【编号】:SPR00758
【产品名称】:Echinophyllin C对照品
【规格】:10mg
【用途】:
上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
Rituximab (Synonyms: 利妥昔单抗; Anti-Human CD20 type I, Chimeric Antibody) 纯度: 98.42%
Rituximab 是一种抗 CD20 嵌合单克隆抗体,用于某些自身免疫疾病和癌症的研究。
Rituximab Chemical Structure
CAS No. : 174722-31-7
规格 | 价格 | 是否有货 | 数量 |
---|---|---|---|
1 mg | ¥2800 | In-stock | |
5 mg | ¥5600 | In-stock | |
25 mg | 询价 | ||
50 mg | 询价 |
* Please select Quantity before adding items.
生物活性 |
Rituximab is an anti-CD20 chimeric monoclonal antibody used to treat certain autoimmune diseases and types of cancer. |
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体外研究 (In Vitro) |
Rituximab inhibits the proliferation of stimulated human B cells, which is associated with a relative increase of B cells with an activated naive phenotype. Aside from this population shift, there are no major changes in phenotype or cytokine profile of the various B-cell subsets. B cells stimulated in the presence of rituximab induces stronger T-cell proliferation, compared to B cells stimulated in the absence of rituximab[1]. All lymphoma cells tested are equally sensitive to antibody-dependent cell-mediated cytotoxicity (ADCC), antibody-mediated phagocytosis of tumor cells, and rituximab-induced apoptosis. Rituximab induces high CDC killing of follicular lymphoma cells[2]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
体内研究 (In Vivo) |
A single injection of rituximab or the murine anti-CD20 Ab 1F5, given i.p. 1 day after the tumor, cures 100% of the animals. Depletion of either NK cells or neutrophils or both in tumor-injected animals does not affect the therapeutic activity of the drug. Similarly, rituximab is able to eradicate tumor cells in athymic nude mice, suggesting that its activity is T cell independent[3]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
Clinical Trial |
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分子量 |
144544.44 |
CAS 号 |
174722-31-7 |
中文名称 |
利妥昔单抗 |
储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
参考文献 |
|
Cell Assay |
A single injection of rituximab or the murine anti-CD20 Ab 1F5, given i.p. 1 day after the tumor, cures 100% of the animals. Depletion of either NK cells or neutrophils or both in tumor-injected animals does not affect the therapeutic activity of the drug. Similarly, rituximab is able to eradicate tumor cells in athymic nude mice, suggesting that its activity is T cell independent[3]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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Animal Administration [1] |
C57BL/6 mice (8-10 wk of age) are inoculated 8×103 EL4-CD20+ cells in 200 μL of saline by tail vein injection. In parallel groups of mice, 150 g of rituximab, murine anti-CD20 IgG2a Ab 1F5, or control anti-human IL-2R Ab daclizumab in 300 μL of saline, or saline only is inoculated i.p. 24 h later[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
参考文献 |
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所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务
【简单介绍】
【详细说明】
昂尼高剪切分散乳化机AD18系列 8G,1-60ml
技术规格
额定电压 |
AC220 V |
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额定频率 |
50/60 Hz |
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输入功率 |
710 W |
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输出功率 |
430 W |
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额定转矩 |
12.1 N.cm |
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工作制式 |
S1 (连续) |
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运行控制方式 |
调速转盘 |
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转速调节范围 (空载) |
13000~34000 rpm |
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转速控制型式 |
6档 |
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工作头最大扭矩 |
12.0 N.cm |
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工作头材质 |
SS316(不锈钢) |
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适配工作头(选购) |
8 G,10 G,12 G ,18 G ,24 G |
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允许环境温度 |
不大于 40 ℃ |
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允许相对湿度 |
不大于 80 % |
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整机外形尺寸 |
215×310×720 mm |
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整机重量 |
11.0 kg |
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分散均质工作头参数: |
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工作头规格 G |
8 |
10 |
12 |
18 |
24 |
处理量(H2O)ml |
15~50 |
20~100 |
30~800 |
50~1500 |
80~5000 |
适合最大粘度 mPa.s |
1000 |
1000 |
1000 |
2000 |
5000 |
转子最大线速度 m/s |
10 |
11 |
12 |
15 |
18 |
最小/最大浸入液体高度 mm |
15/105 |
25/130 |
35/150 |
45/160 |
50/165 |
定子直径 mm |
8 |
10 |
12 |
18 |
24 |
工作头长度 mm |
156 |
182 |
215 |
222 |
225 |
最高使用温度 ℃ |
120 |
120 |
120 |
120 |
120 |
工作头部材质 # |
SS316 |
SS316 |
SS316 |
SS316 |
SS316 |
工作头轴承材质 # |
PTFE |
PTFE |
PTFE |
PTFE |
PTFE |
上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
Darifenacin hydrobromide (Synonyms: 氢溴酸达非那新; UK-88525 hydrobromide) 纯度: 98.28%
Darifenacin hydrobromide (UK-88525 hydrobromide) 是选择性 M3 蕈毒碱受体拮抗剂,pKi 为 8.9。
Darifenacin hydrobromide Chemical Structure
CAS No. : 133099-07-7
规格 | 价格 | 是否有货 | 数量 |
---|---|---|---|
Free Sample (0.1-0.5 mg) | Apply now | ||
10 mM * 1 mL in DMSO | ¥605 | In-stock | |
10 mg | ¥550 | In-stock | |
100 mg | ¥2750 | In-stock | |
200 mg | 询价 | ||
500 mg | 询价 |
* Please select Quantity before adding items.
