康宁corning耗材 142485 Nunc多孔细胞培养板,聚苯乙烯,带盖,已灭菌,孔数,24,建议工作容量,1.0ml/孔,每包/箱数,5/85 LSP Nunc 85 1CS
日度归档:2023年10月1日
BCTC
上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
BCTC 纯度: 99.49%
BCTC作用于前列腺癌 (PCa) DU145细胞,有效且特异性抑制瞬时受体阳离子通道M成员8(TRPM8)。
BCTC Chemical Structure
CAS No. : 393514-24-4
规格 | 价格 | 是否有货 | 数量 |
---|---|---|---|
Free Sample (0.1-0.5 mg) | Apply now | ||
10 mM * 1 mL in DMSO | ¥660 | In-stock | |
5 mg | ¥600 | In-stock | |
10 mg | ¥800 | In-stock | |
50 mg | ¥2800 | In-stock | |
100 mg | 询价 | ||
200 mg | 询价 |
* Please select Quantity before adding items.
BCTC 相关产品
•相关化合物库:
- Bioactive Compound Library Plus
- Membrane Transporter/Ion Channel Compound Library
- Neuronal Signaling Compound Library
- Anti-Cancer Compound Library
- Orally Active Compound Library
- Mechanoreceptors Compound Library
生物活性 |
BCTC is a potent and specific inhibitor of transient receptor potential cation channel subfamily M member 8 (TRPM8) in prostate cancer (PCa) DU145 cells. Target: TRPM8 in vitro: BCTC is a potent and specific antagonist of TRPM8, exerts an anti-tumor effect on the androgen-independent PCa DU145 cells, and the mechanism of how the inhibition functions. BCTC exerts an anti-proliferative effect on DU145 cells and induces tumor suppression through G0/G1 cell cycle arrest, and inhibition of migration and invasion. BCTC demonstrates excellent anti-tumor activity in PCa DU145 cells, and therefore has the potential to become a targeted therapeutic strategy against PCa. [1] in vivo: BCTC is a potent, selective, and orally bioavailable antagonist of rat VR1. BCTC not only blocks the activation of rat VR1 by capsaicin but also by low pH at the native rat VR1 in a skin-nerve preparation. Thus, BCTC has provided us with an opportunity to test our hypothesis that the inhibition of low pH induced activation of VR1 confers in vivo efficacy in models of chronic pain. This report describes the effects of BCTC in models of inflammatory, neuropathic, and capsaicin-induced pain in the rat. The efficacy and side effect profile of BCTC in these models were compared with those of nonsteroidal anti-inflammatory drugs and antiepileptic drugs currently used for the clinical therapy of inflammatory and neuropathic pain, respectively.[2] |
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分子量 |
372.89 |
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Formula |
C20H25ClN4O |
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CAS 号 |
393514-24-4 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : ≥ 50 mg/mL (134.09 mM) * “≥” means soluble, but saturation unknown. 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
*以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
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参考文献 |
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所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务
康宁corning耗材 142475 Nunc多孔细胞培养板,聚苯乙烯,带盖,已灭菌,孔数,24,建议工作容量,1ml/孔,每包/箱数,1/75 LSP Nunc
康宁corning耗材 142475 Nunc多孔细胞培养板,聚苯乙烯,带盖,已灭菌,孔数,24,建议工作容量,1ml/孔,每包/箱数,1/75 LSP Nunc 75 1CS
康宁corning耗材 141086 12孔载板系统,无小室 LSP Nunc
康宁corning耗材 141086 12孔载板系统,无小室 LSP Nunc 4 1CS
康宁corning耗材 141082 12孔载板系统,8um,12个小室/板,4板/箱 LSP Nunc
康宁corning耗材 141082 12孔载板系统,8um,12个小室/板,4板/箱 LSP Nunc 48 1CS
康宁corning耗材 141080 12孔载板系统,3um,12个小室/板,4板/箱 LSP Nunc
康宁corning耗材 141080 12孔载板系统,3um,12个小室/板,4板/箱 LSP Nunc 48 1CS
异胡豆苷对照品_20824-29-7
【编号】:VIP(X)5454
【产品名称】:异胡豆苷对照品
【规格】:5mg
【价格】:3800元
异胡豆苷对照品
AZD-7762
上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
AZD-7762 纯度: 99.95%
AZD-7762 是一种有效的ATP竞争性的细胞周期检测点激酶 (checkpoint kinase,Chk) 抑制剂,抑制Chk1的 IC50 为 5 nM。
AZD-7762 Chemical Structure
CAS No. : 860352-01-8
规格 | 价格 | 是否有货 | 数量 |
---|---|---|---|
Free Sample (0.1-0.5 mg) | Apply now | ||
10 mM * 1 mL in DMSO | ¥972 | In-stock | |
5 mg | ¥884 | In-stock | |
10 mg | ¥1350 | In-stock | |
50 mg | ¥3900 | In-stock | |
100 mg | ¥6700 | In-stock | |
200 mg | 询价 | ||
500 mg | 询价 |
* Please select Quantity before adding items.
