标签归档：vancomycin

Vancomycin FITC conjugate Cat. No. V1-FC-1 1 mg修饰性聚乙二醇

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上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

Vancomycin FITC conjugate

Cat. No. V1-FC-1
Specification
Unit Size 1 mg
Price $385.00

Qty Add to Cart

Synonym: Vancomycin fluorescein, FITC Vancomycin, Fluorescein labeled vancomycin.

Fluorescein Vancomycin (FITC-Vancomycin) is one of Nanocs fluorescent bioconjugates that can be used to detect gram positive bacteria.  Vancomycin is an antibiotic used to treat a number of bacterial infections. FITC vancomycin has excitation/emission wavelength at 495 nm/515 nm.  Fluorescein labeled vancomycin can bind to gram positive bacteria and be detected easily by common fluorescent instruments. 

Product Specifications:

  • Form: In DMSO solution
  • Color: Yellow or orange
  • Ex/Em wavelength: 495 nm/515 nm
  • Concentration: 5-10 mg/mL

Storage Conditions:

  • Store at -20 0C. Protect from light.

Vancomycin 盐酸盐

发表于由

Vancomycin 盐酸盐

现成溶液，100 mg/mL in DMSO

有货

Vancomycin 盐酸盐

CAS编号 1404-93-9 | 品牌：Jinpan
Vancomycin hydrochloride

MSDS

质检证书(CoA)

相似产品

  • 分子式 C66H76Cl3N9O24
  • 分子量1485.71
  • Beilstein号 3704657
  • PubChem编号 6420023

货号 (SKU) 包装规格 是否现货 价格 数量
V432046-10ml 10ml 期货 Vancomycin 盐酸盐  

基本信息

产品名称 Vancomycin 盐酸盐
英文名称 Vancomycin hydrochloride
规格或纯度 现成溶液，100 mg/mL in DMSO
生化机理 Vancomycin is bactericidal in nature, where it inhibits the synthesis of peptidoglycan. It forms hydrogen bond with the peptidoglycan precursor UDP- N -acetylmuramylpentapeptide, and forms a stoichiometric 1:1 complex. Thus, it prevents the growth of the glycan polymer of peptidoglycan by transglycosylase enzyme. It is a frequently used antibiotic for the treatment of peritonitis caused by gram-positive bacteria in patients with continuous ambulatory peritoneal dialysis. In patients with cirrhosis, it is used to control portal systemic encephalopathy. Mice with Clostridium difficile infection (CDI) had better clinical outcome when treated with vancomycin as opposed to the outcome on treatment with metronidazole.

一般描述

General Description

Vancomycin is a glycopeptide antibiotic, which was initially isolated from Streptomyces orientalis . It is effective against multidrug-resistant MRSA strain (methicillin-resistant Staphylococcus aureus ). However, it is nephrotoxic as it is mainly excreted by the kidneys. It has a core heptapeptide having aliphatic amino acids at positions 1 and 3. It is mainly effective against gram-positive bacteria.

Application

Vancomycin hydrochloride may be used- for the assessment of the antimicrobial activity of vancomycin hydrochloride against Mycobacterium tuberculosis in nonreplicating persistence (NRP) using low-oxygen-recovery assay (LORA) and against a luciferase reporter strain of M. tuberculosis in a fermentor-grown culture adapted to low oxygen conditions for the estimation of biomass in a culture of various strains of bacteria as a positive control for E. coli and Staphylococcus aureus in antibacterial activity assay.

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Combustible liquids

General Description

Vancomycin is a glycopeptide antibiotic, which was initially isolated from Streptomyces orientalis . It is effective against multidrug-resistant MRSA strain (methicillin-resistant Staphylococcus aureus ). However, it is nephrotoxic as it is mainly excreted by the kidneys. It has a core heptapeptide having aliphatic amino acids at positions 1 and 3. It is mainly effective against gram-positive bacteria.

Application

Vancomycin hydrochloride may be used- for the assessment of the antimicrobial activity of vancomycin hydrochloride against Mycobacterium tuberculosis in nonreplicating persistence (NRP) using low-oxygen-recovery assay (LORA) and against a luciferase reporter strain of M. tuberculosis in a fermentor-grown culture adapted to low oxygen conditions for the estimation of biomass in a culture of various strains of bacteria as a positive control for E. coli and Staphylococcus aureus in antibacterial activity assay.

