Ganoderic acid F(Synonyms: 灵芝酸F)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Ganoderic acid F (Synonyms: 灵芝酸F) 纯度: 99.00%

Ganoderic acid F 是灵芝酸。Ganoderic acid F 通过抑制血管生成和涉及细胞增殖和/或细胞死亡,致癌作用,氧化应激,钙信号传导和内质网应激的蛋白质改变来显示抗肿瘤和抗转移活性。

Ganoderic acid F(Synonyms: 灵芝酸F)

Ganoderic acid F Chemical Structure

CAS No. : 98665-15-7

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Ganoderic acid F 相关产品

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  • Natural Product Library Plus
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  • Oxygen Sensing Compound Library
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  • Medicine Food Homology Compound Library
  • Traditional Chinese Medicine Monomer Library
  • Anti-Parkinson’s Disease Compound Library
  • Neurodegenerative Disease-related Compound Library
  • Food-Sourced Compound Library

生物活性

Ganoderic acid F is a ganoderic acid. Ganoderic acid F exhibits antitumor and antimetastatic activities through inhibition of angiogenesis and alteration of proteins involving cell proliferation and/or cell death, carcinogenesis, oxidative stress, calcium signaling, and endoplasmic reticulum stress[1][2].

体外研究
(In Vitro)

Ganoderic acid F (48 hours) inhibits the proliferation of HeLa human cervical carcinoma cells with an IC50 value of 19.5 μM[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

570.67

Formula

C32H42O9

CAS 号

98665-15-7

中文名称

灵芝酸F

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
In Vitro: 

DMSO : 100 mg/mL (175.23 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.7523 mL 8.7616 mL 17.5233 mL
5 mM 0.3505 mL 1.7523 mL 3.5047 mL
10 mM 0.1752 mL 0.8762 mL 1.7523 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Teekachunhatean S, et al. Pharmacokinetics of ganoderic acids a and f after oral administration of ling zhi preparation in healthy male volunteers. Evid Based Complement Alternat Med. 2012;2012:780892.

    [2]. Yue QX, et al. Effects of triterpenes from Ganoderma lucidum on protein expression profile of HeLa cells. Phytomedicine. 2010 Jul;17(8-9):606-13.

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赤式-愈创木基 BETA-芥子醇基醚 7-O-葡萄糖苷对照品

赤式-愈创木基 BETA-芥子醇基醚 7-O-葡萄糖苷对照品

  【编号】:SPR04300

  【产品名称】:赤式-愈创木基 BETA-芥子醇基醚 7-O-葡萄糖苷对照品

  【规格】:10mg

  【用途】:

  赤式-愈创木基 BETA-芥子醇基醚 7-O-葡萄糖苷对照品

  编号:SPR04300
  英文名称:erythro-Guaiacylglycerol β-sinapyl ether 7-O-glucoside
  CAS No.:412029-03-9
  分 子 式:C27H36O13
  分 子 量:568.572
  类别:上海金畔生物科技有限公司,天然提取物
  作为标准品,对照品或者供研究用,不能直接用于人体。

宁波新芝超声波提取机Scientz-10T

宁波新芝超声波提取机Scientz-10T

  • 品牌 新芝|SCIENTZ
  • 型号 Scientz-10T
  • 商品详情

    产品说明

    1、本机由超声波发生器和超声波换能器组件两大部分组成。超声波发生器(电源)是将

    220VAC、50Hz的单相电通过变频器件变为20-25kHz、约600V的交变电能、并以适当的阻抗与功率匹配来推动换能器

    作纵向机械振动,振动波通过浸入在样品溶液中的钛合金变幅杆对被破碎的各类细胞产生空化效应,从而达到破碎细胞之目的。

    2、其电原理由整流电源,开关电源、变频系统、功率放大器、锁相频率自动跟踪器、功率调节器、功率检测器、功率保护器及微电脑控制等组成。

    产品特征

    1、随着生物产业的发展,应用超声波提取机所做的实验要求也随之提高,如对样品温度的测定、控制,低温冷却样品及整机的智能化程度的提高等等

    都提出了新的要求,为进一步完善此类仪器的各项性能,我公司在现有各种型号的超声波提取机的基础上,吸收国外最新技术

    结合微电脑控制、选频、测温、保护等软硬件技术而研制的超声波提取机,它具有技术先进、性能可靠、操作简便、外型美观、显示清晰明亮、测温控温精确等优点。

    2、超声波提取机是一种利用强超声在固、液体中产生空化、破碎、乳化,对物质细胞在温控、搅拌状态下按反应条件添加各种反应剂而进行提取物质的一种设备。

    超声波提取机广泛应用于生物化学、微生物学、药物化学、表面化学、物理学、动物学、农学、医学、制药等领域教学、科研、生产。

    3、提取罐采用双层玻璃反应釜.双层玻璃反应釜有框架部分、玻璃部分、电器部分、固定卡件、搅拌部分五部分组成,安装方便。

    容量有1000豪升,2000豪升,5000豪升,10000豪升.15000豪升,30000豪升,50000豪升等不同规格,供用户先用.一种容量一种仪器规格。

     

    技术参数

    产品型号

    Scientz-5T

    Scientz-10T

    Scientz-15T

    Scientz-30T

    Scientz-50T

    工作频率

    20-25 KHz 

    20-25 KHz 

    20-25 KHz 

    20-25 KHz 

    20-25 KHz 

    超声功率

    20-1000(W)

    20-1200(W)

    200-1500(W)

    200-1800(W)

    250-2400(W)

    双层反应釜容量

    5 L

    10 L

    15 L

    30 L

    50 L

    变幅杆直径

    Ф15

    Ф18

    Ф20

    Ф25

    Ф30

    工作电压

    220 V

    220 V

    220 V

    220 V

    220 V

    超声时间

    0.1-99.9 s

    0.1-99.9 s

    0.1-99.9 s

    0.1-99.9 s

    0.1-99.9 s

    间隙时间

    0.1-99.9 s

    0.1-99.9 s

    0.1-99.9 s

    0.1-99.9 s

    0.1-99.9 s

    全程时间

    1-999 min

    1-999 min

    1-999 min

    1-999 min

    1-999 min

    功率设定

    1-99%

    1-99%

    1-99%

    1-99%

    1-99%

    占 空 比

    0.1-99.9%

    0.1-99.9%

    0.1-99.9%

    0.1-99.9%

    0.1-99.9%

    实际温度测量

    搅拌功率

    60 W

    60 W

    90 W

    120 W

    120 W

    搅拌转速

    10-1200 r/min

    10-1200 r/min

    10-1200 r/min

    10-1200 r/min

    10-1200 r/min

    支   架

    不锈钢 

    不锈钢 

    不锈钢 

    不锈钢 

    不锈钢 

    添加剂容量瓶

    加液口/放液口

    有/有

    有/有

    有/有

    有/有

    有/有

    制 冷 量

    500 W

    800 W

    1200 W

    2250 W

    2250 W

    制冷温度

    -5℃-室温

    -5℃-室温

    -5℃-室温

    -5℃-室温

    -5℃-室温

  • Branaplam(Synonyms: LMI070; NVS-SM1)

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

    Branaplam (Synonyms: LMI070; NVS-SM1) 纯度: 99.78%

    Branaplam (LMI070; NVS-SM1) 是一种口服有效和选择性的 SMN2 拼接调节剂,对 SMN 的 EC50 为 20 nM。Branaplam 抑制 hERGIC50 为 6.3 μM。Branaplam 在严重的脊髓性肌萎缩症 (SMA) 小鼠模型中可提高全长 SMN 蛋白并延长其生存期。

    Branaplam(Synonyms: LMI070;  NVS-SM1)

    Branaplam Chemical Structure

    CAS No. : 1562338-42-4

    规格 价格 是否有货 数量
    Free Sample (0.1-0.5 mg)   Apply now  
    10 mM * 1 mL in DMSO ¥1430 In-stock
    2 mg ¥800 In-stock
    5 mg ¥1300 In-stock
    10 mg ¥2200 In-stock
    50 mg ¥8000 In-stock
    100 mg ¥13000 In-stock
    200 mg   询价  
    500 mg   询价  

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    Branaplam 相关产品

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    • Neurodegenerative Disease-related Compound Library
    • Targeted Diversity Library
    • Rare Diseases Drug Library

    生物活性

    Branaplam (LMI070; NVS-SM1) is a highly potent, selective and orally active survival motor neuron-2 (SMN2) splicing modulator with an EC50 of 20 nM for SMN. Branaplam inhibits human-ether-a-go-go-related gene (hERG) with an IC50 of 6.3 μM. Branaplam elevates full-length SMN protein and extends survival in a severe spinal muscular atrophy (SMA) mouse model[1][2].

    IC50 & Target

    IC50: 20 nM (SMN)[1]
    EC50: 6.3 μM (hERG)[2]

    体外研究
    (In Vitro)

    Branaplam (LMI070; NVS-SM1) treatment induces changes in the levels of 175 genes in human fibroblasts[1].

    上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

    体内研究
    (In Vivo)

    Branaplam (LMI070; NVS-SM1; 3, 10, 30 mg/kg; oral) produces dose-dependent elevations of SMN2-FL transcript and SMN protein in brain and spinal cord[1].
    Branaplam (1 mg/kg of IV; 3 mg/kg of PO) has a CL of 25 mL/min/kg and an AUC of 3.03 μM•h[2].
    A single Branaplam (oral; 30 mg/kg) results in significant and durable SMN protein elevation in brain for up to 160 hours in C/+ mice[1].
    Branaplam (oral; 0.03, 0.1, 0.3, 1, 3 mg/kg) improves body weight and extendes lifespan in n SMNΔ7 mice[1].

    上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: C/+ SMA mouse model[1]
    Dosage: 3, 10, 30 mg/kg
    Administration: Oral
    Result: Produced dose-dependent elevations of SMN2-FL transcript and SMN protein in brain and spinal cord.
    Animal Model: Male Sprague-Dawley rat[2]
    Dosage: 1 mg/kg (IV);3 mg/kg (PO) (Pharmacokinetic Analysis)
    Administration: IV or PO
    Result: Had a CL of 25 mL/min/kg and an AUC of 3.03 μM•h.

