Esculin(Synonyms: 秦皮甲素)

发表于2024年4月12日由上海金畔生物科技有限公司

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Esculin (Synonyms: 秦皮甲素) 纯度: 99.97%

Esculin 是一种荧光香豆素葡萄糖苷，是灰树皮的有效成分。Esculin 通过 MAPK 信号通路改善实验性糖尿病肾病 (DN) 的认知障碍，并发挥抗氧化应激和抗炎作用。

Esculin Chemical Structure

CAS No. : 531-75-9

规格	价格	是否有货
Free Sample (0.1-0.5 mg)		Apply now
10 mM * 1 mL in DMSO	￥550	In-stock
500 mg	￥500	In-stock
1 g		询价
5 g		询价

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Esculin 相关产品

•相关化合物库:

Natural Product Library Plus
Bioactive Compound Library Plus
Immunology/Inflammation Compound Library
Kinase Inhibitor Library
MAPK Compound Library
Natural Product Library
Anti-Cancer Compound Library
Anti-Aging Compound Library
Reprogramming Compound Library
Diabetes Related Compound Library
Glycoside Compound Library
Oxygen Sensing Compound Library
Phenols Library
Pyroptosis Compound Library
Traditional Chinese Medicine Monomer Library
FDA Approved & Pharmacopeial Drug Library
Anti-Lung Cancer Compound Library
Anti-Parkinson’s Disease Compound Library
Neurodegenerative Disease-related Compound Library
Angiogenesis Related Compound Library
Food-Sourced Compound Library

生物活性

Esculin, a fluorescent coumarin glucoside, is an active ingredient of ash bark^[1]. Esculin ameliorates cognitive impairment in experimental diabetic nephropathy (DN), and exerts anti‑oxidative stress and anti‑inflammatory effects, via the MAPK signaling pathway^[2].

IC₅₀ & Target^[2]

p38 MAPK

分子量

340.28

Formula

C₁₅H₁₆O₉

CAS 号

531-75-9

中文名称

秦皮甲素；七叶灵；七叶苷；七叶甙；马粟树皮苷

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 100 mg/mL (293.88 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.9388 mL	14.6938 mL	29.3876 mL
5 mM	0.5878 mL	2.9388 mL	5.8775 mL
10 mM	0.2939 mL	1.4694 mL	2.9388 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

参考文献

[1]. Knox K, et al. The Coumarin Glucoside, Esculin, Reveals Rapid Changes in Phloem-Transport Velocity in Response to Environmental Cues. Plant Physiol. 2018 Oct;178(2):795-807.

[2]. Song Y, et al. Esculin ameliorates cognitive impairment in experimental diabetic nephropathy and induces anti-oxidative stress and anti-inflammatory effects via the MAPK pathway. Mol Med Rep. 2018 May;17(5):7395-7402.

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tBID

发表于2024年4月12日由上海金畔生物科技有限公司

tBID 纯度: ≥98.0%

tBID 是同源结构域相互作用蛋白激酶2 (HIPK2) 的选择性抑制剂，IC₅₀值为 0.33 μM。

tBID Chemical Structure

CAS No. : 1639895-85-4

规格	价格	是否有货
10 mM * 1 mL in DMSO	￥4072	In-stock
1 mg	￥1500	In-stock
5 mg	￥3500	In-stock
10 mg	￥5000	In-stock
50 mg	￥15000	In-stock
100 mg	￥21000	In-stock
200 mg		询价
500 mg		询价

* Please select Quantity before adding items.

生物活性

tBID is a selective inhibitor of homeodomain-interacting protein kinase 2 (HIPK2) with an IC₅₀ of 0.33 µM.

IC₅₀ & Target

IC50: 0.33 µM (HIPK2)^[1]

体外研究
(In Vitro)

Homeodomain-interacting protein kinase 2 (HIPK2) is a Ser/Thr kinase controlling cell proliferation and survival. TBID, displays toward HIPK2 unprecedented efficacy (IC₅₀=0.33 µM) and selectivity (Gini coefficient 0.592 out of a panel of 76 kinases). The two other members of the HIPK family, HIPK1 and HIPK3, are also inhibited by TBID albeit less efficiently than HIPK2. The mode of action of TBID is competitive with respect to ATP, consistent with modelling. TBID interacts with the hinge region through hydrophobic interactions between Val 213, Val 261, Phe 277, Leu 280, Met 331, Ile 345, and the tetrabromine moiety, while the symmetric nitrogen atom at position 3 interacts with the catalytic Lys 228, thus playing a crucial role in the binding architecture^[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

528.78

Formula

C₁₁H₃Br₄N₃O₂

CAS 号

1639895-85-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 26 mg/mL (49.17 mM; Need ultrasonic and warming)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.8911 mL	9.4557 mL	18.9115 mL
5 mM	0.3782 mL	1.8911 mL	3.7823 mL
10 mM	0.1891 mL	0.9456 mL	1.8911 mL

参考文献

[1]. Cozza G, et al. Synthesis and properties of a selective inhibitor of homeodomain-interacting protein kinase 2 (HIPK2). PLoS One. 2014 Feb 24;9(2):e89176.

Cell Assay ^[1]	HepG2 cells (human hepatocellular carcinoma) are cultured in Dulbecco’s modified Eagle’s medium supplemented with 10% fetal calf serum, 2 mM L-glutamine, 100 unit/mL penicillin and 100 µg/mL streptomycin. Treatments with TBID are performed in the same medium but with 1% fetal calf serum; control cells are treated with the solvent (DMSO). Cell viability is evaluated by means of MTT^[1] 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献	[1]. Cozza G, et al. Synthesis and properties of a selective inhibitor of homeodomain-interacting protein kinase 2 (HIPK2). PLoS One. 2014 Feb 24;9(2):e89176.

Cell Assay
^[1]

HepG2 cells (human hepatocellular carcinoma) are cultured in Dulbecco’s modified Eagle’s medium supplemented with 10% fetal calf serum, 2 mM L-glutamine, 100 unit/mL penicillin and 100 µg/mL streptomycin. Treatments with TBID are performed in the same medium but with 1% fetal calf serum; control cells are treated with the solvent (DMSO). Cell viability is evaluated by means of MTT^[1]

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献

[1]. Cozza G, et al. Synthesis and properties of a selective inhibitor of homeodomain-interacting protein kinase 2 (HIPK2). PLoS One. 2014 Feb 24;9(2):e89176.

