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Cyclic-di-GMP disodium(Synonyms: c-di-GMP disodium; cyclic diguanylate disodium; 5GP-5GP disodium)

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Cyclic-di-GMP disodium (Synonyms: c-di-GMP disodium; cyclic diguanylate disodium; 5GP-5GP disodium) 纯度: 98.23%

Cyclic di-GMP (c-di-GMP) disodium 是一种 STING 激活剂和无处不在的第二信使，调节生物膜的形成、运动和各种细菌的毒力。

Cyclic-di-GMP disodium(Synonyms: c-di-GMP disodium; cyclic diguanylate disodium; 5GP-5GP disodium)

Cyclic-di-GMP disodium Chemical Structure

CAS No. : 2222132-40-1

规格 价格 是否有货 数量
1 mg ￥2500 In-stock
5 mg ￥7500 In-stock
10 mg ￥12000 In-stock
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Cyclic-di-GMP disodium 相关产品

•相关化合物库:

  • Bioactive Compound Library Plus

生物活性

Cyclic di-GMP (c-di-GMP) disodium is a STING activator and a global bacterial second messenger, which regulates biofilm formation, motility, and virulence in diverse bacterial species[1][2].

IC50 & Target

STING[1]
分子量

734.37

Formula

C20H22N10Na2O14P2
CAS 号

2222132-40-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-80°C, protect from light, stored under nitrogen
溶解性数据
In Vitro: 

H2O : 160 mg/mL (217.87 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.3617 mL 6.8086 mL 13.6171 mL
5 mM 0.2723 mL 1.3617 mL 2.7234 mL
10 mM 0.1362 mL 0.6809 mL 1.3617 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months (protect from light, stored under nitrogen)。-80°C 储存时，请在 6 个月内使用。
参考文献

  • [1]. Wang Z, et, al. STING activator c-di-GMP enhances the anti-tumor effects of peptide vaccines in melanoma-bearing mice. Cancer Immunol Immunother. 2015 Aug;64(8):1057-66.

    [2]. Burdette DL, et, al. STING is a direct innate immune sensor of cyclic di-GMP. Nature. 2011 Sep 25;478(7370):515-8.

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DI-591

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DI-591  纯度: 98.36%

DI-591 是一种有效，高亲和力和细胞渗透性的 DCN1-UBC12 相互作用的抑制剂。DI-591 分别以 Ki 值为 12 nM 和 10.4 nM 与 DCN1 和 DCN2 结合，并且几乎不与 DCN3，DCN4 和 DCN5 蛋白结合。DI-591 选择性抑制 cullin 3 的二烯化，但对其他 cullin 家族成员的二烯化没有影响或影响很小。

DI-591

DI-591 Chemical Structure

CAS No. : 2245887-38-9

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10 mg ￥9800 In-stock
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DI-591 相关产品

•相关化合物库:

  • Bioactive Compound Library Plus

生物活性

DI-591 is a potent, high-affinity and cell-permeable inhibitor of the DCN1-UBC12 interaction. DI-591 binds to DCN1 and DCN2 with Ki values of 12 nM and 10.4 nM, respectively and has no appreciable binding to DCN3, DCN4, and DCN5 proteins. DI-591 selectively inhibits neddylation of cullin 3 but has no or minimal effect on neddylation of other cullin family members[1].

IC50 & Target

DCN1-UBC12[1]
体外研究
(In Vitro)