    Clinical Trial

    分子量

    393.48

    Formula

    C22H27N5O2

    CAS 号

    1562338-42-4

    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    溶解性数据
    In Vitro: 

    DMSO : 6.12 mg/mL (15.55 mM; Need ultrasonic and warming)

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 2.5414 mL 12.7071 mL 25.4143 mL
    5 mM 0.5083 mL 2.5414 mL 5.0829 mL
    10 mM 0.2541 mL 1.2707 mL 2.5414 mL

    *

    请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
    储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

    In Vivo:

    请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

    ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
    分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

    • 1.

      请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 1 mg/mL (2.54 mM); Clear solution

      此方案可获得 ≥ 1 mg/mL (2.54 mM,饱和度未知) 的澄清溶液。

      以 1 mL 工作液为例,取 100 μL 10.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

      将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

    • 2.

      请依序添加每种溶剂: 10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 0.71 mg/mL (1.80 mM); Clear solution

      此方案可获得 ≥ 0.71 mg/mL (1.80 mM,饱和度未知) 的澄清溶液。

      以 1 mL 工作液为例,取 100 μL 7.1 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

      将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
    • 3.

      请依序添加每种溶剂: 10% DMSO    90% corn oil

      Solubility: ≥ 0.71 mg/mL (1.80 mM); Clear solution

      此方案可获得 ≥ 0.71 mg/mL (1.80 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

      以 1 mL 工作液为例,取 100 μL 7.1 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

    • 4.

      请依序添加每种溶剂: 5% DMSO    40% PEG300    5% Tween-80    50% saline

      Solubility: ≥ 0.57 mg/mL (1.45 mM); Clear solution

    • 5.

      请依序添加每种溶剂: 1% DMSO    99% saline

      Solubility: 0.12 mg/mL (0.30 mM); Suspended solution; Need ultrasonic

    *以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
    参考文献
    • [1]. Palacino J, et al. SMN2 splice modulators enhance U1-pre-mRNA association and rescue SMA mice. Nat Chem Biol. 2015 Jul;11(7):511-517.

      [2]. Cheung AK, et al. Discovery of Small Molecule Splicing Modulators of Survival Motor Neuron-2 (SMN2) for the Treatment of Spinal Muscular Atrophy (SMA). J Med Chem. 2018 Dec 27;61(24):11021-11036.

    所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

    Ganoderic acid D(Synonyms: 灵芝酸 D)

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

    Ganoderic acid D (Synonyms: 灵芝酸 D) 纯度: 99.18%

    Ganoderic acid D 是一种高度氧化的四环三萜类化合物 (tetracyclic triterpenoid),是灵芝 (Ganoderma lucidum) 的主要活性成分。Ganoderic acid D 上调 SIRT3 的蛋白质表达并通过 SIRT3 诱导脱乙酰化的亲环蛋白 D (CypD)。Ganoderic acid D 抑制结肠癌细胞的能量重编程,包括结肠癌细胞中的葡萄糖摄取,乳酸产生,丙酮酸和乙酰辅酶的产生。Ganoderic acid D 诱导 HeLa 人宫颈癌细胞凋亡 (apoptosis)。

    Ganoderic acid D(Synonyms: 灵芝酸 D)

    Ganoderic acid D Chemical Structure

    CAS No. : 108340-60-9

    规格 价格 是否有货 数量
    1 mg ¥900 In-stock
    5 mg ¥2300 In-stock
    10 mg   询价  
    50 mg   询价  

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    Ganoderic acid D 相关产品

    相关化合物库:

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    • Epigenetics Compound Library
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    • Anti-Cancer Compound Library
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    • Antioxidants Compound Library
    • Lipid Compound Library
    • Oxygen Sensing Compound Library
    • Medicine Food Homology Compound Library
    • Terpenoids Library
    • Glutamine Metabolism Compound Library
    • Traditional Chinese Medicine Monomer Library
    • Anti-Colorectal Cancer Compound Library

    生物活性

    Ganoderic acid D, a highly oxygenated tetracyclic triterpenoid, is the major active component of Ganoderma lucidum. Ganoderic acid D upregulates the protein expression of SIRT3 and induces the deacetylated cyclophilin D (CypD) by SIRT3. Ganoderic acid D inhibits the energy reprogramming of colon cancer cells including glucose uptake, lactate production, pyruvate and acetyl-coenzyme production in colon cancer cells[1]. Ganoderic acid D induces HeLa human cervical carcinoma apoptosis[2].

    IC50 & Target[1]

    SIRT3

     

    体外研究
    (In Vitro)

    Ganoderic acid D can inhibit the growth of numerous cancer cell lines and it inhibits HeLa human cervical carcinoma cells with an IC50 of 17.3 mM[2]. Ganoderic acid D (1-50 μM; 24-72 hours) reduces the cell survival rate in a dose- and time-dependent manner[2].
    Ganoderic acid D (10, 50 μM; 24, 48 hours) induces G2/M phase arrest[2].
    Ganoderic acid D (10, 50 μM; 24, 48 hours) induces a morphological change typical of apoptosis in HeLa cells[2].
    Ganoderic acid D (10 μM; 48 hours) up-regulates 14-3-3E and PRDX3[2].

    上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

    Cell Viability Assay[2]

    Cell Line: HeLa human cervical carcinoma cell line (CCL-2)
    Concentration: 1, 5, 10, 20, 50 μM
    Incubation Time: 24, 48, 72 hours
    Result: Reduced the cell survival rate in a dose- and time-dependent manner and had an IC50 value of 17.3 μM for 48 hours treatment.

    Cell Cycle Analysis[2]

    Cell Line: HeLa human cervical carcinoma cell line (CCL-2)
    Concentration: 10, 50 μM
    Incubation Time: 24, 48 hours
    Result: Induced G2/M phase arrest.
    Displayed a cell cycle profile with an elevated G2/M cell population after 24-h treatment with 10 μM.

    Apoptosis Analysis[2]

    Cell Line: HeLa human cervical carcinoma cell line (CCL-2)
    Concentration: 10, 50 μM
    Incubation Time: 48 hours
    Result: Induced a morphological change typical of apoptosis in HeLa cells.

    Western Blot Analysis[2]

    Cell Line: HeLa human cervical carcinoma cell line (CCL-2)
    Concentration: 10 μM
    Incubation Time: 48 hours
    Result: Up-regulated 14-3-3E and PRDX3.

    分子量

    514.65

    Formula

    C30H42O7

    CAS 号

    108340-60-9

    中文名称

    灵芝酸 D

    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    溶解性数据
    In Vitro: 

    DMSO : 100 mg/mL (194.31 mM; Need ultrasonic)

    H2O : < 0.1 mg/mL (insoluble)

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 1.9431 mL 9.7153 mL 19.4307 mL
    5 mM 0.3886 mL 1.9431 mL 3.8861 mL
    10 mM 0.1943 mL 0.9715 mL 1.9431 mL

    *

    请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
    储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

    In Vivo:

    请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

    ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
    分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

    • 1.

      请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: 2.5 mg/mL (4.86 mM); Clear solution; Need ultrasonic

      此方案可获得 2.5 mg/mL (4.86 mM) 的澄清溶液。

      以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

      将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

    • 2.

      请依序添加每种溶剂: 10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (4.86 mM); Clear solution

      此方案可获得 ≥ 2.5 mg/mL (4.86 mM,饱和度未知) 的澄清溶液。

      以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

      将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
    • 3.

      请依序添加每种溶剂: 10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (4.86 mM); Clear solution

      此方案可获得 ≥ 2.5 mg/mL (4.86 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

      以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

    *以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
    参考文献
    • [1]. Liu Z, et al. Effect of ganoderic acid D on colon cancer Warburg effect: Role of SIRT3/cyclophilin D. Eur J Pharmacol. 2018 Apr 5;824:72-77.

      [2]. Yue QX, et al. Proteomics characterization of the cytotoxicity mechanism of ganoderic acid D and computer-automated estimation of the possible drug target network. Mol Cell Proteomics. 2008 May;7(5):949-61.

    所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

    英国Electrothermal 3孔多位电加热套EME30250/CE

    【简单介绍】

    英国Electrothermal 3孔多位电加热套EME30250/CE,这种3孔多位电加热套内置电子控制器, 可选择单加热(EME3)或加热/搅拌组合(EMEA3)型号。可以适用FM110 Flow Monitor。外壳通风采用*的气流设计,保证外壳可接触(“cool-to-touch”)。

    【详细说明】

    英国Electrothermal 3孔多位电加热套EME30250/CE

    产品描述:   

       英国Electrothermal 3孔多位电加热套EME30250/CE,这种3孔多位电加热套内置电子控制器, 可以适用FM110 Flow Monitor。外壳通风采用*的气流设计,保证外壳可接触(“cool-to-touch”)。

    技术特点:
    独立内置固态电子控制器,方便加热调节,同时采用消除电打火的机械开关。
    包括三个12.7mm直径的支撑杆
    不同型号三个位置可接受100ml至1000ml的多种圆底烧瓶
    上盖采用聚丙烯,外表面都用静电喷塑,有良好的防化学腐蚀性能
    盘绕的加热元件悬挂在一个隔热盒中,提供佳的热传递和支撑
    接地的保护屏隔开加热器提供更多安全保护
    可更换独立加热盘
    电源打开、加热和磁搅拌都有指示灯

