标签归档：cl

多肽定制H-Phe(4-Cl)-D-Cys-β-(2-pyridyl)-Ala-Trp-Lys-Val-Cys-2-Nal-NH2 编码 [429619-37-4]

发表于由

上海金畔生物科技有限公司可以定制不同序列多肽，可以访问官网了解更多产品信息。

名称 H-Phe(4-Cl)-D-Cys-β-(2-pyridyl)-Ala-Trp-Lys-Val-Cys-2-Nal-NH2
编码 [429619-37-4]
别名 H-Phe(4-Cl)-D-Cys-β-(2-pyridyl)-Ala-Trp-Lys-Val-Cys-2-Nal-NH2
纯度 80%，90%，95%，98%，99%
重量 1mg,5mg,10mg,50mg,100mg,1g
序列（单字母缩写） p-Chloro-F-D-C-β-(2-pyridyl)-AWKVC-2-Nal-NH2
序列（三字母缩写） Phe(4-Cl)-D-Cys-β-(2-pyridyl)-Ala-Trp-Lys-Val-Cys-2-Nal-NH2
基本描述
溶解度
分子量 0
化学式
存储条件 Store at -20°C. Keep tightly closed. Store in a cool dry place.
注释
Documents H-Phe(4-Cl)-D-Cys-β-(2-pyridyl)-Ala-Trp-Lys-Val-Cys-2-Nal-NH2 编码 [429619-37-4]
Figures H-Phe(4-Cl)-D-Cys-β-(2-pyridyl)-Ala-Trp-Lys-Val-Cys-2-Nal-NH2 编码 [429619-37-4]
Reference
C端
N端
化学桥

多肽定制H-Phe(4-Cl)-D-Cys-β-(3-pyridyl)-Ala-D-Trp-Lys-tBu-Gly-Cys-2-Nal-NH2 编码 [209006-18-8]

发表于由

上海金畔生物科技有限公司可以定制不同序列多肽，可以访问官网了解更多产品信息。

名称 H-Phe(4-Cl)-D-Cys-β-(3-pyridyl)-Ala-D-Trp-Lys-tBu-Gly-Cys-2-Nal-NH2
编码 [209006-18-8]
别名 H-Phe(4-Cl)-D-Cys-β-(3-pyridyl)-Ala-D-Trp-Lys-tBu-Gly-Cys-2-Nal-NH2
纯度 80%，90%，95%，98%，99%
重量 1mg,5mg,10mg,50mg,100mg,1g
序列（单字母缩写） p-Chloro-F-D-C-β-(3-pyridyl)-A-D-WK-tBu-GC-2-Nal-NH2
序列（三字母缩写） Phe(4-Cl)-D-Cys-β-(3-pyridyl)-Ala-D-Trp-Lys-tBu-Gly-Cys-2-Nal-NH2
基本描述
溶解度
分子量 0
化学式
存储条件 Store at -20°C. Keep tightly closed. Store in a cool dry place.
注释
Documents H-Phe(4-Cl)-D-Cys-β-(3-pyridyl)-Ala-D-Trp-Lys-tBu-Gly-Cys-2-Nal-NH2 编码 [209006-18-8]
Figures H-Phe(4-Cl)-D-Cys-β-(3-pyridyl)-Ala-D-Trp-Lys-tBu-Gly-Cys-2-Nal-NH2 编码 [209006-18-8]
Reference
C端
N端
化学桥

多肽定制H-Phe(4-Cl)-D-Cys-β-(3-pyridyl)-Ala-D-Trp-N-Me-Lys-Thr-Cys-2-Nal-NH2 编码 [341519-04-8]

