hCAII-IN-3

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

hCAII-IN-3

hCAII-IN-3 (Compound 16) 是一种人碳酸酐酶 (hCA) 抑制剂，对 hCA I、hCA II、hCA IX 和 hCA XII 的 K_i 值分别为 403.8、5.1、10.2 和 5.2 nM。

hCAII-IN-3 Chemical Structure

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生物活性	hCAII-IN-3 (Compound 16) is a human carbonic anhydrase (hCA) inhibitor with K_i values of 403.8, 5.1, 10.2 and 5.2 nM against hCA I, hCA II, hCA IX and hCA XII, respectively. hCA IX-IN-2 shows anticancer activity^[1].
IC₅₀ & Target	K_i: 5.1 nM (hCA II), 5.2 nM (hCA XII), 10.2 nM (hCA IX), 403.8 nM (hCA I)^[1]
分子量	347.43
Formula	C₁₇H₂₁N₃O₃S
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Elbadawi MM, et al. Development of 4-((3-oxo-3-phenylpropyl)amino)benzenesulfonamide derivatives utilizing tail/dual-tail approaches as novel carbonic anhydrase inhibitors. Eur J Med Chem. 2022 Apr 27;238:114412.

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hCAII-IN-2

hCAII-IN-2

hCAII-IN-2 (Compound 11f) 是一种胞质型人碳酸酐酶 (hCA) 抑制剂，对 hCA I、hCA II、hCA IX 和 hCA XII 的 K_i 分别为 261.4、3.8、19.6 和 45.2 nM

hCAII-IN-2 Chemical Structure

CAS No. : 2408599-78-8

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生物活性	hCAII-IN-2 (Compound 11f) is a cytosolic human carbonic anhydrase (hCA) inhibitor with K_i values of 261.4, 3.8, 19.6 and 45.2 nM against hCA I, hCA II, hCA IX and hCA XII, respectively^[1].
IC₅₀ & Target	K_i: 3.8 nM (hCA II), 19.6 nM (hCA IX), 45.2 nM (hCA XII), 261.4 nM (hCA I)^[1]
分子量	519.96
Formula	C₂₅H₁₈ClN₅O₄S
CAS 号	2408599-78-8
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Khalil OM, et al. Pyrrolo and pyrrolopyrimidine sulfonamides act as cytotoxic agents in hypoxia via inhibition of transmembrane carbonic anhydrases. Eur J Med Chem. 2020 Feb 15;188:112021.

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hCAII-IN-1

hCAII-IN-1 (compound 7f) 是一种有效的、选择性的碳酸酐酶 (CA II/IX) 抑制剂，K_is 分别为 1.2 和 113.6 nM。hCAII-IN-1 具有研究癌症疾病的潜力。

hCAII-IN-1 Chemical Structure

CAS No. : 1807520-24-6

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生物活性	hCAII-IN-1 (compound 7f) is a potent and selective inhibitor of carbonic anhydrase (CA II/IX) with K_is of 1.2 and 113.6 nM, respectively. hCAII-IN-1 has the potential for the research of cancer diseases^[1].
分子量	533.40
Formula	C₂₁H₂₁BrN₆O₄S
CAS 号	1807520-24-6
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Nocentini A, et al. Sulfonamide/sulfamate switch with a series of piperazinylureido derivatives: Synthesis, kinetic and in silico evaluation as carbonic anhydrase isoforms I, II, IV, and IX inhibitors. Eur J Med Chem. 2020;186:111896.

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