    技术指标

    材料 聚丙烯上盖和静电喷塑铝 外壳
    大加热元件温度 450?C

    订货信息

    型号 孔数 烧瓶容量 电源 尺寸(d×w ×h) ,mm 包装重量
    EME3 0100/CE 3 3 x 100ml 230V 50/60Hz, 180W 260 x 630 x 90 6.2kg
    EME3 0100/CEX1 3 3 x 100ml 115V 50/60Hz, 210W 260 x 630 x 90 6.2kg
    EME3 0100/CEX6 3 3 x 100ml 230V 50/60Hz, 180W, EU 插头 260 x 630 x 90 6.2kg
    EME3 0250/CE 3 3 x 250ml 230V 50/60Hz, 450W 260 x 630 x 90 6.2kg
    EME3 0250/CEX1 3 3 x 250ml 115V 50/60Hz, 450W 260 x 630 x 90 6.2kg
    EME3 0250/CEX6 3 3 x 250ml 230V 50/60Hz, 450W, EU 插头 260 x 630 x 90 6.2kg
    EME3 0500/CE 3 3 x 500ml 230V 50/60Hz, 600W 260 x 630 x 90 7.4kg
    EME3 0500/CEX1 3 3 x 500ml 115V 50/60Hz, 600W 260 x 630 x 90 7.4kg
    EME3 0500/CEX6 3 3 x 500ml 230V 50/60Hz, 600W, EU 插头 260 x 630 x 90 7.4kg
    EME3 1000/CE 3 3 x 1000ml 230V 50/60Hz, 900W 260 x 630 x 90 7.4kg
    EME3 1000/CEX1 3 3 x 1000ml 115V 50/60Hz, 900W 260 x 630 x 90 7.4kg
    EME3 1000/CEX6 3 3 x 1000ml 230V 50/60Hz, 900W, EU 插头 260 x 630 x 90 7.4kg

      

    支架

     

    特点:
    超坚固的H型基座和坚固的支撑杆,每个型号都配相应夹头,重载型适合SS30。

    技术参数与订货编号:

    产品编号 产品描述 基座尺寸 立杆尺寸 净重
    SS10/1 支架,通用型 400W×350D×25Hmm 16×700mm 7.6kg
    SS10/2 支架,重载型 550W×480D×25Hmm 25×850mm 20.2kg

    Wushanicaritin(Synonyms: 巫山淫羊藿素)

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

    Wushanicaritin (Synonyms: 巫山淫羊藿素) 纯度: 98.11%

    Wushanicaritin 在 DPPH 自由基清除活性测试中显示出显着的抗氧化活性 (IC50=35.3 μM)。Wushanicaritin 具有抗肿瘤作用和抗炎特性。

    Wushanicaritin(Synonyms: 巫山淫羊藿素)

    Wushanicaritin Chemical Structure

    CAS No. : 521-45-9

    规格 价格 是否有货 数量
    10 mg ¥1200 In-stock
    25 mg ¥2200 In-stock
    50 mg ¥3500 In-stock
    100 mg   询价  
    200 mg   询价  

    * Please select Quantity before adding items.

    Wushanicaritin 相关产品

    相关化合物库:

    • Natural Product Library Plus
    • Bioactive Compound Library Plus
    • Immunology/Inflammation Compound Library
    • Natural Product Library
    • Anti-Cancer Compound Library
    • Phenols Library

    生物活性

    Wushanicaritin exhibits significant antioxidant activity (IC50=35.3 μM) in DPPH radical scavenging activity tests. Antitumor effects and anti-inflammatory property[1].

    体外研究
    (In Vitro)

    Wushanicaritin, a natural polyphenol compound, exerts many biological activities. Diphenyl picryl hydrazinyl radical (DPPH) radical scavenging activity tests indicated that Wushanicaritin (IC50=35.3 μM) exhibits significant antioxidant activity comparable to Vitamin C (IC50=32.0 μM)[1].

    Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

    分子量

    386.40

    Formula

    C21H22O7

    CAS 号

    521-45-9

    中文名称

    巫山淫羊藿素

    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    溶解性数据
    In Vitro: 

    DMSO : 9.62 mg/mL (24.90 mM; Need ultrasonic)

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 2.5880 mL 12.9400 mL 25.8799 mL
    5 mM 0.5176 mL 2.5880 mL 5.1760 mL
    10 mM 0.2588 mL 1.2940 mL 2.5880 mL

    *

    请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
    储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

    参考文献
    • [1]. Hong X, et al. In Vitro Glucuronidation of Wushanicaritin by Liver Microsomes, Intestine Microsomes and Expressed Human UDP-Glucuronosyltransferase Enzymes. Int J Mol Sci. 2017 Sep 19;18(9). pii: E1983.

    所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

    G-1

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

    G-1  纯度: 99.51%

    G-1 是一个非甾体,高亲和力且有选择性的 GPR30 激动剂,其 Ki 值为 11 nM。

    G-1

    G-1 Chemical Structure

    CAS No. : 881639-98-1

    规格 价格 是否有货 数量
    10 mM * 1 mL in DMSO ¥850 In-stock
    1 mg ¥550 In-stock
    5 mg ¥940 In-stock
    10 mg ¥1500 In-stock
    50 mg ¥4500 In-stock
    100 mg ¥6500 In-stock
    200 mg   询价  
    500 mg   询价  

    * Please select Quantity before adding items.

    G-1 相关产品

    相关化合物库:

    • Bioactive Compound Library Plus
    • Anti-Cancer Compound Library

    生物活性

    G-1 is a nonsteroidal, high-affinity and selective agonist of GPR30 with a Ki of 11 nM.

    IC50 & Target

    Ki: 11 nM (GPR30)[1]

    体外研究
    (In Vitro)

    G-1 is a nonsteroidal, high-affinity and selective agonist of GPR30 with a Ki of 11 nM[1]. Treatment with G-1 (10 μM and 100 μM) for 48 and 72 h significantly decreases cell proliferation (P<0.001). At 72 h, the IC50 value for G-1 is calculated to be 20 μM. Treatment of A549 cells with G-1 at a concentration of 20 μM reveals a significant increase in apoptosis, consistent with its antiproliferative effect (P<0.001)[2]. Cell cycle analysis of H295R cells after 24 h of G-1 treatment demonstrates a cell cycle arrest in the G2 phase. The presence of G-1 increases Bax expression while decreases Bcl-2[3].

    上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

    体内研究
    (In Vivo)

    The results at 14 days post-injury show that the Basso mouse scale (BMS) scores are significantly higher in the G-1 group compared with the other groups (P<0.05). The number of caspase-3-positive cells in the cross sections is counted, and G-1 group has fewer positive cells compare with the other groups (P<0.05), and there is no difference between the two groups (P>0.05)[1]. G-1 administration produces a statistically significant decrease in tumor volume from day 14 post treatment. Grafted tumors harvested after three-week treatment with G-1 show a significant decrease in tumor weight compare to vehicle treated animals[3].

    上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

    分子量

    412.28

    Formula

    C21H18BrNO3

    CAS 号

    881639-98-1

    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    溶解性数据
    In Vitro: 

    DMSO : 50 mg/mL (121.28 mM; Need ultrasonic)

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 2.4255 mL 12.1277 mL 24.2554 mL
    5 mM 0.4851 mL 2.4255 mL 4.8511 mL
    10 mM 0.2426 mL 1.2128 mL 2.4255 mL

    *

    请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
    储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

    In Vivo:

    请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

    ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
    分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

    • 1.

      请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (6.06 mM); Clear solution

      此方案可获得 ≥ 2.5 mg/mL (6.06 mM,饱和度未知) 的澄清溶液。

      以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

      将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

    • 2.

      请依序添加每种溶剂: 10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: 2.5 mg/mL (6.06 mM); Suspended solution; Need ultrasonic

      此方案可获得 2.5 mg/mL (6.06 mM) 的均匀悬浊液,悬浊液可用于口服和腹腔注射。

      以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

      将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
    • 3.

      请依序添加每种溶剂: 10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (6.06 mM); Clear solution

      此方案可获得 ≥ 2.5 mg/mL (6.06 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

      以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

    *以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
    参考文献
    • [1]. Cheng Q, et al. G-1 exerts neuroprotective effects through G protein-coupled estrogen receptor 1 following spinal cord injury in mice. Biosci Rep. 2016 Aug 31;36(4). pii: e00373.

      [2]. Kurt AH, et al. Oxidative/antioxidative enzyme-mediated antiproliferative and proapoptotic effects of the GPER1 agonist G-1 on lung cancer cells. Oncol Lett. 2015 Nov;10(5):3177-3182.

      [3]. Chimento A, et al. GPER agonist G-1 decreases adrenocortical carcinoma (ACC) cell growth in vitro and in vivo. Oncotarget. 2015 Aug 7;6(22):19190-203.

    Cell Assay
    [2]

    A549 human lung cancer cells are treated with various concentrations (10 nM, 100 nM, 1 μM, 10 μM and 100 μM) of G-1 in 96-well plates and incubated for 48 or 72 h. Following incubation, MTT solution is added to each well at a concentration of 0.5 mg/mL, and incubated for 4 h at 37°C. At the end of this period, 100 µL DMSO solvent is added to each well. The absorbance values [optical density (OD)] at 570 nm of the solution in each well are read using a spectrophotometer[2].

    上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Administration
    [3]

    Four-week-old nu/nu-Forkhead box N1nu female mice are used in this study. H295R cells, 6×106, suspended in 100 μL PBS, are combined with 30 μL of Matrigel (4 mg/mL) and injected subcutaneously in the shoulder of each animal. Mice are treated 21 days after cell injection, when tumors have reached an average volume of about 200 mm3. Animals are randomly assigned to be treated with vehicle or G-1 at a concentration of 2 mg/kg/daily. Drug tolerability is assessed in tumor-bearing mice in terms of: a) lethal toxicity, i.e. any death in treated mice occurring before any death in control mice; b) body weight loss percentage=100-[(body weight on day x/body weight on day 1)×100], where x represents a day during the treatment period. Animals are sacrificed by cervical dislocation 42 days after cell injection[3].

    上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

    参考文献
    • [1]. Cheng Q, et al. G-1 exerts neuroprotective effects through G protein-coupled estrogen receptor 1 following spinal cord injury in mice. Biosci Rep. 2016 Aug 31;36(4). pii: e00373.