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Combustible liquids

相关属性

CAS编号 1404-93-9
储存温度 干燥
RTECS YW4380000
分子量 1485.71
分子式 C66H76Cl3N9O24
品牌 Jinpan
PubChem CID 6420023

Vancomycin hydrochloride(Synonyms: 盐酸万古霉素)

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Vancomycin hydrochloride (Synonyms: 盐酸万古霉素) 纯度: 99.66%

Vancomycin hydrochloride 是用于研究细菌感染 (bacterial) 的抗生素。 它通过抑制易感细菌的细胞壁合成的第二阶段起作用。 Vancomycin hydrochloride 还改变细胞膜的渗透性并选择性地抑制核糖核酸的合成。

Vancomycin hydrochloride(Synonyms: 盐酸万古霉素)

Vancomycin hydrochloride Chemical Structure

CAS No. : 1404-93-9

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1 mL in DMSO ￥550 In-stock
250 mg ￥500 In-stock
1 g ￥990 In-stock
5 g ￥3000 In-stock
10 g   询价  
50 g   询价  

* Please select Quantity before adding items.

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生物活性

Vancomycin hydrochloride is an antibiotic for the treatment of bacterial infections. It acts by inhibiting the second stage of cell wall synthesis of susceptible bacteria. Vancomycin also alters the permeability of the cell membrane and selectively inhibits ribonucleic acid synthesis.

IC50 & Target

Bacterial[1]
体外研究
(In Vitro)

Vancomycin is a large glycopeptide compound with a molecular weight of 1450 Da[1]. Vancomycin is a unique glycopeptide structurally unrelated to any currently available antibiotic. It also has a unique mode of action inhibiting the second stage of cell wall synthesis of susceptible bacteria. Vancomycin is active against a large number of species of Gram-positive bacteria, such as Staphylococcus aureus, Staph. epidermidis, Str. agalactiae, Str. bovis, Str. mutans, viridans streptococci, enterococci[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Vancomycin is administered intravenously, with a standard infusion time of at least 1 h, to minimize infusion-related adverse effects. Subjects with normal creatinine clearance, vancomycin has an α-distribution phase of 30 min to 1 h and a β-elimination half-life of 6-12 h. The volume of distribution is 0.4–1 L/kg. The binding of vancomycin to protein ranges from 10% to 50%. Factors that affect the overall activity of vancomycin include its tissue distribution, inoculum size, and protein-binding effects[1]. Vancomycin treatment of infected mice is associated with improved clinical, diarrhea, and histopathology scores and survival during treatment[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial

分子量

1485.71

Formula

C66H76Cl3N9O24
CAS 号

1404-93-9
中文名称

盐酸万古霉素
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro: 

H2O : 33.33 mg/mL (22.43 mM; Need ultrasonic)

DMSO : 24 mg/mL (16.15 mM; Need ultrasonic and warming)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.6731 mL 3.3654 mL 6.7308 mL
5 mM 0.1346 mL 0.6731 mL 1.3462 mL
10 mM 0.0673 mL 0.3365 mL 0.6731 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： PBS

    Solubility: 130 mg/mL (87.50 mM); Clear solution; Need ultrasonic

  • 2.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (1.40 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (1.40 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 3.

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (1.40 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (1.40 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
  • 4.

    请依序添加每种溶剂： 10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (1.40 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (1.40 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。
参考文献

  • [1]. Rybak MJ, et al. The pharmacokinetic and pharmacodynamic properties of vancomycin. Clin Infect Dis. 2006 Jan 1;42 Suppl 1:S35-9.

    [2]. Watanakunakorn C, et al. Mode of action and in-vitro activity of vancomycin. J Antimicrob Chemother. 1984 Dec;14 Suppl D:7-18.