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Thermo移液器全系列4620300

发表于2024年4月12日由上海金畔生物科技有限公司

Thermo移液器全系列

产品型号：4620300
简要描述：Thermo移液器全系列金畔生物公司供应：ELISA试剂盒,动物血清,荧光定量PCR耗材,移液器吸嘴,微量离心管,进口冻存管,细胞培养皿,培养板,培养瓶,进口吸头,仪器及手套,色谱耗材,针头过滤器,分光光度计。

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产品简介

Thermo移液器全系列

Thermo移液器又名赛默飞世尔移液器、热电移液器、芬兰雷勃移液器，有单道、8道、12道、电动移液器。

Thermo移液器全系列 单道可变量程移液器金畔生物公司供应：ELISA试剂盒,动物血清,荧光定量PCR耗材,移液器吸嘴,微量离心管,进口冻存管,细胞培养皿,培养板,培养瓶,进口吸头,仪器及手套,色谱耗材,针头过滤器,分光光度计。

货号产品名

4620300 Finnpipette Novus 1-10 µl /5-50 µlMicro中文版本单道电动移液器

4620360 Finnpipette Novus 100-1000 µl /500-5000 µl中文版本单道电动移液器

4630300 Finnpipette Novus 1-10 µl /5-50 µl中文版本MCP8道电动移液器

4630350 Finnpipette Novus 30-300 µl 中文版本MCP12道电动移液器

4630360 Finnpipette Novus 5-50 µl 中文版本MCP16道电动移液器

4640000 Finnpipette F3 1-10 μl Micro单道可变量程移液器

4640010 Finnpipette F3 1-10 μl /2-20 μl 通用型单道可变量程移液器

4640040 Finnpipette F3 10-100 μl /20-200 μl单道可变量程移液器

4641010 NFinnpipette F1 0.2-2 μl micro单道可变量程移液器, CE认证

4641050 NFinnpipette F1 2-20 μl micro单道可变量程移液器, CE认证

4641070 NFinnpipette F1 10-100 μl 200μl 300μl单道可变量程移液器, CE认证

4641130 NFinnpipette F1 5-50 μl micro单道可变量程移液器, CE认证

4642050 Finnpipette F2 2-20 μl micro单道可变量程移液器, CE认证

4642060 Finnpipette F2 2-20 μl 单道可变量程移液器, CE认证

4642090 Finnpipette F2 100-1000 μl 单道可变量程移液器, CE认证

4642120 Finnpipette F2 5-50 μl micro单道可变量程移液器, CE认证

4642130 Finnpipette F2 5-50 μl 单道可变量程移液器, CE认证

4650030 Finnpipette F3 10 ul 25 ul 50 ul 固定量程移液器

Thermo 单道可变量程移液器

适应客户：医院检验科PCR实验室，中心实验室，肝病中心；第三方检测机构，科研院所，大专院校，制药厂，试剂生产厂家，疾控中心，检验检疫。

上海精宏全温培养振荡器HZP-250

发表于2024年4月12日由上海金畔生物科技有限公司

上海精宏全温培养振荡器HZP-250

品牌精宏|JINGHONG

型号 HZP-250

商品详情

ZDP型恒温培养振荡器ZDP Series Constant Temperature Shaking Incubator
HZP型全温培养振荡器HZP Series Shaking Incubator with Temperature
特点:工作室配置双层通用振荡平台,又可改为单层满足大规格三角烧瓶高度.

振荡器件：多功能弹簧架、烧瓶夹、试管架、托盘
技术参数.(Specifications):

产品名称Products	恒温温培养振荡器Constant shaking incubator		全温培养振荡器Shaking incubator with temperature
型号 Model	ZDP-150	ZDP-250	HZP-150	HZP-250
电源电压 Mains voltage	220V. 50Hz
旋转频率Temperature control range	30~280rpm
摆振幅度Vibrate Shaking function	φ 28mm
摆板尺寸 Size of board	370×370mm×2层	440×440mm ×2层	370×370mm ×2层	440×440mm×2 层
标准配置Standard configure	100ml×6个,150ml×6个 ,250ml×6个	150ml×6个 ,250ml×6 个 ,500ml× 6个	100ml×6个 ,150ml×6 个 ,250ml ×6个	150ml×6个 ,250ml×6个 ,500ml×6个
最大容量Max dimensions	100ml×28个或250ml×28 个或500ml×9个或1000×5 个	100ml×44 个或250ml ×44个或500ml×14个或1000×9 个	100ML28个或250ML28个或500ML*9个或 1000 ×5个	100ml×44个或 250ml×44个或 500ml×14个或 1000×9个
控温范围 Temperature control range	RT+5~50 ℃		5~50 ℃
控温精度 Teperature control precision	± 0.1 ℃
温度波动Temperature fluctuation	± 0.5 ℃
消耗功率Consumption power	500W	580W	700W	900W

Nalgene耐洁 Economy Wash Bottles 经济洗瓶 125ml （2401-0250）

发表于2024年4月12日由上海金畔生物科技有限公司

Nalgene耐洁 Economy Wash Bottles 经济洗瓶 125ml （2401-0250）

商品品牌： Nalgene耐洁

商品编号：2401-0250

商品价格：请与我们联系

Nalgene耐洁 Economy Wash Bottles 经济洗瓶 125ml （2401-0250）-Nalgene耐洁-2401-0250

产品类别:洗瓶
瓶身材质:LDPE

容量:250ml
品牌属性:进口

实验室耗材|||容量盛液|||洗瓶|||Nalgene耐洁EconomyWashBottles经济洗瓶125ml（2401-0250）

洗瓶经济洗瓶

Nalgene耐洁 Economy Wash Bottles 经济洗瓶 250ml（2401-0250）

LDPE材料，瓶盖PP材料，喷嘴PPCO材料；

喷嘴和瓶盖一体化设计可防漏，可满足常规实验室的要求，比安全洗瓶经济，瓶身硬度适中，一压即喷，非压即止，喷用性能好无液滴残留，回复快。

保证密封

商品属性

产品类别:洗瓶
瓶身材质:LDPE

容量:250ml
品牌属性:进口

商品属性
商品名称	Nalgene耐洁 Economy Wash Bottles 经济洗瓶 125ml （2401-0250）-2401-0250-Nalgene耐洁
型号	2401-0250
类别	实验室耗材\|\|\|容量盛液\|\|\|洗瓶\|\|\|Nalgene耐洁EconomyWashBottles经济洗瓶125ml（2401-0250）
品牌	Nalgene耐洁
品牌简介	Nalgene耐洁
关键字	洗瓶经济洗瓶,经济,喷嘴,瓶盖,材料,硬度,适中

Nalgene耐洁 Economy Wash Bottles 经济洗瓶 125ml （2401-0250）

Tolfenamic Acid-D4(Synonyms: 托芬那酸 D4)

发表于2024年4月12日由上海金畔生物科技有限公司

Tolfenamic Acid-D4 (Synonyms: 托芬那酸 D4)

Tolfenamic Acid-D4 (GEA 6414-D4) 是 Tolfenamic Acid 的氘代物。Tolfenamic Acid (GEA 6414) 是一种非甾体抗炎剂和抗癌剂，能够选择性地抑制 COX-2 的活性，在 LPS 诱导的犬 DH82 单核细胞/巨噬细胞中，对 COX-2 的 IC₅₀ 值为 13.49 μM (3.53 μg/mL)，对 COX-1 无作用。

Tolfenamic Acid-D4 Chemical Structure

CAS No. : 1246820-82-5

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

* Please select Quantity before adding items.

