3-Maleimidopropionic acid

发表于2024年3月20日由上海金畔生物科技有限公司

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

3-Maleimidopropionic acid 纯度: 97.72%

3-Maleimidopropionic acid 是一种 PROTAC linker，属于 alkyl chain 类。可用于合成 PROTAC 分子。

3-Maleimidopropionic acid Chemical Structure

CAS No. : 7423-55-4

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生物活性

3-Maleimidopropionic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs^[1].

IC₅₀ & Target

Alkyl-Chain

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

169.13

Formula

C₇H₇NO₄

CAS 号

7423-55-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

参考文献

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

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Maleimidopropionic acid NHS Cat. No. M-C3S-1 100 mg修饰性聚乙二醇

发表于2024年2月4日由上海金畔生物科技有限公司

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

Maleimidopropionic acid NHS

Cat. No.	M-C3S-1
Specification
Unit Size	100 mg
Price	$385.00

d primary amines, therefore, the reaction requires neutral to basic pH values to proceed. The maleimide group reacts with available –SH groups from naturally occurring or mutagenically derived cysteine residues. Maleimide groups react with sulfhydryl groups at pH 6.5~7.5 at room temperature to form stable thioether bonds.

Physical Properties:

Appearance: Off-white/white solid;
Purity: >95%
Solubility: Soluble in DMF or DMSO; Not soluble in water;

Storage Conditions:

Store at -20 ⁰C, Desiccate.

Maleimidopropionic hydrazide Cat. No. M-C3HZ-1 10 mg修饰性聚乙二醇

发表于2024年1月11日由上海金畔生物科技有限公司

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

Maleimidopropionic hydrazide

Cat. No.	M-C3HZ-1
Specification
Unit Size	10 mg
Price	$385.00

Description:

Nanocs SnapLink maleimide hydrazide is a heterobifunctional crosslinker. This crosslinker contains a hydrazide group that can be reacted with carbohydrate. The maleimide group reacts with sulfhydryl groups at pH 6.5~7.5 to form stable thioether bonds.