生物活性 |
Darifenacin hydrobromide (UK-88525 hydrobromide) is a selective M3 muscarinic receptor antagonist with pKi of 8.9. IC50 value: 8.9 (pKi) [1] Target: M3 receptor in vitro: Darifenacin exerts non-parallel rightward displacement of the agonist curve and also significant depression of the maximum response (+)-cis-Dioxolane produced concentration-dependent contraction of the isolated bladder of rat [1]. Darifenacin produces a concentration dependent increase in R123 (P-gp probe) accumulation in MDCK cells. Darifenacin stimulates ATPase activity in P-gp membrane in a clear concentration dependent response manner with an estimated ED50 value of 1.6 μM. Darifenacin (100 nM) shows a significantly greater permeability for darifenacin in the basolateral to apical direction resulting in an efflux ratio in BBMEC monolayers of approximately 2.6 [2]. in vivo: Darifenacin produces dose-dependent inhibition of amplitude of volume-induced bladder contractions(VIBCAMP), producing 35% inhibition at dose of 283.3 nmol/kg and maximal inhibition of approximately 50–55% [1]. Darifenacin (0.1 mg/kg i.v.) reduces bladder afferent activity in both Aδ and C fibers in female Sprague-Dawley rats, the decrease in afferent spikes in C fibers may be more pronounced than that in Aδ fibers [3]. |
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Clinical Trial |
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分子量 |
507.46 |
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Formula |
C28H31BrN2O2 |
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CAS 号 |
133099-07-7 |
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中文名称 |
氢溴酸达非那新;氢溴酸达菲那新 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
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溶解性数据 |
In Vitro:
DMSO : 33.33 mg/mL (65.68 mM; Need ultrasonic) 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
|
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参考文献 |
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所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务
上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
Dihydroguaiaretic acid 纯度: 98.86%
Dihydroguaiaretic acid,从五味子的果实中分离,具有抗癌活性。
Dihydroguaiaretic acid Chemical Structure
CAS No. : 66322-34-7
规格 | 价格 | 是否有货 | 数量 |
---|---|---|---|
1 mg | ¥1900 | In-stock | |
5 mg | ¥5710 | In-stock | |
10 mg | 询价 | ||
50 mg | 询价 |
* Please select Quantity before adding items.
