标签归档：cooh

F-PEG2-COOH

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

F-PEG2-COOH 

F-PEG2-COOH 是一种 PROTAC linker，属于 PEG 类。可用于合成 PROTAC 分子。

F-PEG2-COOH

F-PEG2-COOH Chemical Structure

CAS No. : 2383964-72-3

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

F-PEG2-COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

166.15

Formula

C6H11FO4
CAS 号

2383964-72-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

NHS PEG COOH Cat. No. PG2-CANS-3k 3400 Da 100 mg修饰性聚乙二醇

发表于由

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

NHS PEG COOH

Cat. No. PG2-CANS-3k NHS PEG COOH Cat. No. PG2-CANS-3k 3400 Da 100 mg
Specification 3400 Da
Unit Size 100 mg
Price $325.00

Qty Add to Cart

Description:

Heterobifunctional PEG derivative that can be used to modify proteins, peptides and other materials via amino or other acid reactive chemical groups. PEGylation can increase solubility and stability and reduce immunogenicity of peptides and proteins. It can also suppress the non-specific binding of charged molecules to the modified surfaces.

Physical Properties:

  • Off-white/white solid or viscous liquid depends on molecule weight;
  • Soluble in regular aqeous solution as well as most organic solvents;

Storage Conditions:

  • Store at -20 0C, dessiccated Protect from light. Avoid frequent thaw and freeze.
Documents
  • SDS
  • DataSheet

NHS PEG COOH Cat. No. PG2-CANS-2k 2000 Da 100 mg修饰性聚乙二醇

发表于由

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

NHS PEG COOH

Cat. No. PG2-CANS-2k NHS PEG COOH Cat. No. PG2-CANS-2k 2000 Da 100 mg
Specification 2000 Da
Unit Size 100 mg
Price $385.00

Qty Add to Cart

Description:

Heterobifunctional PEG derivative that can be used to modify proteins, peptides and other materials via amino or other acid reactive chemical groups. PEGylation can increase solubility and stability and reduce immunogenicity of peptides and proteins. It can also suppress the non-specific binding of charged molecules to the modified surfaces.

Physical Properties:

  • Off-white/white solid or viscous liquid depends on molecule weight;
  • Soluble in regular aqeous solution as well as most organic solvents;

Storage Conditions:

  • Store at -20 0C, dessiccated Protect from light. Avoid frequent thaw and freeze.
Documents
  • SDS
  • DataSheet

Diethoxylsilane-PEG-COOH Cat. No. PG2-CASL2-5k 5000 Da 100 mg修饰性聚乙二醇

发表于由

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

Diethoxylsilane-PEG-COOH

Cat. No. PG2-CASL2-5k Diethoxylsilane-PEG-COOH Cat. No. PG2-CASL2-5k 5000 Da 100 mg
Specification 5000 Da
Unit Size 100 mg
Price $385.00

Qty Add to Cart

Description:

Ethoxy or methoxyl silane functionalized polyethylene glycol, silane PEG (PEG-Si) is a surface reactive PEG derivative that can be used to modify glass, silica and other surfaces via the reaction between hydroxyl group and ethoxyl/methoxyl silane. Pegylation can greatly suppress the non-specific binding of charged molecules to the modified surfaces. And they have wide applications for medica device, biomems or biocompatible material development.

Physical Properties:

  • Off-white/white solid or viscous liquid depends on molecule weight;
  • Soluble in regular aqeous solution as well as most organic solvents;

Storage Conditions:

  • Store at -20 0C, desiccated. Silane PEG tends to hydrolyze from moisture. Avoid frequent thaw and frozen.

Reaction Procedures:

Generally, silane PEG is first dissolved in a mixture of ethanol/water solution, then allow the solution to contact with oxidized glass or silica surface for 30 min to 2 hours. Under this condition, silane PEG should bind to the material covalently.

