Kushenol E is a class of flavonoids isolated from Sophora flavescens and is a non-competitive indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor with an IC50 of 7.7 µM and a Ki of 9.5 µM, has anti-tumor activity[1].
分子量
424.49
Formula
C25H28O6
CAS 号
99119-72-9
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
4°C, sealed storage, away from moisture and light
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
参考文献
[1]. Kwon M, et al. Inhibitory effects of flavonoids isolated from Sophora flavescens on indoleamine 2,3-dioxygenase 1 activity. J Enzyme Inhib Med Chem. 2019 Dec;34(1):1481-1488.
Sophoraflavanone G (Kushenol F) 是从苦参中提取得到的,具有抗肿瘤和抗炎特性。Sophoraflavanone G (Kushenol F) 通过抑制 MAPK 相关途径诱导 MDA-MB-231 和 HL-60 细胞凋亡 (apoptosis)。
Sophoraflavanone G Chemical Structure
CAS No. : 97938-30-2
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5 mg
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100 mg
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Sophoraflavanone G 相关产品
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生物活性
Sophoraflavanone G (Kushenol F) is iaolated from Sophora flavescens and shows anti-tumor and anti-inflammatory properties. Sophoraflavanone G (Kushenol F) induces MDA-MB-231 and HL-60 cells apoptosis through suppression of MAPK-related pathways[1][2].
IC50 & Target
IC50: 29.7 μM (MDA-MB-231 cell)[1]
体外研究 (In Vitro)
Sophoraflavanone G (0 -100 μM; 24 hours) decreases the viability of the HL-60 cells in a dose-dependent manner[1]. Sophoraflavanone G (0 -100 μM; 24 hours) induces HL-60 cell apoptosis, activated caspase-3 and caspase-9, and downregulated Bcl-2 and Bcl-xL. It also upregulates Bax and released cytochrome c from the mitochondria into the cytoplasm, enabling apoptosis via the mitochondrially-mediated “intrinsic” pathway[1] Sophoraflavanone G (0 -40 μM; 24 hours) inhibits MDA-MB-231 cell viability in a concentration-dependent manner, with an IC50 value of 29.7 ± 5.2 μM[2]<.br>
上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量
424.49
Formula
C25H28O6
CAS 号
97938-30-2
中文名称
苦参总黄酮; 苦参酚 F
运输条件
Room temperature in continental US; may vary elsewhere.
[1]. Li ZY, et al. Sophoraflavanone G Induces Apoptosis in Human Leukemia Cells and Blocks MAPK Activation.Am J Chin Med. 2016;44(1):165-76.
[2]. Huang WC, et al. Sophoraflavanone G from Sophora flavescens induces apoptosis in triple-negative breast cancer cells.Phytomedicine. 2019 Aug;61:152852.
Kushenol A (Leachianone E) 从苦参根中分离出来的。Kushenol A 是一种非竞争性酪氨酸酶 (tyrosinase) 抑制剂,可阻止 L-tyrosinase 转化为 L-DOPA,IC50 和 Ki 值分别为 1.1 μM 和 0.4 μM。Kushenol A 是一种类黄酮抗氧化剂,对 α-葡萄糖苷酶 (alpha-glucosidase) (IC50: 45 μM; Ki: 6.8 μM) 和 β-淀粉酶 (beta-amylase) 具有抑制作用。Kushenol A 被认为是化妆品针对皮肤美白和衰老的潜在酶抑制剂。
Kushenol A Chemical Structure
CAS No. : 99217-63-7
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Anti-Obesity Compound Library
Glucose Metabolism Compound Library
生物活性
Kushenol A (Leachianone E) is isolated from the root of Sophora flavescent. Kushenol A is a non-competitive tyrosinase inhibitor to block the conversion of L-tyrosine to L-DOPA, shows IC50 and Kivalues of 1.1 μM and 0.4 μM, respectively[1]. Kushenol A is a flavonoid antioxidant, has inhibitory effects on alpha-glucosidase (IC50: 45 μM; Ki: 6.8 μM) and β-amylase[2]. Kushenol A is confirmed as potential inhibitors of enzymes targeted by cosmetics for skin whitening and aging[1].
Kushenol A (25 μM) exhibits a highly potent inhibitory activity on ABTS+ radical scavenging with an IC50 value of 9.7 ± 0.1 μM, and exhibits inhibits scavenging activity as a percentage 93.7% at 25 μM[1].Kushenol A (0-60 μg/ml; 24 hours) shows considerable cytotoxic effects against NSCLC cells, exhibits IC50 values of 5.3 μg/ml and 20.5 μg/ml for A549 and NCI‐H226 cells, respectively. It shows an IC50 value of 57.2 μg/ml for BEAS-2B cells[3].
Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Viability Assay[3]
Cell Line:
NSCLC cell lines, A549 and NCI-H226Normal human lung epithelial: BEAS-2B
Concentration:
0-60 μg/ml
Incubation Time:
24 hours
Result:
Exhibited considerable cytotoxic effects against NSCLC cells.
分子量
408.49
Formula
C25H28O5
CAS 号
99217-63-7
中文名称
苦参新醇A
运输条件
Room temperature in continental US; may vary elsewhere.
[1]. Kim JH, et al. Kushenol A and 8-prenylkaempferol, tyrosinase inhibitors, derived from Sophora flavescens. J Enzyme Inhib Med Chem. 2018 Dec;33(1):1048-1054.
[2]. Kim JH, et al. Glycosidase inhibitory flavonoids from Sophora flavescens. Biol Pharm Bull. 2006 Feb;29(2):302-5.
[3]. Chen H, et al. A Novel Flavonoid Kushenol Z from Sophora flavescens Mediates mTOR Pathway by Inhibiting Phosphodiesterase and Akt Activity to Induce Apoptosis in Non-Small-Cell Lung Cancer Cells.Molecules. 2019 Dec 4;24(24). pii: E4425.