生物活性 |
Dihydroguaiaretic acid, is isolated from the fruits of Schisandra chinensis with an anti-cancer activty[1]. |
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体外研究 (In Vitro) |
Dihydroguaiaretic acid shows inhibitory effect on Human ovarian cancer cells and A2780 Human endometrial cancer cells Ishikawa with IC50 values of 27.17 μM and 45.46 μM, respectively[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
分子量 |
330.42 |
Formula |
C20H26O4 |
CAS 号 |
66322-34-7 |
运输条件 |
Room temperature in continental US; may vary elsewhere. |
储存方式 |
4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
参考文献 |
|
所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务
【编号】:SPR00718
【产品名称】:ent-16β,17-Dihydroxykauran-19-oic acid对照品
【规格】:10mg
【用途】:
上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
Linsitinib (Synonyms: OSI-906) 纯度: 99.88%
Linsitinib (OSI-906) 是一种有效选择性的,具有口服活性的 IGF-1 和胰岛素受体 (IR) 的双重抑制剂,IC50 分别为 35 和 75 nM。
Linsitinib Chemical Structure
CAS No. : 867160-71-2
规格 | 价格 | 是否有货 | 数量 |
---|---|---|---|
Free Sample (0.1-0.5 mg) | Apply now | ||
10 mM * 1 mL in DMSO | ¥1020 | In-stock | |
2 mg | ¥750 | In-stock | |
5 mg | ¥1100 | In-stock | |
10 mg | ¥1850 | In-stock | |
50 mg | ¥4700 | In-stock | |
100 mg | ¥8100 | In-stock | |
200 mg | 询价 | ||
500 mg | 询价 |
* Please select Quantity before adding items.
生物活性 |
Linsitinib (OSI-906) is a potent, selective and orally bioavailable dual inhibitor of the IGF-1 receptor and insulin receptor (IR) with IC50s of 35 and 75 nM, respectively[1]. |
IC50 & Target |
IC50: 35 nM (IGF-1R), 75 nM (InsR)[1] |
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体外研究 (In Vitro) |
Linsitinib inhibits IGF-1R autophosphorylation and activation of the downstream signaling proteins Akt, ERK1/2 and S6 kinase with IC50 of 0.028 to 0.13 μM. Linsitinib enables an intermediate conformation of the target protein through interactions with the C-helix. Linsitinib displays favorable metabolic stability in liver microsomes. Linsitinib fully inhibits both IR and IGF-1R phosphorylation at a concentration of 1 μM. Linsitinib inhibits proliferation of several tumor cell lines including non-small-cell lung cancer and colorectal cancer (CRC) tumor cell line with EC50 of 0.021 to 0.810 μM[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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体内研究 (In Vivo) |
Linsitinib inhibits tumor growth in an IGF-1R-driven xenograft mouse model, with 100% TGI and 55% regression at a dose of 75 mg/kg and 60% TGI and no regression at a dose of 25 mg/kg. Linsitinib administration induces different elimination half-lives of itself in dog, rat and mice, the elimination half-lives are 1.18 hours, 2.64 hours and 2.14 hours, respectively. Linsitinib administration at different single dose once-daily in femal Sprague-Dawley rat and femal CD-1 mouse reveal that the Vmax is not dose-proportional to Linsitinib dose. Linsitinib elevates the blood glucose levels at a dose of 25 mg/kg after 12 days administration. Linsitinib administration at a single dose of 75 mg/kg in IGF-1R-driven full-length human IGF-1R (LISN) xenograft mouse model achieve maximal inhibition of IGF-1R phosphorylation (80%) between 4 and 24 hours with plasma drug concentrations of 26.6-4.77 μM[1]. Linsitinib administered as a single dose of at 60 mg/kg in NCI-H292 xenografts mice inhibits uptake of glucose at 2, 4, and 24 hours post-treatment in vivo. Linsitinib inhibits the growth of tumors in NCI-H292 xenograft mouse model[2]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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Clinical Trial |
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分子量 |
421.49 |
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Formula |
C26H23N5O |
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CAS 号 |
867160-71-2 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : 50 mg/mL (118.63 mM; Need ultrasonic) 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
|
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参考文献 |
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Kinase Assay [1] |
Protein kinase assays are either performed in-house by ELISA-based assay methods (IGF-1R, IR, EGFR and KDR) or by a radiometric method with ATP at 100 µM concentration. In-house ELISA assays use poly(Glu:Tyr) as the substrate bound to the surface of 96-well assay plates and phosphorylation is detected using an antiphosphotyrosine antibody conjugated to horseradish peroxidase. The bound antibody is quantified using ABTS as the peroxidase substrate by measuring absorbance at 405/490 nm. All assays use purified recombinant kinase catalytic domains. Recombinant enzymes of human IGF-1R or EGFR are expressed as an NH2-terminal glutathione S-transferase fusion protein in insect cells and are purified in house. IC50 values are determined from the sigmoidal dose-response plot of percent inhibition versus log10 compound concentration. A minimum of three measurements, performed in duplicate, are carried out with in-house assays unless otherwise indicated. Linsitinib at a concentration of 1 µM is profiled versus a panel of kinases using the ProfilerProTM Kinase Selectivity Assay Kit. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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Cell Assay [1] |