Materials Required:

  • Pegylation solution: Ethanol/water (w/w, 95%/5%);
  • Silane PEG stock solution, 10~50 mg/mL in pegylation solution, prepare in fresh.
  • Washing solution: Distilled water.

Reaction Steps:

1. Dissolve targeted materials in Pegylation buffer.

2. Add silane PEG stock solution to the targeted conjugation materials with the final concentration keep at least 10 mg/mL. 10~50 molar excess of silane PEG needed for optimal conjugation;

3. Allow mixture agitates at room temperature for 30 min at room temperature or 2 hours at 4 -20 0C.

4. Wash out unreacted materials either by distilled water.

Documents
  • SDS
  • DataSheet

Monoethoxylsilane-PEG-COOH Cat. No. PG2-CASL1-5k 5000 Da 100 mg修饰性聚乙二醇

发表于由

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

Monoethoxylsilane-PEG-COOH

Cat. No. PG2-CASL1-5k Monoethoxylsilane-PEG-COOH Cat. No. PG2-CASL1-5k 5000 Da 100 mg
Specification 5000 Da
Unit Size 100 mg
Price $385.00

Qty Add to Cart

Description:

Ethoxy or methoxyl silane functionalized polyethylene glycol, silane PEG (PEG-Si) is a surface reactive PEG derivative that can be used to modify glass, silica and other surfaces via the reaction between hydroxyl group and ethoxyl/methoxyl silane. Pegylation can greatly suppress the non-specific binding of charged molecules to the modified surfaces. And they have wide applications for medica device, biomems or biocompatible material development.

Physical Properties:

  • Off-white/white solid or viscous liquid depends on molecule weight;
  • Soluble in regular aqeous solution as well as most organic solvents;

Storage Conditions:

  • Store at -20 0C, desiccated. Silane PEG tends to hydrolyze from moisture. Avoid frequent thaw and frozen.

Reaction Procedures:

Generally, silane PEG is first dissolved in a mixture of ethanol/water solution, then allow the solution to contact with oxidized glass or silica surface for 30 min to 2 hours. Under this condition, silane PEG should bind to the material covalently.

Materials Required:

  • Pegylation solution: Ethanol/water (w/w, 95%/5%);
  • Silane PEG stock solution, 10~50 mg/mL in pegylation solution, prepare in fresh.
  • Washing solution: Distilled water.

Reaction Steps:

1. Dissolve targeted materials in Pegylation buffer.

2. Add silane PEG stock solution to the targeted conjugation materials with the final concentration keep at least 10 mg/mL. 10~50 molar excess of silane PEG needed for optimal conjugation;

3. Allow mixture agitates at room temperature for 30 min at room temperature or 2 hours at 4 -20 0C.

4. Wash out unreacted materials either by distilled water.

Documents
  • SDS
  • DataSheet

Silane-PEG-COOH Cat. No. PG2-CASL-1k 1000 Da 100 mg修饰性聚乙二醇

发表于由

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

Silane-PEG-COOH

Cat. No. PG2-CASL-1k Silane-PEG-COOH Cat. No. PG2-CASL-1k 1000 Da 100 mg
Specification 1000 Da
Unit Size 100 mg
Price $425.00

Qty Add to Cart

Description:

Ethoxy or methoxyl silane functionalized polyethylene glycol, silane PEG (PEG-Si) is a surface reactive PEG derivative that can be used to modify glass, silica and other surfaces via the reaction between hydroxyl group and ethoxyl/methoxyl silane. Pegylation can greatly suppress the non-specific binding of charged molecules to the modified surfaces. And they have wide applications for medica device, biomems or biocompatible material development.

Physical Properties:

  • Off-white/white solid or viscous liquid depends on molecule weight;
  • Soluble in regular aqeous solution as well as most organic solvents;

Storage Conditions:

  • Store at -20 0C, desiccated. Silane PEG tends to hydrolyze from moisture. Avoid frequent thaw and frozen.

