JI051 is a stabilizer for the Hes1-PHB2 interaction. JI051 interacts with a cancer-associated protein chaperone prohibitin 2 (PHB2), induces cell-cycle arrest by inhibiting the Notch downstream effector gene Hes1. Anti-cancer activity[1].
体外研究 (In Vitro)
JI051 causes G2/M cell-cycle arrest[1]. JI051 (0.1-10 µM, 24 hours) significantly inhibits cell proliferation of HEK293 cells, with an EC50 of 0.3 μM[1].
上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Proliferation Assay[1]
Cell Line:
HEK293 cells
Concentration:
0.1-10 µM
Incubation Time:
24 hours
Result:
Dose-dependently inhibits the proliferation of HEK293 cells at low concentrations.
分子量
364.44
Formula
C22H24N2O3
CAS 号
2234281-75-3
运输条件
Room temperature in continental US; may vary elsewhere.
[1]. Perron A, et al. Small-molecule screening yields a compound that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone. J Biol Chem. 2018 May 25;293(21):8285-8294.