Megazyme生物及食品酶法检测试剂盒 S-AXBL Azo-Xylan (Birchwood) 100ml 2 vials 2898
日度归档:2023年10月8日
Megazyme生物及食品酶法检测试剂盒 K-LMALMQ L-Malic Acid (MegaQuant format)
Megazyme生物及食品酶法检测试剂盒 K-LMALMQ L-Malic Acid (MegaQuant format) 2988
聚苯乙烯 70000对照品_9003-53-6
【编号】:YJ-190203
【产品名称】:聚苯乙烯 70000对照品
【规格】:20mg
【价格】:560元
聚苯乙烯 70000对照品
癸酸对照品_334-48-5
【编号】:YJ-190210
【产品名称】:癸酸对照品
【规格】:0.2ml/瓶
【价格】:430元
癸酸对照品
食品分析设备、器材|食品|关东化学株式会社
AZD5582
上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
AZD5582 纯度: 98.11%
AZD5582 是 IAP 拮抗剂,可以有效与 cIAP1,cIAP2 和 XIAP 的 BIR3 结构域结合, IC50 值分别为 15,21,15 nM。AZD5582 诱导凋亡 (apoptosis)。
AZD5582 Chemical Structure
CAS No. : 1258392-53-8
规格 | 价格 | 是否有货 | 数量 |
---|---|---|---|
Free Sample (0.1-0.5 mg) | Apply now | ||
10 mM * 1 mL in DMSO | ¥1843 | In-stock | |
2 mg | ¥660 | In-stock | |
5 mg | ¥990 | In-stock | |
10 mg | ¥1800 | In-stock | |
50 mg | ¥5500 | In-stock | |
100 mg | 询价 | ||
200 mg | 询价 |
* Please select Quantity before adding items.
AZD5582 相关产品
•相关化合物库:
- Bioactive Compound Library Plus
- Apoptosis Compound Library
- Anti-Cancer Compound Library
- Peptidomimetic Library
- Anti-Lung Cancer Compound Library
生物活性 |
AZD5582 is an antagonist of the inhibitor of apoptosis proteins (IAPs), which binds to the BIR3 domains cIAP1, cIAP2, and XIAP with IC50s of 15, 21, and 15 nM, respectively. AZD5582 induces apoptosis[1]. |
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IC50 & Target[1] |
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体外研究 (In Vitro) |
AZD5582 (20 nM; 48 hours) inhibits cell viability by cooperation with IFNγ or viral double-stranded RNA (dsRNA) in H1975 NSCLC cells[2]. AZD5582 (20 nM; 17 or 25 hours) downregulates cIAP-1, activates RIPK1 (upstream regulator of caspase-8), and triggers the activation of extrinsic (caspase-8) and intrinsic (caspase-9) apoptosis pathways, causing the cleavage of caspase-3 and caspase-7[2]. AZD5582 (20 nM; 48 hours) involves in apoptosis due to induction of cell death and active caspase-3/8 activities by AZD5582 and IFNγ co-treatment in HCC827 NSCLC cells[2]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability Assay[2]
Apoptosis Analysis[2]
Western Blot Analysis[2]
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体内研究 (In Vivo) |
AZD5582 (intravenous injection; 0.1-3.0 mg/kg; once a week; 2 weeks) causes degradation of cIAP1 and caspase 3 cleavage in tumor cells, and after a two-week treatment, the tumors largely resolved; when the mice are given a medium dose (0.5 mg/kg) of AZD5582, cIAP1 degrades after administration, but it takes a while time to reach apoptosis-inducing effect[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
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分子量 |
1015.29 |
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Formula |
C58H78N8O8 |
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CAS 号 |
1258392-53-8 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
4°C, protect from light, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen) |
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溶解性数据 |
In Vitro:
DMSO : ≥ 66.25 mg/mL (65.25 mM) * “≥” means soluble, but saturation unknown. 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务
4本架用玻璃4入|柴田科技有限公司-环境检测设备、科学仪器的制造销售
产品详细
4本架用玻璃4入
商品代码其他情报(式样)
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上海金畔生物科技有限公司
” 715%2F%3Fc%3D35 “> 715%2F%3Fc%3D35
英国Stuart-SRT6滚轴混合仪器(模拟控制)
【简单介绍】
【详细说明】
Megazyme生物及食品酶法检测试剂盒 O-ABI Arabinobiose (syrup) – 50mg
Megazyme生物及食品酶法检测试剂盒 O-ABI Arabinobiose (syrup) – 50mg 2664
Tizaterkib(Synonyms: AZD0364)
上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
Tizaterkib (Synonyms: AZD0364) 纯度: 99.71%
Tizaterkib (AZD0364) 是一种有效的选择性 ERK2 抑制剂,IC50 为 0.6 nM。详细信息请参考专利文献 WO2017080979A1 中的化合物 example 18。
Tizaterkib Chemical Structure
CAS No. : 2097416-76-5
规格 | 价格 | 是否有货 | 数量 |
---|---|---|---|
10 mM * 1 mL in DMSO | ¥3080 | In-stock | |
5 mg | ¥2800 | In-stock | |
10 mg | ¥4800 | In-stock | |
25 mg | ¥9900 | In-stock | |
50 mg | 询价 |
* Please select Quantity before adding items.
