The native peptide PKTPKKAKKL is derived from histone H1 peptide sequence that is docked in the active site of cyclin-dependent kinase 5. It is an effective CDK5 substrate (Km = 40 碌M).
溶解度
分子量
1218.5
化学式
存储条件
Store at -20°C. Keep tightly closed. Store in a cool dry place.
注释
Documents
Figures
Reference
Lew, J. Biochem. 42, 849 (2003) Sharma, P. et al. J. Biol. Chem. 274, 9600 (1999)
The native peptide PKTPKKAKKL is derived from histone H1 peptide sequence that is docked in the active site of cyclin-dependent kinase 5. It is an effective CDK5 substrate (Km = 40 碌M).
溶解度
分子量
1138.45
化学式
C53H99N15O12
存储条件
Store at -20°C. Keep tightly closed. Store in a cool dry place.
注释
Documents
Figures
Reference
Lew, J. Biochem. 42, 849 (2003) Sharma, P. et al. J. Biol. Chem. 274, 9600 (1999)
Abl Cytosolic Substrate is a substrate for Abelson tyrosine kinase (Abl ). Abl Protein Tyrosine Kinase (AbI) is a truncated form of the v-AbI Protein Tyrosine Kinase, a partner in the Gag-Abl fusion protein of the Abelson murine leukemia virus[1].
分子量
1336.58
Formula
C64H101N15O16
CAS 号
168202-46-8
Sequence
Glu-Ala-Ile-Tyr-Ala-Ala-Pro-Phe-Ala-Lys-Lys-Lys
Sequence Shortening
EAIYAAPFAKKK
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro:
H2O
Peptide Solubility and Storage Guidelines:
1. Calculate the length of the peptide.
2. Calculate the overall charge of the entire peptide according to the following table:
Contents
Assign value
Acidic amino acid
Asp (D), Glu (E), and the C-terminal -COOH.
-1
Basic amino acid
Arg (R), Lys (K), His (H), and the N-terminal -NH2
+1
Neutral amino acid
Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)
0
3. Recommended solution:
Overall charge of peptide
Details
Negative (<0)
1. Try to dissolve the peptide in water first. 2. If water fails, add NH4OH (<50 μL). 3. If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0)
1. Try to dissolve the peptide in water first. 2. If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3. If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)
1. Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2. For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献
[1]. Buchdunger E, et al. Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative. Cancer Res. 1996 Jan 1;56(1):100-4.
HSV-TK substrate is a substrate for HSV-TK, and induces multi-log cytotoxicity in HSV-TK-expressing and bystander cells. HSV-TK substrate shows antitumor activity[1].
分子量
281.27
Formula
C11H15N5O4
CAS 号
111687-37-7
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Shewach DS, et al. Multi-log cytotoxicity of carbocyclic 2′-deoxyguanosine in HSV-TK-expressing human tumor cells. Hum Gene Ther. 2002 Mar 1;13(4):543-51.
The cell-adhesive motif VTCG in region II of malarial circumsporozoite protein has also been found in thrombospondin, properdin, and in a blood-stage antigen of Plasmodium falciparum. It was shown to be the critical sequence for the observed cell-adhesive properties.
溶解度
分子量
1507.78
化学式
C76H98N16O15S1
存储条件
Store at -20°C. Keep tightly closed. Store in a cool dry place.
注释
Documents
Figures
Reference
M.Pennington et al., Innovation and Perspectives in Solid Phase Synthesis &Combinatorial Libraries, 5th International Symposium, London, p. 367, R.Epton, ed., Mayflower Scientific, (1998) S.Jiang et al., Antimicrob. Agents Chemother., 45, 2577 (2001) M.Stadler et al., J. Antibiot., 58, 775 (2005)
Cathepsin D and E FRET Substrate acetate 纯度: 99.06%
Cathepsin D and E FRET Substrate acetate 为 cathepins D 和 E 的荧光底物 (fluorogenic substrate),而不是 B、H 或 I 的荧光底物,它的裂解发生在 Phe-Phe 酰胺键处。Cathepsin D and E FRET Substrate 是用于组织蛋白酶 D 和组织蛋白酶 E 的常规检测和机制研究的有用工具。(激发波长:328 nm; 发射波长:393 nm)
Cathepsin D and E FRET Substrate acetate Chemical Structure
规格
价格
是否有货
数量
5 mg
¥2800
In-stock
10 mg
¥4500
In-stock
25 mg
¥8900
In-stock
50 mg
询价
100 mg
询价
* Please select Quantity before adding items.
Cathepsin D and E FRET Substrate acetate 相关产品
•相关化合物库:
Bioactive Compound Library Plus
Peptide Library
生物活性
Cathepsin D and E FRET Substrate acetate is a fluorogenic substrate for cathepsins D and E and not for B, H or L. The cleavage occurs at the Phe-Phe amide bond resul. Cathepsin D and E FRET Substrate is a valuable tool for routine assays and for mechanistic studies on cathepsins E and D[1].
[1]. Wu X, et al. Discovery of Nonquinone Substrates for NAD(P)H: Quinone Oxidoreductase 1 (NQO1) as Effective Intracellular ROS Generators for the Treatment of Drug-Resistant Non-Small-Cell Lung Cancer. J Med Chem. 2018 Dec 27;61(24):11280-11297.
DAPK Substrate Peptide 是一种合成的死亡相关蛋白激酶 (DAPK) 的肽底物, Km 为 9 μM。
DAPK Substrate Peptide Chemical Structure
CAS No. : 386769-53-5
规格
是否有货
100 mg
询价
250 mg
询价
500 mg
询价
* Please select Quantity before adding items.
DAPK Substrate Peptide 的其他形式现货产品:
DAPK Substrate Peptide TFA
生物活性
DAPK Substrate Peptide is a synthetic peptide substrate for death associated protein kinase (DAPK), with a Km of 9 μM[1].
分子量
1578.82
Formula
FK2NPSVY
CAS 号
386769-53-5
Sequence
Lys-Lys-Arg-Pro-Gln-Arg-Arg-Tyr-Ser-Asn-Val-Phe
Sequence Shortening
KKRPQRRYSNVF
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Velentza AV. A protein kinase associated with apoptosis and tumor suppression: structure, activity, and discovery of peptide substrates. J Biol Chem. 2001;276(42):38956-38965.
DAPK Substrate Peptide 是一种合成的死亡相关蛋白激酶 (DAPK) 的肽底物, Km 为 9 μM。
DAPK Substrate Peptide Chemical Structure
CAS No. : 386769-53-5
规格
是否有货
100 mg
询价
250 mg
询价
500 mg
询价
* Please select Quantity before adding items.
DAPK Substrate Peptide 的其他形式现货产品:
DAPK Substrate Peptide TFA
生物活性
DAPK Substrate Peptide is a synthetic peptide substrate for death associated protein kinase (DAPK), with a Km of 9 μM[1].
分子量
1578.82
Formula
FK2NPSVY
CAS 号
386769-53-5
Sequence
Lys-Lys-Arg-Pro-Gln-Arg-Arg-Tyr-Ser-Asn-Val-Phe
Sequence Shortening
KKRPQRRYSNVF
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Velentza AV. A protein kinase associated with apoptosis and tumor suppression: structure, activity, and discovery of peptide substrates. J Biol Chem. 2001;276(42):38956-38965.