上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
Namodenoson (Synonyms: CF-102; 2-Cl-IB-MECA) 纯度: 99.63%
Namodenoson (CF-102) 是一个选择性的 A3 腺苷受体 (A3AR) 激动剂 (Ki=0.33 nM),选择性分别是 A1,A2 的 2500 和 1400 倍。
Namodenoson Chemical Structure
CAS No. : 163042-96-4
规格 | 价格 | 是否有货 | 数量 |
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10 mM * 1 mL in DMSO | ¥1318 | In-stock | |
2 mg | ¥550 | In-stock | |
5 mg | ¥1100 | In-stock | |
10 mg | ¥1950 | In-stock | |
25 mg | ¥3700 | In-stock | |
50 mg | ¥5400 | In-stock | |
100 mg | ¥7900 | In-stock | |
200 mg | 询价 | ||
500 mg | 询价 |
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生物活性 |
Namodenoson (CF-102) is a selective A3 adenosine receptor (A3AR) agonist (Ki=0.33 nM). Namodenoson displays 2500- and 1400-fold selectivity over A1 and A2A receptors respectively[1][2]. |
IC50 & Target |
Ki:0.33 nM (A3 adenosine receptor)[1][2]. |
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体外研究 (In Vitro) |
In human ADF cells of astroglial lineage, 100 nM Namodenoson (2-Cl-IB-MECA) caused a marked reorganization of the cytoskeleton, with appearance of stress fibres and numerous cell protrusions. High concentrations of Namodenoson (2-Cl-IB-MECA) directly cause influx of Ca2+[2]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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体内研究 (In Vivo) |
Intravenous administration of 200 μg/kg Namodenoson (2-Cl-IB-MECA) resulted in a short-lasting hypotension, which was accompanied by a 50-100-fold increase in plasma histamine concentrations. Administration of a second dose of Namodenoson (2-Cl-IB-MECA) did not elicit any hemodynamic effects[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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Clinical Trial |
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分子量 |
544.73 |
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Formula |
C18H18ClIN6O4 |
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CAS 号 |
163042-96-4 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : ≥ 31 mg/mL (56.91 mM) * “≥” means soluble, but saturation unknown. 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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