发表于由

上海金畔生物科技有限公司可以定制不同序列多肽，可以访问官网了解更多产品信息。

名称 H-Phe(4-Cl)-D-Cys-β-(3-pyridyl)-Ala-D-Trp-N-Me-Lys-Thr-Cys-2-Nal-NH2
编码 [341519-04-8]
别名 H-Phe(4-Cl)-D-Cys-β-(3-pyridyl)-Ala-D-Trp-N-Me-Lys-Thr-Cys-2-Nal-NH2
纯度 80%，90%，95%，98%，99%
重量 1mg,5mg,10mg,50mg,100mg,1g
序列（单字母缩写） p-Chloro-F-D-C-β-(3-pyridyl)-A-D-W-N-Me-KTC-2-Nal-NH2
序列（三字母缩写） Phe(4-Cl)-D-Cys-β-(3-pyridyl)-Ala-D-Trp-N-Me-Lys-Thr-Cys-2-Nal-NH2
基本描述
溶解度
分子量 0
化学式
存储条件 Store at -20°C. Keep tightly closed. Store in a cool dry place.
注释
Documents H-Phe(4-Cl)-D-Cys-β-(3-pyridyl)-Ala-D-Trp-N-Me-Lys-Thr-Cys-2-Nal-NH2 编码 [341519-04-8]
Figures H-Phe(4-Cl)-D-Cys-β-(3-pyridyl)-Ala-D-Trp-N-Me-Lys-Thr-Cys-2-Nal-NH2 编码 [341519-04-8]
Reference
C端
N端
化学桥

三信CL200+ 笔式pH/余氯/ORP计

发表于由

三信CL200+ 笔式pH/余氯/ORP计

  • 品牌 三信|SANXIN
  • 型号 CL200+
  • 商品详情

    产品特征

    1、配置pH、余氯、ORP三种电极，仪器可自动识别电极。

    2、具有自动校准、自动温度补偿、数据储存、pH电极失效提醒、低电压显示、自动关机等智能化功能。

    3、带线条图的大型液晶显示屏，可同时显示测量值和温度值。

    4、在同类仪器中首次采用了平面pH电极。可用于各种介质的pH测试，包括溶液、微量溶液、以及湿润的固体和半固体表面，如皮肤、肉制品、水果、布料、纸张、奶酪等等。

    5、测量水溶液的总余氯，包括游离氯（Cl2），次氯酸盐（OCl-）和氯的含氮化合物（如氯胺T）。每次测试使用一粒试剂片，无需其他复杂的试剂

    6、符合IP57防水等级，配置校正溶液、测量杯和手提箱。

     

     技术参数

    pH

    测量范围

    分辨率

    准确度

    温度补偿范围

    0 ~ 14.00pH

    0.01 pH

    ±0.01 pH

    （0 ~ 90）℃（自动）

    ORP

    测量范围

    分辨率

    准确度

    ±999mV

    1mV

    ±4mV

    余氯

    测量范围

    分辨率

    准确度

    温度补偿范围

    0.01~10.00ppm（总余氯）

    0.01ppm

    ±10%读数值，±0.01ppm（0.05~5.00ppm）

    （0 ~ 60）℃（自动）

    温度

    测量范围

    分辨率

    准确度

    （-5 ~ 90）℃

    0.1℃

    （-5 ~ 50）℃/±0.1℃，（50~ 90）℃/±3℃

    其他技术参数

    数据储存

    显示屏

    电池低电压显示

    pH电极失效显示

    电源

    尺寸和重量

    15组

    线条图多功能液晶显示屏

    液晶屏显示“BAT”字符

    液晶屏闪烁“RENEW”字符

    CR2032锂电池四颗

    (36×173×41)mm/110g

    工作条件

    环境温度

    相对湿度

    IP等级

    -5 ~ 50 ℃（0.01级）

    ≤80%RH

    IP57 防尘防水

     

    • 三信CL200笔式余氯计

    发表于由

    三信CL200笔式余氯计

  • 品牌 三信|SANXIN
  • 型号 CL200
  • 商品详情

    产品特征

    1、测量水溶液的总余氯，包括游离氯（Cl2），次氯酸盐（OCl-）和氯的含氮化合物（如氯胺T）。

    每次测试使用一粒试剂片，无需其他复杂的试剂。

    2、具有自动校准、自动温度补偿、数据储存、 低电压显示、自动关机等智能化功能。

    3、带线条图的大型液晶显示屏，可同时显示测量值和温度值。

    4、符合IP57防水等级，配置校正溶液、测量杯和手提箱。

     