Tizaterkib 相关产品
•相关化合物库:
- Bioactive Compound Library Plus
- Immunology/Inflammation Compound Library
- Kinase Inhibitor Library
- MAPK Compound Library
- Stem Cell Signaling Compound Library
- Anti-Cancer Compound Library
- Anti-Aging Compound Library
- Reprogramming Compound Library
- Oxygen Sensing Compound Library
- Glutamine Metabolism Compound Library
- Anti-Pancreatic Cancer Compound Library
- Anti-Obesity Compound Library
- Angiogenesis Related Compound Library
- Targeted Diversity Library
- Anti-Liver Cancer Compound Library
- Anti-Colorectal Cancer Compound Library
生物活性 |
Tizaterkib (AZD0364) is a potent and selective ERK2 inhibitor extracted from patent WO2017080979A1, compound example 18, has an IC50 of 0.6 nM. |
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IC50 & Target[1] |
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体外研究 (In Vitro) |
Tizaterkib is measured in the ERK2 mass spectrometry and A375 phospho-p90RSK assays with IC50s of 0.6 nM and 5.7 nM, respectively. Tizaterkib can inhibit the growth of a panel of cancer cell lines (A549, H2122, H2009, and Calu6 cell lines) with KRAS mutations as a monotherapy and this effect is synergistically enhanced by treatment with Selumetinib[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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体内研究 (In Vivo) |
Tumor growth inhibition by Tizaterkib ethanesulfonic acid (Example 18a) in combination with MEK inhibitor Selumetinib is measured. Studies are performed in the A549 xenograft model. Selumetinib is dosed twice daily (BiD) 8 hours apart and Tizaterkib ethanesulfonic acid is dosed once daily (QD) 4 hours after the first Selumetinib dose. Both compounds are dosed continuously for 3 weeks. Both vehicles are dosed in the vehicle group. Both Selumetinib and Tizaterkib ethanesulfonic acid reduce tumor growth relative to vehicle only control. The combination of Selumetinib and Tizaterkib ethanesulfonic acid results in a reduction in tumor growth[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
494.50 |
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Formula |
C24H24F2N8O2 |
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CAS 号 |
2097416-76-5 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : ≥ 100 mg/mL (202.22 mM) * “≥” means soluble, but saturation unknown. 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
*以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
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参考文献 |
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Cell Assay [1] |
KRAS-mutant Non-Small Cell Lung Cancer (NSCLC) A549, H2122, H2009, and Calu6 cell lines are seeded in 384-well black, clear bottomed plates, cultured for 18-24 hours and treated with increasing concentrations of AZD-0364 (7.143 nM, 61 nM, 357 nM, 2.143 μM and 10 μM) and Selumetinib (0-10 μM) in a 6×6 dosing matrix. Cells are seeded at a concentration such that cells in untreated wells are approximately 80% confluent at the end of the assay. After 3 days of treatment, live cell number is determined using a Sytox Green endpoint[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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Animal Administration [1] |
Mice[1] 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
参考文献 |
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所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务
Megazyme生物及食品酶法检测试剂盒 I-AZDAR AZCL-Arabinan (Debranched) 3g
Megazyme生物及食品酶法检测试剂盒 I-AZDAR AZCL-Arabinan (Debranched) 3g 2898
Megazyme生物及食品酶法检测试剂盒 E-FRMXLQ Fructanase Mixture (Purified) 20ml
Megazyme生物及食品酶法检测试剂盒 E-FRMXLQ Fructanase Mixture (Purified) 20ml 3024
Odoroside A
上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
Odoroside A 纯度: 98.75%
Odoroside A 是从夹竹桃叶中提取的一种有效成分。Odoroside A 具有抗癌活性。Odoroside A 通过 ROS/p53 信号通路诱导细胞凋亡和细胞周期阻滞,导致肿瘤细胞死亡。
Odoroside A Chemical Structure
CAS No. : 12738-19-1
规格 | 价格 | 是否有货 | 数量 |
---|---|---|---|
1 mg | ¥2400 | In-stock | |
5 mg | ¥6500 | In-stock | |
10 mg | ¥9500 | In-stock | |
50 mg | 询价 | ||
100 mg | 询价 |
* Please select Quantity before adding items.
