro)	CB2 receptor agonist 3 (Compound 2a) is also shown to be agonist in an in vitro model based on human promyelocytic leukemia HL-60 cells^[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	440.36
Formula	C₂₄H₂₃Cl₂N₃O
CAS 号	919077-81-9
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Murineddu G, et al. Tricyclic pyrazoles. 4. Synthesis and biological evaluation of analogues of the robust and selective CB2 cannabinoid ligand 1-(2′,4′-dichlorophenyl)-6-methyl-N-piperidin-1-yl-1,4-dihydroindeno[1,2-c]pyrazole-3-carboxamide. J Med Chem. 2006;49(25):7502-7512.

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TLR7 agonist 4

发表于2023年12月22日由上海金畔生物科技有限公司

TLR7 agonist 4

TLR7 agonist 4 (Compound 1.2) 是一种 TLR7 激动剂，EC₅₀ 为 4.3 nM。

TLR7 agonist 4 Chemical Structure

CAS No. : 2413016-42-7

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生物活性

TLR7 agonist 4 (Compound 1.2) is a TLR7 agonist with an EC₅₀ of 4.3 nM^[1].

IC₅₀ & Target

TLR7

4.3 nM (EC₅₀)

分子量

442.55

Formula

C₂₃H₃₄N₆O₃

CAS 号

2413016-42-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Sean Wesley, et al. Antibody conjugates of toll-like receptor agonists. WO2020056192A1.

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EphA2 agonist 2

发表于2023年12月21日由上海金畔生物科技有限公司

EphA2 agonist 2

EphA2 agonist 2 (Lead compound) 是一种选择性的 EphA2 激动剂，具有抗肿瘤活性。EphA2 agonist 2 能透过血脑屏障

EphA2 agonist 2 Chemical Structure

CAS No. : 2169273-66-7

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生物活性	EphA2 agonist 2 (Lead compound) is a selective EphA2 agonist with antitumor activities. EphA2 agonist 2 can cross the BBB^[1].
体外研究 (In Vitro)	EphA2 agonist 2 (Lead compound) shows antiproliferation activity with IC₅₀ values of 2.1 ± 1.05 μM and 5.2 ± 2.56 μM against U251 EphA2 overexpressed and U251 wild type cells, respectively^[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	772.94
Formula	C₄₀H₅₆N₁₀O₆
CAS 号	2169273-66-7
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Orahoske CM, et al. Dimeric small molecule agonists of EphA2 receptor inhibit glioblastoma cell growth. Bioorg Med Chem. 2020 Sep 15;28(18):115656.

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Nurr1 agonist 1

发表于2023年12月15日由上海金畔生物科技有限公司

Nurr1 agonist 1

Nurr1 agonist 1 是一种神经保护的转录因子 Nurr1 的反向激动剂工具。

Nurr1 agonist 1 Chemical Structure

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生物活性	Nurr1 agonist 1 is an inverse agonist tool for the neuroprotective transcription factor Nurr1.
分子量	266.29
Formula	C₁₆H₁₄N₂O₂
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Zaienne D, et al. Development and Profiling of Inverse Agonist Tools for the Neuroprotective Transcription Factor Nurr1. J Med Chem. 2021 Oct 28;64(20):15126-15140.

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Nurr1 agonist 1

发表于2023年12月15日由上海金畔生物科技有限公司

Nurr1 agonist 1

Nurr1 agonist 1 是一种神经保护的转录因子 Nurr1 的反向激动剂工具。

Nurr1 agonist 1 Chemical Structure

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生物活性	Nurr1 agonist 1 is an inverse agonist tool for the neuroprotective transcription factor Nurr1.
分子量	266.29
Formula	C₁₆H₁₄N₂O₂
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Zaienne D, et al. Development and Profiling of Inverse Agonist Tools for the Neuroprotective Transcription Factor Nurr1. J Med Chem. 2021 Oct 28;64(20):15126-15140.

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Nurr1 agonist 1

发表于2023年12月15日由上海金畔生物科技有限公司

Nurr1 agonist 1

Nurr1 agonist 1 是一种神经保护的转录因子 Nurr1 的反向激动剂工具。

Nurr1 agonist 1 Chemical Structure

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生物活性	Nurr1 agonist 1 is an inverse agonist tool for the neuroprotective transcription factor Nurr1.
分子量	266.29
Formula	C₁₆H₁₄N₂O₂
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Zaienne D, et al. Development and Profiling of Inverse Agonist Tools for the Neuroprotective Transcription Factor Nurr1. J Med Chem. 2021 Oct 28;64(20):15126-15140.

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EphA2 agonist 1

发表于2023年12月15日由上海金畔生物科技有限公司

EphA2 agonist 1

EphA2 agonist 1 (Compound 7bg) 是一种有效的 EphA2 receptor 激动剂。EphA2 agonist 1 对 EphA2 过表达的胶质瘤细胞具有很强的活性和选择性，并能刺激EphA2磷酸化。

EphA2 agonist 1 Chemical Structure

CAS No. : 2611459-57-3

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生物活性	EphA2 agonist 1 (Compound 7bg) is a potent EphA2 receptor agonist. EphA2 agonist 1 shows great potency and selectivity toward EphA2 overexpressed glioblastoma cells and stimulates EphA2 phosphorylation^[1].
IC₅₀ & Target	EphA2^[1]
体外研究 (In Vitro)	EphA2 agonist 1 (Compound 7bg) inhibits cell proliferation with IC₅₀ values of 1.90 ± 0.55 μM and 7.91 ± 2.28 μM against U251 EphA2 overexpressed and U251 wild type cells, respectively^[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	1019.07
Formula	C₅₀H₅₈N₁₂O₁₂
CAS 号	2611459-57-3
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Orahoske CM, et al. Dimeric small molecule agonists of EphA2 receptor inhibit glioblastoma cell growth. Bioorg Med Chem. 2020 Sep 15;28(18):115656.

