【编号】:SPR02564
【产品名称】:匹克拉林碱对照品
【规格】:10mg
【用途】:
产品名称 | 克拉维酸钾:纤维素 (1:1) |
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英文名称 | Potassium clavulanate:cellulose (1:1) |
运输条件 | 冰袋运输 |
生化机理 | 克拉维酸是一种 β-内酰胺酶抑制剂,常用于增强阿莫西林的抗菌活性。克拉维酸是一种与青霉素有关的 β-内酰胺抗生素。克拉维酸竞争性地且不可逆地抑制多种 β-内酰胺酶,β-内酰胺酶广泛存在于对青霉素和头孢菌素具有抗性的微生物中。克拉维酸也是中枢神经系统的调节剂。它增强了 PC12 和 SH-SY5Y 细胞中的多巴胺释放,而不会影响多巴胺的合成。 |
应用
克拉维酸用作细菌 β-内酰胺酶的抑制剂。它是由棒状链霉菌发酵产生的。单独使用时,其抗菌活性较弱,但与阿莫西林联用时,则具有很高的活性。与阿莫西林一起,可用于治疗由金黄色葡萄球菌、脆弱拟杆菌、流感嗜血杆菌和大肠杆菌引起的感染。它已用于治疗儿童急性细菌性鼻窦炎和慢性腺扁桃体肥大。
Description
Clavulanate is used as an inhibitor of bacterial β-lactamase enzymes. It is produced by the fermentation ofStreptomyces clavuligerus. It has weak antibacterial activity when used alone but is very active when used with amoxicillin. With Amoxicillin, it is used to treat infections caused byStaph. aureus,Bacteroides fragilis,H. influenzaandE. coli.. It has been used to treat acute bacterial sinusitis in children and chronic adenotonsillar hypertrophy.
储存温度 | 2-8°C储存 |
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品牌 | Jinpan |
备注 | 克拉维酸钾和纤维素的混合物将容器密闭存放在干燥通风处。存放期间切勿让产品与水接触。储存等级(TRGS 510):易燃固体危险品。 |
产品名称 | 克拉霉素 |
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英文名称 | Clarithromycin |
规格或纯度 | ≥95% (HPLC) |
生化机理 | Clarithromycin inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation. Clarithromycin is first metabolized to 14-OH clarithromycin, which is active and works synergistically with its parent compound. Clarithromycin penetrates the bacteria cell wall and reversibly binds to domain V of the 23S ribosomal RNA of the 50S subunit of the bacterial ribosome, blocking translocation of aminoacyl transfer-RNA and polypeptide synthesis. Clarithromycin also inhibits the hepatic microsomal CYP3A4 isoenzyme and P-glycoprotein, an energy-dependent drug efflux pump. 克拉霉素是一种大环内酯类抗生素,能干扰细菌蛋白质的合成。克拉霉素是红霉素的酸稳定形式,对革兰氏阴性细菌特别有效。它的半衰期很短,但是其代谢产物 14-羟基克拉霉素对某些细菌的活性几乎是克拉霉素的两倍。 |
制备说明
Practically insoluble in water, soluble in acetone and methylene chloride, slightly soluble in methanol.
General Description
Chemical structure: macrolide
Application
Clarithromycin is a semisynthetic macrolide antibiotic that is derived from erythromycin. Clarithromycin may be bacteriostatic or bactericidal depending on the organism and drug concentration . Clarithromycin may be used to attenuate cardiac transplantation rejection via matrix metalloproteinase suppression. Clarithromycin has been used to study inflammatory markers in chronic obstructive pulmonary disease (COPD). It is used to study bacterial protein synthesis and peptide translation.
Other Notes
Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.
CAS编号 | 81103-11-9 |
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比旋光度 | -92°C |
熔点 | 225°C |
RTECS | KF4997000 |
分子量 | 747.95 |
分子式 | C38H69NO13 |
品牌 | Jinpan |
PubChem CID | 84029 |
产品名称 | 克拉霉素 |
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英文名称 | Clarithromycin |
规格或纯度 | 96.0-102.0%(HPLC) |
运输条件 | 冰袋运输 |
生化机理 | 克拉霉素具有杀菌活性,包括对 麻风分枝杆菌 ,和 鸟分枝杆菌 复合体的抗分枝杆菌活性。 克拉霉素在胃酸中稳定。 克拉霉素是一种大环内酯类抗生素,能干扰细菌蛋白质的合成。克拉霉素是红霉素的酸稳定形式,对革兰氏阴性细菌特别有效。它的半衰期很短,但是其代谢产物 14-羟基克拉霉素对某些细菌的活性几乎是克拉霉素的两倍。 |
应用
克拉霉素已用于研究其对钾通道 KCNJ5 WT 的影响。
其他说明
将容器密闭保存在干燥和通风良好的地方。在干燥处保存。
制备说明
几乎不溶于水,可溶于丙酮和二氯甲烷,微溶于甲醇。
Application
Clarithromycin has been used to study its effect on the potassium channel KCNJ5 WT .