生物活性	Tolfenamic Acid-D4 (GEA 6414-D4) is the deuterium labeled Tolfenamic Acid. Tolfenamic Acid (GEA 6414) is a non-steroidal anti-inflammatory and anti-cancer agent, selectively inhibits COX-2, with an IC₅₀ of 13.49 μM (3.53 μg/mL) in LPS-treated (COX-2) canine DH82 monocyte/macrophage cells, but shows no effect on COX-1^[1]^[2].
体外研究 (In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	265.73
Formula	C₁₄H₈D₄ClNO₂
CAS 号	1246820-82-5
中文名称	托芬那酸 D4
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Kay-Mugford P, et al. In vitro effects of nonsteroidal anti-inflammatory drugs on cyclooxygenase activity in dogs. Am J Vet Res. 2000 Jul;61(7):802-10. [3]. Maliakal P, et al. Chemopreventive effects of tolfenamic acid against esophageal tumorigenesis in rats. Invest New Drugs. 2012 Jun;30(3):853-61. [4]. Sankpal UT, et al. Tolfenamic acid-induced alterations in genes and pathways in pancreatic cancer cells. Oncotarget. 2017 Feb 28;8(9):14593-14603

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FTI-2153

发表于2024年4月12日由上海金畔生物科技有限公司

FTI-2153 纯度: 98.41%

FTI-2153 是一种有效、高度选择性的法尼基转移酶 farnesyltransferase (FTase) 抑制剂，IC₅₀ 为 1.4 nM。FTI-2153 有效抑制 H-Ras 蛋白的加工修饰，IC₅₀ 值为 10 nM，对其抑制活性是对 Rap1A 蛋白加工的 3000 多倍。

FTI-2153 Chemical Structure

CAS No. : 344900-92-1

规格	价格	是否有货
10 mM * 1 mL in DMSO	￥4620	In-stock
5 mg	￥4500	In-stock
10 mg	￥8000	In-stock
25 mg	￥15500	In-stock
50 mg	￥23500	In-stock
100 mg	￥34000	In-stock
200 mg		询价
500 mg		询价

* Please select Quantity before adding items.

FTI-2153 相关产品

•相关化合物库:

Bioactive Compound Library Plus
Metabolism/Protease Compound Library
Anti-Cancer Compound Library
Anti-Lung Cancer Compound Library
Anti-Pancreatic Cancer Compound Library
Targeted Diversity Library

生物活性

FTI-2153 is a potent and highly selective inhibitor of farnesyltransferase (FTase), with an IC₅₀ of 1.4 nM. FTI-2153 is >3000-fold more potent at blocking H-Ras (IC₅₀, 10 nM) than Rap1A processing. Anti-cancer activity^[1].

体外研究
(In Vitro)

FTI-2153, inhibits bipolar spindle formation during mitosis independently of transformation and Ras and p53 mutation status in two human lung cancer cell lines^[2].
FTI-2153 increases the percentage of prometaphase cells with ring-like DNA morphology in transformed and non-transformed cells^[2].
FTI-2153 (15 μM) inhibits T-24 and Calu-1 cell growth by 38 and 36%, respectively. NIH3T3, HFF and HT-1080 are less sensitive and are inhibited by only 8, 8 and 13%, respectively. A-549 and OVCAR3 cell growth is inhibited by 25 and 22%, respectively. Thus, even though T-24 and Calu-1 cells are equisensitive to FTI-2153 cell growth inhibition, FTI-2153 inhibits bipolar spindle formation only in Calu-1 cells. HFF and NIH3T3 cells are both resistant to FTI2153 growth inhibition, yet only NIH3T3 cells are resistant to FTI-2153 inhibition of bipolar spindle formation^[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:	NIH3T3, HFF, HT1080, T-24, OVCAR3, A-549 and Calu-1 CELLS.
Concentration:	48 h.
Incubation Time:	15 μM.
Result:	When A-549 cells were treated with FTI-2153 (15 μM for 48 h), the proportion of cells at prometaphase increased relative to the other phases of mitosis. FTI-2153 accumulated cells at prometaphase with a rosette-like morphology where chromosomes form a ring surrounding a monoaster of microtubules. In all cells, except for T-24 and NIH3T3, FTI-2153 treatment increased the proportion of mitotic cells in prometaphase and decreased the percentage of cells in telophase/cytokinesis. In HT1080 cells, the percentage of cells in prometaphase and telophase/ cytokinesis were 5 and 85% in control cells and 55 and 35% in Treated cells, respectively. Similarly results were also found in HFF cells. Calu-1 and A-549 cells, as described previously, had similarly large changes, whereas OVCAR3 had smaller changes. In contrast, FTI-2153 did not significantly affect the distribution of the different phases of mitosis in T-24 and NIH3T3 cells.

分子量

466.60

Formula

C₂₅H₃₀N₄O₃S

CAS 号

344900-92-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 100 mg/mL (214.32 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.1432 mL	10.7158 mL	21.4316 mL
5 mM	0.4286 mL	2.1432 mL	4.2863 mL
10 mM	0.2143 mL	1.0716 mL	2.1432 mL

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline

Solubility: ≥ 2.5 mg/mL (5.36 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (5.36 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (5.36 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (5.36 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
3.

请依序添加每种溶剂： 10% DMSO 90% corn oil

Solubility: ≥ 2.5 mg/mL (5.36 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (5.36 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在上海金畔生物科技有限公司网站选购。

参考文献

[1]. Sun J, et al. Antitumor efficacy of a novel class of non-thiol-containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I: combination therapy with the cytotoxic agents cisplatin, Taxol, and gemcitabine. Cancer Res. 1999 Oct 1;59(19):4919-26.

