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Nedaplatin (Synonyms: NSC 375101D) 纯度: ≥98.0%
Nedaplatin (NSC 375101D) 是顺铂衍生物和DNA损伤剂。
Nedaplatin Chemical Structure
CAS No. : 95734-82-0
规格 | 价格 | 是否有货 | 数量 |
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10 mg | ¥810 | In-stock | |
50 mg | ¥3096 | In-stock | |
100 mg | 询价 | ||
200 mg | 询价 |
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Nedaplatin 相关产品
•相关化合物库:
- Drug Repurposing Compound Library Plus
- FDA-Approved Drug Library Plus
- FDA-Approved Drug Library Mini
- Bioactive Compound Library Plus
生物活性 |
Nedaplatin (NSC 375101D) is a derivative of cisplatin and DNA damage agent. |
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体外研究 (In Vitro) |
Nedaplatin (NSC 375101D, NDP) is a derivative of cisplatin which produced less nausea & vomiting and nephrotoxicity. the effect of NDP on the 7-ethyl-1-hydroxy-CPT (the active form of CPT-11)-induced inhibitory effect on DNA topoisomerase I was examined. The topoisomerase I-inhibitory effect of 7-ethyl-1-hydroxy-CPT was enhanced 10-fold in the presence of Nedaplatin (NSC 375101D, NDP) at microgram/milliliter concentrations[1]. Nedaplatin (NSC 375101D, NDP) was developed as a second generation platinum complex. Because it has greater antitumour activity and lower nephrotoxicity than cisplatin (CDDP). At the high-dose of Nedaplatin (NSC 375101D, NDP) in FN therapy, a reduction of tumour size and long-term tumour-free survival were frequently observed. The survival effect of the combinations of Nedaplatin (NSC 375101D, NDP) with 5-FU was superior to those of the combination of CDDP with 5-FU. In conclusion, the sequence-dependent antitumour efficacy and toxicity of the combination of NDP or CDDP with 5-FU was demonstrated in this study, and FN therapy appeared to be the most efficient regimen as a clinical therapy[2]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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Clinical Trial |
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分子量 |
303.18 |
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Formula |
C2H6N2O3Pt |
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CAS 号 |
95734-82-0 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
*该产品在溶液状态不稳定,建议您现用现配,即刻使用。 |
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溶解性数据 |
In Vitro:
H2O : 13.6 mg/mL (44.86 mM; Need ultrasonic and warming; DMSO can inactivate Nedaplatin’s activity) DMF : < 1 mg/mL (insoluble; DMSO can inactivate Nedaplatin’s activity) 配制储备液
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请根据产品在不同溶剂中的溶解度,选择合适的溶剂配制储备液;该产品在溶液状态不稳定,建议您现用现配,即刻使用。 |
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参考文献 |
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