Isotretinoin-d5 (13-cis-Retinoic acid-d5) is the deuterium labeled Isotretinoin. Isotretinoin(13-cis-Retinoic acid) is a medication used for the research of severe acne. It was first developed to be used as a chemotherapy medication for the treatment of brain cancer, pancreatic cancer and more[1][2].
体外研究 (In Vitro)
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量
305.47
Formula
C20H23D5O2
中文名称
异维甲酸 d5
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
[2]. Thielitz, A. and H. Gollnick, [Isotretinoin. How should it be used?]. Hautarzt, 2013. 64(4): p. 263-8.
[3]. Norris, D.A., et al., Isotretinoin produces significant inhibition of monocyte and neutrophil chemotaxis in vivo in patients with cystic acne. J Invest Dermatol, 1987. 89(1): p. 38-43.
[4]. Rademaker, M., J.M. Wishart, and N.M. Birchall, Isotretinoin 5 mg daily for low-grade adult acne vulgaris – a placebo-controlled, randomized double-blind study. J Eur Acad Dermatol Venereol, 2013.
[5]. Dicken, C.H., Isotretinoin treatment of pityriasis rubra pilaris. J Am Acad Dermatol, 1987. 16(2 Pt 1): p. 297-301.
Liarozole (R75251; R85246) is an imidazole derivative and orally active retinoic acid (RA) metabolism-blocking agent (RAMBA). Liarozole inhibits the cytochrome P450 (CYP26)-dependent 4-hydroxylation of retinoic acid (IC50=7 μM), resulting in increased tissue levels of retinoic acid. Liarozole shows antitumoral properties[1][2][3].
[1]. Kuijpers AL, et al. The effects of oral liarozole on epidermal proliferation and differentiation in severe plaque psoriasis are comparable with those of acitretin. Br J Dermatol. 1998;139(3):380-389.
[2]. Lucker GP, et al. Oral treatment of ichthyosis by the cytochrome P-450 inhibitor liarozole. Br J Dermatol. 1997;136(1):71-75.
[3]. Wouters W, et al. Effects of liarozole, a new antitumoral compound, on retinoic acid-induced inhibition of cell growth and on retinoic acid metabolism in MCF-7 human breast cancer cells. Cancer Res. 1992;52(10):2841-2846.
[4]. Pignatello MA, et al. Liarozole markedly increases all trans-retinoic acid toxicity in mouse limb bud cell cultures: a model to explain the potency of the aromatic retinoid (E)-4-[2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthylenyl)-1-propenyl] benzoic acid. Toxicol Appl Pharmacol. 2002; 178(3):186-194.
[5]. Van Wauwe J, et al. Liarozole, an inhibitor of retinoic acid metabolism, exerts retinoid-mimetic effects in vivo. J Pharmacol Exp Ther. 1992;261(2):773-779.
[6]. Stearns ME, et al. Liarozole and 13-cis-retinoic acid anti-prostatic tumor activity [published correction appears in Cancer Res 1993 Dec 1;53(23):5831]. Cancer Res. 1993;53(13):3073-3077.
Retinoic acid PEG Biotin is one of Nanocs bioactive Vitamin A/Retinoic acid PEG derivatives that can be used to for drμg delivery or bioassay development. Retinoic acid is an essential substances for chordate animals from fish to human. Pegylated retinoic acid provides better water solubility. Nanocs can provide other retinoic acid or tetinol PEG derivatives based on customer request.
Retinoic acid PEG Biotin is one of Nanocs bioactive Vitamin A/Retinoic acid PEG derivatives that can be used to for drug delivery or bioassay development. Retinoic acid is an essential substances for chordate animals from fish to human. Pegylated retinoic acid provides better water solubility. Nanocs can provide other retinoic acid or tetinol PEG derivatives based on customer request.
相关属性
溶解性
Yellow solid or viscous liquid depends on molecule weight;Soluble in regular aqeous solution as well as most organic solvents;
Retinoic acid PEG NHS is one of Nanocs bioactive Vitamin A/Retinoic acid PEG derivatives that can be used to for drμg delivery or bioassay development. Retinoic acid is an essential substances for chordate animals from fish to human. Pegylated retinoic acid provides better water solubility. Nanocs can provide other retinoic acid or tetinol PEG derivatives based on customer request.
Retinoic acid PEG NHS is one of Nanocs bioactive Vitamin A/Retinoic acid PEG derivatives that can be used to for drug delivery or bioassay development. Retinoic acid is an essential substances for chordate animals from fish to human. Pegylated retinoic acid provides better water solubility. Nanocs can provide other retinoic acid or tetinol PEG derivatives based on customer request.
相关属性
溶解性
Yellow solid or viscous liquid depends on molecule weight;Soluble in regular aqeous solution as well as most organic solvents;