林可霉素 盐酸盐

一般描述

化学结构：大环内酯

应用

盐酸林可霉素是一种抗生素，用于研究蛋白质合成抑制、细菌抗生素耐药性以及蛋白质和表面活性剂的结合 它是由 链霉菌 var. Lincolnensis 产生，并已用于治疗 金黄色葡萄球菌 、 链球菌 、以及 脆弱拟杆菌 的感染。

制备说明

该产品在水中的溶解度为50 mg/mL，产生澄清无色的溶液。

General Description

Chemical structure: macrolide

Application

Lincomycin hydrochloride is an antibiotic used to study the inhibition of protein synthesis, bacterial antibiotic resistance, and protein and surfactant binding It is produced by Streptomyces lincolnensis var. lincolnensis and has been used in the treatment of Staphylococcal , Streptococcal , and Bacteroides fragilis infections.

林可霉素 盐酸盐

制备说明

This product is soluble in water at 50 mg/mL, yielding a clear, colorless solution.

General Description

Chemical structure: macrolide

Application

Lincomycin hydrochloride is an antibiotic used to study the inhibition of protein synthesis, bacterial antibiotic resistance and protein and surfactant binding. It is produced by Streptomyces lincolnensis var. lincolnensis, and has been used in the treatment of Staphylococcal, Streptococcal, and Bacterioides fragilis infections.

盐酸林可霉素B

林可霉素2-棕榈酸酯盐酸盐

7-表林可霉素盐酸盐

Product Application：

An epimer of Lincomycin ; a 6-amino, 6-deoxy-octopyraninose with strong antibiotic activity. A less potent bactericidal than its (7R)-epimer.

Product Application：

An epimer of Lincomycin ; a 6-amino, 6-deoxy-octopyraninose with strong antibiotic activity. A less potent bactericidal than its (7R)-epimer.

2,3,4-三-O-三甲基甲硅烷基林可霉素

林可霉素2,4-二磷酸

林可霉素2,7-二棕榈酸酯

7-表林可霉素2,7-二棕榈酸酯

林可霉素

林可霉素是一种极性的水溶性广谱抗生素，最早于1962年由Upjohn的研究人员从[Streptomyces licolnensis]中分离出来。林可霉素是一种独特的结构类型，即林可酰胺，它含有稀有氨基酸4-丙基-N-甲基脯氨酸，与同样稀有的氨基甲基硫代-章吡喃糖苷偶联。经常将林可霉素和半合成类似物误认为是氨基糖苷，但几乎没有或没有结构相似性。林可霉素是一种广谱抗生素，具有抗厌氧细菌和原生动物的活性。林可霉素通过与23S核糖体亚基结合而起作用，从而阻止了蛋白质的合成。对林可霉素进行了广泛的研究，引用了7,0

Lincomycin is a polar, water soluble, broad spectrum antibiotic first isolated from|Streptomyces licolnensis|by researchers at Upjohn in 1962. Lincomycin was the first of a unique structural class, the lincosamides, containing a rare amino acid, 4-propyl-N- methylproline, coupled to an equally rare aminomethylthio- octopyranoside sugar. Lincomycin and semi-synthetic analogues are often incorrectly considered to be aminoglycosides but share little or no structural similarity. Lincomycin is a broad spectrum antibiotic with activity against anaerobic bacteria and protozoans. Lincomycin acts by binding to the 23S ribosomal subunit, blocking protein synthesis. Lincomycin has been extensively studied with over 7,000 literature citations.

林可霉素2-磷酸盐

林可霉素2磷酸酯是林可霉素的衍生物，林可霉素是一种林可酰胺抗生素，可在23S rRNA的肽基转移酶环区内形成交联。林可霉素2-磷酸酯也称为克林霉素磷酸酯EP杂质F，甲基6,8-二脱氧-6-[[[（（2S，4R）-1-甲基-4-丙基-2-吡咯烷基]羰基]氨基] -1 -硫代-D-赤型-α-D-半乳糖-奥古吡喃糖苷2-（磷酸二氢）和甲基6,8-二脱氧-6-[[[[（（2S，4R）-1-甲基-4-丙基吡咯烷-2-酰基]羰基]氨基] -2-O-膦酰基-1-硫代-D-赤型-α-D-半乳糖基-章吡喃糖苷。

Lincomycin 2-Phosphate is the derivative of Lincomycin, a lincosamide antibiotic that forms cross-links within the peptidyl transferase loop region of 23S rRNA. Lincomycin 2-Phosphate is also known as Clindamycin Phosphate EP Impurity F, methyl 6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-D-erythro-α-D-galacto-Octopyranoside 2-(dihydrogen phosphate), and methyl 6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propylpyrrolidin-2-yl]carbonyl]amino]-2-O-phosphono-1-thio-D-erythro-α-D-galacto-octopyranoside.

盐酸林可霉素

Information

Lincomycin hydrochloride (Lincocin, NSC 70731) is the monohydrated salt of lincomycin, a substance produced by the growth of a member of the lincolnensis group of Streptomyces lincolnensis.
In vitro

In vivo

Cell Data

cell lines：MDA-MB-361, MDA-MB-231, MDA-MB-468, BT549, LNCap, A549, H1975, H157, H460, U87MG, A498, 786-O, HCT116, MG63, Rat1, HEK293, and HeLa

Concentrations：

Incubation Time：

Powder Purity:≥95%