Odoroside A 相关产品
•相关化合物库:
- Natural Product Library Plus
- Bioactive Compound Library Plus
生物活性 |
Odoroside A is an active ingredient extracted from the leaves of Nerium oleander Linn. Odoroside A has anti-cancer activity. Odoroside A could induce apoptosis and cell cycle arrest through ROS/p53 signaling pathway, leading to the tumor cell death[1]. |
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分子量 |
518.68 |
Formula |
C30H46O7 |
CAS 号 |
12738-19-1 |
运输条件 |
Room temperature in continental US; may vary elsewhere. |
储存方式 |
-20°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |
参考文献 |
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所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务
聚苯乙烯150000对照品_9003-53-6
【编号】:YJ-190204
【产品名称】:聚苯乙烯150000对照品
【规格】:20mg
【价格】:550元
聚苯乙烯150000对照品
硬脂富马酸钠对照品_4070-80-8
【编号】:YJ-190219
【产品名称】:硬脂富马酸钠对照品
【规格】:20mg
【价格】:380元
硬脂富马酸钠对照品
Megazyme生物及食品酶法检测试剂盒 E-TMPK Thymidylate Kinase (prokaryote)
Megazyme生物及食品酶法检测试剂盒 E-TMPK Thymidylate Kinase (prokaryote) 3078
Megazyme生物及食品酶法检测试剂盒 I-RCLAMYF RedCL-Amylose (fine) 5g
Megazyme生物及食品酶法检测试剂盒 I-RCLAMYF RedCL-Amylose (fine) 5g 2466
GW3965 hydrochloride
上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
GW3965 hydrochloride 纯度: 99.73%
GW3965 hydrochloride 是肝 X 受体 (LXR) 激动剂,对 hLXRα 和 hLXRβ 的 EC50 分别为 190 nM 和 30 nM。
GW3965 hydrochloride Chemical Structure
CAS No. : 405911-17-3
规格 | 价格 | 是否有货 | 数量 |
---|---|---|---|
Free Sample (0.1-0.5 mg) | Apply now | ||
10 mM * 1 mL in DMSO | ¥953 | In-stock | |
5 mg | ¥700 | In-stock | |
10 mg | ¥1000 | In-stock | |
50 mg | ¥3900 | In-stock | |
100 mg | ¥7400 | In-stock | |
200 mg | 询价 | ||
500 mg | 询价 |
* Please select Quantity before adding items.