[2]. N C Crespo, et al. The farnesyltransferase inhibitor, FTI-2153, inhibits bipolar spindle formation during mitosis independently of transformation and Ras and p53 mutation status. Cell Death Differ. 2002 Jul;9(7):702-9.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

EUTECH PC450型pH/mV/电导率/TDS测量仪

发表于2024年4月12日由上海金畔生物科技有限公司

【简单介绍】

美国EUTECH PC450型pH/mV/电导率/TDS测量仪的特点：大屏幕，自定义背光屏-可同时显示测量值和温度
耐用的防水、防尘设计，防护等级达到IP67
PC450可使用单根复合pH/电导率电极或独立的pH和电导率电极

【详细说明】

EUTECH PC450型pH/mV/电导率/TDS测量仪

产品简述：

Eutech™ PC 450 多参数测量仪为实验室的多参数研究工作提供一体化解决方案。多参数 Eutech PC 450 可测量 pH 值/mV/电导率/总溶解固体/温度。它可以使用 pH 值/电导率探头，也可以使用单独的 pH 值探头和电导率探头。

按一下按钮即可在 pH 值、mV、电导率和 TDS 之间切换
大型背光定制显示屏 – 便于查看测量值以及温度
Grip-Clip™ – 快速方便地将单独的 pH 电极和电导电极同时固定到样品容器或烧杯上
使用 USA 或 NIST 缓冲液组，自动进行多达 5 点的校准（使用 DIN 时多达 6 点）。通过新的手动选项可采用多达 5 种自定义缓冲液标准品校准
自动缓冲液识别 – 自动识别正确的 pH 缓冲液，便于快速校准
直观的用户友好式图标 – 电极状态显示 pH 斜率或电池常数
在 5 个范围内自动调整电导率量程，量程介于 0 至 199.9 mS 之间 – 多达 5 个校准点
可选电池常数 – 0.10、1.00 或 10.0
可在 0.00 至 10.00% 之间调节–每 ºC 的温度系数
电导率到 TDS 转换因子 – 可在 0.40 至 1.00 之间调节
可选择 ºC/ºF – 选择更适合您应用的单位
准备就绪指示器、手动或自动测量保持功能和可选的自动关闭功能
可存储多达 500 个数据集；利用选配的数据线缆，轻松实现 USB 或 RS232 输出
内置实时时钟可对存储的数据和校准数据标注时间和日期标记戳 – 符合 GLP（良好实验室规范）的标准
内置支架，带壁装选件 – 便于在工作台上进行测量和储存

技术参数:

pH量程:-2.00-16.00pH
pH分辨率:0.01 pH
pH精度:±0.01 pH
校正点: 多至6点 (USA & NIST & CUSTOM) (DIN)
ORP量程:±2000 mV
ORP分辨率:0.1 mV ±999.9 mV；小于1 mV
ORP精度:±0.2 mV +2 LSD 或读数的 +0.5 %（两者取优）
校正点:±200 Mv
电导率量程: 0 to 200 mS
电导率分辨率: 0.01 μS 到 0.1 mS
电导率精度: 全量程±1 %
校正点: 自动或手动校正； 1 点/量程
TDS总溶解固体量程: 0 到 200 ppt (TDS系数1.0)
TDS总溶解固体分辨率: 0.01 ppm 到 0.1 ppt
TDS总溶解固体精度: 全量程±1 %
校正点: 手动; 1 点/量程
盐度量程：0 to 50ppt
盐度分辨率：0.01
盐度精度：全量程±1 %
校正点：手动或自动
温度量程：-10.0 到 110.0 oC (14.0 到 230.0 oF)
温度分辨率：0.1 oC/oF
温度精度：±0.5 oC； ±0.9 oF
校正点：0.1叠增偏移量，±10 oC或±18 oF
显示：三线界面自定义LCD
存储器:多到500组数据采集
输出：USB或RS232
实时时钟：校准和存储的数据集包含时间和日期
温度补偿：自动或手动，从-10 to 110 oc
压力或盐度补偿：手动
电源：2节AA电池（标配），>100小时(背光灯关闭)，AC适配器（可选配）
仪表尺寸：20×8.3×5.7 cm
包装尺寸：23×23×7cm
仪表重量：0.5kg
包装重量：0.7kg

EUTECH PC450型pH/mV/电导率/TDS测量仪

产品配置：

ECPCWP45000

PC450 Meter only 仅PC 450仪表：主机，2节AA电池

ECPCWP45004

PC 450 Meter with separate pH & cond probes 包括PC 450仪表和pH&电导率/ATC电极：主机，双液接pH电极；电导率电极（K=1.0），电极固定插槽，2节AA电池

ECPCWP45004K

PC450 Meter with separate pH & cond probes Kit PC 450仪表套装：主机，双液接pH电极，电导率电极K=1.0），电极固定插槽，2节AA电池，便携式箱，USB线缆；校准溶液

ECPCWP45003

PC450 Meter with Combi probe包括PC 450仪表和复合电极：主机，复合pH/电导率/ATC

电极，2节AA电池

ECPCWP45003K

PC450 Meter Combi probe KIT PC 450仪表和复合电极套装：主机，复合pH电极/电导率电极，电极固定插槽，2节AA电池，便携式箱，USB线缆；校准溶液

多肽定制Crustacean Erythrophore Concentrating Hormone 编码 [37933-92-9]

发表于2024年4月12日由上海金畔生物科技有限公司

上海金畔生物科技有限公司可以定制不同序列多肽，可以访问官网了解更多产品信息。

名称	Crustacean Erythrophore Concentrating Hormone
编码	[37933-92-9]
别名	Crustacean Erythrophore Concentrating Hormone
纯度	80%，90%，95%，98%，99%
重量	1mg,5mg,10mg,50mg,100mg,1g
序列（单字母缩写）	PYRLNFSPGW-NH2
序列（三字母缩写）	Pyr-Leu-Asn-Phe-Ser-Pro-Gly-Trp-NH2
基本描述
溶解度
分子量	930.04
化学式	C45H59N11O11
存储条件	Store at -20°C. Keep tightly closed. Store in a cool dry place.
注释
Documents
Figures
Reference
C端
N端
化学桥

AX-15836

发表于2024年4月12日由上海金畔生物科技有限公司

AX-15836 纯度: 99.96%

AX-15836是有效，选择性的ERK5抑制剂，IC₅₀值为8 nM。

AX-15836 Chemical Structure

CAS No. : 2035509-96-5

规格	价格	是否有货
10 mM * 1 mL in DMSO	￥2712	In-stock
2 mg	￥1100	In-stock
5 mg	￥1900	In-stock
10 mg	￥2800	In-stock
25 mg	￥5800	In-stock
50 mg	￥9800	In-stock
100 mg		询价
200 mg		询价

* Please select Quantity before adding items.

AX-15836 相关产品

•相关化合物库:

Bioactive Compound Library Plus
Immunology/Inflammation Compound Library
Kinase Inhibitor Library
MAPK Compound Library
Stem Cell Signaling Compound Library
Anti-Cancer Compound Library
Anti-Aging Compound Library
Reprogramming Compound Library
Oxygen Sensing Compound Library
Glutamine Metabolism Compound Library
Angiogenesis Related Compound Library
Targeted Diversity Library
Anti-Liver Cancer Compound Library
Anti-Colorectal Cancer Compound Library

生物活性

AX-15836 is a potent and selective ERK5 inhibitor with an IC₅₀ of 8 nM.