Reaction Procedures:

Generally, silane PEG is first dissolved in a mixture of ethanol/water solution, then allow the solution to contact with oxidized glass or silica surface for 30 min to 2 hours. Under this condition, silane PEG should bind to the material covalently.

Materials Required:

  • Pegylation solution: Ethanol/water (w/w, 95%/5%);
  • Silane PEG stock solution, 10~50 mg/mL in pegylation solution, prepare in fresh.
  • Washing solution: Distilled water.

Reaction Steps:

1. Dissolve targeted materials in Pegylation buffer.

2. Add silane PEG stock solution to the targeted conjugation materials with the final concentration keep at least 10 mg/mL. 10~50 molar excess of silane PEG needed for optimal conjugation;

3. Allow mixture agitates at room temperature for 30 min at room temperature or 2 hours at 4 -20 0C.

4. Wash out unreacted materials either by distilled water.

Documents
  • SDS
  • DataSheet

SiR-COOH

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

SiR-COOH 

SiR-COOH 可用于跟踪模型药物在 GFP 标记细胞中的位置。

SiR-COOH

SiR-COOH Chemical Structure

CAS No. : 1418275-26-9

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

SiR-COOH could be used to follow the intracellular location of the model therapeutic drug in GFP cells (Abs, 645 nm; Em, 676 nm)[1].

体外研究
(In Vitro)

SiR-COOH could be used to conjugated inhibitors such as UNC2025 (Mer inhibitor). SiR-COOH is especially useful for small-molecule probes: it exhibits bright photostable fluorescence at near-infrared wavelengths, which are ideal for imaging deep through tissue; fluorescence is robust across physiological environments with little toxicity; it is amenable to super-resolution microscopy; and it exhibits an optimal degree of hydrophilicity for live-cell imaging[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

472.61

Formula

C27H28N2O4Si
CAS 号

1418275-26-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Eunha Kim, et al. Red Si-rhodamine drug conjugates enable imaging in GFP cells. Chem Commun (Camb). 2014 May 4;50(34):4504-7.

    [2]. Miles A Miller, et al. Near infrared imaging of Mer tyrosine kinase (MERTK) using MERi-SiR reveals tumor associated macrophage uptake in metastatic disease. Chem Commun (Camb). 2017 Dec 19;54(1):42-45.https://pubmed.ncbi.nlm.nih.gov/29185561

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

SiR-COOH

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

SiR-COOH 

SiR-COOH 可用于跟踪模型药物在 GFP 标记细胞中的位置。

SiR-COOH

SiR-COOH Chemical Structure

CAS No. : 1418275-26-9

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

SiR-COOH could be used to follow the intracellular location of the model therapeutic drug in GFP cells (Abs, 645 nm; Em, 676 nm)[1].

体外研究
(In Vitro)

SiR-COOH could be used to conjugated inhibitors such as UNC2025 (Mer inhibitor). SiR-COOH is especially useful for small-molecule probes: it exhibits bright photostable fluorescence at near-infrared wavelengths, which are ideal for imaging deep through tissue; fluorescence is robust across physiological environments with little toxicity; it is amenable to super-resolution microscopy; and it exhibits an optimal degree of hydrophilicity for live-cell imaging[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

472.61

Formula

C27H28N2O4Si
CAS 号

1418275-26-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Eunha Kim, et al. Red Si-rhodamine drug conjugates enable imaging in GFP cells. Chem Commun (Camb). 2014 May 4;50(34):4504-7.

    [2]. Miles A Miller, et al. Near infrared imaging of Mer tyrosine kinase (MERTK) using MERi-SiR reveals tumor associated macrophage uptake in metastatic disease. Chem Commun (Camb). 2017 Dec 19;54(1):42-45.https://pubmed.ncbi.nlm.nih.gov/29185561

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

SiR-COOH

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

SiR-COOH 

SiR-COOH 可用于跟踪模型药物在 GFP 标记细胞中的位置。

SiR-COOH

SiR-COOH Chemical Structure

CAS No. : 1418275-26-9

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

SiR-COOH could be used to follow the intracellular location of the model therapeutic drug in GFP cells (Abs, 645 nm; Em, 676 nm)[1].

