标签归档：maleimidobutyric

4-Maleimidobutyric acid

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

4-Maleimidobutyric acid 

4-Maleimidobutyric acid 是一种 PROTAC linker，属于 alkyl chain 类。可用于合成 PROTAC 分子。

4-Maleimidobutyric acid

4-Maleimidobutyric acid Chemical Structure

CAS No. : 57078-98-5

规格 价格 是否有货 数量
500 mg ￥500 In-stock
1 g   询价  
5 g   询价  

* Please select Quantity before adding items.

生物活性

4-Maleimidobutyric acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

Alkyl-Chain

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

183.16

Formula

C8H9NO4
CAS 号

57078-98-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献

  • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

4-Maleimidobutyric acid NHS, GMBS Cat. No. M-C4S-1 50 mg修饰性聚乙二醇

发表于由

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

4-Maleimidobutyric acid NHS, GMBS

Cat. No. M-C4S-1 4-Maleimidobutyric acid NHS, GMBS Cat. No. M-C4S-1 50 mg
Specification
Unit Size 50 mg
Price $385.00

Qty Add to Cart

Description:

Nanocs maleidobutyric acid NHS, also called GMPS, is an amine and sulfhydryl crosslinker with a short space arm between maleimide and NHS. This crossliker is non-cleavable and membrane permeable. It contains an amine reactive NHS ester and a sulfhydryl reactive maleimide group. NHS esters react with deprotonated primary amines, therefore, the reaction requires neutral to basic pH values to proceed. The maleimide group reacts with available –SH groups from naturally occurring or mutagenically derived cysteine residues. Maleimide groups react with sulfhydryl groups at pH 6.5~7.5 at room temperature to form stable thioether bonds.

Physical Properties:

  • Appearance: Off-white/white solid;
  • Purity: >95%
  • Solubility: Soluble in DMF or DMSO; Not soluble in water;

Storage Conditions:

  • Store at -20 0C. Desiccate.