    [3]. Warren CA, et al. Vancomycin treatment’s association with delayed intestinal tissue injury, clostridial overgrowth, and recurrence of Clostridium difficile infection in mice. Antimicrob Agents Chemother. 2013 Feb;57(2):689-96.
Animal Administration
[3]

Mice: One set of experiments is performed in which infected mice are treated with vancomycin (50 mg/kg) daily for 1, 2, 3, or 5 days and are observed for 21 days postinfection or with vancomycin (20 mg/kg) daily for either 5 or 10 days and monitoring for 15 days postinfection[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

  • [1]. Rybak MJ, et al. The pharmacokinetic and pharmacodynamic properties of vancomycin. Clin Infect Dis. 2006 Jan 1;42 Suppl 1:S35-9.

    [2]. Watanakunakorn C, et al. Mode of action and in-vitro activity of vancomycin. J Antimicrob Chemother. 1984 Dec;14 Suppl D:7-18.

    [3]. Warren CA, et al. Vancomycin treatment’s association with delayed intestinal tissue injury, clostridial overgrowth, and recurrence of Clostridium difficile infection in mice. Antimicrob Agents Chemother. 2013 Feb;57(2):689-96.

Cas(1404-90-6), Vancomycin, 万古霉素,Vancomycin,

发表于由

万古霉素

USP,≥950μg/mg

有货

Cas(1404-90-6), Vancomycin, 万古霉素,Vancomycin,

CAS编号 1404-90-6 | 品牌：Jinpan
Vancomycin

MSDS

质检证书(CoA)

相似产品

  • 分子式 C66H75Cl2N9O24
  • 分子量1449.25

货号 (SKU) 包装规格 是否现货 价格 数量
V301569-250mg 250mg 现货 Cas(1404-90-6), Vancomycin, 万古霉素,Vancomycin,  
V301569-1g 1g 现货 Cas(1404-90-6), Vancomycin, 万古霉素,Vancomycin,  
V301569-5g 5g 现货 Cas(1404-90-6), Vancomycin, 万古霉素,Vancomycin,  
V301569-25g 25g 现货 Cas(1404-90-6), Vancomycin, 万古霉素,Vancomycin,  
V301569-100g 100g 现货 Cas(1404-90-6), Vancomycin, 万古霉素,Vancomycin,  

基本信息

产品名称 万古霉素
英文名称 Vancomycin
别名 万古霉素
规格或纯度 USP,≥950μg/mg
运输条件 超低温冰袋运输
生化机理 Vancomycin 是用于研究细菌感染 (bacterial) 的抗生素。 它通过抑制易感细菌的细胞壁合成的第二阶段起作用。 Vancomycin 还改变细胞膜的渗透性并选择性地抑制核糖核酸的合成。

一般描述

Vancomycin is an antibiotic for the treatment of bacterial infections.

Vancomycin is an antibiotic for the treatment of bacterial infections.

相关属性

CAS编号 1404-90-6
敏感性 对湿度敏感
溶解性 DMSO 29 mg/mL;Insoluble in water and Ethanol
储存温度 -20°C储存
分子量 1449.25
分子式 C66H75Cl2N9O24
品牌 Jinpan

Vancomycin

发表于由

Vancomycin

10mM in DMSO

有货

Vancomycin

CAS编号 1404-90-6 | 品牌：Jinpan
Vancomycin

MSDS

质检证书(CoA)

相似产品

  • 分子式 C66H75Cl2N9O24
  • 分子量1449.25

货号 (SKU) 包装规格 是否现货 价格 数量
V421514-1ml 1ml 期货 Vancomycin  

基本信息

产品名称 Vancomycin
英文名称 Vancomycin
别名 万古霉素
规格或纯度 10mM in DMSO
运输条件 超低温冰袋运输
生化机理 Vancomycin 是用于研究细菌感染 (bacterial) 的抗生素。 它通过抑制易感细菌的细胞壁合成的第二阶段起作用。 Vancomycin 还改变细胞膜的渗透性并选择性地抑制核糖核酸的合成。

一般描述

Vancomycin is an antibiotic for the treatment of bacterial infections.

Vancomycin is an antibiotic for the treatment of bacterial infections.

相关属性

CAS编号 1404-90-6
储存温度 -80℃储存
分子量 1449.25
分子式 C66H75Cl2N9O24
品牌 Jinpan