IC₅₀ & Target^[1]

ERK5

8 nM (IC₅₀)

体外研究
(In Vitro)

AX-15836 shows more than 1,000-fold selectivity for ERK5 over a panel of over 200 kinases. It also exhibits selectivity over BRD4 with a K_d of 3,600 nM. AX15836 shows similar intracellular potency (4–9 nM) across all cells tested, including peripheral blood mononuclear cells (PBMCs), endothelial cells, and oncogenic cell lines. AX15836 was completely ineffective (EC₅₀>10 μM) to suppress inflammatory cytokine response, suggesting that it was the BRD inhibition component of the compounds that mediated cytokine reduction. In HUVEC and HeLa cell types, samples treated with AX15836 shows very few genes to be differentially expressed. AX15836 could clearly inhibit the EGF-stimulated, phosphorylated form of ERK5 in HeLa cells^[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

648.78

Formula

C₃₂H₄₀N₈O₅S

CAS 号

2035509-96-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 100 mg/mL (154.14 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.5414 mL	7.7068 mL	15.4135 mL
5 mM	0.3083 mL	1.5414 mL	3.0827 mL
10 mM	0.1541 mL	0.7707 mL	1.5414 mL

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline

Solubility: ≥ 2.5 mg/mL (3.85 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (3.85 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (3.85 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (3.85 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
3.

请依序添加每种溶剂： 10% DMSO 90% corn oil

Solubility: ≥ 2.5 mg/mL (3.85 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (3.85 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在上海金畔生物科技有限公司网站选购。

参考文献

[1]. Lin EC, et al. ERK5 kinase activity is dispensable for cellular immune response and proliferation. Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):11865-11870.

Cell Assay ^[1]	For proliferation studies, cells are treated with eight-point serial dilution series of AX-15836 (starting concentration of 15 μM) or with DMSO vehicle (0.25% final volume). For MM.1S cells, compound was added 1 h before adding recombinant human IL-6 at 5 nM. After 3 d, the relative number of viable cells was measured via quantitation of ATP using CellTiter-Glo 2.0 reagent. Luminescence was read on the Synergy 2 multimode reader^[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献	[1]. Lin EC, et al. ERK5 kinase activity is dispensable for cellular immune response and proliferation. Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):11865-11870.

Cell Assay
^[1]

For proliferation studies, cells are treated with eight-point serial dilution series of AX-15836 (starting concentration of 15 μM) or with DMSO vehicle (0.25% final volume). For MM.1S cells, compound was added 1 h before adding recombinant human IL-6 at 5 nM. After 3 d, the relative number of viable cells was measured via quantitation of ATP using CellTiter-Glo 2.0 reagent. Luminescence was read on the Synergy 2 multimode reader^[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献

[1]. Lin EC, et al. ERK5 kinase activity is dispensable for cellular immune response and proliferation. Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):11865-11870.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

9-cis,13-cis-Retinoic acid-d5(Synonyms: 异维甲酸 d5)

发表于2024年4月12日由上海金畔生物科技有限公司

9-cis,13-cis-Retinoic acid-d5 (Synonyms: 异维甲酸 d5)

9-cis,13-cis-Retinoic acid-d5 是 Isotretinoin 的氘代物。Isotretinoin(13-cis-Retinoic acid)可作用于重度粉刺，还可用于脑癌，胰腺癌等化疗。

9-cis,13-cis-Retinoic acid-d5 Chemical Structure

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

* Please select Quantity before adding items.

生物活性	9-cis,13-cis-Retinoic acid-d5 is the deuterium labeled Isotretinoin. Isotretinoin (13-cis-Retinoic acid) is a medication used for the treatment of severe acne. It was first developed to be used as a chemotherapy medication for the treatment of brain cancer, pancreatic cancer and more^[1]^[2].
体外研究 (In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	305.47
Formula	C₂₀H₂₃D₅O₂
中文名称	异维甲酸 d5
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Thielitz, A. and H. Gollnick, [Isotretinoin. How should it be used?]. Hautarzt, 2013. 64(4): p. 263-8. [3]. Norris, D.A., et al., Isotretinoin produces significant inhibition of monocyte and neutrophil chemotaxis in vivo in patients with cystic acne. J Invest Dermatol, 1987. 89(1): p. 38-43. [4]. Rademaker, M., J.M. Wishart, and N.M. Birchall, Isotretinoin 5 mg daily for low-grade adult acne vulgaris – a placebo-controlled, randomized double-blind study. J Eur Acad Dermatol Venereol, 2013. [5]. Dicken, C.H., Isotretinoin treatment of pityriasis rubra pilaris. J Am Acad Dermatol, 1987. 16(2 Pt 1): p. 297-301.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

上海精宏全温培养振荡器HZP-150

发表于2024年4月12日由上海金畔生物科技有限公司

上海精宏全温培养振荡器HZP-150

品牌精宏|JINGHONG

型号 HZP-150

商品详情

振荡器件：多功能弹簧架、烧瓶夹、试管架、托盘
技术参数.(Specifications):

产品名称Products	恒温温培养振荡器Constant shaking incubator		全温培养振荡器Shaking incubator with temperature
型号 Model	ZDP-150	ZDP-250	HZP-150	HZP-250
电源电压 Mains voltage	220V. 50Hz
旋转频率Temperature control range	30~280rpm
摆振幅度Vibrate Shaking function	φ 28mm
摆板尺寸 Size of board	370×370mm×2层	440×440mm ×2层	370×370mm ×2层	440×440mm×2 层
标准配置Standard configure	100ml×6个,150ml×6个 ,250ml×6个	150ml×6个 ,250ml×6 个 ,500ml× 6个	100ml×6个 ,150ml×6 个 ,250ml ×6个	150ml×6个 ,250ml×6个 ,500ml×6个
最大容量Max dimensions	100ml×28个或250ml×28 个或500ml×9个或1000×5 个	100ml×44 个或250ml ×44个或500ml×14个或1000×9 个	100ML28个或250ML28个或500ML*9个或 1000 ×5个	100ml×44个或 250ml×44个或 500ml×14个或 1000×9个
控温范围 Temperature control range	RT+5~50 ℃		5~50 ℃
控温精度 Teperature control precision	± 0.1 ℃
温度波动Temperature fluctuation	± 0.5 ℃
消耗功率Consumption power	500W	580W	700W	900W

Polystyrene beads, FITC labeled Cat. No. PS10u-FC-1 10 um 0.5 mL修饰性聚乙二醇

发表于2024年4月12日由上海金畔生物科技有限公司

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

Polystyrene beads, FITC labeled

Cat. No.	PS10u-FC-1
Specification	10 um
Unit Size	0.5 mL
Price	$385.00

Description:

Polystyrene Particles from Nanocs have narrow size distribution yet with multiple size selection from 20 nm to 10 microns. These particles are suspended in 1% aqeuous solution. Standard deviation of these particles is in the range of 10% of listed size parameter. These particles have wide applications in diagnostic reagents and bioassay development. They can be further modified with different surface coatings and functional groups. Nanocs surface modified polystyrene particles provide more choices for in-vitro or in-vivo applications of those nanoparticles. Customer conjugation and modification is available upon request.

