Kuwanon E 是从桑树中分到的黄酮类化合物,对人单核细胞白血病细胞系具有细胞毒性,并降低 IL-1β 的水平。
Kuwanon E Chemical Structure
CAS No. : 68401-05-8
规格
价格
是否有货
1 mg
¥2860
询问价格 & 货期
5 mg
¥8570
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生物活性
Kuwanon E is a flavonoid isolated from Morus alba, cytotoxic to human monocytic leukemic cell lines, and reduces the level of IL-1β[1].
IC50 & Target
Kuwanon E shows cytotoxic activity against THP-1 human monocytic leukemic cell line, with an IC50 of 4.0±0.08 μM[1].
分子量
424.49
Formula
C25H28O6
CAS 号
68401-05-8
中文名称
桑黄酮 E;桑酮 E;桑皮酮 E
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Zelová H, et al. Evaluation of anti-inflammatory activity of prenylated substances isolated from Morus alba and Morus nigra. J Nat Prod. 2014 Jun 27;77(6):1297-303.
Kuwanon H 是桑白皮中的黄酮类化合物,为非肽类蛙皮素受体 (bombesin receptor) 拮抗剂。Kuwanon H 可特异性抑制细胞内胃泌激素释放肽 CRP 与(GRP-preferring recepotr) 受体的结合,Ki 值为 290 nM。
Kuwanon H Chemical Structure
CAS No. : 76472-87-2
规格
价格
是否有货
数量
1 mg
¥1900
In-stock
5 mg
询价
10 mg
询价
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Kuwanon H 相关产品
•相关化合物库:
Natural Product Library Plus
Bioactive Compound Library Plus
GPCR/G Protein Compound Library
Natural Product Library
Anti-Cancer Compound Library
Phenols Library
Traditional Chinese Medicine Monomer Library
Flavonoids Library
Targeted Diversity Library
生物活性
Kuwanon H is a flavonoid isolated from Morus bombycis, which acts as a potent non-peptide bombesin receptor antagonist. Kuwanon H selectively inhibits binding of gastrin releasing peptide CRP to GRP-preferring recepotr, with a Ki value of 290 nM in cells[1].
IC50 & Target
Ki: 290 nM (GRP-preferring recepotr)[1]
分子量
760.82
Formula
C45H44O11
CAS 号
76472-87-2
中文名称
桑皮酮 H;桑黄酮 H
运输条件
Room temperature in continental US; may vary elsewhere.
将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
参考文献
[1]. Mihara S, et al. Non-peptide bombesin receptor antagonists, kuwanon G and H, isolated from mulberry. Biochem Biophys Res Commun. 1995 Aug 15;213(2):594-9.