标签归档：falcarindiol

Falcarindiol(Synonyms: 法卡林二醇)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Falcarindiol (Synonyms: 法卡林二醇)

Falcarindiol 是一种具有口服活性的聚乙炔氧脂，可激活 PPARγ 并增加细胞中胆固醇转运蛋白 ABCA1 的表达。Falcarindiol 诱导细胞凋亡和自噬。Falcarindiol 具有抗炎、抗菌、抗癌和抗糖尿病的特性。

Falcarindiol(Synonyms: 法卡林二醇)

Falcarindiol Chemical Structure

CAS No. : 55297-87-5

规格 价格 是否有货
5 mg ￥3700 询问价格 & 货期
10 mg ￥6000 询问价格 & 货期

* Please select Quantity before adding items.

生物活性

Falcarindiol, an orally active polyacetylenic oxylipin, activates PPARγ and increases the expression of the cholesterol transporter ABCA1 in cells. Falcarindiol induces apoptosis and autophagy. Falcarindiol has anti-inflammatory, antifungal, anticancer and antidiabetic properties[1][2].

IC50 & Target[1]

PPARγ

 

体外研究
(In Vitro)

Falcarindiol (3, 6, 12, 24 µM; for 24 hours) significantly decreases cell viability of MDA-MB-231 and MDA-MB-468 cells. Cell viability of MCF-10A cells is unchanged until the dose of Falcarindiol reaches to 24 uM. Falcarindiol preferentially induces cell death in breast cancer cells[1].
Falcarindiol (6 uM; for 2 hours) induces autophagy and causes significant level of LC3-I converted to LC3-II in MDA-MB-231, MDA-MB-468 and SKBR3 cells[1].
Falcarindiol (6 uM; for 2, 4, 8, 24 hours) increases the level of GRP78 in MDA-MB-231 cells in dose- and time-dependent manner[1].
Falcarindiol (1-20 µM) has no effect on hMSCs and HT-29 cell viability. Falcarindiol with only concentrations above 50 µM exhibits a toxic effect on the cells[2].
Falcarindiol (5 µM; 10 min, 1 h and 24 h) causes a significant upregulation on PPARγ2 expression at 24 h[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Falcarindiol (7 µg/g; diet) increases ABCA1 expression in neoplastic tissue in five weeks old male rats[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

260.37

Formula

C17H24O2
CAS 号

55297-87-5
中文名称

法卡林二醇；镰叶芹二醇；发卡二醇
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Tingting Lu, et al. Autophagy contributes to falcarindiol-induced cell death in breast cancer cells with enhanced endoplasmic reticulum stress. PLoS One. 2017 Apr 25;12(4):e0176348.

    [2]. Camilla Bertel Andersen, et al. Falcarindiol Purified From Carrots Leads to Elevated Levels of Lipid Droplets and Upregulation of Peroxisome Proliferator-Activated Receptor-γ Gene Expression in Cellular Models. Front Pharmacol. 2020 Aug 28;11:565524.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Falcarindiol(Synonyms: 法卡林二醇)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Falcarindiol (Synonyms: 法卡林二醇)

Falcarindiol 是一种具有口服活性的聚乙炔氧脂，可激活 PPARγ 并增加细胞中胆固醇转运蛋白 ABCA1 的表达。Falcarindiol 诱导细胞凋亡和自噬。Falcarindiol 具有抗炎、抗菌、抗癌和抗糖尿病的特性。

Falcarindiol(Synonyms: 法卡林二醇)

Falcarindiol Chemical Structure

CAS No. : 55297-87-5

规格 价格 是否有货
5 mg ￥3700 询问价格 & 货期
10 mg ￥6000 询问价格 & 货期

* Please select Quantity before adding items.

生物活性

Falcarindiol, an orally active polyacetylenic oxylipin, activates PPARγ and increases the expression of the cholesterol transporter ABCA1 in cells. Falcarindiol induces apoptosis and autophagy. Falcarindiol has anti-inflammatory, antifungal, anticancer and antidiabetic properties[1][2].

IC50 & Target[1]

PPARγ

 

体外研究
(In Vitro)

Falcarindiol (3, 6, 12, 24 µM; for 24 hours) significantly decreases cell viability of MDA-MB-231 and MDA-MB-468 cells. Cell viability of MCF-10A cells is unchanged until the dose of Falcarindiol reaches to 24 uM. Falcarindiol preferentially induces cell death in breast cancer cells[1].
Falcarindiol (6 uM; for 2 hours) induces autophagy and causes significant level of LC3-I converted to LC3-II in MDA-MB-231, MDA-MB-468 and SKBR3 cells[1].
Falcarindiol (6 uM; for 2, 4, 8, 24 hours) increases the level of GRP78 in MDA-MB-231 cells in dose- and time-dependent manner[1].
Falcarindiol (1-20 µM) has no effect on hMSCs and HT-29 cell viability. Falcarindiol with only concentrations above 50 µM exhibits a toxic effect on the cells[2].
Falcarindiol (5 µM; 10 min, 1 h and 24 h) causes a significant upregulation on PPARγ2 expression at 24 h[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Falcarindiol (7 µg/g; diet) increases ABCA1 expression in neoplastic tissue in five weeks old male rats[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

260.37

Formula

C17H24O2
CAS 号

55297-87-5
中文名称

法卡林二醇；镰叶芹二醇；发卡二醇
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Tingting Lu, et al. Autophagy contributes to falcarindiol-induced cell death in breast cancer cells with enhanced endoplasmic reticulum stress. PLoS One. 2017 Apr 25;12(4):e0176348.