     技术参数

    余氯

    测量范围

    分辨率

    准确度

    温度补偿范围

    0.01~10.00ppm（总余氯）

    0.01ppm

    ±10%读数值，±0.01ppm（0.05~5.00ppm）

    （0 ~ 60）℃（自动）

    温度

    测量范围

    分辨率

    准确度

    （-5 ~ 90）℃

    0.1℃

    （-5 ~ 50）℃/±0.1℃，（50~ 90）℃/±3℃

    其他技术参数

    数据储存

    显示屏

    电池低电压显示

    pH电极失效显示

    电源

    尺寸和重量

    15组

    线条图多功能液晶显示屏

    液晶屏显示“BAT”字符

    液晶屏闪烁“RENEW”字符

    CR2032锂电池四颗

    (36×173×41)mm/110g

    工作条件

    环境温度

    相对湿度

    IP等级

    -5 ~ 50 ℃（0.01级）

    ≤80%RH

    IP57 防尘防水

    • Cl-PEG6-acid

    发表于由

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

    Cl-PEG6-acid 

    Cl-PEG6-acid 是一种 PROTAC linker，属于 PEG 类。可用于合成 PROTAC 分子。

    Cl-PEG6-acid

    Cl-PEG6-acid Chemical Structure

    CAS No. : 2365309-92-6

    规格 是否有货
    100 mg   询价  
    250 mg   询价  
    500 mg   询价  

    * Please select Quantity before adding items.

    生物活性

    Cl-PEG6-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

    IC50 & Target

    PEGs

     

    体外研究
    (In Vitro)

    PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

    Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    358.81

    Formula

    C14H27ClO8
    CAS 号

    2365309-92-6
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    参考文献

    • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

    所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

    Cl-PEG6-acid

    发表于由

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

    Cl-PEG6-acid 

    Cl-PEG6-acid 是一种 PROTAC linker，属于 PEG 类。可用于合成 PROTAC 分子。

    Cl-PEG6-acid

    Cl-PEG6-acid Chemical Structure

    CAS No. : 2365309-92-6

    规格 是否有货
    100 mg   询价  
    250 mg   询价  
    500 mg   询价  

    * Please select Quantity before adding items.

    生物活性

    Cl-PEG6-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

    IC50 & Target

    PEGs

     

    体外研究
    (In Vitro)

    PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

    Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    358.81

    Formula

    C14H27ClO8
    CAS 号

    2365309-92-6
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    参考文献

    • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

    所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

    Cl-PEG6-acid

    发表于由

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

    Cl-PEG6-acid 

    Cl-PEG6-acid 是一种 PROTAC linker，属于 PEG 类。可用于合成 PROTAC 分子。

    Cl-PEG6-acid

    Cl-PEG6-acid Chemical Structure

    CAS No. : 2365309-92-6

    规格 是否有货
    100 mg   询价  
    250 mg   询价  
    500 mg   询价  

    * Please select Quantity before adding items.

    生物活性

    Cl-PEG6-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

    IC50 & Target

    PEGs

     

    体外研究
    (In Vitro)

    PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

    上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    358.81

    Formula

    C14H27ClO8
    CAS 号

    2365309-92-6
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    参考文献

    • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

    所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

    Cl-PEG4-acid

    发表于由

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

    Cl-PEG4-acid 

    Cl-PEG4-acid 是一种 PROTAC linker，属于 PEG 类。可用于合成 PROTAC 分子。

    Cl-PEG4-acid

    Cl-PEG4-acid Chemical Structure

    CAS No. : 158553-98-1

    规格 是否有货
    100 mg   询价  
    250 mg   询价  
    500 mg   询价  

    * Please select Quantity before adding items.

    生物活性

    Cl-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

    IC50 & Target

    PEGs

     

    体外研究
    (In Vitro)

    PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

    Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    270.71

    Formula

    C10H19ClO6
    CAS 号

    158553-98-1
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    参考文献

    • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

    所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

    Cl-PEG4-acid

    发表于由

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

    Cl-PEG4-acid 

    Cl-PEG4-acid 是一种 PROTAC linker，属于 PEG 类。可用于合成 PROTAC 分子。

    Cl-PEG4-acid

    Cl-PEG4-acid Chemical Structure

    CAS No. : 158553-98-1

    规格 是否有货
    100 mg   询价  
    250 mg   询价  
    500 mg   询价  

    * Please select Quantity before adding items.