GW3965 hydrochloride 相关产品
•相关化合物库:
- Bioactive Compound Library Plus
- Metabolism/Protease Compound Library
- Anti-Cancer Compound Library
- Diabetes Related Compound Library
- Anti-Cardiovascular Disease Compound Library
- Lipid Metabolism Compound Library
- Targeted Diversity Library
生物活性 |
GW3965 hydrochloride is a potent and selective liver X receptor (LXR) agonist with EC50s of 190 nM and 30 nM for hLXRα and hLXRβ, respectively[1][2][3]. |
IC50 & Target |
EC50: 190 nM (hLXRα), 30 nM (hLXRβ)[4] |
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体外研究 (In Vitro) |
GW3965 hydrochloride promotes GBM cell death in vitro with enhanced efficacy in EGFRvIII-expressing tumor cells. GW3965 hydrochloride up-regulates expression of the cholesterol transporter gene ABCA1 and the E3 ubiquitin ligase IDOL and reduces LDLR levels[2]. LXR ligands inhibits platelet aggregation and calcium mobilization stimulated by collagen or CRP. GW3965 hydrochloride (1 or 5 μM) displays a minor inhibitory effect on fibrinogen binding and P-selectin exposure, when platelets are stimulated with 1 μg/mL CRP. But using higher concentrations of GW3965 hydrochloride (10 μM) or T0901317 (40 μM), the levels of fibrinogen and P-selectin on the platelet surface are reduced[3]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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体内研究 (In Vivo) |
GW3965 hydrochloride induces an increase of neuroactive steroids in the spinal cord, the cerebellum and the cerebral cortex of STZ-rats, but not in the CNS of non-pathological animals. GW3965 hydrochloride treatment induces an increase of dihydroprogesterone in the spinal cord of diabetic animals in association with an increase of myelin basic protein expression[1]. GW3965 hydrochloride (40 mg/kg, p.o.) strongly induces ABCA1 expression and reduces LDLR expression, and this is accompanied by 59% inhibition of tumor growth, and a 25-fold increase in GBM cell apoptosis in vivo[2]. GW3965 hydrochloride (2 mg/kg, i.v.) increases bleeding time and modulated platelet thrombus formation in vivo[3]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
618.51 |
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Formula |
C33H32Cl2F3NO3 |
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CAS 号 |
405911-17-3 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
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溶解性数据 |
In Vitro:
DMSO : 100 mg/mL (161.68 mM; Need ultrasonic) H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble) 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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Cell Assay [2] |
Cells are seeded in 96 wells and are treated after 24 hours with different drugs indicated in each experiment in medium containing 1% FBS or lipoprotein deficient serum. Relative proliferation is determined using Cell Proliferation Assay Kit. Cells are incubated 1.5 hrs after adding tetrazolium salt WST-1 [2-(4-iodophenyl)-3- (4-nitrophenyl)-5-(2, 4-disulfo-phenyl)-2H-tetrazolium, monosodium salt] at 5% CO2, 37ºC and the absorbance of the treated and untreated cells are measured using a microplate reader at 420 to 480 nm. Cells seeded in 12 well plates are counted using a hemocytometer, and dead cells are assessed using trypan blue exclusion assays. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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Animal Administration [1] |
Diabetes is induced in two-month-old male rats by a single i.p. injection of freshly prepared STZ (65 mg/kg) in 0.09 M citrate buffer, pH 4.8. Control animals are injected with 0.09 mol/L citrate buffer at pH 4.8. Hyperglycemia is confirmed 48 h after streptozotocin injection by measuring tail vein blood glucose levels using a glucometer OneTouch Ultra2. Only animals with mean plasma glucose levels over 300 mg/mL are classified as diabetic. Glycemia is also assessed before treatment with Ro5-4864 or GW3965 hydrochloride and before death. Two months after STZ injection, diabetic animals are treated once a week with Ro5-4864 (3 mg/kg) or GW3965 hydrochloride (50 mg/kg). Thus, they receive four subcutaneous injections in a month. Control diabetic rats receive 200 μL of vehicle (sesame oil). Four-month-old non-diabetic male rats are injected, following the same experimental schedule, with Ro5-4864, GW3965 hydrochloride or vehicle. Rats are killed 24 h after the last treatment. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
参考文献 |
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所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务
Megazyme生物及食品酶法检测试剂盒 K-DMAL D-Malic Acid
Megazyme生物及食品酶法检测试剂盒 K-DMAL D-Malic Acid 3438
Megazyme生物及食品酶法检测试剂盒 O-AOC Arabino-Octaose (powder) – 10mg
Megazyme生物及食品酶法检测试剂盒 O-AOC Arabino-Octaose (powder) – 10mg 2142