Physical Properties:

1% suspension in aqueous solution, other concentration available upon request;

Storage Conditions:

Store at 4 ⁰C.

IPR-803

发表于2024年4月12日由上海金畔生物科技有限公司

IPR-803 纯度: 98.03%

IPR-803 是一种有效的 uPAR•uPA 蛋白-蛋白相互作用 (PPI) 抑制剂。IPR-803 直接与 uPAR 绑定，具有亚微摩尔的亲和力。IPR-803 具有抗肿瘤活性。

IPR-803 Chemical Structure

CAS No. : 892243-35-5

规格	价格	是否有货
10 mM * 1 mL in DMSO	￥3630	In-stock
5 mg	￥3300	In-stock
10 mg	￥5500	In-stock
25 mg	￥9800	In-stock
50 mg		询价
100 mg		询价

* Please select Quantity before adding items.

IPR-803 相关产品

•相关化合物库:

Bioactive Compound Library Plus
Metabolism/Protease Compound Library
Anti-Cancer Compound Library
Anti-Breast Cancer Compound Library

生物活性

IPR-803 is a potent inhibitor of the uPAR•uPA protein-protein interaction (PPI). IPR-803 binds directly to uPAR with sub-micromolar affinity. IPR-803 displays anti-tumor activity^[1].

IC₅₀ & Target

Ki: 0.2 μM (PPI)^[1]

体外研究
(In Vitro)

IPR-803 blocks invasion of breast cancer cells line MDA-MB-231, and inhibits matrix metalloproteinase (MMP) breakdown of the extracellular matrix (ECM)^[1].
IPR-803 impairs MDA-MB-231 cell adhesion and migration^[1].
IPR-803 induces a concentration-dependent impairment of cell adhesion with an IC₅₀ of approximately 30 μM^[1].
IPR-803 inhibits MDA-MB-231 cells growth with an IC₅₀ of 58 μM^[1].
IPR-803 (0-200 μM; 3 days) blocks the invasion of MDA-MB-231 cells, and most of the inhibition of cell invasion is unlikely due to cytotoxicity of the compound^[1].
IPR-803 (1-50 μM; 24 hours) does not have a significant effect on apoptosis or necrosis^[1].
IPR-803 (50 μM; 30 minutes) shows inhibition of MAPK phosphorylation^[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:	MDA-MB-231 cells
Concentration:	0 μM, 50 μM, 150 μM, 200 μM
Incubation Time:	3 days
Result:	Displays 90 percent blockage of invasion that is observed at 50 μM.

体内研究
(In Vivo)

IPR-803 (200 mg/kg; i.g.; three times a week; for 5 weeks) impairs breast cancer metastasis, but no statistical significance to the differences in body weight between treated and untreated^[1].
IPR-803 has a low oral bioavailability at 4 percent, and remains high concentration even after 10 hours in tumor tissue^[1].
IPR-803 exhibits a half-life (t1/2) of 5 hours^[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	NSG mice with MDA-MB-231 cells xenograft^[1]
Dosage:	200 mg/kg
Administration:	Oral gavage; three times a week; for 5 weeks
Result:	Impaired metastasis to the lungs.

Animal Model:	NOD/SCID mice^[1]
Dosage:	200 mg/kg (Pharmacokinetic Study)
Administration:	Oral administration
Result:	t1/2=5 hours.

分子量

453.49

Formula

C₂₇H₂₃N₃O₄

CAS 号

892243-35-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 7.69 mg/mL (16.96 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.2051 mL	11.0256 mL	22.0512 mL
5 mM	0.4410 mL	2.2051 mL	4.4102 mL
10 mM	0.2205 mL	1.1026 mL	2.2051 mL

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

1.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)

Solubility: ≥ 0.77 mg/mL (1.70 mM); Clear solution

此方案可获得 ≥ 0.77 mg/mL (1.70 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 7.7 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明

*以上所有助溶剂都可在上海金畔生物科技有限公司网站选购。

参考文献

[1]. Mani T, et al. Small-molecule inhibition of the uPAR•uPA interaction: synthesis, biochemical, cellular, in vivo pharmacokinetics and efficacy studies in breast cancer metastasis. Bioorg Med Chem. 2013 Apr 1;21(7):2145-55.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

PHSJ-4F实验室pH计粮食重金属检测仪

发表于2024年4月12日由上海金畔生物科技有限公司

【简单介绍】

品牌	其他品牌	类型	实验室
测量范围	0-14

PHSJ-4F实验室pH计，仪器级别：0.001 级；自动识别 23 种缓冲溶液，自动 1-3 点校准，手动自动温补；具有电极性能提醒和电极标定提醒功能；具有标准USB通讯接口以及REX数据采集软件。
标准配置：PHSJ-4F 主机、E-301-D 复合 pH 电极、pH 标准粉剂。
现货常备

【详细说明】

PHSJ-4F实验室pH计

仪器功能：

PHSJ-4F实验室台式pH计，仪器级别：0.001 级。采用新型材料PC面板，轻触数字式按键，可靠耐用；支持自动温度补偿，自动识别5种缓冲溶液，支持1-3点校准；支持USB连接PC、串口打印机；允许打印输出测量结果。

产品特点

大屏幕点阵式液晶显示，直观清晰、内容全面；

采用新型材料PC面板，轻触数字式按键，可靠耐用；

3种读数模式：Smart-Read功能，智能判别终点；

Timed-Read功能，自动定时存贮读数；

Cont- Read功能，连续测量（支持间隔连续测量）；

支持电极性能提醒功能和电极标定提醒功能；

支持自动温度补偿，自动识别5种缓冲溶液，支持1-3点校准；

支持存贮500套测量数据，符合GLP规范，支持数据的查阅、删除和打印；

支持USB连接PC、串口打印机；允许打印输出测量结果；

具有断电保护功能，断电后数据不会丢失；

支持固件升级。

主要技术指标：

型号		PHSJ-4F
仪器级别		0.001级
测量参数		pH值、mV（ORP）、温度值
测量范围	pH	（-2.000～20.000）pH
	mV	（-1999.9～1999.9）mV
	温度	（-5.0～110.0）℃
分辨率	pH	0.001pH
	mV	0.1mV
	温度	0.1℃
基本误差	pH	±0.002pH
	mV	±0.03%FS
	温度	±0.2℃
稳定性		（±0.002pH±1个字）/3h
电源		直流通用电源（9V DC，800mA，内正外负）
尺寸（mm），重量（kg）		280×215×92，1