      [2]. Kurt AH, et al. Oxidative/antioxidative enzyme-mediated antiproliferative and proapoptotic effects of the GPER1 agonist G-1 on lung cancer cells. Oncol Lett. 2015 Nov;10(5):3177-3182.

      [3]. Chimento A, et al. GPER agonist G-1 decreases adrenocortical carcinoma (ACC) cell growth in vitro and in vivo. Oncotarget. 2015 Aug 7;6(22):19190-203.

    所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

    泽兰内酯对照品

    泽兰内酯对照品

      【编号】:SPR04293

      【产品名称】:泽兰内酯对照品

      【规格】:10mg

      【用途】:

      泽兰内酯对照品

      编号:SPR04293
      英文名称:Eupatolide
      CAS No.:6750-25-0
      分 子 式:C15H20O3
      分 子 量:248.322
      类别:上海金畔生物科技有限公司,天然提取物
      作为标准品,对照品或者供研究用,不能直接用于人体。

    Polyphyllin I(Synonyms: 重楼皂苷I)

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

    Polyphyllin I (Synonyms: 重楼皂苷I) 纯度: 99.61%

    Polyphyllin I 是一种从 Paris polyphylla 中提取的生物活性成分,具有很强的抗肿瘤活性。Polyphyllin I 是JNK 信号通路的激活剂,也是 PDK1/Akt/mTOR 信号传导的抑制剂。Polyphyllin I 诱导自噬,G2/M 期阻滞和细胞凋亡。

    Polyphyllin I(Synonyms: 重楼皂苷I)

    Polyphyllin I Chemical Structure

    CAS No. : 50773-41-6

    规格 价格 是否有货 数量
    5 mg ¥600 In-stock
    10 mg ¥1000 In-stock
    20 mg ¥1800 In-stock
    50 mg   询价  
    100 mg   询价  

    * Please select Quantity before adding items.

    Polyphyllin I 相关产品

    相关化合物库:

    • Natural Product Library Plus
    • Bioactive Compound Library Plus
    • Apoptosis Compound Library
    • Immunology/Inflammation Compound Library
    • Kinase Inhibitor Library
    • MAPK Compound Library
    • PI3K/Akt/mTOR Compound Library
    • Stem Cell Signaling Compound Library
    • Natural Product Library
    • Anti-Cancer Compound Library
    • Autophagy Compound Library
    • Anti-Aging Compound Library
    • Antioxidants Compound Library
    • Differentiation Inducing Compound Library
    • Reprogramming Compound Library
    • Glycoside Compound Library
    • Lipid Compound Library
    • Oxygen Sensing Compound Library
    • Glycolysis Compound Library
    • Cytoskeleton Compound Library
    • Glutamine Metabolism Compound Library
    • Traditional Chinese Medicine Monomer Library
    • Anti-Breast Cancer Compound Library
    • Anti-Lung Cancer Compound Library
    • Anti-Pancreatic Cancer Compound Library
    • Anti-Blood Cancer Compound Library
    • Anti-Cancer Metabolism Compound Library
    • Anti-Obesity Compound Library
    • Angiogenesis Related Compound Library
    • Transcription Factor Targeted Library
    • Glucose Metabolism Compound Library
    • Anti-Liver Cancer Compound Library
    • Anti-Colorectal Cancer Compound Library

    生物活性

    Polyphyllin I is a bioactive constituent extracted from Paris polyphylla, has strong anti-tumor activity. Polyphyllin I is an activator of the JNK signaling pathway and is an inhibitor of PDK1/Akt/mTOR signaling. Polyphyllin I induces autophagy, G2/M phase arrest and apoptosis[1][2][3].

    IC50 & Target

    JNK signaling[2]
    PDK1/Akt/mTOR signaling[3]

    分子量

    855.02

    Formula

    C44H70O16

    CAS 号

    50773-41-6

    中文名称

    重楼皂苷I

    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    溶解性数据
    In Vitro: 

    DMSO : 100 mg/mL (116.96 mM; Need ultrasonic)

    H2O : < 0.1 mg/mL (ultrasonic) (insoluble)

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 1.1696 mL 5.8478 mL 11.6956 mL
    5 mM 0.2339 mL 1.1696 mL 2.3391 mL
    10 mM 0.1170 mL 0.5848 mL 1.1696 mL

    *

    请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
    储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

    In Vivo:

    请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

    ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
    分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

    • 1.

      请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 0.83 mg/mL (0.97 mM); Clear solution

      此方案可获得 ≥ 0.83 mg/mL (0.97 mM,饱和度未知) 的澄清溶液。

      以 1 mL 工作液为例,取 100 μL 8.3 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

      将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

    • 2.

      请依序添加每种溶剂: 10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 0.83 mg/mL (0.97 mM); Clear solution

      此方案可获得 ≥ 0.83 mg/mL (0.97 mM,饱和度未知) 的澄清溶液。

      以 1 mL 工作液为例,取 100 μL 8.3 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

      将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
    • 3.

      请依序添加每种溶剂: 10% DMSO    90% corn oil

      Solubility: ≥ 0.83 mg/mL (0.97 mM); Clear solution

      此方案可获得 ≥ 0.83 mg/mL (0.97 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

      以 1 mL 工作液为例,取 100 μL 8.3 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

    *以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
    参考文献
    • [1]. Kong M, et al. Effects of polyphyllin I on growth inhibition of human non-small lung cancer cells and in xenograft. Acta Biochim Biophys Sin (Shanghai). 2010 Nov;42(11):827-33.

      [2]. Liu J, et al. Polyphyllin I induces G2/M phase arrest and apoptosis in U251 human glioma cells via mitochondrial dysfunction and the JNK signaling pathway. Acta Biochim Biophys Sin (Shanghai). 2017 Jun 1;49(6):479-486.

      [3]. He J, et al. Polyphyllin I induces autophagy and cell cycle arrest via inhibiting PDK1/Akt/mTOR signal and downregulating cyclin B1 in human gastric carcinoma HGC-27 cells. Biomed Pharmacother. 2019 Sep;117:109189.

    所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

    英国Electrothermal 3孔多位电加热套EME3和EMEA3系列

    【简单介绍】

    英国Electrothermal 3孔多位电加热套EME3和EMEA3系列,这种3孔多位电加热套内置电子控制器, 可选择单加热(EME3)或加热/搅拌组合(EMEA3)型号。可以适用FM110 Flow Monitor。外壳通风采用*的气流设计,保证外壳可接触(“cool-to-touch”)。

    【详细说明】

    英国Electrothermal 3孔多位电加热套EME3和EMEA3系列

    产品描述:   

       英国Electrothermal 3孔多位电加热套EME3和EMEA3系列,这种3孔多位电加热套内置电子控制器, 可选择单加热(EME3)或加热/搅拌组合(EMEA3)型号。可以适用FM110 Flow Monitor。外壳通风采用*的气流设计,保证外壳可接触(“cool-to-touch”)。

    单加热和加热/搅拌型号共有特点:
    独立内置固态电子控制器,方便加热调节,同时采用消除电打火的机械开关。
    包括三个12.7mm直径的支撑杆
    不同型号三个位置可接受100ml至1000ml的多种圆底烧瓶
    上盖采用聚丙烯,外表面都用静电喷塑,有良好的防化学腐蚀性能
    盘绕的加热元件悬挂在一个隔热盒中,提供佳的热传递和支撑
    接地的保护屏隔开加热器提供更多安全保护
    可更换独立加热盘
    电源打开、加热和磁搅拌都有指示灯

    加热/搅拌EMEA3型号更多特点:
    加热/搅拌型号可以在加热同时使用搅拌功能
    搅拌速度在50至1000rpm之间
    三个位置的搅拌速度由一个开关控制
    质量保证: 一年零部件
    认证: CE

    技术指标

    材料 聚丙烯上盖和静电喷塑铝 外壳
    大加热元件温度 450oC

    单加热型号订货信息

    型号 孔数 烧瓶容量 电源 尺寸(d×w ×h) ,mm 包装重量
    EME3 0100/CE 3 3 x 100ml 230V 50/60Hz, 180W 260 x 630 x 90 6.2kg
    EME3 0100/CEX1 3 3 x 100ml 115V 50/60Hz, 210W 260 x 630 x 90 6.2kg
    EME3 0100/CEX6 3 3 x 100ml 230V 50/60Hz, 180W, EU 插头 260 x 630 x 90 6.2kg
    EME3 0250/CE 3 3 x 250ml 230V 50/60Hz, 450W 260 x 630 x 90 6.2kg
    EME3 0250/CEX1 3 3 x 250ml 115V 50/60Hz, 450W 260 x 630 x 90 6.2kg
    EME3 0250/CEX6 3 3 x 250ml 230V 50/60Hz, 450W, EU 插头 260 x 630 x 90 6.2kg
    EME3 0500/CE 3 3 x 500ml 230V 50/60Hz, 600W 260 x 630 x 90 7.4kg
    EME3 0500/CEX1 3 3 x 500ml 115V 50/60Hz, 600W 260 x 630 x 90 7.4kg
    EME3 0500/CEX6 3 3 x 500ml 230V 50/60Hz, 600W, EU 插头 260 x 630 x 90 7.4kg
    EME3 1000/CE 3 3 x 1000ml 230V 50/60Hz, 900W 260 x 630 x 90 7.4kg
    EME3 1000/CEX1 3 3 x 1000ml 115V 50/60Hz, 900W 260 x 630 x 90 7.4kg
    EME3 1000/CEX6 3 3 x 1000ml 230V 50/60Hz, 900W, EU 插头 260 x 630 x 90 7.4kg