    生物活性

    Cl-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

    IC50 & Target

    PEGs

     

    体外研究
    (In Vitro)

    PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

    Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    270.71

    Formula

    C10H19ClO6
    CAS 号

    158553-98-1
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    参考文献

    • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

    所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

    Cl-PEG4-acid

    发表于由

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

    Cl-PEG4-acid 

    Cl-PEG4-acid 是一种 PROTAC linker，属于 PEG 类。可用于合成 PROTAC 分子。

    Cl-PEG4-acid

    Cl-PEG4-acid Chemical Structure

    CAS No. : 158553-98-1

    规格 是否有货
    100 mg   询价  
    250 mg   询价  
    500 mg   询价  

    * Please select Quantity before adding items.

    生物活性

    Cl-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

    IC50 & Target

    PEGs

     

    体外研究
    (In Vitro)

    PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

    上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    270.71

    Formula

    C10H19ClO6
    CAS 号

    158553-98-1
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    参考文献

    • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

    所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

    PEG2-Cl

    发表于由

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

    PEG2-Cl 

    PEG2-Cl 是一种 PROTAC linker，属于 PEG 类。可用于合成 PROTAC 分子。

    PEG2-Cl

    PEG2-Cl Chemical Structure

    CAS No. : 78925-46-9

    规格 是否有货
    100 mg   询价  
    250 mg   询价  
    500 mg   询价  

    * Please select Quantity before adding items.

    生物活性

    PEG2-Cl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

    IC50 & Target

    PEGs

     

    体外研究
    (In Vitro)

    PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

    Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    138.59

    Formula

    C5H11ClO2
    CAS 号

    78925-46-9
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    参考文献

    • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

    所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

    PEG2-Cl

    发表于由

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

    PEG2-Cl 

    PEG2-Cl 是一种 PROTAC linker，属于 PEG 类。可用于合成 PROTAC 分子。

    PEG2-Cl

    PEG2-Cl Chemical Structure

    CAS No. : 78925-46-9

    规格 是否有货
    100 mg   询价  
    250 mg   询价  
    500 mg   询价  

    * Please select Quantity before adding items.

    生物活性

    PEG2-Cl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

    IC50 & Target

    PEGs

     

    体外研究
    (In Vitro)

    PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

    上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    138.59

    Formula

    C5H11ClO2
    CAS 号

    78925-46-9
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    参考文献

    • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

    所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

    PEG2-Cl

    发表于由

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

    PEG2-Cl 

    PEG2-Cl 是一种 PROTAC linker，属于 PEG 类。可用于合成 PROTAC 分子。

    PEG2-Cl

    PEG2-Cl Chemical Structure

    CAS No. : 78925-46-9

    规格 是否有货
    100 mg   询价  
    250 mg   询价  
    500 mg   询价  

    * Please select Quantity before adding items.

    生物活性

    PEG2-Cl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

    IC50 & Target

    PEGs

     

    体外研究
    (In Vitro)

    PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

    Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    138.59

    Formula

    C5H11ClO2
    CAS 号

    78925-46-9
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    参考文献

    • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

    所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

    Cl-4AS-1

    发表于由

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

    Cl-4AS-1 

    Cl-4AS-1 是一种有效的类固醇雄激素受体 (AR) 激动剂 (IC50 为 12 nM)，也是 5α- 还原酶 I 型和 II 型的抑制剂 (IC50 分别为 6 和 10 nM)。

    Cl-4AS-1

    Cl-4AS-1 Chemical Structure

    CAS No. : 188589-66-4

    规格 是否有货
    100 mg   询价  
    250 mg   询价  
    500 mg   询价  

    * Please select Quantity before adding items.

    生物活性

    Cl-4AS-1, a potent steroidal androgen receptor (AR) agonist (IC50 = 12 nM), is also an inhibitor of 5α-reductase types I and II (IC50 = 6 and 10 nM, respectively)[1][2].