Other Notes
Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.
CAS编号 | 81103-11-9 |
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比旋光度 | -92°C |
熔点 | 225°C |
储存温度 | 2-8°C储存 |
RTECS | KF4997000 |
分子量 | 747.95 |
分子式 | C38H69NO13 |
品牌 | Jinpan |
PubChem CID | 84029 |
产品名称 | 克拉霉素,现成溶液 |
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英文名称 | Clarithromycin, Ready Made Solution |
别名 | 6-O-methyl erythromycin |
英文别名 | 6-O-methyl erythromycin |
规格或纯度 | 50 mg/mL in DMSO |
生化机理 | Macrolides, such as clarithromycin, prevent protein synthesis in bacteria, by binding to 50S ribosomal subunit. It also binds to other ribosomal proteins, and prevents the translocation of pepti-dyl-tRNA. In patients with refractory asthma, it is capable of regulating the levels of interleukin-8 (IL-8), and neutrophil accumulation and activation in lungs. Thus, it might be used as an additional therapy in asthma to reduce noneosinophilic airway inflammation. |
General Description
Clarithromycin is a macrolide antibiotic, which has both antibacterial and anti-inflammatory actions. It is a semi-synthetic 14-membered derivative of erythromycin A, which is resistant to degradation under acidic conditions.
Application
Clarithromycin may be used for- the study of the effects of clarithromycin on rate-dependent changes in QT, T p-e and proarrhythmic events performed on arterially perfused rabbit left ventricular wedge preparations the culture of parasites expressing GFP (green fluorescence protein) targeted to the apicoplast, to be further used for microscopy-based assays the study of the synergism of NAB741 with clarithromycin in microtiter plates.
Other Notes
Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Combustible liquids
General Description
Clarithromycin is a macrolide antibiotic, which has both antibacterial and anti-inflammatory actions. It is a semi-synthetic 14-membered derivative of erythromycin A, which is resistant to degradation under acidic conditions.
Application
Clarithromycin may be used for- the study of the effects of clarithromycin on rate-dependent changes in QT, T p-e and proarrhythmic events performed on arterially perfused rabbit left ventricular wedge preparations the culture of parasites expressing GFP (green fluorescence protein) targeted to the apicoplast, to be further used for microscopy-based assays the study of the synergism of NAB741 with clarithromycin in microtiter plates.
Other Notes
Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Combustible liquids
CAS编号 | 81103-11-9 |
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比旋光度 | -92°C |
熔点 | 225°C |
储存温度 | 干燥 |
RTECS | KF4997000 |
分子量 | 747.95 |
分子式 | C38H69NO13 |
品牌 | Jinpan |
PubChem CID | 84029 |
【编号】:LY3105
【产品名称】:克拉霉素对照品
【规格】:10mg
【用途】:
产品名称 | N-去甲基克拉霉素 |
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英文名称 | N-Desmethyl Clarithromycin |
英文别名 | N-Demethyl-6-O-methylerythromycin; 3″-N-Demethylclarithromycin; N-(Desmethyl)clarithromycin |
运输条件 | 超低温冰袋运输 |
N-去甲基克拉霉素是克拉霉素和D杂质的代谢产物。
N-Desmethyl Clarithromycin is a metabolite of Clarithromycin as well as the D impurity.
CAS编号 | 101666-68-6 |
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熔点 | 200-202° C |
溶解性 | Soluble in Chloroform, Dimethyl Sulfoxide, Ethanol and Ethyl Acetate |
储存温度 | -20°C储存 |
分子量 | 733.93 |
分子式 | C37H67NO13 |
品牌 | Jinpan |
Smiles | CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2CC(C)(OC)C(O)C(C)O2)[C@H](C)[C@@H](OC2OC(C)CC(NC)C2O)[C@@](C)(C[C@@H](C)C(=O)[C@H]( |
PubChem CID | 11072636 |
产品名称 | 克拉霉素杂质 |
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英文名称 | 3-O-De(cladinosyl)-8,9,10,11-tetradehydro-9-deoxo-11,12-dideoxy-9,12-epoxy Clarithromycin |
运输条件 | 常规运输 |
CAS编号 | 127157-35-1 |
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分子量 | 553.73 |
分子式 | C30H51NO8 |
品牌 | Jinpan |
产品名称 | 克拉霉素N-氧化物 |
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英文名称 | Clarithromycin 9-Oxime |
英文别名 | Oxacyclotetradecane Erythromycin Derivative;6-O-Methylerythromycin A 9-Oxime |
规格或纯度 | 95% |
运输条件 | 超低温冰袋运输 |
CAS编号 | 103450-87-9 |
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敏感性 | 易吸潮 |
熔点 | >168° C (dec.) |
溶解性 | Chloroform (Slightly), Methanol (Slightly) |
储存温度 | -20°C储存,充氩 |
分子量 | 762.97 |
分子式 | C₃₈H₇₀N₂O₁₃ |
品牌 | Jinpan |