    [2]. Camilla Bertel Andersen, et al. Falcarindiol Purified From Carrots Leads to Elevated Levels of Lipid Droplets and Upregulation of Peroxisome Proliferator-Activated Receptor-γ Gene Expression in Cellular Models. Front Pharmacol. 2020 Aug 28;11:565524.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Falcarindiol(Synonyms: 法卡林二醇)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Falcarindiol (Synonyms: 法卡林二醇)

Falcarindiol 是一种具有口服活性的聚乙炔氧脂，可激活 PPARγ 并增加细胞中胆固醇转运蛋白 ABCA1 的表达。Falcarindiol 诱导细胞凋亡和自噬。Falcarindiol 具有抗炎、抗菌、抗癌和抗糖尿病的特性。

Falcarindiol(Synonyms: 法卡林二醇)

Falcarindiol Chemical Structure

CAS No. : 55297-87-5

规格 价格 是否有货
5 mg ￥3700 询问价格 & 货期
10 mg ￥6000 询问价格 & 货期

* Please select Quantity before adding items.

生物活性

Falcarindiol, an orally active polyacetylenic oxylipin, activates PPARγ and increases the expression of the cholesterol transporter ABCA1 in cells. Falcarindiol induces apoptosis and autophagy. Falcarindiol has anti-inflammatory, antifungal, anticancer and antidiabetic properties[1][2].

IC50 & Target[1]

PPARγ

 

体外研究
(In Vitro)

Falcarindiol (3, 6, 12, 24 µM; for 24 hours) significantly decreases cell viability of MDA-MB-231 and MDA-MB-468 cells. Cell viability of MCF-10A cells is unchanged until the dose of Falcarindiol reaches to 24 uM. Falcarindiol preferentially induces cell death in breast cancer cells[1].
Falcarindiol (6 uM; for 2 hours) induces autophagy and causes significant level of LC3-I converted to LC3-II in MDA-MB-231, MDA-MB-468 and SKBR3 cells[1].
Falcarindiol (6 uM; for 2, 4, 8, 24 hours) increases the level of GRP78 in MDA-MB-231 cells in dose- and time-dependent manner[1].
Falcarindiol (1-20 µM) has no effect on hMSCs and HT-29 cell viability. Falcarindiol with only concentrations above 50 µM exhibits a toxic effect on the cells[2].
Falcarindiol (5 µM; 10 min, 1 h and 24 h) causes a significant upregulation on PPARγ2 expression at 24 h[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Falcarindiol (7 µg/g; diet) increases ABCA1 expression in neoplastic tissue in five weeks old male rats[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

260.37

Formula

C17H24O2
CAS 号

55297-87-5
中文名称

法卡林二醇；镰叶芹二醇；发卡二醇
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Tingting Lu, et al. Autophagy contributes to falcarindiol-induced cell death in breast cancer cells with enhanced endoplasmic reticulum stress. PLoS One. 2017 Apr 25;12(4):e0176348.

    [2]. Camilla Bertel Andersen, et al. Falcarindiol Purified From Carrots Leads to Elevated Levels of Lipid Droplets and Upregulation of Peroxisome Proliferator-Activated Receptor-γ Gene Expression in Cellular Models. Front Pharmacol. 2020 Aug 28;11:565524.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

(+)-(3R,8S)-Falcarindiol(Synonyms: (3R,8S)-Falcarindiol; 3(R),8(S),9(Z)-Falcarindiol)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

(+)-(3R,8S)-Falcarindiol (Synonyms: (3R,8S)-Falcarindiol; 3(R),8(S),9(Z)-Falcarindiol) 纯度: 99.88%

(+)-(3R,8S)-Falcarindiol 是从胡萝卜中得到的聚乙炔，具有抗分歧杆菌 (antimycobacterial) 作用，对 Mycobacterium tuberculosis H37Ra 的最低抑制浓度 MIC 和 IC50 值分别为 24 μM 和 6 μM。具有抗肿瘤和抗炎作用。

(+)-(3R,8S)-Falcarindiol(Synonyms: (3R,8S)-Falcarindiol; 3(R),8(S),9(Z)-Falcarindiol)

(+)-(3R,8S)-Falcarindiol Chemical Structure

CAS No. : 225110-25-8

规格 价格 是否有货 数量
1 mg ￥800 In-stock
5 mg ￥2800 In-stock
10 mg ￥4400 In-stock
50 mg   询价  
100 mg   询价  

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(+)-(3R,8S)-Falcarindiol 相关产品

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生物活性

(+)-(3R,8S)-Falcarindiol is a polyacetylene found in carrots, has antimycobacterial activity, with an IC50 of 6 μM and MIC of 24 μM against Mycobacterium tuberculosis H37Ra[1][2]. Antineoplastic and anti-inflammatory activity[2].

IC50 & Target

IC50: 6 μM (Mycobacterium tuberculosis H37Ra)[1]
分子量

260.37

Formula

C17H24O2
CAS 号

225110-25-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献

  • [1]. O’Neill T, et al. The Canadian medicinal plant Heracleum maximum contains antimycobacterial diynes and furanocoumarins. J Ethnopharmacol. 2013 May 2;147(1):232-7.

    [2]. Kobaek-Larsen M, et al. Effect of the dietary polyacetylenes falcarinol and falcarindiol on the gut microbiota composition in a rat model of colorectal cancer. BMC Res Notes. 2018 Jun 27;11(1):411.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务