    加热/搅拌型号订货信息

    型号 孔数 烧瓶容量 电源 尺寸(d×w ×h) ,mm 包装重量
    EMEA3 0100/CE 3 3 x 100ml 230V 50/60Hz, 220W 260 x 630 x 90 6.2kg
    EMEA3 0100/CEX1 3 3 x 100ml 115V 50/60Hz, 220W 260 x 630 x 90 6.2kg
    EMEA3 0100/CEX6 3 3 x 100ml 230V 50/60Hz, 220W, EU 插头 260 x 630 x 90 6.2kg
    EMEA3 0250/CE 3 3 x 250ml 230V 50/60Hz, 490W 260 x 630 x 90 6.2kg
    EMEA3 0250/CEX1 3 3 x 250ml 115V 50/60Hz, 490W 260 x 630 x 90 6.2kg
    EMEA3 0250/CEX6 3 3 x 250ml 230V 50/60Hz, 490W, EU 插头 260 x 630 x 90 6.2kg
    EMEA3 0500/CE 3 3 x 500ml 230V 50/60Hz, 640W 260 x 630 x 90 7.4kg
    EMEA3 0500/CEX1 3 3 x 500ml 115V 50/60Hz, 640W 260 x 630 x 90 7.4kg
    EMEA3 0500/CEX6 3 3 x 500ml 230V 50/60Hz, 640W, EU 插头 260 x 630 x 90 7.4kg
    EMEA3 1000/CE 3 3 x 1000ml 230V 50/60Hz, 940W 260 x 630 x 90 7.4kg
    EMEA3 1000/CEX1 3 3 x 1000ml 115V 50/60Hz, 940W 260 x 630 x 90 7.4kg
    EMEA3 1000/CEX6 3 3 x 1000ml 230V 50/60Hz, 940W, EU 插头 260 x 630 x 90 7.4kg

      

    支架

     

    特点:
    超坚固的H型基座和坚固的支撑杆,每个型号都配相应夹头,重载型适合SS30。

    技术参数与订货编号:

    产品编号 产品描述 基座尺寸 立杆尺寸 净重
    SS10/1 支架,通用型 400W×350D×25Hmm 16×700mm 7.6kg
    SS10/2 支架,重载型 550W×480D×25Hmm 25×850mm 20.2kg

    ___________________________________________________________________________________

    流量监控器

    型号:FM110

    流量监控器是和多位(提取)电加热套EME和EMEA系列一起使用。Electrothermal新的FM110流量监控器使用在加热制冷应用和过程控制中,监控液体流量,提供更多安全性能。整个涡轮组件用各种化学防腐材料制造,比如PVDF,宝石,陶瓷和氟橡胶。

    有两种型号流量监控器可选,应用于不同流量范围:

    FM110            0.5至15升/分钟
    FM1102B          0.1至5升/分钟

    一旦引发了警报,流量监控器的输出开关将关闭,切断与电加热套的连接。
    控制器机身后部附带支撑杆夹,可以安装标准的12.5mm直径支撑杆。

    技术指标

    电源 110 – 120V, 50/60Hz; 220 – 240V, 50/60Hz
    大负载电流 115V型号:15A; 230V 型号:10A
    主输出 不可拆卸3芯电源线模压IEC插座(230V)或USA插座(115V)
    遥控报警输出 2-pin DIN 插座; 5-pin DIN 插座
    支撑杆尺寸 12.7mm直径
    手动重置控制 2位拨动开关(前面板)
    重置模式控制 2位拨动开关(侧面板)
    操作室温范围 5℃至40℃
    流体温度 -30℃至+80℃

    订货信息

    型号 描述
    FM110* 流量监控器; 0.5 – 15 L/min流速
    FM1102B* 流量监控器; 0.1 – 5 L/min流速

    附件-订货信息

    货号 描述
    AZ6745 电源线、标准 IEC插头和引线固定装置(UK).
    AZ6747 电源线、标准 IEC插头和引线固定装置(Schuko).
    AZ6705 温度探针 高250℃
    AZ6706 温度探针 高400℃
    AZ6741 温度探针 高800℃
    M6332 伸长引线(Europe)
    M6902 伸长引线(UK)

      ?

    宁波新芝超声波提取机Scientz-5T

    宁波新芝超声波提取机Scientz-5T

  • 品牌 新芝|SCIENTZ
  • 型号 Scientz-5T
  • 商品详情

    产品说明

    1、本机由超声波发生器和超声波换能器组件两大部分组成。超声波发生器(电源)是将

    220VAC、50Hz的单相电通过变频器件变为20-25kHz、约600V的交变电能、并以适当的阻抗与功率匹配来推动换能器,

    作纵向机械振动,振动波通过浸入在样品溶液中的钛合金变幅杆对被破碎的各类细胞产生空化效应,从而达到破碎细胞之目的。

    2、其电原理由整流电源,开关电源、变频系统、功率放大器、锁相频率自动跟踪器、功率调节器、功率检测器、功率保护器及微电脑控制等组成。

    产品特征

    1、随着生物产业的发展,应用超声波提取机所做的实验要求也随之提高,如对样品温度的测定、控制,低温冷却样品及整机的智能化程度的提高等等

    都提出了新的要求,为进一步完善此类仪器的各项性能,我公司在现有各种型号的超声波提取机的基础上

    吸收国外最新技术,结合微电脑控制、选频、测温、保护等软硬件技术而研制的超声波提取机

    它具有技术先进、性能可靠、操作简便、外型美观、显示清晰明亮、测温控温精确等优点。

    2、超声波提取机是一种利用强超声在固、液体中产生空化、破碎、乳化,对物质细胞在温控、搅拌状态下,按反应条件添加各种反应剂而进行提取物质的一种设备。

    超声波提取机广泛应用于生物化学、微生物学、药物化学、表面化学、物理学、动物学、农学、医学、制药等领域教学、科研、生产。

    3、提取罐采用双层玻璃反应釜.双层玻璃反应釜有框架部分、玻璃部分、电器部分、固定卡件、搅拌部分五部分组成,安装方便。

    容量有1000豪升,2000豪升,5000豪升,10000豪升.15000豪升,30000豪升,50000豪升等不同规格,供用户先用.一种容量一种仪器规格。

    技术参数

    产品型号

    Scientz-5T

    Scientz-10T

    Scientz-15T

    Scientz-30T

    Scientz-50T

    工作频率

    20-25 KHz 

    20-25 KHz 

    20-25 KHz 

    20-25 KHz 

    20-25 KHz 

    超声功率

    20-1000(W)

    20-1200(W)

    200-1500(W)

    200-1800(W)

    250-2400(W)

    双层反应釜容量

    5 L

    10 L

    15 L

    30 L

    50 L

    变幅杆直径

    Ф15

    Ф18

    Ф20

    Ф25

    Ф30

    工作电压

    220 V

    220 V

    220 V

    220 V

    220 V

    超声时间

    0.1-99.9 s

    0.1-99.9 s

    0.1-99.9 s

    0.1-99.9 s

    0.1-99.9 s

    间隙时间

    0.1-99.9 s

    0.1-99.9 s

    0.1-99.9 s

    0.1-99.9 s

    0.1-99.9 s

    全程时间

    1-999 min

    1-999 min

    1-999 min

    1-999 min

    1-999 min

    功率设定

    1-99%

    1-99%

    1-99%

    1-99%

    1-99%

    占 空 比

    0.1-99.9%

    0.1-99.9%

    0.1-99.9%

    0.1-99.9%

    0.1-99.9%

    实际温度测量

    搅拌功率

    60 W

    60 W

    90 W

    120 W

    120 W

    搅拌转速

    10-1200 r/min

    10-1200 r/min

    10-1200 r/min

    10-1200 r/min

    10-1200 r/min

    支   架

    不锈钢 

    不锈钢 

    不锈钢 

    不锈钢 

    不锈钢 

    添加剂容量瓶

    加液口/放液口

    有/有

    有/有

    有/有

    有/有

    有/有

    制 冷 量

    500 W

    800 W

    1200 W

    2250 W

    2250 W

    制冷温度

    -5℃-室温

    -5℃-室温

    -5℃-室温

    -5℃-室温

    -5℃-室温

  • Tanomastat(Synonyms: BAY 12-9566)

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

    Tanomastat (Synonyms: BAY 12-9566)

    Tanomastat (BAY 12-9566) 是一种口服生物有效的含锌羧基的非肽联苯基质金属蛋白酶 (MMPs) 抑制剂。抑制MMP-2、MMP-3、MMP-9、MMP-13 的 Ki 值分别为 11、143、301 和 1470 nM。Tanomastat 在几种实验性肿瘤模型中具有抗侵袭和抗转移活性。

    Tanomastat(Synonyms: BAY 12-9566)

    Tanomastat Chemical Structure

    CAS No. : 179545-77-8

    规格 是否有货
    100 mg   询价  
    250 mg   询价  
    500 mg   询价  

    * Please select Quantity before adding items.

    生物活性

    Tanomastat (BAY 12-9566) is an orally bioavailable, non-peptidic biphenyl matrix metalloproteinases (MMPs) inhibitor with a Zn-binding carboxyl group. The Ki values are 11, 143, 301, and 1470 nM for MMP-2, MMP-3, MMP-9, MMP-13 respectively. Tanomastat shows anti-invasive and antimetastatic activity in several experimental tumor models[1][2][3].

    IC50 & Target[1]

    MMP-2

    11 nM (Ki)

    MMP-3

    143 nM (Ki)

    MMP-9

    301 nM (Ki)

    MMP-13

    1470 nM (Ki)

    体外研究
    (In Vitro)

    Tanomastat (BAY 12-9566) (1-10000 nM; 6 hours) prevents matrix invasion by endothelial cells in a concentration-dependent manner (IC50=840 nM), without affecting cell proliferation[2].
    Tanomastat (BAY 12-9566) (1-00 µM; 5 days) inhibits tubule formation completely at 15-100 µM[3].

    Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

    体内研究
    (In Vivo)

    Tanomastat (BAY 12-9566) (100 mg/kg; p.o.; daily for a 7-week period) inhibits local tumor regrowth without causing any toxic effect, and inhibits the number and volume of lung metastases[3].

    Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Six- to eight-week-old female BALB/c nude mice (bearing MDA-MB-435 cells)[3]
    Dosage: 100 mg/kg
    Administration: p.o.; daily for a 7-week period
    Result: Inhibited local tumor regrowth by 58% without causing any toxic effect, and inhibited the number and volume of lung metastases by 57 and 88%, respectively.