DI-591 (Compound 44) binds to DCN1 and DCN2 with Ki values of 12 nM and 10.4 nM, respectively and has no appreciable binding to DCN3, DCN4, and DCN5 proteins. Hence, DI-591 displays a very-high binding affinity to recombinant human DCN1 and DCN2 proteins and >1000-fold selectivity over recombinant human DCN3-5 proteins[1].
DI-591 (Compound 44; 0-10 μM; 1 hour; KYSE70 cells) binds to both cellular DCN1 and DCN2 proteins and disrupts the association of cellular DCN1 and UBC12 proteins[1].
DI-591 (Compound 44; 10 μM; 24 hours; THLE2 cells) treatment robustly increases the mRNA levels of NQO1 and HO1, leading to upregulation of HO1 protein in the cells. Significantly, DI-591 has no effect on the mRNA level of NRF2[1].
The selective inhibition of neddylation of cullin 3 by DI-591 leads to accumulation NRF2 protein and its transcriptional activation. Knockdown experiments indicate that DCN1, but not DCN2, plays a key role in regulation of neddylation of cullin 3 but not of other cullins. DI-591 is an excellent probe compound to investigate the role of the cullin 3 CRL (Cullin-RING E3 ubiquitin ligase) in biological processes and human diseases[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: KYSE70 cells
Concentration: 0 μM, 1 μM, 3 Μm or 10 μM
Incubation Time: 1 hour
Result: Potently bound to cellular DCN1 and DCN2 proteins. Enhanced the stability of DCN1 and DCN2 protein in a dose-dependent manner.

RT-PCR[1]

Cell Line: THLE2 cells
Concentration: 10 μM
Incubation Time: 24 hours
Result: Robustly increases the mRNA levels of NQO1 and HO1.

分子量

585.80

Formula

C31H47N5O4S
CAS 号

2245887-38-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 12.5 mg/mL (21.34 mM; ultrasonic and warming and heat to 60°C)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.7071 mL 8.5353 mL 17.0707 mL
5 mM 0.3414 mL 1.7071 mL 3.4141 mL
10 mM 0.1707 mL 0.8535 mL 1.7071 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1.25 mg/mL (2.13 mM); Clear solution

    此方案可获得 ≥ 1.25 mg/mL (2.13 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 12.5 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 1.25 mg/mL (2.13 mM); Clear solution

    此方案可获得 ≥ 1.25 mg/mL (2.13 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 12.5 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
  • 3.

    请依序添加每种溶剂： 10% DMSO    90% corn oil

    Solubility: ≥ 1.25 mg/mL (2.13 mM); Clear solution

    此方案可获得 ≥ 1.25 mg/mL (2.13 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 12.5 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
参考文献

  • [1]. Zhou H, et al. A potent small-molecule inhibitor of the DCN1-UBC12 interaction that selectively blocks cullin 3 neddylation. Nat Commun. 2017 Oct 27;8(1):1150.

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Mc-O-Si(di-iso)-Cl

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Mc-O-Si(di-iso)-Cl 

Mc-O-Si(di-iso)-Cl 是一种可降解 (cleavable) 的 ADC linker，可用于合成抗体偶联药物 (ADC)，例如 Gemcitabine-O-Si(di-iso)-O-Mc (HY-130812)。

Mc-O-Si(di-iso)-Cl

Mc-O-Si(di-iso)-Cl Chemical Structure

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生物活性

Mc-O-Si(di-iso)-Cl is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs), such as Gemcitabine-O-Si(di-iso)-O-Mc (HY-130812) )[1].

IC50 & Target[1]

Cleavable

 

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker)[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

331.91

Formula

C15H26ClNO3Si
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Finniss, M. C., et al. A versatile acid-labile linker for antibody–drug conjugates. Med. Chem. Commun., 2014, 5(9), 1355-1358.

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MAL-di-EG-Val-Cit-PAB-MMAF

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MAL-di-EG-Val-Cit-PAB-MMAF  纯度: 98.02%

MAL-di-EG-Val-Cit-PAB-MMAF 由ADC linker (MAL-di-EG-Val-Cit-PAB) 和有效的微管蛋白聚合阻断剂 (MMAF, Monomethyl auristatin F) 组成。

MAL-di-EG-Val-Cit-PAB-MMAF

MAL-di-EG-Val-Cit-PAB-MMAF Chemical Structure

规格 价格 是否有货 数量
5 mg ￥10200 In-stock
10 mg ￥16200 In-stock
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生物活性

MAL-di-EG-Val-Cit-PAB-MMAF consists the ADCs linker (MAL-di-EG-Val-Cit-PAB) and potent tubulin polymerization blocker (MMAF, Monomethyl auristatin F)[1].

