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Estradiol 3-sulfamate (Synonyms: 雌二醇 3-氨基磺酸; BLE 00084; E2MATE; ES-J 995) 纯度: 99.74%
Estradiol 3-sulfamate (BLE 00084; E2MATE; ES-J 995) 是一种长效和有口服活性的类固醇硫酸酯酶 (steroid sulfatase) 抑制剂;抑制雌酮硫酸酯酶的 IC50 值为251 nM,Ki 值为133 nM。
Estradiol 3-sulfamate Chemical Structure
CAS No. : 172377-52-5
规格 | 价格 | 是否有货 | 数量 |
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10 mM * 1 mL in DMSO | ¥3093 | In-stock | |
1 mg | ¥2000 | In-stock | |
5 mg | ¥4000 | In-stock | |
10 mg | ¥6800 | In-stock | |
20 mg | ¥12000 | In-stock | |
50 mg | 询价 | ||
100 mg | 询价 |
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Estradiol 3-sulfamate 相关产品
•相关化合物库:
- Bioactive Compound Library Plus
生物活性 |
Estradiol 3-sulfamate (BLE 00084; E2MATE; ES-J 995) is a potent, long-acting, and orally active steroid sulfatase inhibitor; inhibits estrone sulfatase with an IC50 of 251 nM and a Ki of 133 nM. |
IC50 & Target |
IC50: 251 nM (estrone sulfatase)[1] Ki: 133 nM (estrone sulfatase)[1] |
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体外研究 (In Vitro) |
Introduction of a fluoro, chloro, or bromo moiety at the C-2 position of EMATE and Estradiol 3-sulfamate and that of a fluoro moiety at the C-4 position of the parent sulfamates markedly increase the estrone sulfatase inhibitory activity[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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体内研究 (In Vivo) |
Estradiol 3-sulfamate is readily transformed and absorbed in the gut into its oxidative metabolite, EMATE, and both compounds have already been shown to be potent, long-acting, and orally active STS inhibitors[2]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
351.46 |
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Formula |
C18H25NO4S |
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CAS 号 |
172377-52-5 |
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中文名称 |
雌二醇 3-氨基磺酸 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : 62.5 mg/mL (177.83 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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