    分子量

    410.91

    Formula

    C23H19ClO3S

    CAS 号

    179545-77-8

    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式
    Powder -20°C 3 years
    In solvent -80°C 6 months
    -20°C 1 month
    参考文献
    • [1]. Leung D, et al. Protease inhibitors: current status and future prospects. J Med Chem. 2000 Feb 10;43(3):305-41.

      [2]. Gatto C, et al. BAY 12-9566, a novel inhibitor of matrix metalloproteinases with antiangiogenic activity. Clin Cancer Res. 1999 Nov;5(11):3603-7.

      [3]. Nozaki S, et al. Activity of biphenyl matrix metalloproteinase inhibitor BAY 12-9566 in a human breast cancerorthotopic model. Clin Exp Metastasis. 2003;20(5):407-12.

    所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

    Episesartemin A对照品

    Episesartemin A对照品

      【编号】:SBP04253

      【产品名称】:Episesartemin A对照品

      【规格】:10mg

      【用途】:

      Episesartemin A对照品

      编号:SBP04253
      英文名称:Episesartemin A
      CAS No.:77449-31-1
      分 子 式:C23H26O8
      分 子 量:430.453
      类别:上海金畔生物科技有限公司,天然提取物
      作为标准品,对照品或者供研究用,不能直接用于人体。

    Tauroursodeoxycholate(Synonyms: 牛磺熊去氧胆酸; Tauroursodeoxycholic acid; TUDCA; UR 906)

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

    Tauroursodeoxycholate (Synonyms: 牛磺熊去氧胆酸; Tauroursodeoxycholic acid; TUDCA; UR 906) 纯度: ≥98.0%

    Tauroursodeoxycholate (Tauroursodeoxycholic acid) 是一种内质网应激抑制剂。Tauroursodeoxycholate 显著降低凋亡分子如 caspase-3caspase-12 表达。Tauroursodeoxycholate 也抑制 ERK

    Tauroursodeoxycholate(Synonyms: 牛磺熊去氧胆酸; Tauroursodeoxycholic acid;  TUDCA;  UR 906)

    Tauroursodeoxycholate Chemical Structure

    CAS No. : 14605-22-2

    规格 价格 是否有货 数量
    Free Sample (0.1-0.5 mg)   Apply now  
    10 mM * 1 mL in Water ¥660 In-stock
    50 mg ¥600 In-stock
    100 mg   询价  
    200 mg   询价  

    * Please select Quantity before adding items.

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    • Diabetes Related Compound Library
    • Lipid Compound Library
    • Oxygen Sensing Compound Library
    • Endoplasmic Reticulum Stress Compound Library
    • Pyroptosis Compound Library
    • Glutamine Metabolism Compound Library
    • FDA Approved & Pharmacopeial Drug Library
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    生物活性

    Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

    IC50 & Target[1][2]

    ERK

     

    Caspase-3

     

    Caspase-12

     

    Human Endogenous Metabolite

     

    体外研究
    (In Vitro)

    Tauroursodeoxycholate (TUDCA) suppresses both viability and migration of vascular smooth muscle cells (VSMCs) through inhibition of ERK phosphorylation, by induction of mitogen-activated protein kinase phosphatase-1 (MKP-1) via PKCα. Tauroursodeoxycholate inhibits both the proliferation and migration of VSMCs via inhibition of ERK, through Ca2+-dependent PKCα translocation. Tauroursodeoxycholate prevents platelet-derived growth factor (PDGF) and vascular injury-induced MMP-9 expression. The knock-down of MKP-1 using specific si-RNA restores the reduced VSMC viability by Tauroursodeoxycholate (200 μM), which suggests that anti-proliferative effect of Tauroursodeoxycholate depended on the MKP-1 expression[1].

    上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

    体内研究
    (In Vivo)

    The effects of Tauroursodeoxycholate (TUDCA) on proliferation and apoptosis of VSMCs in vivo are examined using immunohistochemistry for proliferating cell nuclear antigen (PCNA) and the transferase dUTP nick-end labelling (TUNEL) assay. Tauroursodeoxycholate (10, 50, and 100 mg/kg) increases the caspase 3 activity of injured tissues in a dose-dependent manner, indicating that Tauroursodeoxycholate induces apoptosis of VSMCs in the neointima. Using the injured tissues, further examination and comparison of the phosphorylation level of ERK and MMP-9 expression is performed at 1 week after injury, compared with normal controls. Balloon injury increased both the phosphorylation of ERK and expression of MMP-9 in the tissues. Tauroursodeoxycholate (10, 50, and 100 mg/kg) inhibits phosphorylation of ERK and MMP-9 expression in a dose-dependent manner[1]. Tauroursodeoxycholate (TUDCA) is a hydrophilic bile acid. Tauroursodeoxycholate as a cytoprotective agent improves liver function and can prevent hepatocellular carcinoma by reducing ER stress and apoptosis. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3, caspase-12, C/EBP homologous protein, c-Jun N-terminal kinase (JNK), activating transcription factor 4 (ATF4), X-box binding protein (XBP), and eukaryotic initiation factor 2α (eIF2α) in Ang II induced ApoE-/- mice (p<0.05). Tauroursodeoxycholate reduces Angiotensin (Ang) II induced abdominal aortic aneurysm (AAA) formation in ApoE-/- mice. Tauroursodeoxycholate is used at a dose of 0.5 g/kg/day in treating Ang II induced ApoE-/- mice (ER stress inhibitor group). Systolic blood pressure (141.3±5.6 mmHg vs 145.9±8.9 mmHg; p>0.05) and total cholesterol levels (663.6±88.7 mg/dL vs 655.7±65.4 mg/dL; p>0 .05) do not differ between the AAA model group and Tauroursodeoxycholate group. In addition, maximum aortic diameter is significantly smaller in those in Tauroursodeoxycholate group compared with those in the AAA model group (0.95±0.03 mm vs 1.79±0.04 mm; p<0.05). AAA lesion areas are also smaller in those in Tauroursodeoxycholate group than in those in the AAA model group (0.37±0.03 mm2 vs 1.51±0.06 mm2; p<0.05)[2].

    上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

    Clinical Trial

    分子量

    499.70

    Formula

    C26H45NO6S

    CAS 号

    14605-22-2

    中文名称

    牛磺熊去氧胆酸;牛磺熊脱氧胆酸

    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    溶解性数据
    In Vitro: 

    DMSO : 50 mg/mL (100.06 mM; Need ultrasonic)

    H2O : 12.5 mg/mL (25.02 mM; Need ultrasonic)

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 2.0012 mL 10.0060 mL 20.0120 mL
    5 mM 0.4002 mL 2.0012 mL 4.0024 mL
    10 mM 0.2001 mL 1.0006 mL 2.0012 mL

    *

    请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
    储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

    参考文献
    • [1]. Kim SY, et al. Tauroursodeoxycholate (TUDCA) inhibits neointimal hyperplasia by suppression of ERK viaPKCα-mediated MKP-1 induction. Cardiovasc Res. 2011 Nov 1;92(2):307-16.

      [2]. Qin Y, et al. Tauroursodeoxycholic Acid Attenuates Angiotensin II Induced Abdominal Aortic Aneurysm Formation in Apolipoprotein E-deficient Mice by Inhibiting Endoplasmic Reticulum Stress. Eur J Vasc Endovasc Surg. 2017 Mar;53(3):337-345.

    Cell Assay
    [1]

    Cell viability and proliferation are measured using Ez-Cytox. VSMCs (5×103 cells) are seeded onto 96-well plates in Smooth Muscle Cell Growth Medium 2 (SMCGM2) and cultured. After serum starvation, Tauroursodeoxycholate (0, 50, 100, and 200 μM) is added to the hVSMCs, with or without 1,2-bis(o-aminophenoxy) ethane-N,N,N′,N′-tetraacetic acid tetra(acetoxymethyl) ester (BAPTA, 10 μM) and 7-hydroxystaurosporine (H7, 10 μM) and cultured for 24 h. To assess the effect of Tauroursodeoxycholate on the PDGF-stimulated hVSMC proliferation, hVSMCs are seeded onto 96-well plates and cultured. After serum starvation, Tauroursodeoxycholate (0, 50, 100, and 200 μM) is added to the hVSMCs, with or without PDGF-BB (50 ng/mL) and cultured. After addition of 10 μL of Ez-Cytox into each well, cell viability is evaluated by measuring the optical density at 450 nm[1].

    上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Administration
    [1][2]

    Rats[1]
    Sprague-Dawley rats are anaesthetized with a combined anaesthetic (Ketamine, 70 mg/kg; Xylazine, 7 mg/kg ip). Tauroursodeoxycholate is administered orally once a day, in different concentrations (i.e. vehicle, 10, 50, and 100 mg/kg) for 2 weeks. The carotid arteries are fixed by perfusion with 4% formaldehyde, then the tissues are embedded in paraffin, and sections (8 μm) are stained with H&E[1].
    Mice[2]
    Thirty ApoE-/- C57BL/6 male mice aged 8 weeks are randomly divided into three groups (n=10 in each group): (i) sham operated and injected with physiologic (0.9%) saline as vehicle (normal: group); (ii) mini-osmotic pumps are implanted subcutaneously into the right flank of ApoE-/- mice to release Ang II (1000 ng/kg/min) over the course of 28 days (AAA model group); (iii) AAA model mice treated with Tauroursodeoxycholate daily for 4 weeks at a dosage of 0.5 g/kg/day in drinking water (Tauroursodeoxycholate group). Mice are sacrificed after 28 days of Ang II infusion[2].

    上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

    参考文献
    • [1]. Kim SY, et al. Tauroursodeoxycholate (TUDCA) inhibits neointimal hyperplasia by suppression of ERK viaPKCα-mediated MKP-1 induction. Cardiovasc Res. 2011 Nov 1;92(2):307-16.