IC50 & Target

Auristatin

 

分子量

1476.75

Formula

C73H113N13O19
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, stored under nitrogen

*该产品在溶液状态不稳定，建议您现用现配，即刻使用。
溶解性数据
In Vitro: 

DMSO : 230 mg/mL (155.75 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.6772 mL 3.3858 mL 6.7716 mL
5 mM 0.1354 mL 0.6772 mL 1.3543 mL
10 mM 0.0677 mL 0.3386 mL 0.6772 mL

*

请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液；该产品在溶液状态不稳定，建议您现用现配，即刻使用。
参考文献

  • [1]. McCombs JR, et al. Antibody drug conjugates: design and selection of linker, payload and conjugation chemistry. AAPS J. 2015 Mar;17(2):339-51.

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DI-87

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DI-87 

DI-87 是一种具有口服活性的，选择性的脱氧胞苷激酶 (dCK) 抑制剂，EC50 为 10.2 nM。DI-87 具有抗肿瘤活性，可通过联合用药来抑制表达 dCK 的肿瘤。

DI-87

DI-87 Chemical Structure

CAS No. : 2107280-55-5

规格 价格 是否有货
5 mg ￥8500 询问价格 & 货期
10 mg ￥14500 询问价格 & 货期

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生物活性

DI-87 is an orally active and selective deoxycytidine kinase (dCK) inhibitor with an EC50 of 10.2 nM. DI-87 has antitumor activity and is used in combination therapy against tumors expressing dCK[1].

IC50 & Target

EC50: 10.2 nM (dCK)[1]
体外研究
(In Vitro)

(S)-DI-87 exhibits a much higher IC50 value (IC50=468 nM) relative to DI-87 ((R)-DI-8) (IC50=3.15 nM) in CEM T-ALL cells for inhibition of dCK activity[1].
DI-87 (1 µM; for 72 hours) rescues human cell line CCRF-CEM (CEM) cells from the anti-proliferative effects of gemcitabine, a dCK-dependent nucleoside analog prodrug, with an EC50 of 10.2 nM[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

DI-87 (5-25 mg/kg; oral gavage) exhibits full dCK inhibition for 27 hours, and enzyme activity fully recovered by 36 hours with 25 mg/kg dose[1].
DI-87 (10-50 mg/kg; oral) has plasma concentrations of between 1 and 3 hours and plasma half-life of 4 hours[1].
DI-87 (10 mg/kg/day or 25 mg/kg/twice a day; oral; for 16-18 days) with thymidine (2 g/kg; ip; twice a day) results in reduced tumor growth in male NSG mice implanted with CEM tumors[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 8-12 week-old male or female NSG mice with CEM tumor xenografts[1]
Dosage: 5, 10, 25 mg/kg
Administration: Oral gavage
Result: The 25 mg/kg dose exhibited full dCK inhibition for 27 hours, and enzyme activity fully recovered by 36 hours. The 10 mg/kg dose resulted in full inhibition with recovery initiating at the 12 hours time point. The 5 mg/kg dose resulted in minimal dCK inhibition with rapid recovery.
Animal Model: Female NSG mice with CEM tumors[1]
Dosage: 10, 25, or 50 mg/kg
Administration: Oral
Result: Had plasma concentrations of between 1 and 3 hours and plasma half-life of 4 hours.
Had tumor concentrations lower than plasma and had a later, more sustained peak at 3-9 hours.

分子量

502.65

Formula

C23H30N6O3S2
CAS 号

2107280-55-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Soumya Poddar, et al. Development and Preclinical Pharmacology of a Novel dCK Inhibitor, DI-87. Biochem Pharmacol. 2020 Feb;172:113742.

