Aristolochic acid D 是从 Aristolochia indica 分离得到的马兜铃酸衍生物。马兜铃酸是肾毒素和致癌物。
Aristolochic acid D Chemical Structure
CAS No. : 17413-38-6
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生物活性
Aristolochic acid D is an aristolochic acid derivative isolated from stems of Aristolochia indica. Aristolochic acid is nephrotoxin and carcinogen[1].
分子量
357.27
Formula
C17H11NO8
CAS 号
17413-38-6
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Powder
-20°C
3 years
4°C
2 years
In solvent
-80°C
6 months
-20°C
1 month
参考文献
[1]. Kupchan SM, et al. The isolation and structural elucidation of novel derivatives of aristolochic acid from Aristolochia indica. J Org Chem. 1968 Oct;33(10):3735-8.
[2]. Balachandran P, et al. Structure activity relationships of aristolochic acid analogues: toxicity in cultured renal epithelial cells. Kidney Int. 2005 May;67(5):1797-805.
Aristolochic acid B 是马兜铃酸 (AA) 的主要成分之一,来自马兜铃科 (Aristolochiaceae) 分类群的天然产物。 已知马兜铃酸是有效的诱变剂和致癌物质。Aristolochic acid B 在体内表现出比 Aristolochic acid I 更大的致癌风险。
Aristolochic acid B Chemical Structure
CAS No. : 475-80-9
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生物活性
Aristolochic acid B is one of the major components of Aristolochic acids (AA) which are natural products derived from taxa in the Aristolochiaceae. Aristolochic acid is known to be a potent mutagen and carcinogen. Aristolochic acid B showes more carcinogenic risk than Aristolochic acid A in vivo[1].
分子量
311.25
Formula
C16H9NO6
CAS 号
475-80-9
中文名称
马兜铃酸 B
运输条件
Room temperature in continental US; may vary elsewhere.
[1]. Xing G, et al. Comparison of the mutagenicity of aristolochic acid I and aristolochic acid II in the gpt delta transgenic mouse kidney. Mutat Res. 2012 Mar 18;743(1-2):52-8.
Aristolochic acid C 是马兜铃酸 (Aristolochic acid) 的衍生物。Aristolochic acid 是磷脂酶 A (phospholipase A2,PLA2) 抑制剂,作用于拟南芥,可破坏间期细胞的周质微管列阵和抑制根生长。
Aristolochic acid C Chemical Structure
CAS No. : 4849-90-5
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生物活性
Aristolochic acid C is a derivative of Aristolochic acid. Aristolochic acid is a phospholipase A2 (PLA2) inhibitor, which disrupts cortical microtubule arrays and root growth in Arabidopsis[1].
分子量
327.25
Formula
C16H9NO7
CAS 号
4849-90-5
中文名称
马兜铃酸 C
运输条件
Room temperature in continental US; may vary elsewhere.
Aristolochic acid A (Aristolochic acid I; TR 1736) 是植物提取物 Aristolochic acids 的主要成分,其存在于 Aristolochia 和 Asarum 草本植物中。Aristolochic acid A 显着降低激活蛋白1 (AP-1) 和 NF-κB 活性。Aristolochic acid A 降低人细胞中膀胱癌相关 BLCAP 基因表达。
Aristolochic acid A Chemical Structure
CAS No. : 313-67-7
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数量
10 mM * 1 mL in DMSO
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100 mg
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生物活性
Aristolochic acid A (Aristolochic acid I; TR 1736) is the main component of plant extract Aristolochic acids, which are found in various herbal plants of genus Aristolochia and Asarum. Aristolochic acid A significantly reduces both activator protein 1 (AP-1) and NF-κB activities. Aristolochic acid A reduces BLCAP gene expression in human cell lines[1].
体外研究 (In Vitro)
Aristolochic acid A (150, 200 μM, 24 hours) inhibits the cell viabilities of kidney cells HEK293 and HK-2[1]. Aristolochic acid A (100, 200 μM, 24 hours) causes a concentration-dependent decrease in bladder cancer-associated protein (BLCAP) mRNA levels in kidney cells (HEK 293 and HK-2) , and bladder cancer cell line (HT-1376)[1]. Aristolochic acid A (100, 200 μM, 24 hours) weakens the BLCAP protein signals in a dose-dependent manner in both HEK293 and HT-1376 cells[1].
上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Viability Assay[1]
Cell Line:
Kidney cells (HEK 293 and HK-2)
Concentration:
50, 100, 150, 200 μM
Incubation Time:
24 hours
Result:
The cell viabilities of HEK293 and HK-2 were lower than that of vehicle-treated cultures until 150 μM and 200 μM.
RT-PCR[1]
Cell Line:
Kidney cells (HEK 293 and HK-2), and bladder cancer cell line (HT-1376)
Concentration:
100, 200 μM
Incubation Time:
24 hours
Result:
Down regulated the levels of BLCAP mRNA.
Western Blot Analysis[1]
Cell Line:
HEK293 and HT-1376 cells
Concentration:
100, 200 μM
Incubation Time:
24 hours
Result:
Reduced the BLCAP protein expression in a dose-dependent manner.
分子量
341.27
Formula
C17H11NO7
CAS 号
313-67-7
中文名称
马兜铃酸 A
运输条件
Room temperature in continental US; may vary elsewhere.
[1]. Huang YT, et al. Aristolochic acid I interferes with the expression of BLCAP tumor suppressor gene in human cells. Toxicol Lett. 2018 Jul;291:129-137.