    IC50 & Target

    IC50: 12 nM (androgen receptor); 6 nM (5α-reductase types I); 10 nM (5α-reductase types II)[1][2]
    体外研究
    (In Vitro)

    Cl-4AS-1 suppresses MMP-1 promoter activity in 22Rv1 human prostate cancer cells[1].
    Cl-4AS-1 (10 μM) effectively promotes the AR N/C interaction, with an average maximal activity of 35.3%[1].

    Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
    体内研究
    (In Vivo)

    Cl-4AS-1 produces no significant reduction in prostate weight in intact animals and in castrates rats caused a significant increase of ventral prostate weight[1].

    Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: ORX rats[1]
    Dosage: 10 mg/kg
    Administration: I.s.; 7 days
    Result: Effect of Cl-4AS-1 on prostate and seminal vesicle growth.

    分子量

    441.01

    Formula

    C26H33ClN2O2
    CAS 号

    188589-66-4
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    参考文献

    • [1]. Schmidt A, et al. Identification of anabolic selective androgen receptor modulators with reduced activities in reproductive tissues and sebaceous glands. J Biol Chem. 2009 Dec 25;284(52):36367-36376.

      [2]. Tolman RL, et al. 4-Methyl-3-oxo-4-aza-5alpha-androst-1-ene-17beta-N-aryl-carboxamides: an approach to combined androgen blockade [5alpha-reductase inhibition with androgen receptor binding in vitro]. J Steroid Biochem Mol Biol. 1997 Mar;60(5-6):303-9.

    所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

    Cl-4AS-1

    发表于由

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

    Cl-4AS-1 

    Cl-4AS-1 是一种有效的类固醇雄激素受体 (AR) 激动剂 (IC50 为 12 nM)，也是 5α- 还原酶 I 型和 II 型的抑制剂 (IC50 分别为 6 和 10 nM)。

    Cl-4AS-1

    Cl-4AS-1 Chemical Structure

    CAS No. : 188589-66-4

    规格 是否有货
    100 mg   询价  
    250 mg   询价  
    500 mg   询价  

    * Please select Quantity before adding items.

    生物活性

    Cl-4AS-1, a potent steroidal androgen receptor (AR) agonist (IC50 = 12 nM), is also an inhibitor of 5α-reductase types I and II (IC50 = 6 and 10 nM, respectively)[1][2].

    IC50 & Target

    IC50: 12 nM (androgen receptor); 6 nM (5α-reductase types I); 10 nM (5α-reductase types II)[1][2]
    体外研究
    (In Vitro)

    Cl-4AS-1 suppresses MMP-1 promoter activity in 22Rv1 human prostate cancer cells[1].
    Cl-4AS-1 (10 μM) effectively promotes the AR N/C interaction, with an average maximal activity of 35.3%[1].

    Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
    体内研究
    (In Vivo)

    Cl-4AS-1 produces no significant reduction in prostate weight in intact animals and in castrates rats caused a significant increase of ventral prostate weight[1].

    Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: ORX rats[1]
    Dosage: 10 mg/kg
    Administration: I.s.; 7 days
    Result: Effect of Cl-4AS-1 on prostate and seminal vesicle growth.

    分子量

    441.01

    Formula

    C26H33ClN2O2
    CAS 号

    188589-66-4
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    参考文献

    • [1]. Schmidt A, et al. Identification of anabolic selective androgen receptor modulators with reduced activities in reproductive tissues and sebaceous glands. J Biol Chem. 2009 Dec 25;284(52):36367-36376.

      [2]. Tolman RL, et al. 4-Methyl-3-oxo-4-aza-5alpha-androst-1-ene-17beta-N-aryl-carboxamides: an approach to combined androgen blockade [5alpha-reductase inhibition with androgen receptor binding in vitro]. J Steroid Biochem Mol Biol. 1997 Mar;60(5-6):303-9.

    所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

    Cl-4AS-1

    发表于由

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

    Cl-4AS-1 

    Cl-4AS-1 是一种有效的类固醇雄激素受体 (AR) 激动剂 (IC50 为 12 nM)，也是 5α- 还原酶 I 型和 II 型的抑制剂 (IC50 分别为 6 和 10 nM)。

    Cl-4AS-1

    Cl-4AS-1 Chemical Structure

    CAS No. : 188589-66-4

    规格 是否有货
    100 mg   询价  
    250 mg   询价  
    500 mg   询价  

    * Please select Quantity before adding items.

