标签归档：aminoundecanoic

Boc-11-aminoundecanoic acid

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Boc-11-aminoundecanoic acid 

Boc-11-aminoundecanoic acid 是基于 Alkyl/ether 结构的 PROTAC linker, 可以用来制备 MS432 (HY-130602)。

Boc-11-aminoundecanoic acid

Boc-11-aminoundecanoic acid Chemical Structure

CAS No. : 10436-25-6

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Boc-11-aminoundecanoic acid is an Alkyl/ether-based PROTAC linker can be used in the synthesis of MS432 (HY-130602)[1].

IC50 & Target

Alkyl/ether

 

体外研究
(In Vitro)

MS432 is a first-in-class and highly selective PD0325901-based VHL-recruiting PROTAC degrader for MEK1 and MEK2[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.
PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

301.42

Formula

C16H31NO4
CAS 号

10436-25-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献

  • [1]. Wei J, et al.Discovery of a First-in-Class Mitogen-Activated Protein Kinase Kinase 1/2 Degrader.J Med Chem. 2019 Dec 12;62(23):10897-10911.

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11-Aminoundecanoic acid(Synonyms: 11-氨基十一酸)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

11-Aminoundecanoic acid (Synonyms: 11-氨基十一酸) 纯度: ≥97.0%

11-Aminoundecanoic acid 是一种 PROTAC linker，属于 alkyl chain 类。11-Aminoundecanoic acid 可用于合成 PROTAC 分子。

11-Aminoundecanoic acid(Synonyms: 11-氨基十一酸)

11-Aminoundecanoic acid Chemical Structure

CAS No. : 2432-99-7

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥500 In-stock
100 mg ￥400 In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

11-Aminoundecanoic acid is an alkyl chain based PROTAC linker can be used in the synthesis of PROTACs.

IC50 & Target

Alkyl-Chain

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

201.31

Formula

C11H23NO2
CAS 号

2432-99-7
中文名称

11-氨基十一酸
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 3.33 mg/mL (16.54 mM; ultrasonic and adjust pH to 2 with HCl)

H2O : < 0.1 mg/mL (ultrasonic;adjust pH to 3 with HCl) (insoluble)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 4.9675 mL 24.8373 mL 49.6746 mL
5 mM 0.9935 mL 4.9675 mL 9.9349 mL
10 mM 0.4967 mL 2.4837 mL 4.9675 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Pillow TH, et al. Antibody Conjugation of a Chimeric BET Degrader Enables in vivo Activity. ChemMedChem. 2019 Oct 31.

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