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9-Decyn-1-ol
9-Decyn-1-ol 是一种 PROTAC linker，属于 alkyl/ether 类，可用于合成一系列 PROTAC 分子，如 9-Decyn-1-ol 将 GDC-0068 和 Lenalidomide 偶联可合成 INY-03-041 (HY-133120)。INY-03-041 是一种有效的选择性 PROTAC Akt 降解剂。INY-03-041 抑制 Akt1，Akt2 和 Akt3，IC50 分别为 2.0 nM，6.8 nM 和 3.5 nM。
9-Decyn-1-ol Chemical Structure
CAS No. : 17643-36-6
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| 100 mg | 询价 | ||
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| 生物活性 |
9-Decyn-1-ol is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. 9-Decyn-1-ol can be used to conjugate GDC-0068 with Lenalidomide to generate INY-03-041. INY-03-041 is a potent, highly selective and PROTAC-based pan-Akt degrader. INY-03-041 inhibits Akt1, Akt2 and Akt3 with IC50s of 2.0 nM, 6.8 nM and 3.5 nM, respectively[1]. |
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| IC50 & Target[1] |
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| 体外研究 (In Vitro) |
9-Decyn-1-ol can be used to conjugate GDC-0068 with Lenalidomide to generate INY-03-041. INY-03-041 is a pan-AKT degrader consisting of the ATP-competitive AKT inhibitor GDC-0068 conjugated to Lenalidomide by a linker[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
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| 分子量 |
154.25 |
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| Formula |
C10H18O |
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| CAS 号 |
17643-36-6 |
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
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| 参考文献 |
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