上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
iHCK-37 (Synonyms: ASN05260065) 纯度: 99.69%
iHCK-37 (ASN05260065) 是一种有效的特异性 Hck 抑制剂,Ki 值为 0.22 μM。iHCK-37 阻断 HIV-1 病毒复制,其 EC50 值为 12.9 μM。iHCK-37 可用于慢性髓系白血病(CML)研究。
iHCK-37 Chemical Structure
CAS No. : 516478-09-4
规格 | 价格 | 是否有货 | 数量 |
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5 mg | ¥3800 | In-stock | |
10 mg | ¥6000 | In-stock | |
25 mg | ¥11500 | In-stock | |
50 mg | 询价 | ||
100 mg | 询价 |
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iHCK-37 相关产品
•相关化合物库:
- Bioactive Compound Library Plus
- Anti-Infection Compound Library
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- Protein Tyrosine Kinase Compound Library
- Anti-Cancer Compound Library
- Reprogramming Compound Library
- Anti-Pancreatic Cancer Compound Library
- Anti-Blood Cancer Compound Library
- Angiogenesis Related Compound Library
生物活性 |
iHCK-37 (ASN05260065) is a potent and specific Hck inhibitor with a Ki value of 0.22 μM. iHCK-37 blocks HIV-1 viral replication with an EC50 value of 12.9 μM. iHCK-37 is used for chronic myeloid leukemia (CML) research[1]. |
IC50 & Target |
Ki: 0.22 μM (Hck)[1] |
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体外研究 (In Vitro) |
iHCK-37 (5.0-20 μM; 24 hours) exhibits a potent in vitro antiproliferative activity. The dose (μM) for growth inhibition (GI50) is 5.0-5.8 μM for AML cell lines (HL60, KG1a and U937) and 9.1-19.2 μM for chronic myeloid leukemia cell lines (HEL and K562)[2].iHCK-37 (3-9 μM; plus Erythropoietin) leads to a decrease in ERK, AKT and P70S6K phosphorylation of in lentivirus HCK silenced K562 and U937 cell lines[2].iHCK-37 (3-9 μM) results in a decrease of p-HCK, p-ERK, p-AKT, p-70S6 in the cell line KG1a (AML/CD34+), in a dose-dependent manner[2]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability Assay[1]
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分子量 |
544.73 |
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Formula |
C30H32N4O2S2 |
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CAS 号 |
516478-09-4 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : 275 mg/mL (504.84 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
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参考文献 |
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