For assays of cell proliferation, cells are seeded into 96-well plates in appropriate media containing FCS 10% and incubated for 3 days in the presence of Linsitinib at various concentrations. Inhibition of cell growth is determined by luminescent quantitation of intracellular ATP content using CellTiterGlo. Data is presented as a fraction of maximal proliferation, calculated by dividing the cellular density in the presence of varying concentrations of Linsitinib by the cellular density of control cells treated with vehicle (DMSO) only. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
Animal Administration [1] |
Cells are harvested from cell culture flasks during exponential cell growth, washed twice with sterile PBS to a suitable concentration before subcutaneous implantation on the right flank of female nu/nu CD-1 mice. Tumors are established to 200±50 mm3 in size before randomization into treatment groups of eight mice each for efficacy studies. Linsitinib or vehicle is administered orally as indicated. The %TGI values indicated are the median %TGI over the entire dosing period. TGI of at lease 505 is considered significant. Growth delay is calculated as T-C shere T and C are the times in days for mean tumor size in the treated (T) and control (C) groups to reach 400% of the initial tumor volume. Cures are excluded from this calculation. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
参考文献 |
|
所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务
上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
PP121 纯度: 99.08%
PP121是多靶点激酶抑制剂,抑制 mTOR,DNK-PK,VEGFR2,Src,PDGFR 的 IC50 值分别为10,60,12,14,2 nM。
PP121 Chemical Structure
CAS No. : 1092788-83-4
规格 | 价格 | 是否有货 | 数量 |
---|---|---|---|
Free Sample (0.1-0.5 mg) | Apply now | ||
10 mM * 1 mL in DMSO | ¥921 | In-stock | |
10 mg | ¥837 | In-stock | |
50 mg | ¥2976 | In-stock | |
100 mg | ¥3950 | In-stock | |
200 mg | 询价 | ||
500 mg | 询价 |
* Please select Quantity before adding items.
生物活性 |
PP121 is a multi-targeted kinase inhibitor with IC50s of 10, 60, 12, 14, 2 nM for mTOR, DNK-PK, VEGFR2, Src, PDGFR, respectively. |
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IC50 & Target[1] |
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体外研究 (In Vitro) |
PP121 blocks the PI3K pathway by direct inhibition of PI3K/mTOR in two glioblastoma cell lines, U87 and LN229. PP121 potently inhibits the proliferation of a diverse panel of tumor cell lines containing mutations in the PI3-K pathway components PIK3CA, PTEN, or RAS. PP121 induces a G0G1 arrest in most tumor cells. PP121 directly inhibits Src in cells and reverses its biochemical and morphological effects. PP121 potently inhibits the Ret kinase domain in vitro (IC50<1 nm). pp121 potently blocks vegf stimulated activation of the pi3-k and mapk pathways. inhibits vegfr2 autophosphorylation at low nanomolar concentrations, confirming that this molecule directly targets in cells. bcr-abl induced tyrosine phosphorylation k562 cells as well baf3 express bcr-abl[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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体内研究 (In Vivo) |
Oral administration of PP121 remarkably inhibits Eca-109 xenograft growth. Mice body weights are not significantly affected by PP121 or the vehicle treatment. PP121 oral administration dramatically inhibits activations of Akt-mTOR and NFkB in xenograft tumors. p-Akt Ser 473 and p-IKKa/b are both inhibited by PP121 administration[2]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
319.36 |
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Formula |
C17H17N7 |
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CAS 号 |
1092788-83-4 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : 20 mg/mL (62.63 mM; Need ultrasonic) 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
|
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参考文献 |
|
Kinase Assay [1] |
Purified kinase domains are incubated with inhibitors (PP121) at 2- or 4-fold dilutions over a concentration range of 50- 0.001 µM or with vehicle (0.1% DMSO) in the presence of 10 µM ATP, 2.5 µCi of γ- 32P-ATP and substrate. Reactions are terminated by spotting onto nitrocellulose or phosphocellulose membranes, depending on the substrate; this membrane is then washed 5-6 times to remove unbound radioactivity and dried. Transferred radioactivity is quantitated by phosphorimaging and IC50 values are calculated by fitting the data to a sigmoidal doseresponse using Prism software[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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Cell Assay |
