标签归档：nme

Fmoc-NMe-PEG4-NHS ester

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Fmoc-NMe-PEG4-NHS ester 

Fmoc-NMe-PEG4-NHS ester 是一种 PROTAC linker，属于 PEG 类。可用于合成 PROTAC 分子。

Fmoc-NMe-PEG4-NHS ester

Fmoc-NMe-PEG4-NHS ester Chemical Structure

CAS No. : 2228857-30-3

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Fmoc-NMe-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

598.64

Formula

C31H38N2O10
CAS 号

2228857-30-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Fmoc-NMe-PEG4-C2-acid

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Fmoc-NMe-PEG4-C2-acid 

Fmoc-NMe-PEG4-C2-acid 是一种 PROTAC linker，属于 PEG 类。可用于合成 PROTAC 分子。

Fmoc-NMe-PEG4-C2-acid

Fmoc-NMe-PEG4-C2-acid Chemical Structure

CAS No. : 2170240-98-7

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Fmoc-NMe-PEG4-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

Alkyl/ether

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

501.57

Formula

C27H35NO8
CAS 号

2170240-98-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献

  • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

c(phg-isoDGR-(NMe)k)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

c(phg-isoDGR-(NMe)k) 

c(phg-isoDGR-(NMe)k) 是有效选择性的 α5β1 整合素 配体，IC50 为 2.9 nM。

c(phg-isoDGR-(NMe)k)

c(phg-isoDGR-(NMe)k) Chemical Structure

CAS No. : 1844830-65-4

规格 价格 是否有货
1 mg ￥5500 询问价格 & 货期
5 mg ￥9800 询问价格 & 货期
10 mg ￥15000 询问价格 & 货期

* Please select Quantity before adding items.

c(phg-isoDGR-(NMe)k) 的其他形式现货产品:

c(phg-isoDGR-(NMe)k) TFA

生物活性

c(phg-isoDGR-(NMe)k) is a selective and potent α5β1-integrin ligand with an IC50 of 2.9 nM[1].

IC50 & Target

IC50: 2.9 nM (α5β1)[1]
体内研究
(In Vivo)

c(phg-isoDGR-(NMe)k) is trimerized with the chelator TRAP and used as a positron-emission tomography tracer for monitoring α5β1 integrin expression in a M21 mouse xenograft[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

603.67

Formula

C27H41N9O7
CAS 号

1844830-65-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Kapp TG, et al. N-Methylation of isoDGR Peptides: Discovery of a Selective α5β1-Integrin Ligand as a Potent Tumor Imaging Agent. J Med Chem. 2018 Mar 22;61(6):2490-2499.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Boc-NMe-Val-Val-Dil-Dap-OH

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Boc-NMe-Val-Val-Dil-Dap-OH 

Boc-NMe-Val-Val-Dil-Dap-OH 是一种可降解 (cleavable) 的 ADC 连接桥，用于抗体药物结合物 (ADCs) 的合成。

Boc-NMe-Val-Val-Dil-Dap-OH

Boc-NMe-Val-Val-Dil-Dap-OH Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Boc-NMe-Val-Val-Dil-Dap-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

IC50 & Target

Cleavable

 

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

684.90

Formula

C35H64N4O9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Boc-NMe-Val-Val-Dil-Dap-OH

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Boc-NMe-Val-Val-Dil-Dap-OH 

Boc-NMe-Val-Val-Dil-Dap-OH 是一种可降解 (cleavable) 的 ADC 连接桥，用于抗体药物结合物 (ADCs) 的合成。

Boc-NMe-Val-Val-Dil-Dap-OH

Boc-NMe-Val-Val-Dil-Dap-OH Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Boc-NMe-Val-Val-Dil-Dap-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

IC50 & Target

Cleavable

 

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

684.90

Formula

C35H64N4O9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Boc-NMe-Val-Val-Dil-Dap-OH

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Boc-NMe-Val-Val-Dil-Dap-OH 

Boc-NMe-Val-Val-Dil-Dap-OH 是一种可降解 (cleavable) 的 ADC 连接桥，用于抗体药物结合物 (ADCs) 的合成。

Boc-NMe-Val-Val-Dil-Dap-OH

Boc-NMe-Val-Val-Dil-Dap-OH Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Boc-NMe-Val-Val-Dil-Dap-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

IC50 & Target

Cleavable

 

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

684.90

Formula

C35H64N4O9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

c(phg-isoDGR-(NMe)k) TFA

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

c(phg-isoDGR-(NMe)k) TFA 

c(phg-isoDGR-(NMe)k) TFA 是有效选择性的 α5β1 整合素配体，IC50 为 2.9 nM。

c(phg-isoDGR-(NMe)k) TFA

c(phg-isoDGR-(NMe)k) TFA Chemical Structure

规格 价格 是否有货 数量
1 mg ￥5500 In-stock
5 mg ￥9800 In-stock
10 mg ￥15000 In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

生物活性

c(phg-isoDGR-(NMe)k) TFA is a selective and potent α5β1-integrin ligand with an IC50 of 2.9 nM[1].

IC50 & Target

IC50: 2.9 nM (α5β1)[1]
体内研究
(In Vivo)

c(phg-isoDGR-(NMe)k) TFA is trimerized with the chelator TRAP and used as a positron-emission tomography tracer for monitoring α5β1 integrin expression in a M21 mouse xenograft[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

717.69

Formula

C29H42F3N9O9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro: 

DMSO : 250 mg/mL (348.34 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.3934 mL 6.9668 mL 13.9336 mL
5 mM 0.2787 mL 1.3934 mL 2.7867 mL
10 mM 0.1393 mL 0.6967 mL 1.3934 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Kapp TG, et al. N-Methylation of isoDGR Peptides: Discovery of a Selective α5β1-Integrin Ligand as a Potent Tumor Imaging Agent. J Med Chem. 2018 Mar 22;61(6):2490-2499.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

(NMe)G-R-G-D-S-P 编码

发表于由
名称 (NMe)G-R-G-D-S-P
编码
别名 (NMe)G-R-G-D-S-P
纯度 80%，90%，95%，98%，99%
重量 1mg,5mg,10mg,50mg,100mg,1g
序列（单字母缩写） Sar-RGDSP
序列（三字母缩写） H-Sar-Arg-Gly-Asp-Ser-Pro-OH (trifluoroacetate salt)
基本描述 alphav β3 Integrin Binding RGD Peptide RGD Tumor Targeting and Tumor Imaging Peptide
溶解度
分子量 601.6
化学式 C23H39N9O10
存储条件 Store at -20°C. Keep tightly closed. Store in a cool dry place.
注释
Documents (NMe)G-R-G-D-S-P 编码
Figures (NMe)G-R-G-D-S-P 编码
Reference
C端
N端
化学桥