    生物活性

    Cl-4AS-1, a potent steroidal androgen receptor (AR) agonist (IC50 = 12 nM), is also an inhibitor of 5α-reductase types I and II (IC50 = 6 and 10 nM, respectively)[1][2].

    IC50 & Target

    IC50: 12 nM (androgen receptor); 6 nM (5α-reductase types I); 10 nM (5α-reductase types II)[1][2]
    体外研究
    (In Vitro)

    Cl-4AS-1 suppresses MMP-1 promoter activity in 22Rv1 human prostate cancer cells[1].
    Cl-4AS-1 (10 μM) effectively promotes the AR N/C interaction, with an average maximal activity of 35.3%[1].

    上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
    体内研究
    (In Vivo)

    Cl-4AS-1 produces no significant reduction in prostate weight in intact animals and in castrates rats caused a significant increase of ventral prostate weight[1].

    上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: ORX rats[1]
    Dosage: 10 mg/kg
    Administration: I.s.; 7 days
    Result: Effect of Cl-4AS-1 on prostate and seminal vesicle growth.

    分子量

    441.01

    Formula

    C26H33ClN2O2
    CAS 号

    188589-66-4
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    参考文献

    • [1]. Schmidt A, et al. Identification of anabolic selective androgen receptor modulators with reduced activities in reproductive tissues and sebaceous glands. J Biol Chem. 2009 Dec 25;284(52):36367-36376.

      [2]. Tolman RL, et al. 4-Methyl-3-oxo-4-aza-5alpha-androst-1-ene-17beta-N-aryl-carboxamides: an approach to combined androgen blockade [5alpha-reductase inhibition with androgen receptor binding in vitro]. J Steroid Biochem Mol Biol. 1997 Mar;60(5-6):303-9.

    所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

    Thalidomide-5-PEG2-Cl

    发表于由

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

    Thalidomide-5-PEG2-Cl 

    Thalidomide-5-PEG2-Cl 是一种基于 Thalidomide 的，可募集 CRBN 蛋白的 cereblon 配体。Thalidomide-5-PEG2-Cl 可通过 linker 与靶蛋白配体连接，形成 PROTAC 分子。

    Thalidomide-5-PEG2-Cl

    Thalidomide-5-PEG2-Cl Chemical Structure

    CAS No. : 2230956-57-5

    规格 是否有货
    100 mg   询价  
    250 mg   询价  
    500 mg   询价  

    * Please select Quantity before adding items.

    生物活性

    Thalidomide-5-PEG2-Cl is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-PEG2-Cl can be connected to the ligand for protein by a linker to form PROTACs[1].

    IC50 & Target[1]

    Cereblon

     

    体外研究
    (In Vitro)

    PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

    Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    380.78

    Formula

    C17H17ClN2O6
    CAS 号

    2230956-57-5
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    参考文献

    • [1]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-994.

    所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

    Thalidomide-5,6-Cl

    发表于由

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

    Thalidomide-5,6-Cl 

    Thalidomide-5,6-Cl 是一种基于 Thalidomide 的，可募集 CRBN 蛋白的 cereblon 配体。Thalidomide-5,6-Cl 可通过 linker 与靶蛋白配体连接，形成 PROTAC 分子。

    Thalidomide-5,6-Cl

    Thalidomide-5,6-Cl Chemical Structure

    CAS No. : 2648939-40-4

    规格 是否有货
    100 mg   询价  
    250 mg   询价  
    500 mg   询价  

    * Please select Quantity before adding items.

    生物活性

    Thalidomide-5,6-Cl is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5,6-Cl can be connected to the ligand for protein by a linker to form PROTACs.

    体外研究
    (In Vitro)

    Thalidomide-5,6-Cl is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5,6-Cl can be connected to the ligand for protein by a linker to form PROTACs.

    Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    327.12

    Formula

    C13H8Cl2N2O4
    CAS 号

    2648939-40-4
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    参考文献

    • [1]. Zhang NN, et, al. A Thermostable mRNA Vaccine against COVID-19. Cell. 2020 Sep 3;182(5):1271-1283.e16.

    所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务