PHSJ-4F实验室pH计

标准配置

PHSJ-4F 主机、E-301-D 复合 pH 电极、pH 标准粉剂。

不锈钢普及系列单只千克砝码 2Kg F2

发表于2024年4月12日由上海金畔生物科技有限公司

不锈钢普及系列单只千克砝码 2Kg F2

商品品牌：富月

商品编号：2Kg F2

商品价格：请与我们联系

不锈钢普及系列单只千克砝码 2Kg F2-富月-2Kg F2

产品类型:单个砝码
砝码等级:F2

产品规格:2Kg
材质:不锈钢

实验室常用设备|||天平、泵|||砝码|||不锈钢普及系列单只千克砝码2KgF2

不锈钢/单个/砝码组合/砝码

不锈钢普及系列单只克砝码 2Kg F2

材质：不锈钢

等级：F1、F2、M1

磁化率<0.05

密度：7.9g/cm³

极化强度：F1<=25UT;F2<=80UT;M1<=250UT

包装：环保铝盒、塑料盒

内衬：国产环保泡棉

商品属性

产品类型:单个砝码
砝码等级:F2

产品规格:2Kg
材质:不锈钢

商品属性
商品名称	不锈钢普及系列单只千克砝码 2Kg F2-2Kg F2-富月
型号	2Kg F2
类别	实验室常用设备\|\|\|天平、泵\|\|\|砝码\|\|\|不锈钢普及系列单只千克砝码2KgF2
品牌	富月
品牌简介	富月
关键字	不锈钢/单个/砝码组合/砝码,砝码,不锈钢,系列,组合,内衬,密度

不锈钢普及系列单只千克砝码 2Kg F2

3α-Aminocholestane(Synonyms: 3α-氨基胆甾烷)

发表于2024年4月12日由上海金畔生物科技有限公司

3α-Aminocholestane (Synonyms: 3α-氨基胆甾烷) 纯度: ≥98.0%

3α-Aminocholestane 是含有选择性 SH2 结构域的肌醇-5′-磷酸酶 1 (SHIP1) 的抑制剂，其 IC₅₀ 值约为 2.5 μM。

3α-Aminocholestane Chemical Structure

CAS No. : 2206-20-4

规格	价格	是否有货
Free Sample (0.1-0.5 mg)		Apply now
10 mM * 1 mL in Ethanol	￥938	In-stock
5 mg	￥1100	In-stock
10 mg	￥1800	In-stock
25 mg	￥3600	In-stock
50 mg	￥5600	In-stock
100 mg	￥8900	In-stock
200 mg		询价
500 mg		询价

* Please select Quantity before adding items.

3α-Aminocholestane 相关产品

•相关化合物库:

Bioactive Compound Library Plus
Metabolism/Protease Compound Library
Anti-Cancer Compound Library
Anti-Blood Cancer Compound Library
Phosphatase Inhibitor Library

生物活性

3α-Aminocholestane is a selective SH2 domain-containing inositol-5′-phosphatase 1 (SHIP1) inhibitor with an IC₅₀ of ~2.5 μM.

IC₅₀ & Target

IC50: 2.5 μM (SHIP1)^[1]

体外研究
(In Vitro)

OPM2 cell viability is effectively reduced by 3α-Aminocholestane (3AC) treatment. RPMI8226 and U266 cells show significantly less sensitivity to 3α-Aminocholestane treatment when compare with OPM2 cells, although viability is decreased significantly at concentrations of ≥12.5 μM. Treatment with 3α-Aminocholestane for 36 h severely reduces the percentage of cells in the S phase, which is accompanied by an increase of cells in the G2/M phase. In contrast, in the less proliferative RPMI8226 and U266 cells, cell cycle progression is blocked in the G0/G1 phase upon 3α-Aminocholestane treatment, in conjunction with a reduced percentage of cells undergoing the S phase^[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

It is found that 3α-Aminocholestane (3AC) results in reduced multiple myeloma (MM) growth in vivo, as determined by quantitation of free human Igλ light chain in the plasma after OPM2 challenge. In addition, reduced numbers of circulating OPM2 cells, as determined by human HLA-ABC staining, is observed in peripheral blood from 3α-Aminocholestane-treated mice compare with vehicle controls. Most importantly, 3α-Aminocholestane treatment results in significantly enhanced survival of mice after tumor challenge. In 3α-Aminocholestane-treated mice that resist treatment, it is found that MM tumors exhibit an upregulation of SHIP2, reminiscent of in vitro treatment of OPM2 cells and suggesting that SHIP1 inhibition may select for tumor cells with increased SHIP2 expression^[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

387.68

Formula

C₂₇H₄₉N

CAS 号

2206-20-4

中文名称

3α-氨基胆甾烷；3alpha-氨基胆甾烷

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

Ethanol : 50 mg/mL (128.97 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.5794 mL	12.8972 mL	25.7945 mL
5 mM	0.5159 mL	2.5794 mL	5.1589 mL
10 mM	0.2579 mL	1.2897 mL	2.5794 mL

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

1.

请依序添加每种溶剂： 10% EtOH 40% PEG300 5% Tween-80 45% saline

Solubility: ≥ 3.25 mg/mL (8.38 mM); Clear solution

此方案可获得 ≥ 3.25 mg/mL (8.38 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 32.5 mg/mL 的澄清 EtOH 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂： 10% EtOH 90% corn oil

Solubility: ≥ 3.25 mg/mL (8.38 mM); Clear solution

此方案可获得 ≥ 3.25 mg/mL (8.38 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

以 1 mL 工作液为例，取 100 μL 32.5 mg/mL 的澄清 EtOH 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在上海金畔生物科技有限公司网站选购。

参考文献

[1]. Chen Z, et al. Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia. Nature. 2015 May 21;521(7552):357-61.

[2]. Gwenny M Fuhler, et al. Therapeutic Potential of SH2 Domain-Containing Inositol-5′-Phosphatase 1 (SHIP1) and SHIP2 Inhibition in Cancer. Mol Med. 2012 Feb 10;18:65-75.