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TLR7/8 agonist 6

发表于2023年11月27日由上海金畔生物科技有限公司

TLR7/8 agonist 6

TLR7/8 agonist 6 (Compound 4) 是 TLR7/8 的有效激动剂，IC₅₀ 值分别为 0.18 和 5.34 μM。TLR7/8 agonist 6 是一种咪唑喹啉衍生物化合物。Toll 样受体 (TLR) 7 和 8 是开发用于治疗传染病、癌症和自身免疫性疾病的免疫调节药物的关键靶点。

TLR7/8 agonist 6 Chemical Structure

CAS No. : 2115702-83-3

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生物活性	TLR7/8 agonist 6 (Compound 4) is the potent agonist of TLR7/8 with IC₅₀s of 0.18 and 5.34 μM, respectively. TLR7/8 agonist 6 is an imidazoquinoline derivative compound. Toll-like receptors (TLRs) 7 and 8 are key targets in the development of immunomodulatory drugs for treating infectious disease, cancer, and autoimmune disorders^[1].
分子量	417.50
Formula	C₂₄H₂₇N₅O₂
CAS 号	2115702-83-3
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Yang M, et al. Toll-like receptor 7 and 8 imidazoquinoline-based agonist/antagonist pairs. Bioorg Med Chem Lett. 2022;59:128548.

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TLR7/8 agonist 6

发表于2023年11月27日由上海金畔生物科技有限公司

TLR7/8 agonist 6

TLR7/8 agonist 6 Chemical Structure

CAS No. : 2115702-83-3

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生物活性	TLR7/8 agonist 6 (Compound 4) is the potent agonist of TLR7/8 with IC₅₀s of 0.18 and 5.34 μM, respectively. TLR7/8 agonist 6 is an imidazoquinoline derivative compound. Toll-like receptors (TLRs) 7 and 8 are key targets in the development of immunomodulatory drugs for treating infectious disease, cancer, and autoimmune disorders^[1].
分子量	417.50
Formula	C₂₄H₂₇N₅O₂
CAS 号	2115702-83-3
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Yang M, et al. Toll-like receptor 7 and 8 imidazoquinoline-based agonist/antagonist pairs. Bioorg Med Chem Lett. 2022;59:128548.

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TLR7/8 agonist 6

发表于2023年11月27日由上海金畔生物科技有限公司

TLR7/8 agonist 6

TLR7/8 agonist 6 Chemical Structure

CAS No. : 2115702-83-3

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生物活性	TLR7/8 agonist 6 (Compound 4) is the potent agonist of TLR7/8 with IC₅₀s of 0.18 and 5.34 μM, respectively. TLR7/8 agonist 6 is an imidazoquinoline derivative compound. Toll-like receptors (TLRs) 7 and 8 are key targets in the development of immunomodulatory drugs for treating infectious disease, cancer, and autoimmune disorders^[1].
分子量	417.50
Formula	C₂₄H₂₇N₅O₂
CAS 号	2115702-83-3
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Yang M, et al. Toll-like receptor 7 and 8 imidazoquinoline-based agonist/antagonist pairs. Bioorg Med Chem Lett. 2022;59:128548.

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GLP-1R agonist 4

发表于2023年11月19日由上海金畔生物科技有限公司

GLP-1R agonist 4

GLP-1R agonist 4 是一种有效的 GLP-1R 激动剂。胰高血糖素样肽-1 (GLP-1) 是一种由下消化道 L 细胞分泌的肠道降血糖激素。GLP-1R agonist 4 具有糖尿病研究潜力 (摘自专利 WO2019239319A1，化合物 96)。

GLP-1R agonist 4 Chemical Structure

CAS No. : 2401894-26-4

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生物活性	GLP-1R agonist 4 is a potent agonist of GLP-1R. Glucagon-like peptide-1 (GLP-1) is an intestinal hypoglycemic hormone secreted by L-cells in the lower gastrointestinal tract. GLP-1R agonist 4 has the potential for the research of diabetes (extracted from patent WO2019239319A1, compound 96)^[1].
分子量	610.05
Formula	C₃₂H₃₀ClF₂N₃O₅
CAS 号	2401894-26-4
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Gary Erik Aspnes, et al. Glp-1 receptor agonists and uses thereof. Patent WO2019239319A1.

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标签归档：agonist

TLR7/8 agonist 4

TLR7/8 agonist 4 hydroxy-PEG10-acid

STING agonist-4

STING agonist-4 相关产品

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TLR7/8 agonist 4 TFA

TLR7/8 agonist 4 hydroxy-PEG10-acid hydrochloride

TLR7/8 agonist 3

TLR7/8 agonist 3 相关产品

•相关化合物库:

TRPM8 agonist WS-3

TRPM8 agonist WS-3 相关产品

•相关化合物库:

CB2 receptor agonist 3(Synonyms: GP2a)

CB2 receptor agonist 3(Synonyms: GP2a)

CB2 receptor agonist 3(Synonyms: GP2a)

TLR7 agonist 4

EphA2 agonist 2

Nurr1 agonist 1

Nurr1 agonist 1

Nurr1 agonist 1

EphA2 agonist 1

TLR7/8 agonist 6

TLR7/8 agonist 6

TLR7/8 agonist 6

GLP-1R agonist 4