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Di(N-succinimidyl)adipate

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Di(N-succinimidyl)adipate 

Di(N-succinimidyl)adipate 是一种 PROTAC linker，属于 alkyl chain 类。可用于合成 PROTAC 分子。

Di(N-succinimidyl)adipate

Di(N-succinimidyl)adipate Chemical Structure

CAS No. : 59156-70-6

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生物活性

Di(N-succinimidyl)adipate is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

Alkyl-Chain

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

340.29

Formula

C14H16N2O8
CAS 号

59156-70-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

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Di(N-succinimidyl)adipate

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Di(N-succinimidyl)adipate 

Di(N-succinimidyl)adipate 是一种 PROTAC linker，属于 alkyl chain 类。可用于合成 PROTAC 分子。

Di(N-succinimidyl)adipate

Di(N-succinimidyl)adipate Chemical Structure

CAS No. : 59156-70-6

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

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生物活性

Di(N-succinimidyl)adipate is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

Alkyl-Chain

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

340.29

Formula

C14H16N2O8
CAS 号

59156-70-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

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PEG di-iodoacetate, IA-PEG-IA Cat. No. PG2-IA-5k 5000 Da 100 mg修饰性聚乙二醇

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PEG di-iodoacetate, IA-PEG-IA

Cat. No. PG2-IA-5k PEG di-iodoacetate, IA-PEG-IA Cat. No. PG2-IA-5k 5000 Da 100 mg
Specification 5000 Da
Unit Size 100 mg
Price $285.00

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Description:

Iodoacetyl (IA) functionalized polyethylene glycol (IA PEG) is a thiol (-SH) group reactive PEG derivative that can be used to modify biomolecules or other materials via their available thiol groups. Iodine group can be easily replaced by thiol group to form a stable carbon thiol bond.

Physical Properties:

  • Off-white/white solid or viscous liquid depends on molecule weight;
  • Soluble in regular aqeous solution as well as most organic solvents;

Storage Conditions:

  • Store at -20 0C, dessiccated Protect from light. Avoid frequent thaw and freeze.
Documents
  • SDS
  • DataSheet

PEG Di-acrylate, Acrylate PEG Acrylate Cat. No. PG2-ACR-5k 5000 Da 1 g修饰性聚乙二醇

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PEG Di-acrylate, Acrylate PEG Acrylate

Cat. No. PG2-ACR-5k PEG Di-acrylate, Acrylate PEG Acrylate Cat. No. PG2-ACR-5k 5000 Da 1 g
Specification 5000 Da
Unit Size 1 g
Price $385.00

Qty Add to Cart

Description:

Acrylate functionalized polyethylene glycol (PEG Acrylate) is a reactive PEG derivative that can be used to modify proteins, peptides and other materials via available acrylic groups. It is also a polymerizable PEG that can form biocompatible hydrogel. PEGylation can increase solubility and stability and reduce immunogenicity of peptides and proteins. It can also suppress the non-specific binding of charged molecules to the modified surfaces.

Physical Properties:

  • Off-white/white solid or viscous liquid depends on molecule weight;
  • Soluble in regular aqeous solution as well as most organic solvents;

Storage Conditions:

  • Store at -20 0C, dessiccated Protect from light. Avoid frequent thaw and freeze.
Documents
  • SDS
  • DataSheet

PEG di-iodoacetate, IA-PEG-IA Cat. No. PG2-IA-3k 3400 Da 100 mg修饰性聚乙二醇

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PEG di-iodoacetate, IA-PEG-IA

Cat. No. PG2-IA-3k PEG di-iodoacetate, IA-PEG-IA Cat. No. PG2-IA-3k 3400 Da 100 mg
Specification 3400 Da
Unit Size 100 mg
Price $325.00

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Description:

Iodoacetyl (IA) functionalized polyethylene glycol (IA PEG) is a thiol (-SH) group reactive PEG derivative that can be used to modify biomolecules or other materials via their available thiol groups. Iodine group can be easily replaced by thiol group to form a stable carbon thiol bond.

Physical Properties:

  • Off-white/white solid or viscous liquid depends on molecule weight;
  • Soluble in regular aqeous solution as well as most organic solvents;

Storage Conditions:

  • Store at -20 0C, dessiccated Protect from light. Avoid frequent thaw and freeze.
Documents
  • SDS
  • DataSheet

PEG Di-acrylate, Acrylate PEG Acrylate Cat. No. PG2-ACR-3k 3400 Da 1 g修饰性聚乙二醇

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上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

PEG Di-acrylate, Acrylate PEG Acrylate

Cat. No. PG2-ACR-3k PEG Di-acrylate, Acrylate PEG Acrylate Cat. No. PG2-ACR-3k 3400 Da 1 g
Specification 3400 Da
Unit Size 1 g
Price $385.00

Qty Add to Cart

Description:

Acrylate functionalized polyethylene glycol (PEG Acrylate) is a reactive PEG derivative that can be used to modify proteins, peptides and other materials via available acrylic groups. It is also a polymerizable PEG that can form biocompatible hydrogel. PEGylation can increase solubility and stability and reduce immunogenicity of peptides and proteins. It can also suppress the non-specific binding of charged molecules to the modified surfaces.