      [2]. Qin Y, et al. Tauroursodeoxycholic Acid Attenuates Angiotensin II Induced Abdominal Aortic Aneurysm Formation in Apolipoprotein E-deficient Mice by Inhibiting Endoplasmic Reticulum Stress. Eur J Vasc Endovasc Surg. 2017 Mar;53(3):337-345.

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    英国Electrothermal 6孔多位(提取)电加热套EME60500/CE

    【简单介绍】

    英国Electrothermal 6孔多位(提取)电加热套EME60500/CE,这种6 孔多位电加热套内置电子控制器,可以适用FM110 Flow Monitor。外壳通风采用*的气流设计,保证外壳可接触“cool-to-touch”。独立内置固态电子控制器,方便加热调节,同时采用消除电打火的机械开关。

    【详细说明】

    英国Electrothermal 6孔多位(提取)电加热套EME60500/CE

    产品描述:   

       英国Electrothermal 6孔多位(提取)电加热套EME60500/CE,这种6 孔多位电加热套内置电子控制器, 可以适用FM110 Flow Monitor。外壳通风采用*的气流设计,保证外壳可接触“cool-to-touch”。

    产品特点:

    1. 上盖采用聚丙烯,外表面都用静电喷塑,有良好的防化学腐蚀性能
    2. 独立内置固态电子控制器,方便加热调节,同时采用消除电打火的机械开关。
    3. 包括三个12.7mm直径的支撑杆
    4. 不同型号六个位置可接受100ml至1000ml的多种圆底烧瓶
    5. 盘绕的加热元件悬挂在一个隔热盒中,提供佳的热传递和支撑
    6. 可更换独立加热盘
    7. 电源打开、加热和磁搅拌都有指示灯
    8. 接地的保护屏隔开加热器提供更多安全保护

    技术指标

    材料 聚丙烯上盖和静电喷塑铝 外壳
    大加热元件温度 450?C

    订货信息

    型号 孔数 烧瓶容量 电源 尺寸(d×w ×h) ,mm 包装重量
    EMEA6 0100/CE 6 6 x 100ml 230V 50/60Hz, 500W 260 x 1200 x 90 10.1kg
    EMEA6 0100/CEX1 6 6 x 100ml 115V 50/60Hz, 440W 260 x 1200 x 90 10.1kg
    EMEA6 0100/CEX6 6 6 x 100ml 230V 50/60Hz, 500W, EU插头 260 x 1200 x 90 10.1kg
    EMEA6 0250/CE 6 6 x 250ml 230V 50/60Hz, 980W 260 x 1200 x 90 10.1kg
    EMEA6 0250/CEX1 6 6 x 250ml 115V 50/60Hz, 9800W 260 x 1200 x 90 10.1kg
    EMEA6 0250/CEX6 6 6 x 250ml 230V 50/60Hz, 980W, EU插头 260 x 1200 x 90 10.1kg
    EMEA6 0500/CE 6 6 x 500ml 230V 50/60Hz, 1280W 260 x 1200 x 90 12.5kg
    EMEA6 0500/CEX1 6 6 x 500ml 115V 50/60Hz, 1280W 260 x 1200 x 90 12.5kg
    EMEA6 0500/CEX6 6 6 x 500ml 230V 50/60Hz, 1280W, EU插头 260 x 1200 x 90 12.5kg
    EMEA6 1000/CE 6 6 x 1000ml 230V 50/60Hz, 1880W 260 x 1200 x 90 12.5kg
    EMEA6 1000/CEX1 6 6 x 1000ml 115V 50/60Hz, 1880W 260 x 1200 x 90 12.5kg
    EMEA6 1000/CEX6 6 6 x 1000ml 230V 50/60Hz, 1880W, EU插头 260 x 1200 x 90 12.5kg

      

    ____________________________________________________________________________________-

    流量监控器

    型号:FM110

    流量监控器是和多位(提取)电加热套EME和EMEA系列一起使用。Electrothermal新的FM110流量监控器使用在加热制冷应用和过程控制中,监控液体流量,提供更多安全性能。整个涡轮组件用各种化学防腐材料制造,比如PVDF,宝石,陶瓷和氟橡胶。

    有两种型号流量监控器可选,应用于不同流量范围:

    FM110            0.5至15升/分钟
    FM1102B          0.1至5升/分钟

    一旦引发了警报,流量监控器的输出开关将关闭,切断与电加热套的连接。
    控制器机身后部附带支撑杆夹,可以安装标准的12.5mm直径支撑杆。

    技术指标

    电源 110 – 120V, 50/60Hz; 220 – 240V, 50/60Hz
    大负载电流 115V型号:15A; 230V 型号:10A
    主输出 不可拆卸3芯电源线模压IEC插座(230V)或USA插座(115V)
    遥控报警输出 2-pin DIN 插座; 5-pin DIN 插座
    支撑杆尺寸 12.7mm直径
    手动重置控制 2位拨动开关(前面板)
    重置模式控制 2位拨动开关(侧面板)
    操作室温范围 5℃至40℃
    流体温度 -30℃至+80℃

    订货信息

    型号 描述
    FM110* 流量监控器; 0.5 – 15 L/min流速
    FM1102B* 流量监控器; 0.1 – 5 L/min流速

    附件-订货信息

    货号 描述
    AZ6745 电源线、标准 IEC插头和引线固定装置(UK).
    AZ6747 电源线、标准 IEC插头和引线固定装置(Schuko).
    AZ6705 温度探针 高250℃
    AZ6706 温度探针 高400℃
    AZ6741 温度探针 高800℃
    M6332 伸长引线(Europe)
    M6902 伸长引线(UK)

      ?

    Higenamine hydrochloride(Synonyms: Norcoclaurine hydrochloride)

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

    Higenamine hydrochloride (Synonyms: Norcoclaurine hydrochloride) 纯度: 98.98%

    Higenamine hydrochloride (Norcoclaurine hydrochloride) 是一种 β2-AR 激动剂,是用于心力衰竭相关研究的中药乌头的关键成分。Higenamine hydrochloride (Norcoclaurine hydrochloride) 具有抗凋亡作用。

    Higenamine hydrochloride(Synonyms: Norcoclaurine hydrochloride)

    Higenamine hydrochloride Chemical Structure

    CAS No. : 11041-94-4

    规格 价格 是否有货 数量
    10 mM * 1 mL in DMSO ¥550 In-stock
    100 mg ¥500 In-stock
    200 mg   询价  
    500 mg   询价  

    * Please select Quantity before adding items.

    Higenamine hydrochloride 相关产品

    相关化合物库:

    • Natural Product Library Plus
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    生物活性

    Higenamine hydrochloride (Norcoclaurine hydrochloride), a β2-AR agonist, is a key component of the Chinese herb aconite root that prescribes for treating symptoms of heart failure in the oriental Asian countries. Higenamine hydrochloride (Norcoclaurine hydrochloride) has anti-apoptotic effects[1][2].

    IC50 & Target

    β2-AR[1]

    Clinical Trial

    分子量

    307.77

    Formula

    C16H18ClNO3

    CAS 号

    11041-94-4

    中文名称

    盐酸去甲乌头碱

    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式

    4°C, sealed storage, away from moisture and light

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

    溶解性数据
    In Vitro: 

    DMSO : 100 mg/mL (324.92 mM; Need ultrasonic)

    H2O : 10 mg/mL (32.49 mM; Need ultrasonic)

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 3.2492 mL 16.2459 mL 32.4918 mL
    5 mM 0.6498 mL 3.2492 mL 6.4984 mL
    10 mM 0.3249 mL 1.6246 mL 3.2492 mL

    *

    请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
    储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

    In Vivo:

    请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

    ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
    分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

    • 1.

      请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.08 mg/mL (6.76 mM); Clear solution

      此方案可获得 ≥ 2.08 mg/mL (6.76 mM,饱和度未知) 的澄清溶液。

      以 1 mL 工作液为例,取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

      将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

    • 2.

      请依序添加每种溶剂: 10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.08 mg/mL (6.76 mM); Clear solution

      此方案可获得 ≥ 2.08 mg/mL (6.76 mM,饱和度未知) 的澄清溶液。

      以 1 mL 工作液为例,取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

      将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
    *以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
    参考文献
    • [1]. Wu MP, et al. Higenamine protects ischemia/reperfusion induced cardiac injury and myocyte apoptosis through activation of β2-AR/PI3K/AKT signaling pathway. Pharmacol Res. 2016 Feb;104:115-23.

      [2]. Lee SR, et al. Acute oral intake of a higenamine-based dietary supplement increases circulating free fatty acidsand energy expenditure in human subjects. Lipids Health Dis. 2013 Oct 21;12:148.

    所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

    GPP78(Synonyms: CAY10618)

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

    GPP78 (Synonyms: CAY10618) 纯度: ≥99.0%

    GPP78 (CAY10618) 是一种有效的烟酰胺磷酸核糖转移酶 (Nampt) 抑制剂,对 NAD 消耗的 IC50 为 3 nM。GPP78 通过诱导自噬对神经母细胞瘤细胞 SH-SY5Y 具有毒性,IC50 为 3.8 nM。GPP78 具有抗癌和抗炎作用。

    GPP78(Synonyms: CAY10618)

    GPP78 Chemical Structure

    CAS No. : 1202580-59-3

    规格 价格 是否有货 数量
    5 mg (11.38 mM * 1 mL in Methanol) ¥5400 In-stock

    * Please select Quantity before adding items.

    生物活性

    GPP78 (CAY10618) is a potent Nampt inhibitor with an IC50 of 3.0 nM for nicotinamide adenine dinucleotide (NAD) depletion. GPP78 is cytotoxic to neuroblastoma cell line SH-SY5Y cells with an IC50 of 3.8 nM by inducing autophagy. GPP78 has anti-cancer and anti-inflammatory effects[1][2].