Cell Assay ^[2]	Cells are treated in triplicate or more with increasing concentrations of compounds (including 3α-Aminocholestane). Cell viability is determined with a Cell Counting Kit according to the manufacturer’s instructions. The odds density (OD) of compound (including 3α-Aminocholestane )-treated cells is divided by the OD of their vehicle control, and the viability is expressed as a percentage of untreated cells. Results are expressed as mean±standard error of the mean (SEM) of three individual experiments. For phosphatidyl inositol phosphates (PIP) add-back experiments, MCF-7 cells are treated for 2 h with 10 μM SHIP inhibitors (including 3α-Aminocholestane ), after which cells are washed and fresh medium is added. Cells are subsequently cultured in the absence (0 μM) or presence (10 or 20 μM) of either PtdIns(3,4)P₂-diC16 (P-3416) or PtdIns(3,5)P₂-diC16 (P-3516) for 36 h, after which cell viability is determined by the Cell Counting Kit^[2]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration ^[2]	NOD/SCID/γcIL2R (NSG) mice are injected intraperitoneally with 1×10⁷ OPM2 cells and 6 h later receive an initial injection of 3α-Aminocholestane (3AC) or vehicle. 3α-Aminocholestane is suspended in a 0.3% Klucel/H₂O solution at 11.46 mM and administered by intraperitoneal injection of 100 μL solution. Vehicle-treated mice receive 100 μL injection of 0.3% Klucel/H₂O solution. The mice are then treated with 3α-Aminocholestane or vehicle daily for the next 6 d and then twice per week in the remaining 15 wks of the survival study^[2]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献	[1]. Chen Z, et al. Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia. Nature. 2015 May 21;521(7552):357-61. [2]. Gwenny M Fuhler, et al. Therapeutic Potential of SH2 Domain-Containing Inositol-5′-Phosphatase 1 (SHIP1) and SHIP2 Inhibition in Cancer. Mol Med. 2012 Feb 10;18:65-75.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

营养琼脂培养基

发表于2024年4月12日由上海金畔生物科技有限公司

上海金畔生物科技有限公司可以定制生产国产培养基，可以访问官网了解更多产品信息。
营养琼脂培养基

：

英文名称：	Nutrient Agar Medium
产品货号：	JP0109-7
产品规格：	250g
130元
保质期：	三年
产品用途：	用于药品中细菌总数计数
备注：

产品介绍:

用途：用于一般细菌培养、转种、复壮、增菌

成分(g/L)：

蛋白胨 10.0

牛肉浸出粉 3.0

氯化钠 5.0

琼脂 14.0

pH值7.2 ± 0.2 25℃

检验原理：蛋白胨和牛肉粉提供氮源、维生素、氨基酸和碳源，氯化钠能维持均衡的渗透压，琼脂是培养基的凝固剂。

用法：称取本品 32.0g ,加热溶解于 1000ml 纯化水中,分装三角瓶,115℃高压灭菌 30分钟,备用。

不同细菌在营养琼脂上的生长特征

营养琼脂培养基（中国药典）微生物灵敏度试验:

按标签用法制备培养基，接种以下质控菌株，放置30-35℃需氧培养18-24小时。
注：回收率计算时，用TSA琼脂做对照培养基。

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Canagliflozin-d4(Synonyms: JNJ 28431754-d4)

发表于2024年4月12日由上海金畔生物科技有限公司

Canagliflozin-d4 (Synonyms: JNJ 28431754-d4)

Canagliflozin D4 是 Canagliflozin 的氘代化合物。Canagliflozin 是一种选择性的 SGLT2 抑制剂。

Canagliflozin-d4 Chemical Structure

CAS No. : 1997338-61-0

规格	价格	是否有货
1 mg	￥4500	询问价格 & 货期
5 mg	￥15000	询问价格 & 货期
10 mg	￥25000	询问价格 & 货期

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生物活性	Canagliflozin D4 is a deuterium labeled Canagliflozin. Canagliflozin is a selective SGLT2 inhibitor^[1].
分子量	448.54
Formula	C₂₄H₂₁D₄FO₅S
CAS 号	1997338-61-0
中文名称	卡格列净 d4
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Liang Y, et al. Effect of canagliflozin on renal threshold for glucose, glycemia, and body weight in normal and diabetic animal models. PLoS One. 2012;7(2):e30555.

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5ml无菌微量离心管圆底/尖底,螺旋盖/按盖23-1195

发表于2024年4月12日由上海金畔生物科技有限公司

5ml无菌微量离心管圆底/尖底,螺旋盖/按盖

产品型号：23-1195
简要描述：5ml无菌微量离心管圆底/尖底,螺旋盖/按盖金畔生物公司供应：ELISA试剂盒,动物血清,荧光定量PCR耗材,移液器吸嘴,微量离心管,进口冻存管,细胞培养皿,培养板,培养瓶,进口吸头,仪器及手套,色谱耗材,针头过滤器,分光光度计。

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产品简介

5ml无菌微量离心管圆底/尖底,螺旋盖/按盖上海金畔生物科技有限公司供应：ELISA试剂盒，动物血清，移液器吸嘴，离心管，冻存管，培养皿，全系荧光定量PCR耗材。

微量离心管Microcentrifuge Tubes-SmartTube

品牌：Crystalgen

产品货号产品详情

23-1195 5.0 ml 微量离心管，圆底，按盖，无DNA酶/RNA酶无热源, 灭菌

23-2284 5.0 ml 微量离心管,尖底，螺旋盖，无DNA酶/RNA酶无热源, 灭菌

23-2285 5.0 ml 微量离心管,尖底，按盖，无DNA酶/RNA酶无热源, 灭菌

规格：

250支/包, 10包/箱 (2500支/箱)

100支/包，20包/箱(2000支/箱)

5ml无菌微量离心管圆底/尖底,螺旋盖/按盖

23-2052B1.70ml 微量离心管,无DNA酶/RNA酶无热源, 蓝色，灭菌

23-2052O1.70ml 微量离心管,无DNA酶/RNA酶无热源, 橙色，灭菌

23-2052AS1.70ml 微量离心管,无DNA酶/RNA酶无热源, 五色混装(红黄橙蓝紫)，灭菌

23-20551.70ml 微量离心管,无DNA酶/RNA酶无热源, 硅化，灭菌

23-11922.0 ml 微量离心管,无DNA酶/RNA酶无热源, 灭菌

23-2062加样槽/V型,5-50ml 独立包装, 灭菌

23-2063加样槽/V型,5-50ml，灭菌

BS-9684人羧乙基赖氨酸(CEL)ELISA试剂盒

BS-9685人羧甲基赖氨酸(CML)ELISA试剂盒

BS-9686人封闭抗体(BA)ELISA试剂盒

BS-9687人B7同源体4(B7-H4)ELISA试剂盒

BS-9688人Stathmin(STMN)ELISA试剂盒

BS-9690人硝基酪氨酸(NT)ELISA试剂盒

BS-9693人1-磷酸鞘氨醇(S1P)ELISA试剂盒

BS-9694人胶原酶III(Collagenase III)ELISA试剂盒

适应客户：医院检验科PCR实验室，中心实验室，肝病中心；第三方检测机构，科研院所，大专院校，制药厂，试剂生产厂家，疾控中心，检验检疫。

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