Physical Properties:

  • Off-white/white solid or viscous liquid depends on molecule weight;
  • Soluble in regular aqeous solution as well as most organic solvents;

Storage Conditions:

  • Store at -20 0C, dessiccated Protect from light. Avoid frequent thaw and freeze.
Documents
  • SDS
  • DataSheet

PEG di-iodoacetate, IA-PEG-IA Cat. No. PG2-IA-2k 2000 Da 100 mg修饰性聚乙二醇

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上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

PEG di-iodoacetate, IA-PEG-IA

Cat. No. PG2-IA-2k PEG di-iodoacetate, IA-PEG-IA Cat. No. PG2-IA-2k 2000 Da 100 mg
Specification 2000 Da
Unit Size 100 mg
Price $385.00

Qty Add to Cart

Description:

Iodoacetyl (IA) functionalized polyethylene glycol (IA PEG) is a thiol (-SH) group reactive PEG derivative that can be used to modify biomolecules or other materials via their available thiol groups. Iodine group can be easily replaced by thiol group to form a stable carbon thiol bond.

Physical Properties:

  • Off-white/white solid or viscous liquid depends on molecule weight;
  • Soluble in regular aqeous solution as well as most organic solvents;

Storage Conditions:

  • Store at -20 0C, dessiccated Protect from light. Avoid frequent thaw and freeze.
Documents
  • SDS
  • DataSheet

PEG Di-acrylate, Acrylate PEG Acrylate Cat. No. PG2-ACR-2k 2000 Da 1 g修饰性聚乙二醇

发表于由

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

PEG Di-acrylate, Acrylate PEG Acrylate

Cat. No. PG2-ACR-2k PEG Di-acrylate, Acrylate PEG Acrylate Cat. No. PG2-ACR-2k 2000 Da 1 g
Specification 2000 Da
Unit Size 1 g
Price $385.00

Qty Add to Cart

Description:

Acrylate functionalized polyethylene glycol (PEG Acrylate) is a reactive PEG derivative that can be used to modify proteins, peptides and other materials via available acrylic groups. It is also a polymerizable PEG that can form biocompatible hydrogel. PEGylation can increase solubility and stability and reduce immunogenicity of peptides and proteins. It can also suppress the non-specific binding of charged molecules to the modified surfaces.

Physical Properties:

  • Off-white/white solid or viscous liquid depends on molecule weight;
  • Soluble in regular aqeous solution as well as most organic solvents;

Storage Conditions:

  • Store at -20 0C, dessiccated Protect from light. Avoid frequent thaw and freeze.
Documents
  • SDS
  • DataSheet

PEG di-iodoacetate, IA-PEG-IA Cat. No. PG2-IA-1k 1000 Da 100 mg修饰性聚乙二醇

发表于由

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

PEG di-iodoacetate, IA-PEG-IA

Cat. No. PG2-IA-1k PEG di-iodoacetate, IA-PEG-IA Cat. No. PG2-IA-1k 1000 Da 100 mg
Specification 1000 Da
Unit Size 100 mg
Price $425.00

Qty Add to Cart

Description:

Iodoacetyl (IA) functionalized polyethylene glycol (IA PEG) is a thiol (-SH) group reactive PEG derivative that can be used to modify biomolecules or other materials via their available thiol groups. Iodine group can be easily replaced by thiol group to form a stable carbon thiol bond.