Cells grown in 96-well plates are treated with PP121 at 4-fold dilutions (10 µM – 0.040 μM) or vehicle (0.1% DMSO). After 72 h cells are exposed to Resazurin sodium salt (22 µM) and fluorescence is quantified. IC50 values are calculated. For proliferation assays involving single cell counting, non-adherent cells are plated at low density (3–5% confluence) and treated with drug (2.5 µM) or vehicle (0.1% DMSO). Cells are diluted into trypan blue daily and viable cells counted using a hemocytometer[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
Animal Administration [2] |
Mice: Eca-109 cells are injected into the axillary regions of nude mice (5×106 cells/mouse). When the tumor volumes reach around 200 mm3, the mice are randomly separated to three groups: Untreated control, PP121 (30 mg/kg) and vehicle (10% 1-methyl-2-pyrrolidinone and 90% PEG 300) group. Tumor volumes and the mice body weights are measured every 10 d[2]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
参考文献 |
|
所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务
【简单介绍】
【详细说明】
上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
Acetamide (Synonyms: 乙酰胺) 纯度: ≥98.0%
Acetamide 是合成甲胺,硫代乙酰胺和杀虫剂中间体,也用作皮革,布料和涂料中的增塑剂。 Acetamide 具有致癌性。
Acetamide Chemical Structure
CAS No. : 60-35-5
规格 | 价格 | 是否有货 | 数量 |
---|---|---|---|
Free Sample (0.1-0.5 mg) | Apply now | ||
10 mM * 1 mL in Water | ¥550 | In-stock | |
5 g | ¥500 | In-stock | |
10 g | 询价 | ||
50 g | 询价 |
* Please select Quantity before adding items.
生物活性 |
Acetamide is used as an intermediate in the synthesis of methylamine, thioacetamide, and insecticides, and as a plasticizer in leather, cloth and coatings. Acetamide has carcinogenicity[1][2]. |
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IC50 & Target |
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分子量 |
59.07 |
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Formula |
C2H5NO |
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CAS 号 |
60-35-5 |
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中文名称 |
乙酰胺 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
H2O : 50 mg/mL (846.45 mM; Need ultrasonic) 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
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参考文献 |
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昂尼高剪切分散乳化机AD18系列 10G, 3-150ml
技术规格
额定电压 |
AC220 V |
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额定频率 |
50/60 Hz |
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输入功率 |
710 W |
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输出功率 |
430 W |
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额定转矩 |
12.1 N.cm |
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工作制式 |
S1 (连续) |
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运行控制方式 |
调速转盘 |
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转速调节范围 (空载) |
13000~34000 rpm |
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转速控制型式 |
6档 |
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工作头最大扭矩 |
12.0 N.cm |
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工作头材质 |
SS316(不锈钢) |
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适配工作头(选购) |
8 G,10 G,12 G ,18 G ,24 G |
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允许环境温度 |
不大于 40 ℃ |
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允许相对湿度 |
不大于 80 % |
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整机外形尺寸 |
215×310×720 mm |
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整机重量 |
11.0 kg |
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分散均质工作头参数: |
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工作头规格 G |
8 |
10 |
12 |
18 |
24 |
处理量(H2O)ml |
15~50 |
20~100 |
30~800 |
50~1500 |
80~5000 |
适合最大粘度 mPa.s |
1000 |
1000 |
1000 |
2000 |
5000 |
转子最大线速度 m/s |
10 |
11 |
12 |
15 |
18 |
最小/最大浸入液体高度 mm |
15/105 |
25/130 |
35/150 |
45/160 |
50/165 |
定子直径 mm |
8 |
10 |
12 |
18 |
24 |
工作头长度 mm |
156 |
182 |
215 |
222 |
225 |
最高使用温度 ℃ |
120 |
120 |
120 |
120 |
120 |
工作头部材质 # |
SS316 |
SS316 |
SS316 |
SS316 |
SS316 |
工作头轴承材质 # |
PTFE |
PTFE |
PTFE |
PTFE |
PTFE |
上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
Geldanamycin (Synonyms: 格尔德霉素) 纯度: 99.78%
Geldanamycin是 Hsp90 抑制剂,具有抗许多革兰氏阳性和一些革兰氏阴性细菌的活性。Geldanamycin 还具有抗流感病毒 H5N1 的活性。
Geldanamycin Chemical Structure
CAS No. : 30562-34-6
规格 | 价格 | 是否有货 | 数量 |
---|---|---|---|
Free Sample (0.1-0.5 mg) | Apply now | ||
10 mM * 1 mL in DMSO | ¥1544 | In-stock | |
5 mg | ¥1252 | In-stock | |
10 mg | ¥1989 | In-stock | |
50 mg | 询价 | ||
100 mg | 询价 |
* Please select Quantity before adding items.