体外研究
(In Vitro)

SiR-COOH could be used to conjugated inhibitors such as UNC2025 (Mer inhibitor). SiR-COOH is especially useful for small-molecule probes: it exhibits bright photostable fluorescence at near-infrared wavelengths, which are ideal for imaging deep through tissue; fluorescence is robust across physiological environments with little toxicity; it is amenable to super-resolution microscopy; and it exhibits an optimal degree of hydrophilicity for live-cell imaging[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

472.61

Formula

C27H28N2O4Si
CAS 号

1418275-26-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Eunha Kim, et al. Red Si-rhodamine drug conjugates enable imaging in GFP cells. Chem Commun (Camb). 2014 May 4;50(34):4504-7.

    [2]. Miles A Miller, et al. Near infrared imaging of Mer tyrosine kinase (MERTK) using MERi-SiR reveals tumor associated macrophage uptake in metastatic disease. Chem Commun (Camb). 2017 Dec 19;54(1):42-45.https://pubmed.ncbi.nlm.nih.gov/29185561

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Acryloyl-PEG-COOH Cat. No. PG2-ARCA-5k 5000 Da 100 mg修饰性聚乙二醇

发表于由

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

Acryloyl-PEG-COOH

Cat. No. PG2-ARCA-5k Acryloyl-PEG-COOH Cat. No. PG2-ARCA-5k 5000 Da 100 mg
Specification 5000 Da
Unit Size 100 mg
Price $385.00

Qty Add to Cart

Description:

Heterobifunctional PEG derivative that can be used to modify proteins, peptides and other materials via amino or other acid reactive chemical groups. PEGylation can increase solubility and stability and reduce immunogenicity of peptides and proteins. It can also suppress the non-specific binding of charged molecules to the modified surfaces.

Physical Properties:

  • Off-white/white solid or viscous liquid depends on molecule weight;
  • Soluble in regular aqeous solution as well as most organic solvents;

Storage Conditions:

  • Store at -20 0C, dessiccated Protect from light. Avoid frequent thaw and freeze.
Documents
  • SDS
  • DataSheet

Acryloyl-PEG-COOH Cat. No. PG2-ARCA-3k 3400 Da 100 mg修饰性聚乙二醇

发表于由

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

Acryloyl-PEG-COOH

Cat. No. PG2-ARCA-3k Acryloyl-PEG-COOH Cat. No. PG2-ARCA-3k 3400 Da 100 mg
Specification 3400 Da
Unit Size 100 mg
Price $385.00

Qty Add to Cart

Description:

Heterobifunctional PEG derivative that can be used to modify proteins, peptides and other materials via amino or other acid reactive chemical groups. PEGylation can increase solubility and stability and reduce immunogenicity of peptides and proteins. It can also suppress the non-specific binding of charged molecules to the modified surfaces.

Physical Properties:

  • Off-white/white solid or viscous liquid depends on molecule weight;
  • Soluble in regular aqeous solution as well as most organic solvents;

Storage Conditions:

  • Store at -20 0C, dessiccated Protect from light. Avoid frequent thaw and freeze.
Documents
  • SDS
  • DataSheet

Thalidomide-5-COOH

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Thalidomide-5-COOH 

Thalidomide-5-COOH 是一种基于 Thalidomide 的，可募集 CRBN 蛋白的 cereblon 配体。Thalidomide-5-COOH 可通过 linker 与靶蛋白配体连接，形成 PROTAC 分子。

Thalidomide-5-COOH

Thalidomide-5-COOH Chemical Structure

CAS No. : 1216805-11-6

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Thalidomide-5-COOH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-COOH can be connected to the ligand for protein by a linker to form PROTACs[1].