    IC50 & Target

    Nampt[1];
    Autophagy[1]

    体外研究
    (In Vitro)

    GPP78 (Compound 8; 10 nM; 24-40 hours; SH-SY5Y cells) treatment with cells, punctate staining of LC3-II and the formation of autophagolysosomes are observable. LC3-II is membrane-bound and is present in autophagosomes[1].
    GPP78 (Compound 8) inhibits the growth of most cell lines tested, with nanomolar potency (GI50) in cell lines derived from leukemia, lung, CNS, colon, melanoma, ovarian, renal, and prostate cancers. GPP78 appears truly cytotoxic in melanoma cell lines, while in the others it is mainly cytostatic[1].

    Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

    Western Blot Analysis[1]

    Cell Line: SH-SY5Y cells
    Concentration: 10 nM
    Incubation Time: 24 hours, 40 hours
    Result: Punctate staining of LC3-II and the formation of autophagolysosomes were observable.

    体内研究
    (In Vivo)

    GPP78 (10 mg/kg; intraperitoneal injection; daily; 1 hour or 6 hours after SCI; for 19 days; male adult CD1 mice) treatment reduces the severity of spinal cord trauma in SCI mice[2].

    Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male adult CD1 mice (25-30 g) with spinal cord injury (SCI)[2]
    Dosage: 10 mg/kg
    Administration: Intraperitoneal injection; daily; 1 hour or 6 hours after SCI; for 19 days
    Result: Significantly reduced the demyelination associated with SCI. And significantly ameliorated the functional deficits induced by SCI.

    分子量

    439.55

    Formula

    C27H29N5O

    CAS 号

    1202580-59-3

    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式

    Solution, -20°C, 2 years

    参考文献
    • [1]. Colombano G, et al. A novel potent nicotinamide phosphoribosyltransferase inhibitor synthesized via click chemistry. J Med Chem. 2010 Jan 28;53(2):616-23.

      [2]. Esposito E, et al. The NAMPT inhibitor FK866 reverts the damage in spinal cord injury. J Neuroinflammation. 2012 Apr 10;9:66.

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    Canagliflozin(Synonyms: 卡格列净; JNJ 28431754)

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

    Canagliflozin (Synonyms: 卡格列净; JNJ 28431754) 纯度: 99.66%

    Canagliflozin (JNJ 28431754) 是一种选择性的 SGLT2 抑制剂,作用于表达 mSGLT2,rSGLT2 和 hSGLT2 的 CHO细胞,IC50 分别为 2 nM,3.7 nM 和 4.4 nM。

    Canagliflozin(Synonyms: 卡格列净; JNJ 28431754)

    Canagliflozin Chemical Structure

    CAS No. : 842133-18-0

    规格 价格 是否有货 数量
    Free Sample (0.1-0.5 mg)   Apply now  
    10 mM * 1 mL in DMSO ¥1045 In-stock
    5 mg ¥950 In-stock
    10 mg ¥1400 In-stock
    50 mg ¥2900 In-stock
    100 mg ¥4200 In-stock
    200 mg   询价  
    500 mg   询价  

    * Please select Quantity before adding items.

    Canagliflozin 相关产品

    相关化合物库:

    • Drug Repurposing Compound Library Plus
    • FDA-Approved Drug Library Plus
    • FDA-Approved Drug Library Mini
    • Bioactive Compound Library Plus
    • Membrane Transporter/Ion Channel Compound Library
    • FDA-Approved Drug Library
    • Anti-Cancer Compound Library
    • Drug Repurposing Compound Library
    • Diabetes Related Compound Library
    • Anti-COVID-19 Compound Library
    • Orally Active Compound Library
    • FDA Approved & Pharmacopeial Drug Library
    • Children’s Drug Library

    生物活性

    Canagliflozin (JNJ 28431754) is a selective SGLT2 inhibitor with IC50s of 2 nM, 3.7 nM, and 4.4 nM for mSGLT2, rSGLT2, and hSGLT2 in CHOK cells, respectively[1].

    IC50 & Target

    IC50: 2/3.7/4.4 nM (mSGLT2/rSGLT2/hSGLT2, in CHOK cells)[1]

    体外研究
    (In Vitro)

    Canagliflozin inhibits Na+-dependent 14C-AMG uptake in CHO-hSGLT2 cells, with an IC50 of 4.4±1.2 nM. Similar IC50 values are obtained in CHO-rSGLT2 and CHO-mSGLT2 cells (IC50 = 3.7 and 2.0 nM for rat and mouse SGLT2, respectively). Canagliflozin inhibits 14C-AMG uptake in CHO-hSGLT1 and mSGLT1 cells with IC50 of 684±159 nM and >1,000 nM, respectively[1].

    上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

    体内研究
    (In Vivo)

    Canagliflozin (30 mg/kg treatment for 4 weeks) reduces blood glucose (BG) levels, respiratory exchange ratio, and body weight gain in DIO mice[1].
    Canagliflozin (3 mg/kg for 3 weeks) increases urinary glucose excretion (UGE) with no significant change in total food intake compared with that in vehicle-treated rats, leading to a decrease in body weight In ZF rats[1].

    上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Diet-induced obese, insulin resistantmice (DIO) Mice[1]
    Dosage: 30 mg/kg
    Administration: Oral gavage; daily; 4 weeks
    Result: Reduced BG levels, respiratory exchange ratio, and body weight gain.
    Animal Model: Male Zucker fatty (ZF) obese, insulin resistant rats[1]
    Dosage: 3 mg/kg
    Administration: Oral gavage; daily; 3 weeks
    Result: UGE was increased with no significant change in total food intake compared with that in vehicle-treated rats, leading to a decrease in body weight.

    Clinical Trial

    分子量

    444.52

    Formula

    C24H25FO5S

    CAS 号

    842133-18-0

    中文名称

    卡格列净;坎格列净

    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    溶解性数据
    In Vitro: 

    DMSO : ≥ 50 mg/mL (112.48 mM)

    * “≥” means soluble, but saturation unknown.

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 2.2496 mL 11.2481 mL 22.4962 mL
    5 mM 0.4499 mL 2.2496 mL 4.4992 mL
    10 mM 0.2250 mL 1.1248 mL 2.2496 mL

    *

    请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
    储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

    In Vivo:

    请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

    ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
    分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

    • 1.

      请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (5.62 mM); Clear solution

      此方案可获得 ≥ 2.5 mg/mL (5.62 mM,饱和度未知) 的澄清溶液。

      以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

      将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

    • 2.

      请依序添加每种溶剂: 10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (5.62 mM); Clear solution

      此方案可获得 ≥ 2.5 mg/mL (5.62 mM,饱和度未知) 的澄清溶液。

      以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

      将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
    • 3.

      请依序添加每种溶剂: 10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (5.62 mM); Clear solution

      此方案可获得 ≥ 2.5 mg/mL (5.62 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

      以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

    • 4.

      请依序添加每种溶剂: 5% DMSO    40% PEG300    5% Tween-80    50% saline

      Solubility: ≥ 2.5 mg/mL (5.62 mM); Clear solution

    • 5.

      请依序添加每种溶剂: 5% DMSO    95% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (5.62 mM); Clear solution

    • 6.

      请依序添加每种溶剂: 1% DMSO    99% saline

      Solubility: ≥ 0.5 mg/mL (1.12 mM); Clear solution

    *以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
    参考文献
    • [1]. Liang Y, et al. Effect of canagliflozin on renal threshold for glucose, glycemia, and body weight in normal and diabetic animal models. PLoS One. 2012;7(2):e30555.

    所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

    宁波新芝聚能恒温超声波萃取仪Scientz-1000C

    宁波新芝聚能恒温超声波萃取仪Scientz-1000C

  • 品牌 新芝|SCIENTZ
  • 型号 Scientz-1000C
  • 商品详情

    产品说明

    1、C系列聚能恒温超声萃取仪是应用现代超声波技术结合智能低温恒温系统作为物理手段的新型超声波萃取/提取装置

    主要由大功率超声波发生系统、加热系统、压缩机制冷系统、测温控温系统、搅拌系统等组成。

    2、采用20KHz聚焦式大功率超声波换能器,直接将超声波探头浸入盛放物料的容器中,温度传感器对物料进行测温

    把盛有物料的容器放入恒温容器内,可以根据用户的需要设置所需温度,使物料在低温恒温的环境下在超声波的直接作用下充分快速的萃取/提取。

    产品特征

    1、采用触摸屏集成控制技术

    2、超声波采用锁相环频率自动跟踪技术

    3、友好美观的人机界面操作即可设置数据、存储数据和控制工作状态

    4、换能器的振荡频率经相位取样使锁相环实现频率自动跟踪

    5、功率设定和温度测量电路使单片机实现超声波发射功率和超温保护及报警功能

    6、7寸TFY触摸屏显示

    技术参数

    型号

    Scientz-1000C

    超声功率MAX

    1800 W

    反应瓶容积

    1000 ml

    探头直径

    Ф20 mm 

    功率可调范围

    30%-100%

    超声频率

    20KHz±1KHz

    超声总时间

    1-999 min可设

    超声时间

    1-99 S可设

    间隙时间

    1-99 S可设

    搅 拌 仪

    1%-30%可设(最高转速1000 r/min)有需要的用户可选购与四口瓶配用

    压缩机功率

    500 W

    加热功率

    2000 W

    控温方式

    PID自动控温

    测温方式

    双通道测温,监控反应体系和恒温工作槽内实时温度。

    控温范围

    0-99 ℃

    控温波动度

    ≦±1 ℃

    恒温容积

    6 L

    异常报警功能

    有,设备具有故障自诊断及报警提示功能

    运行记录方式

    设备具有工作曲线画面,全程记录运行中温度等参数变化信息

    设备控制方式

    7寸TFT触摸屏显示与单片机集成控制

    设备操作方式

    触屏上直接操作,设置温度、功率、时间等参数

    USB通讯口

    设备自带USB通讯口,插上优盘,可将曲线等信息以图片形式保存到优盘

    远程通讯串口

    此功能为选配项,有需要的用户可选购(含上位机软件)与电脑相连

    反应瓶

    常规为三口瓶,有需要的用户可选购五口瓶