生物活性 |
Geldanamycin is a Hsp90 inhibitor with antimicrobial activity against many Gram-positive and some Gram-negative bacteria. Geldanamycin has anti-influenza virus H5N1 activities. |
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IC50 & Target |
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体外研究 (In Vitro) |
Geldanamycin significantly delays and reduces viperin expression, indicating that IRF3 is involved in viperin induction in RAW264.7 cells[1]. Geldanamycin (GA), a benzoquinone ansamycin, protected against neuronal injury induced by oxygen-glucose deprivation (OGD)/zVAD treatment in cultured primary neurons. More importantly, Geldanamycin decreases RIP1 protein level in a time and concentration-dependent manner. Geldanamycin also decreases the Hsp90 protein level, which causes instability of RIP1 protein, resulting in decreased RIP1 protein level but not RIP1 mRNA level after Geldanamycin treatment[2]. Geldanamycin (GA) is identified as the first natural product inhibitor of Hsp90 that binds to the N-terminal ATPase domain of Hsp90 to inhibit its chaperone function, and significantly induces tumor cell death via an apoptotic mechanism[3]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
560.64 |
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Formula |
C29H40N2O9 |
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CAS 号 |
30562-34-6 |
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中文名称 |
格尔德霉素 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : 50 mg/mL (89.18 mM; Need ultrasonic) 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务
【简单介绍】
【详细说明】
上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
(-)-Epigallocatechin-3-(3”-O-methyl) gallate (Synonyms: (-)-EGCG-3”-O-ME) 纯度: ≥99.0%
(-)-Epigallocatechin-3-(3”-O-methyl) gallate 是从茶叶中分离出的一种天然产物,具有很强的抗氧化和细胞毒性。(-)-Epigallocatechin-3-(3”-O-methyl) gallate 对大鼠癌细胞具有较强的细胞毒性。
(-)-Epigallocatechin-3-(3”-O-methyl) gallate Chemical Structure
CAS No. : 83104-87-4
规格 | 价格 | 是否有货 | 数量 |
---|---|---|---|
1 mg | ¥4760 | In-stock | |
5 mg | ¥14290 | 询价 | |
10 mg | 询价 | ||
50 mg | 询价 |
* Please select Quantity before adding items.
生物活性 |
(-)-Epigallocatechin-3-(3”-O-methyl) gallate is a natural product isolated from the tea leaf, with strong antioxidative activity. (-)-Epigallocatechin-3-(3”-O-methyl) gallate has a strong cytotoxic activity for rat cancer cells[1]. |
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分子量 |
472.40 |
Formula |
C23H20O11 |
CAS 号 |
83104-87-4 |
运输条件 |
Room temperature in continental US; may vary elsewhere. |
储存方式 |
4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
参考文献 |
|
所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务
上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
AZD3514 纯度: 99.32%
AZD3514是口服的雄激素受体负调节剂,Ki为2.2 μM,可降低AR蛋白的表达。
AZD3514 Chemical Structure
CAS No. : 1240299-33-5
规格 | 价格 | 是否有货 | 数量 |
---|---|---|---|
Free Sample (0.1-0.5 mg) | Apply now | ||
10 mM * 1 mL in DMSO | ¥850 | In-stock | |
5 mg | ¥744 | In-stock | |
10 mg | ¥1302 | In-stock | |
50 mg | ¥3720 | In-stock | |
100 mg | ¥6045 | In-stock | |
200 mg | 询价 | ||
500 mg | 询价 |
* Please select Quantity before adding items.
