Euphorbia factor L2 是从大戟种子中分离得到的一种赤藓烷二萜 (Euphorbia lathyris L.),具有抗癌活性。Euphorbia factor L2 显示强烈的细胞毒性并通过线粒体途径诱导细胞凋亡。
Euphorbia Factor L2 Chemical Structure
CAS No. : 218916-51-9
规格
价格
是否有货
数量
10 mM * 1 mL in DMSO
¥4670
In-stock
5 mg
¥3300
In-stock
10 mg
¥5500
In-stock
50 mg
询价
100 mg
询价
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Euphorbia Factor L2 相关产品
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生物活性
Euphorbia factor L2, a lathyrane diterpenoid isolated from caper euphorbia seed (the seeds of Euphorbia lathyris L.), has been traditionally applied to treat cancer. Euphorbia factor L2 shows potent cytotoxicity and induces apoptosis via a mitochondrial pathway[1].
分子量
642.73
Formula
C38H42O9
CAS 号
218916-51-9
中文名称
大戟因子L2
运输条件
Room temperature in continental US; may vary elsewhere.
Room temperature in continental US; may vary elsewhere.
储存方式
Sealed storage, away from moisture and light
Powder
-80°C
2 years
-20°C
1 year
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
In Vitro:
H2O
Peptide Solubility and Storage Guidelines:
1. Calculate the length of the peptide.
2. Calculate the overall charge of the entire peptide according to the following table:
Contents
Assign value
Acidic amino acid
Asp (D), Glu (E), and the C-terminal -COOH.
-1
Basic amino acid
Arg (R), Lys (K), His (H), and the N-terminal -NH2
+1
Neutral amino acid
Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)
0
3. Recommended solution:
Overall charge of peptide
Details
Negative (<0)
1. Try to dissolve the peptide in water first. 2. If water fails, add NH4OH (<50 μL). 3. If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0)
1. Try to dissolve the peptide in water first. 2. If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3. If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)
1. Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2. For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献
[1]. [1]. Naider F, et al. The alpha-factor mating pheromone of Saccharomyces cerevisiae: a model for studying the interaction of peptide hormones and G protein-coupled receptors. Peptides. 2004 Sep;25(9):1441-63.
Euphorbia Factor L1 is a diterpenoid from Euphorbia lathyris L., reduces the expression of Bcl-2, PI3K, AKT and mTOR protein and mRNA, upregulates cleaved caspase-9 and caspase-3 levels, buts shows no effect on pro-caspase-9 and pro-caspase-3. Euphorbia Factor L1 induces apoptosis, has anticancer, antiadipogenesis, antiosteoclastogenesis and multidrug resistance-modulating effect[1].
分子量
552.66
Formula
C32H40O8
CAS 号
76376-43-7
中文名称
大戟因子 L1
运输条件
Room temperature in continental US; may vary elsewhere.
[1]. Zhu A, et al. Effect of euphorbia factor L1 on oxidative stress, apoptosis, and autophagy in human gastric epithelial cells. Phytomedicine. 2019 Apr 16;64:152929.
This peptide represents the N-terminus of the parathyroid hormone (PTH) and can be used to represent full length PTH in studying the specificity of assays that distinguish between full length PTH and N-terminally truncated PTH for the diagnosis of endocrine and osteological diseases.
溶解度
分子量
4675.4
化学式
C207H334N66O58
存储条件
Store at -20°C. Keep tightly closed. Store in a cool dry place.
For exerting its anti-inflammatory and immunomodulatory activity, the peptide hormone thymulin, pEAKSQGGSN, requires the presence of Zn(II). Thymulin showed promising results in experimental models of lung diseases as well as potential as an analgesic peptide.
溶解度
分子量
1005.05
化学式
C39H68N14O17
存储条件
Store at -20°C. Keep tightly closed. Store in a cool dry place.