AZD-7762 相关产品
•相关化合物库:
- Clinical Compound Library Plus
- Bioactive Compound Library Plus
- Cell Cycle/DNA Damage Compound Library
- Kinase Inhibitor Library
- Anti-Cancer Compound Library
- Clinical Compound Library
- Anti-Aging Compound Library
- Anti-Blood Cancer Compound Library
生物活性 |
AZD-7762 is a potent ATP-competitive checkpoint kinase (Chk) inhibitor in with an IC50 of 5 nM for Chk1. |
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IC50 & Target[1] |
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体外研究 (In Vitro) |
AZD-7762 (AZD7762) is an equally potent inhibitor of Chk1 and Chk2 in vitro. AZD-7762 potently inhibits Chk1 and Chk2, abrogates DNA damage-induced S and G2 checkpoints, enhances the efficacy of NSC 613327 and SKF 104864A, and modulates downstream checkpoint pathway proteins. AZD-7762 potently inhibits Chk1 phosphorylation of a cdc25C peptide with an IC50 of 5 nM as measured by a scintillation proximity assay. The Ki for AZD-7762 is determined to be 3.6 nM. Kinetic characterization suggests that AZD-7762 binds in the ATP-binding site of Chk1 and is thought to compete directly for ATP binding in a reversible manner. AZD-7762 is shown to abrogate the G2 arrest induced by Camptothecin with an average EC50 of 10 nM (n=12) and maximal abrogation in the range of 100 nM[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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体内研究 (In Vivo) |
In the rat H460-DNp53 xenograft study, AZD-7762 (AZD7762) potentiates the antitumor activity of NSC 613327 in a dose-dependent manner by a decrease in %T/C with increasing dose (48% and 32%, 10 and 20 mg/kg AZD-7762, respectively). In the mouse xenograft study in combination with CPT-11, SW620 established tumors are treated with vehicle, CPT-11 alone, AZD-7762 alone, or AZD-7762 in combination with CPT-11. AZD-7762 dosed alone shows insignificant antitumor activity, whereas CPT-11 alone displays striking and significant activity (%T/C with increasing dose is 9 and 1, respectively ). In combination with AZD-7762, %T/C increases significantly to -66% and -67%, respectively[1]. AZD7762 combination with CX-5461 induces cancer cell death of Tp53-null (Tp53-/-) Eμ-Myc lymphoma cells in vitro and in vivo[2]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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Clinical Trial |
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分子量 |
362.42 |
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Formula |
C17H19FN4O2S |
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CAS 号 |
860352-01-8 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : 100 mg/mL (275.92 mM; Need ultrasonic) 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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Cell Assay [1] |
SW620 (5.5×103 per well) or MDA-MB-231 (5×103 per well) cells are seeded in 96-well plates and incubated overnight. Cells are dosed for 24 h with a 9-point titration of NSC 613327 ranging from 0.01 to 100 nM with or without a constant dose of AZD-7762 (300 nM). Control wells are dosed with vehicle alone (0.1% DMSO) or 300 nM AZD-7762. After 24 h, medium is removed and AZD-7762 alone is added back to the wells treated previously with AZD-7762 for an additional 24 h. Cells are then incubated in drug-free medium for an additional 72 h. The effect on cell proliferation is determined by MTS assay[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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Animal Administration [1][2] |