生物活性 |
AZD3514 is a potent and oral androgen receptor downregulator with Ki of 2.2 μM and has ability of reducing AR protein expression. IC50 Value: 2.2 uM (Ki) Target: androgen receptor AZD3514 binds to the AR ligand binding domain and has selectivity for binding to AR over other nuclear hormone receptors [1]. in vitro: AZD3514 inhibits cell growth in prostate cancer cells expressing wild-type (VCaP) and mutated (T877A) AR (LNCaP), but is inactive in AR-negative prostate cancer cells, indicating a dependency on AR for efficacy [2]. in vivo: We assessed activity initially in the Hershberger castrated rat assay in which oral dosing of AZD3514 (100mg/kg once-daily for 7 days) significantly inhibited testosterone-induced growth of sexual accessory organs [2]. Clinical trial: Open-label Prostate Cancer Study. Phase 1 |
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Clinical Trial |
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分子量 |
519.56 |
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Formula |
C25H32F3N7O2 |
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CAS 号 |
1240299-33-5 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : ≥ 100 mg/mL (192.47 mM) * “≥” means soluble, but saturation unknown. 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
|
所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务
上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
GSK-J4 纯度: 99.64%
GSK-J4 是一种有效的 H3K27me3/me2 去甲基化酶 JMJD3/KDM6B 和 UTX/KDM6A 双抑制剂,IC50 分别为 8.6 μM 和 6.6 μM。GSK-J4 抑制 LPS 诱导的人原代巨噬细胞产生 TNF-α,IC50 值为 9 μM。GSK-J4 是 GSK-J1 的细胞通透性前药。GSK-J4 诱导内质网应激相关的细胞凋亡 (apoptosis)。
GSK-J4 Chemical Structure
CAS No. : 1373423-53-0
规格 | 价格 | 是否有货 | 数量 |
---|---|---|---|
10 mM * 1 mL in DMSO | ¥1320 | In-stock | |
10 mg | ¥1200 | In-stock | |
50 mg | ¥4500 | In-stock | |
100 mg | 询价 | ||
200 mg | 询价 |
* Please select Quantity before adding items.
生物活性 |
GSK-J4 is a potent dual inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A with IC50s of 8.6 and 6.6 μM, respectively. GSK-J4 inhibits LPS-induced TNF-α production in human primary macrophages with an IC50 of 9 μM. GSK J4 is a cell permeable prodrug of GSK-J1[1][2][3]. GSK-J4 induces endoplasmic reticulum stress-related apoptosis[4]. |
IC50 & Target |
IC50: 8.6 µM (JMJD3/KDM6B), 6.6 µM (UTX/KDM6A)[6] |
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体外研究 (In Vitro) |
GSK-J4 has cellular activity in Flag-JMJD3-transfected HeLa cells, in which GSK-J4 prevents the JMJD3-induced loss of nuclear H3K27me3 immunostaining. Administration of GSK-J4 increases total nuclear H3K27me3 levels in untransfected cells. GSK-J4 significantly reduces the expression of 16 of 34 LPS-driven cytokines, including tumour-necrosis factor-α (TNF-α)[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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体内研究 (In Vivo) |
GSK-J4 Hydrochloride (10 mg/kg; i.p.; thrice-weekly for 10 weeks) attenuates the development of kidney disease in diabetic mice[2]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
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分子量 |
417.50 |
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Formula |
C24H27N5O2 |
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CAS 号 |
1373423-53-0 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : ≥ 36 mg/mL (86.23 mM) * “≥” means soluble, but saturation unknown. 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
|
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参考文献 |
|
所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务
上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
Silvestrol aglycone (enantiomer) 纯度: 99.10%
Silvestrol aglycone enantiomer 是 Silvestrol 的糖苷配基对映体,是一种环戊苯并呋喃核酚。
Silvestrol aglycone (enantiomer) Chemical Structure
CAS No. : 1112993-18-6
规格 | 价格 | 是否有货 | 数量 |
---|---|---|---|
5 mg | ¥9500 | In-stock | |
10 mg | 询价 | ||
50 mg | 询价 |
* Please select Quantity before adding items.
生物活性 |
Silvestrol aglycone enantiomer is a cyclopenta benzofuran core phenol[1]. |
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分子量 |
478.49 |
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Formula |
C27H26O8 |
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CAS 号 |
1112993-18-6 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : ≥ 114 mg/mL (238.25 mM) * “≥” means soluble, but saturation unknown. 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
|
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参考文献 |
|
所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务