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

302.24

Formula

C14H10N2O6
CAS 号

1216805-11-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Liu K, et, al. Design and biological characterization of hybrid compounds of curcumin and thalidomide for multiple myeloma. Org Biomol Chem. 2013 Aug 7;11(29):4757-63.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Thalidomide-5-COOH

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Thalidomide-5-COOH 

Thalidomide-5-COOH 是一种基于 Thalidomide 的，可募集 CRBN 蛋白的 cereblon 配体。Thalidomide-5-COOH 可通过 linker 与靶蛋白配体连接，形成 PROTAC 分子。

Thalidomide-5-COOH

Thalidomide-5-COOH Chemical Structure

CAS No. : 1216805-11-6

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Thalidomide-5-COOH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-COOH can be connected to the ligand for protein by a linker to form PROTACs[1].

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

302.24

Formula

C14H10N2O6
CAS 号

1216805-11-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Liu K, et, al. Design and biological characterization of hybrid compounds of curcumin and thalidomide for multiple myeloma. Org Biomol Chem. 2013 Aug 7;11(29):4757-63.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Thalidomide-5-COOH

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Thalidomide-5-COOH 

Thalidomide-5-COOH 是一种基于 Thalidomide 的，可募集 CRBN 蛋白的 cereblon 配体。Thalidomide-5-COOH 可通过 linker 与靶蛋白配体连接，形成 PROTAC 分子。

Thalidomide-5-COOH

Thalidomide-5-COOH Chemical Structure

CAS No. : 1216805-11-6

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Thalidomide-5-COOH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-COOH can be connected to the ligand for protein by a linker to form PROTACs[1].

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

302.24

Formula

C14H10N2O6
CAS 号

1216805-11-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Liu K, et, al. Design and biological characterization of hybrid compounds of curcumin and thalidomide for multiple myeloma. Org Biomol Chem. 2013 Aug 7;11(29):4757-63.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Acryloyl-PEG-COOH Cat. No. PG2-ARCA-2k 2000 Da 100 mg修饰性聚乙二醇

发表于由

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

Acryloyl-PEG-COOH

Cat. No. PG2-ARCA-2k Acryloyl-PEG-COOH Cat. No. PG2-ARCA-2k 2000 Da 100 mg
Specification 2000 Da
Unit Size 100 mg
Price $385.00

Qty Add to Cart

Description:

Heterobifunctional PEG derivative that can be used to modify proteins, peptides and other materials via amino or other acid reactive chemical groups. PEGylation can increase solubility and stability and reduce immunogenicity of peptides and proteins. It can also suppress the non-specific binding of charged molecules to the modified surfaces.

Physical Properties:

  • Off-white/white solid or viscous liquid depends on molecule weight;
  • Soluble in regular aqeous solution as well as most organic solvents;

Storage Conditions:

  • Store at -20 0C, dessiccated Protect from light. Avoid frequent thaw and freeze.
Documents
  • SDS
  • DataSheet

Acryloyl-PEG-COOH Cat. No. PG2-ARCA-10k 10000 Da 100 mg修饰性聚乙二醇

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Acryloyl-PEG-COOH

Cat. No. PG2-ARCA-10k Acryloyl-PEG-COOH Cat. No. PG2-ARCA-10k 10000 Da 100 mg
Specification 10000 Da
Unit Size 100 mg
Price $385.00

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Description:

Heterobifunctional PEG derivative that can be used to modify proteins, peptides and other materials via amino or other acid reactive chemical groups. PEGylation can increase solubility and stability and reduce immunogenicity of peptides and proteins. It can also suppress the non-specific binding of charged molecules to the modified surfaces.