Physical Properties:

  • Off-white/white solid or viscous liquid depends on molecule weight;
  • Soluble in regular aqeous solution as well as most organic solvents;

Storage Conditions:

  • Store at -20 0C, dessiccated Protect from light. Avoid frequent thaw and freeze.
Documents
  • SDS
  • DataSheet

PEG Di-acrylate, Acrylate PEG Acrylate Cat. No. PG2-ACR-10k 10000 Da 1 g修饰性聚乙二醇

发表于由

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

PEG Di-acrylate, Acrylate PEG Acrylate

Cat. No. PG2-ACR-10k PEG Di-acrylate, Acrylate PEG Acrylate Cat. No. PG2-ACR-10k 10000 Da 1 g
Specification 10000 Da
Unit Size 1 g
Price $385.00

Qty Add to Cart

Description:

Acrylate functionalized polyethylene glycol (PEG Acrylate) is a reactive PEG derivative that can be used to modify proteins, peptides and other materials via available acrylic groups. It is also a polymerizable PEG that can form biocompatible hydrogel. PEGylation can increase solubility and stability and reduce immunogenicity of peptides and proteins. It can also suppress the non-specific binding of charged molecules to the modified surfaces.

Physical Properties:

  • Off-white/white solid or viscous liquid depends on molecule weight;
  • Soluble in regular aqeous solution as well as most organic solvents;

Storage Conditions:

  • Store at -20 0C, dessiccated Protect from light. Avoid frequent thaw and freeze.
Documents
  • SDS
  • DataSheet

PEG Di-acrylate, Acrylate PEG Acrylate Cat. No. PG2-ACR-20k 20000 Da 1 g修饰性聚乙二醇

发表于由

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

PEG Di-acrylate, Acrylate PEG Acrylate

Cat. No. PG2-ACR-20k PEG Di-acrylate, Acrylate PEG Acrylate Cat. No. PG2-ACR-20k 20000 Da 1 g
Specification 20000 Da
Unit Size 1 g
Price $385.00

Qty Add to Cart

Description:

Acrylate functionalized polyethylene glycol (PEG Acrylate) is a reactive PEG derivative that can be used to modify proteins, peptides and other materials via available acrylic groups. It is also a polymerizable PEG that can form biocompatible hydrogel. PEGylation can increase solubility and stability and reduce immunogenicity of peptides and proteins. It can also suppress the non-specific binding of charged molecules to the modified surfaces.

Physical Properties:

  • Off-white/white solid or viscous liquid depends on molecule weight;
  • Soluble in regular aqeous solution as well as most organic solvents;

Storage Conditions:

  • Store at -20 0C, dessiccated Protect from light. Avoid frequent thaw and freeze.
Documents
  • SDS
  • DataSheet

Cyclic-di-GMP sodium(Synonyms: c-di-GMP sodium; cyclic diguanylate sodium; 5GP-5GP sodium)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Cyclic-di-GMP sodium (Synonyms: c-di-GMP sodium; cyclic diguanylate sodium; 5GP-5GP sodium)

Cyclic di-GMP sodium (c-di-GMP sodium) 是一种 STING 激活剂和无处不在的第二信使，调节生物膜的形成、运动和各种细菌的毒力。

Cyclic-di-GMP sodium(Synonyms: c-di-GMP sodium; cyclic diguanylate sodium; 5GP-5GP sodium)

Cyclic-di-GMP sodium Chemical Structure

规格 价格 是否有货
1 mg ￥2500 询问价格 & 货期
5 mg ￥7500 询问价格 & 货期

* Please select Quantity before adding items.

Cyclic-di-GMP sodium 的其他形式现货产品:

Cyclic-di-GMP Cyclic-di-GMP diammonium Cyclic-di-GMP disodium

生物活性

Cyclic di-GMP sodium (c-di-GMP sodium) is a STING activator and a global bacterial second messenger, which regulates biofilm formation, motility, and virulence in diverse bacterial species[1][2].

Formula

C20H24N10O14P2.xNa
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Burdette DL, Monroe KM, Sotelo-Troha K, et al. STING is a direct innate immune sensor of cyclic di-GMP. Nature. 2011;478(7370):515-518. Published 2011 Sep 25.

