Curcumol(Synonyms: 姜黄醇; (-)-Curcumol)

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Curcumol (Synonyms: 姜黄醇; (-)-Curcumol) 纯度: 99.49%

Curcumol ((-)-Curcumol) 是一种具有生物活性的倍半萜,具有许多药理活性,例如抗癌,抗微生物,抗真菌,抗病毒和抗炎。Curcumol 通过靶向关键信号通路 (如 MAPK/ERK,PI3K/Akt 和 NF-κB) 而在许多癌细胞中有效地诱导凋亡 (apoptosis),这些信号通路在几种癌症中通常被异常调节。

Curcumol(Synonyms: 姜黄醇; (-)-Curcumol)

Curcumol Chemical Structure

CAS No. : 4871-97-0

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ¥550 In-stock
5 mg ¥500 In-stock
10 mg ¥700 In-stock
50 mg   询价  
100 mg   询价  

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Curcumol 相关产品

相关化合物库:

  • Natural Product Library Plus
  • Drug Repurposing Compound Library Plus
  • Clinical Compound Library Plus
  • Bioactive Compound Library Plus
  • Apoptosis Compound Library
  • NF-κB Signaling Compound Library
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  • Anti-Cancer Compound Library
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  • Drug Repurposing Compound Library
  • Medicine Food Homology Compound Library
  • Terpenoids Library
  • Traditional Chinese Medicine Monomer Library
  • Anti-Breast Cancer Compound Library
  • Food-Sourced Compound Library

生物活性

Curcumol ((-)-Curcumol), a bioactive sesquiterpenoid, possesses numerous pharmacological activities like anticancer, antimicrobial, antifungal, antiviral, and antiinflammatory. Curcumol is a potent inducer of apoptosis in numerous cancer cells via targeting key signaling pathways as MAPK/ERK, PI3K/Akt and NF-κB which are generally deregulated in several cancers[1].

体外研究
(In Vitro)

Curcumol ((-)-Curcumol) is the major component extracted from root of Rhizoma Curcumae. Curcumol exerts anticancer effect in cholangiocarcinoma cells via down-regulating CDKL3[2]
. Curcumol induces cell cycle arrest in colon cancer cells via reactive oxygen species and Akt/ GSK3β/cyclin D1 pathway[3]
. Curcumol suppresses breast cancer cell metastasis by inhibiting MMP-9 via JNK1/2 and Akt-dependent NF-κB signaling pathways[4].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

分子量

236.35

Formula

C15H24O2

CAS 号

4871-97-0

中文名称

姜黄醇

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : ≥ 100 mg/mL (423.10 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 4.2310 mL 21.1551 mL 42.3101 mL
5 mM 0.8462 mL 4.2310 mL 8.4620 mL
10 mM 0.4231 mL 2.1155 mL 4.2310 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: 10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (10.58 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (10.58 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

*以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
参考文献
  • [1]. Wei W, et al. Curcumol: From Plant Roots to Cancer Roots. Int J Biol Sci. 2019;15(8):1600-1609. Published 2019 Jun 4.

    [2]. Zhang J, et al. Curcumol Exerts Anticancer Effect in Cholangiocarcinoma Cells via Down-Regulating CDKL3. Front Physiol. 2018;9:234. Published 2018 Mar 20.

    [3]. Wang J, et al. Curcumol induces cell cycle arrest in colon cancer cells via reactive oxygen species and Akt/ GSK3β/cyclin D1 pathway. J Ethnopharmacol. 2018;210:1-9.

    [4]. Ning L, et al. Curcumol Suppresses Breast Cancer Cell Metastasis by Inhibiting MMP-9 Via JNK1/2 and Akt-Dependent NF-κB Signaling Pathways. Integr Cancer Ther. 2016;15(2):216-225.

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