Golgicide A (GCA) 是一种有效的,高度特异性的,可逆的顺式高尔基体 ADP-核糖基化因子鸟嘌呤核苷酸交换因子 (ArfGEF GBF1)抑制剂。Golgicide A 可抑制柯萨奇病毒 B3 (CVB3) 和其他人类肠道病毒的复制。
Golgicide A Chemical Structure
CAS No. : 1139889-93-2
规格
价格
是否有货
数量
10 mM * 1 mL in DMSO
¥710
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5 mg
¥650
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10 mg
¥1150
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50 mg
¥4500
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100 mg
¥7800
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200 mg
询价
500 mg
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Golgicide A 相关产品
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生物活性
Golgicide A (GCA) is a potent, highly specific, and reversible inhibitor of the cis-Golgi ADP-ribosylation factor guanine nucleotide exchange factors (ArfGEF) GBF1[1]. Golgicide A drastically reduced replication of coxsackievirus B3 (CVB3) and other human enterovirus species[2].
IC50 & Target
GBF1[1]
体外研究 (In Vitro)
Golgicide A (GCA) is a potent and highly effective inhibitor of shiga toxin activity. Golgicide A (GCA) inhibits the effect of shiga toxin on protein synthesis with an IC50 of 3.3 μM[1].
上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量
284.30
Formula
C17H14F2N2
CAS 号
1139889-93-2
运输条件
Room temperature in continental US; may vary elsewhere.
[1]. Sáenz JB, et al. Golgicide A reveals essential roles for GBF1 in Golgi assembly and function. Nat Chem Biol. 2009 Mar;5(3):157-65.
[2]. van der Linden L, et al. Differential effects of the putative GBF1 inhibitors Golgicide A and AG1478 on enterovirus replication. J Virol. 2010 Aug;84(15):7535-42.