Mice and Rats[1] 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
参考文献 |
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所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务
hnRNPK-IN-1
上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
hnRNPK-IN-1 纯度: 97.11%
hnRNPK-IN-1 是一种异质核糖核蛋白 K (hnRNPK) 结合配体,用 SPR 和 MST 测量的 Kd 值分别为 4.6 μM 和 2.6 μM。hnRNPK-IN-1 通过破坏 hnRNPK 和 c-myc 启动子的结合来抑制 c-myc 转录。hnRNPK-IN-1诱导 Hela 细胞凋亡 (apoptosis),并具有很强的抗肿瘤活性。
hnRNPK-IN-1 Chemical Structure
CAS No. : 2313528-04-8
规格 | 价格 | 是否有货 | 数量 |
---|---|---|---|
5 mg | ¥5500 | In-stock | |
10 mg | ¥8800 | In-stock | |
25 mg | ¥18000 | In-stock | |
50 mg | ¥30000 | In-stock | |
100 mg | ¥46000 | In-stock | |
200 mg | 询价 | ||
500 mg | 询价 |
* Please select Quantity before adding items.
hnRNPK-IN-1 相关产品
•相关化合物库:
- Bioactive Compound Library Plus
- Apoptosis Compound Library
- Anti-Cancer Compound Library
- Glutamine Metabolism Compound Library
- Transcription Factor Targeted Library
生物活性 |
hnRNPK-IN-1 is a heterogeneous nuclear ribonucleoprotein K (hnRNPK) binding ligand with Kd values of 4.6 μM and 2.6 μM measured with SPR and MST, respectively. hnRNPK-IN-1 inhibits c-myc transcription by disrupting the binding of hnRNPK and c-myc promoter. hnRNPK-IN-1 induces Hela cells apoptosis and has strongly anti-tumor activities[1]. |
IC50 & Target |
Kd: 4.6 μM (hnRNPK; SPR assay) and 2.6 μM (hnRNPK; MST assay)[1] |
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体外研究 (In Vitro) |
hnRNPK-IN-1 (Compound 25; 1.25-5 μM; 24 hours) treatment induces Hela cells apoptosis could be due to its repression of cmyc transcription[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. Apoptosis Analysis[1]
RT-PCR[1]
Western Blot Analysis[1]
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体内研究 (In Vivo) |
hnRNPK-IN-1 (Compound 25; 6.7-20 mg/kg; i.p.; once a day; for three weeks) exhibits good tumor growth inhibition in a Hela xenograft tumor model[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
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分子量 |
419.43 |
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Formula |
C23H21N3O5 |
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CAS 号 |
2313528-04-8 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : 5 mg/mL (11.92 mM; ultrasonic and warming and heat to 80°C) 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
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参考文献 |
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所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务
康宁corning耗材 141078 12孔载板系统,0.4um,12个小室/板,4板/箱 LSP Nunc
康宁corning耗材 141078 12孔载板系统,0.4um,12个小室/板,4板/箱 LSP Nunc 48 1CS
康宁corning耗材 141008 24孔载板系统,无小室 LSP Nunc
康宁corning耗材 141008 24孔载板系统,无小室 LSP Nunc 4 1CS
康宁corning耗材 141006 24孔载板系统,8um,24个小室/板,4板/箱 LSP Nunc
康宁corning耗材 141006 24孔载板系统,8um,24个小室/板,4板/箱 LSP Nunc 96 1CS
康宁corning耗材 141004 24孔载板系统,3um,24个小室/板,4板/箱 LSP Nunc
康宁corning耗材 141004 24孔载板系统,3um,24个小室/板,4板/箱 LSP Nunc 96 1CS
Alprenolol(Synonyms: 阿普洛尔; (RS)-Alprenolol; dl-Alprenolol)
上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
Alprenolol (Synonyms: 阿普洛尔; (RS)-Alprenolol; dl-Alprenolol) 纯度: 99.87%
Alprenolol是一个非选择性的beta阻断剂,也是5-HT1A受体的拮抗剂。
Alprenolol Chemical Structure
CAS No. : 13655-52-2
规格 | 价格 | 是否有货 | 数量 |
---|---|---|---|
50 mg | ¥660 | In-stock | |
100 mg | ¥1100 | In-stock | |
200 mg | 询价 | ||
500 mg | 询价 |
* Please select Quantity before adding items.