    [2]. Wang Z, et al. STING activator c-di-GMP enhances the anti-tumor effects of peptide vaccines in melanoma-bearing mice. Cancer Immunol Immunother. 2015;64(8):1057-1066.

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Cyclic-di-GMP sodium(Synonyms: c-di-GMP sodium; cyclic diguanylate sodium; 5GP-5GP sodium)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Cyclic-di-GMP sodium (Synonyms: c-di-GMP sodium; cyclic diguanylate sodium; 5GP-5GP sodium)

Cyclic di-GMP sodium (c-di-GMP sodium) 是一种 STING 激活剂和无处不在的第二信使，调节生物膜的形成、运动和各种细菌的毒力。

Cyclic-di-GMP sodium(Synonyms: c-di-GMP sodium; cyclic diguanylate sodium; 5GP-5GP sodium)

Cyclic-di-GMP sodium Chemical Structure

规格 价格 是否有货
1 mg ￥2500 询问价格 & 货期
5 mg ￥7500 询问价格 & 货期

* Please select Quantity before adding items.

Cyclic-di-GMP sodium 的其他形式现货产品:

Cyclic-di-GMP Cyclic-di-GMP diammonium Cyclic-di-GMP disodium

生物活性

Cyclic di-GMP sodium (c-di-GMP sodium) is a STING activator and a global bacterial second messenger, which regulates biofilm formation, motility, and virulence in diverse bacterial species[1][2].

Formula

C20H24N10O14P2.xNa
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Burdette DL, Monroe KM, Sotelo-Troha K, et al. STING is a direct innate immune sensor of cyclic di-GMP. Nature. 2011;478(7370):515-518. Published 2011 Sep 25.

    [2]. Wang Z, et al. STING activator c-di-GMP enhances the anti-tumor effects of peptide vaccines in melanoma-bearing mice. Cancer Immunol Immunother. 2015;64(8):1057-1066.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Cyclic-di-GMP sodium(Synonyms: c-di-GMP sodium; cyclic diguanylate sodium; 5GP-5GP sodium)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Cyclic-di-GMP sodium (Synonyms: c-di-GMP sodium; cyclic diguanylate sodium; 5GP-5GP sodium)

Cyclic di-GMP sodium (c-di-GMP sodium) 是一种 STING 激活剂和无处不在的第二信使，调节生物膜的形成、运动和各种细菌的毒力。

Cyclic-di-GMP sodium(Synonyms: c-di-GMP sodium; cyclic diguanylate sodium; 5GP-5GP sodium)

Cyclic-di-GMP sodium Chemical Structure

规格 价格 是否有货
1 mg ￥2500 询问价格 & 货期
5 mg ￥7500 询问价格 & 货期

* Please select Quantity before adding items.

Cyclic-di-GMP sodium 的其他形式现货产品:

Cyclic-di-GMP Cyclic-di-GMP diammonium Cyclic-di-GMP disodium

生物活性

Cyclic di-GMP sodium (c-di-GMP sodium) is a STING activator and a global bacterial second messenger, which regulates biofilm formation, motility, and virulence in diverse bacterial species[1][2].

Formula

C20H24N10O14P2.xNa
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Burdette DL, Monroe KM, Sotelo-Troha K, et al. STING is a direct innate immune sensor of cyclic di-GMP. Nature. 2011;478(7370):515-518. Published 2011 Sep 25.

    [2]. Wang Z, et al. STING activator c-di-GMP enhances the anti-tumor effects of peptide vaccines in melanoma-bearing mice. Cancer Immunol Immunother. 2015;64(8):1057-1066.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

4′,4”’-Di-O-methylisochamaejasmin

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

4′,4”’-Di-O-methylisochamaejasmin 

4′,4”’-Di-O-methylisochamaejasmin 具有抗肿瘤效果。

4

4′,4”’-Di-O-methylisochamaejasmin Chemical Structure

CAS No. : 1620921-68-7

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

4′,4”’-Di-O-methylisochamaejasminexhibits anti-cancer effect[1].

分子量

570.54

Formula

C32H26O10
CAS 号

1620921-68-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Application of stellera chamaejasme extract in anti-cancer effect. CN103933027A.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务