Physical Properties:

  • Off-white/white solid or viscous liquid depends on molecule weight;
  • Soluble in regular aqeous solution as well as most organic solvents;

Storage Conditions:

  • Store at -20 0C, dessiccated Protect from light. Avoid frequent thaw and freeze.
Documents
  • SDS
  • DataSheet

Carbonylacrylic PEG COOH Cat. No. PG2-CACR-5k 5000 Da 50 mg修饰性聚乙二醇

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Carbonylacrylic PEG COOH

Cat. No. PG2-CACR-5k
Specification 5000 Da
Unit Size 50 mg
Price $385.00

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Synonym: Carboxylic acid PEG Carbonylacrylic, Carbonylacrylic PEG acid

Description:

Carbonylacrylic PEG COOH is a thiol and amine reactive heterobifunctional PEG derivatives. Similar to Maleimide PEG, carbonylacrylic group can react with thiol group quickly to form a stable thiol ether bond. Carboxylic acid group, -COOH, on the other hand, can be activated to react to amine or hydryoxy groups.

Product Specifications:

  • Form: Solid
  • Apearance: Light yellow/off-white
  • Reactive groups: Carbonylacrylic and COOH
  • Reactive to: Sulfhydryl and primary amine/hydroxyl groups
  • Solubility: Soluble in water

Storage:

  • Store at -20 0C. Desiccate.

Methotrexate PEG2000 COOH Cat. No. MTX-CA-PG3-1 5 mg修饰性聚乙二醇

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Methotrexate PEG2000 COOH

Cat. No. MTX-CA-PG3-1
Specification
Unit Size 5 mg
Price $485.00

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Synonym: Methotrexate PEG2000 Acid, COOH PEG Methotrexate, MTX PEG2000 COOH, Carboxylic Acid PEG MTX

Product Specifications:

  • Form: Solid;
  • Color: Yellow;
  • Functional groups: Carboxylic acid (COOH);
  • Reactive to: Primary amine;
  • Solubility: Soluble in DMSO.

Storage Conditions:

  • Store at -20 0C. Protect from light.

Related Products:

Methotrexate PEG NHS, Methotrexate PEG3 amine, Methotrexate PEG Maleimide, Methotrexate PEG Biotin, Methotrexate PEG DBCO, Methotrexate PEG FITC.

DMG PEG2000 COOH Cat. No. DMG-PEG2k-CA 50 mg修饰性聚乙二醇

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DMG PEG2000 COOH

Cat. No. DMG-PEG2k-CA
Specification
Unit Size 50 mg
Price $385.00

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Synonym: PEG2000-DMG-Carboxylic acid, DMG-PEG2000-COOH, COOH-DMG-PEG2000, DMG-PEG2000-Acid, Carboxylic-acid-PEG2000-DMG,  1,2-dimyristoyl-rac-glycero-3-polyethylene glycol 2000 acid

Product Specifications:

  • Form: Solid
  • Color: White
  • Lipid type: DMG (1,2-dimyristoyl-rac-glycerol), C14 saturated
  • Functional tag: Carboxylic acd, -COOH
  • Reactive to: Amine, hydroxyl, etc.
  • PEG type: 2000 PEG, 45 PEG units

Storage:

  • Store at -20 0C.

Thalidomide-4-O-C10-COOH

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Thalidomide-4-O-C10-COOH  纯度: 98.86%

Thalidomide-4-O-C10-COOH 是一种 E3 连接酶配体-连接子共轭物，可用于合成 PROTAC。

Thalidomide-4-O-C10-COOH

Thalidomide-4-O-C10-COOH Chemical Structure

CAS No. : 2379870-45-6

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg)   Apply now  
25 mg ￥8800 In-stock
50 mg ￥14000 In-stock
100 mg   询价  
200 mg   询价  

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生物活性

Thalidomide-4-O-C10-COOH is a E3 ligase ligand-linker conjugate that can be used in the synthesis of PROTACs.

分子量

458.50

Formula

C24H30N2O7
CAS 号

2379870-45-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
参考文献

  • [1]. Powell CE, et al. Selective degradation-inducing probes for studying cereblon (CRBN) biology. RSC Med Chem. 2021 Jul 6;12(8):1381-1390.

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