Alprenolol 相关产品
•相关化合物库:
- Drug Repurposing Compound Library Plus
- FDA-Approved Drug Library Plus
- FDA-Approved Drug Library Mini
- Bioactive Compound Library Plus
生物活性 |
Alprenolol is a non-selective beta blocker as well as 5-HT1A receptor antagonist. The reference for administration is 10 mg/kg. |
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IC50 & Target |
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分子量 |
249.35 |
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Formula |
C15H23NO2 |
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CAS 号 |
13655-52-2 |
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中文名称 |
阿普洛尔;稀丙洛尔;烯丙洛尔;烯丙心安;心得舒 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
*该产品在溶液状态不稳定,建议您现用现配,即刻使用。 |
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溶解性数据 |
In Vitro:
DMSO : 250 mg/mL (1002.61 mM; Need ultrasonic) H2O : < 0.1 mg/mL (insoluble) 配制储备液
*
请根据产品在不同溶剂中的溶解度,选择合适的溶剂配制储备液;该产品在溶液状态不稳定,建议您现用现配,即刻使用。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务
康宁corning耗材 141002 24孔载板系统,0.4um,24个小室/板,4板/箱 LSP Nunc
康宁corning耗材 141002 24孔载板系统,0.4um,24个小室/板,4板/箱 LSP Nunc 96 1CS
康宁corning耗材 140685 Nunc多孔细胞培养板,聚苯乙烯,带盖,Nunclon△表面,孔数,6,建议工作容量,3ml/孔,每包/箱数5/85 LSP Nunc
康宁corning耗材 140685 Nunc多孔细胞培养板,聚苯乙烯,带盖,Nunclon△表面,孔数,6,建议工作容量,3ml/孔,每包/箱数5/85 LSP Nunc 85 1CS
N-苯乙基肉桂酰胺对照品_103188-43-8
【编号】:VIP(XL)05457
【产品名称】:N-苯乙基肉桂酰胺对照品
【规格】:5mg;98%
【用途】:
N-苯乙基肉桂酰胺对照品
康宁corning耗材 140675 Nunc多孔细胞培养板,聚苯乙烯,带盖,Nunclon△表面,孔数,6,建议工作容量,3ml/孔,每包/箱数1/75 LSP Nunc
康宁corning耗材 140675 Nunc多孔细胞培养板,聚苯乙烯,带盖,Nunclon△表面,孔数,6,建议工作容量,3ml/孔,每包/箱数1/75 LSP Nunc 75 1CS
康宁corning耗材 140156 OmniTracy塑料盘NunclonTM△,外部尺寸128*86mm,聚苯乙烯,已灭菌,数量每包/箱10/90,颜色,透明 LSP Nunc
康宁corning耗材 140156 OmniTracy塑料盘NunclonTM△,外部尺寸128*86mm,聚苯乙烯,已灭菌,数量每包/箱10/90,颜色,透明 LSP Nunc 90 1CS
康宁corning耗材 137103 Nunc F96 MicroWellTM微孔板,聚苯乙烯,外部尺寸128*86mm,颜色,黑色,数量每包/每箱,10/160,表面,细胞培养 LSP Nunc 10
康宁corning耗材 137103 Nunc F96 MicroWellTM微孔板,聚苯乙烯,外部尺寸128*86mm,颜色,黑色,数量每包/每箱,10/160,表面,细胞培养 LSP Nunc 10 160 1CS