蛎灰菌素A

Ostreogrycin A, also known as Virginiamycin M1, is a streptogramin macrolide antibiotic. Ostreogrycin A interacts with the bacterial 50S ribosome, inhibiting its function in a reversible manner. Activity of Ostreogrycin A at the ribosome blocks translation and produces a bacteriostatic effect. With addition of Virginiamycin S1 , the two antibiotics produce a synergistic bacteriocidal effect. The combination of these compounds, available as a Virginimycin complex , demonstrate efficacy against a broad range of bacteria.A bacteriostatic inhibitor of translation at the 50S ribosome

Ostreogrycin A, also known as Virginiamycin M1, is a streptogramin macrolide antibiotic. Ostreogrycin A interacts with the bacterial 50S ribosome, inhibiting its function in a reversible manner. Activity of Ostreogrycin A at the ribosome blocks translation and produces a bacteriostatic effect. With addition of Virginiamycin S1 , the two antibiotics produce a synergistic bacteriocidal effect. The combination of these compounds, available as a Virginimycin complex , demonstrate efficacy against a broad range of bacteria.
A bacteriostatic inhibitor of translation at the 50S ribosome

尼日利亚菌素钠

纺锤菌素 二盐酸盐

链霉菌Streptomyces netropsis产生的抗生素。溶于水(30mg/ml，80℃，＞0.5mg/ml，25℃)，不溶于一般有机溶剂。盐酸盐吸湿性强。含n-甲基吡咯寡肽，结合到dsDNA的富AT序列上，尤其在小的凹槽位点。这样，它保护该区域免受DNase I和内切核酸酶切割，也抑制拓扑异构酶。 纺锤菌素打乱细胞分裂周期，延长G期，并使分裂停止在G期。 医药上具有抗细菌、真菌、锥体虫、牛痘病毒、噬菌体等作用。

根赤壳菌素

Radicicol, a microbial cell differentiation modulator originally extracted from Neocosmospora tenuicristata, has been shown to inhibit proliferation and plasminogen activator production by vascular endothelial cells. Radicicol inhibits the expression of Cox-2 (IC50 = 27 nM) without affecting Cox-1 expression in LPS-stimulated macrophages. It is also a potent inhibitor of Hsp90. Experiments sμggest that radicicol reduces the intracellular level of autophosphorylation of p60v-src as well as other tyrosine-phosphorylated proteins via inhibition of SRC kinases. In addition, radicicol has demonstrated the ability to inhibit K-ras signaling pathway which includes phosphorylation of Raf-1, MAPKK, and MAPK.A potent inhibitor of Hsp90, SRC, and Cox-2

Radicicol, a microbial cell differentiation modulator originally extracted from Neocosmospora tenuicristata, has been shown to inhibit proliferation and plasminogen activator production by vascular endothelial cells. Radicicol inhibits the expression of Cox-2 (IC50 = 27 nM) without affecting Cox-1 expression in LPS-stimulated macrophages. It is also a potent inhibitor of Hsp90. Experiments suggest that radicicol reduces the intracellular level of autophosphorylation of p60v-src as well as other tyrosine-phosphorylated proteins via inhibition of SRC kinases. In addition, radicicol has demonstrated the ability to inhibit K-ras signaling pathway which includes phosphorylation of Raf-1, MAPKK, and MAPK.
A potent inhibitor of Hsp90, SRC, and Cox-2

酒石酸泰洛星

磷酸泰乐菌素

链脲佐菌素

链脲佐菌素是一种氨基葡萄糖-亚硝基脲(glucosamine-nitrosourea)，是一种DNA烷基化试剂，能通过GLUT2葡萄糖转运蛋白（GLUT2 glucose transport protein）独自进入细胞。对胰腺胰岛内胰岛素诱发的β-细胞具毒性。链脲佐菌素对GLUT2 阳性神经内分泌肿瘤细胞有毒性作用。一种含N-亚硝基的化合物，在胰腺胰岛充当一氧化氮的供体；诱导产生糖尿病动物模式的胰岛素分泌细胞的死亡。高效DNA甲基化试剂，能诱发染色体断裂。对表达GLUT2葡萄糖转运体（GLUT2 glucose transporter）的神经内分泌肿瘤细胞系具细胞毒性。医学研究上链脲佐菌素用于诱导Type 1 糖尿病。 医学研究上链脲佐菌素用于诱导Type 1 糖尿病。

Streptozotocin, a glucosamine-nitrosourea, is a DNA alkylating agent that enters cells exclusively via the GLUT2 glucose transport protein. Streptozocin, a diabetagen, is especially toxic to pancreatic islet insulin-producing β-cells. It is toxic to GLUT2 positive neuroendocrine tumor cells.
An NO donor and DNA methylating agent; Streptozotocin is used in medicine as a drug against certain cancers of the Langerhans Islets. It is cytotoxic to neuroendocrine tumor cell lines that express the GLUT2 glucose transporter; Streptozocin is used to induce Type 1 diabetes for medical research.

蛇形菌素标准溶液

Diacetoxyscirpenol is a mycotoxin belonging to 12,13-epoxytrichothecene group, produced by several Fusarium strains together with some other toxins such as T2 and HT2 toxins. Causes fusarium toxicosis in farm animals.Diacetoxyscirpenol (Anguidine) and its derivates possess anticancer properties. Diacetoxyscirpenol (Anguidine) inhibits initiation of protein synthesis, resulting in the death of rapidly proliferating cells. Diacetoxyscirpenol (Anguidine) also has been shown to both potentiate and protect against the cytotoxic effects of other drμgs. There were 14 clinical trials reported, all in the area of colorectal tumors and leukemia. No records found after 1985. Apoptosis inducement.

Diacetoxyscirpenol is a mycotoxin belonging to 12,13-epoxytrichothecene group, produced by several Fusarium strains together with some other toxins such as T2 and HT2 toxins. Causes fusarium toxicosis in farm animals.
Diacetoxyscirpenol (Anguidine) and its derivates possess anticancer properties. Diacetoxyscirpenol (Anguidine) inhibits initiation of protein synthesis, resulting in the death of rapidly proliferating cells. Diacetoxyscirpenol (Anguidine) also has been shown to both potentiate and protect against the cytotoxic effects of other drugs. There were 14 clinical trials reported, all in the area of colorectal tumors and leukemia. No records found after 1985. Apoptosis inducement.